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公开(公告)号：US5145962A
公开(公告)日：1992-09-08
申请号：US681828
申请日：1991-04-08
IPC分类号： C07K14/64
CPC分类号： C07K14/64 , Y10S530/851 , Y10S530/853
摘要： Genes and DNA transfer vector for the expression of human preprorelaxin; subunits thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Methods for synthesis of the peptides involving recombinant DNA techniques.
摘要翻译： 用于表达人类前释放酶的基因和DNA转移载体; 其包括用于表达人促松弛素的基因和转移载体及其单独的A，B和C肽链; 和所有这些基因的等同物。 涉及重组DNA技术的肽的合成方法。
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公开(公告)号：US5179195A
公开(公告)日：1993-01-12
申请号：US665129
申请日：1991-03-06
IPC分类号： C07K14/64
CPC分类号： C07K14/64 , Y10S530/851 , Y10S530/853
摘要： Genes and DNA transfer vectors for the expression of human preprorelaxin; sub-units thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Methods for synthesis of the peptides involving recombinant DNA techniques.
摘要翻译： 用于表达人类前释放蛋白的基因和DNA转移载体; 亚单位，包括人prorelaxin表达的基因和转移载体及其各自的A，B和C肽链; 和所有这些基因的等同物。 涉及重组DNA技术的肽的合成方法。
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3.发明授权Molecular cloning and characterization of a further gene sequence coding for human relaxin 失效编码人类松弛素的另一个基因序列的分子克隆和表征
公开(公告)号：US4758516A
公开(公告)日：1988-07-19
申请号：US560790
申请日：1983-12-13
IPC分类号： C07H21/02 , A61K38/22 , A61P13/02 , A61P15/00 , C07H21/04 , C07K1/113 , C07K14/575 , C07K14/64 , C12N1/00 , C12N1/21 , C12N15/00 , C12N15/09 , C12P21/00 , C12P21/02 , C12R1/00 , C12R1/19 , C12N1/20 , C07H17/00
CPC分类号： C07K14/64
摘要： Genes and DNA transfer vectors for the expression of human preprorelaxin; sub-units thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Methods for synthesis of the peptides involving recombinant DNA techniques.
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4.发明授权Process for synthesizing human H2-prorelaxin, human H2-relaxin and fusion proteins thereof 失效合成人H2-松弛素，人H2-松弛素及其融合蛋白的方法
公开(公告)号：US5326694A
公开(公告)日：1994-07-05
申请号：US871318
申请日：1992-04-20
CPC分类号： C07K14/64 , Y10S530/851 , Y10S530/853
摘要： Genes and DNA transfer vectors for the expression of human preprorelaxin; sub-units thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Methods for synthesis of the peptides involving recombinant DNA techniques.
摘要翻译： 用于表达人类前释放蛋白的基因和DNA转移载体; 亚单位，包括人prorelaxin表达的基因和转移载体及其各自的A，B和C肽链; 和所有这些基因的等同物。 涉及重组DNA技术的肽的合成方法。
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5.发明授权Process for synthesizing human H1-prorelaxin, H1-relaxin and fusion proteins thereof 失效人H1-前舒缩素，H1-松弛素及其融合蛋白的合成方法
公开(公告)号：US5320953A
公开(公告)日：1994-06-14
申请号：US921090
申请日：1992-07-29
CPC分类号： C07K14/64
摘要： Genes and DNA transfer vector for the expression of human prepororelaxin; subunits thereof, including genes and transfer vectors for expression of human profelaxin and the individual A, B and C peptide chains thereof; and equivalents of al such genes. Methods for synthesis of the peptides involving recombinant DNA techniques.
摘要翻译： 用于人类前激素的表达的基因和DNA转移载体; 其包括用于表达人类profelaxin及其个体A，B和C肽链的基因和转移载体; 和这些基因的等价物。 涉及重组DNA技术的肽的合成方法。
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6.发明授权Molecular cloning and characterization of a gene sequence coding for human relaxin 失效编码人类松弛素的基因序列的分子克隆和表征
公开(公告)号：US5053488A
公开(公告)日：1991-10-01
申请号：US549668
申请日：1990-07-06
IPC分类号： C07K14/64
CPC分类号： C07K14/64 , Y10S530/851 , Y10S530/853
摘要： Genes and DNA transfer vectors for the expression of human preprorelaxin; sub-units thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Method for synthesis of the peptides involving recombinant DNA techniques are provided.
摘要翻译： 用于表达人类前释放蛋白的基因和DNA转移载体; 亚单位，包括人prorelaxin表达的基因和转移载体及其单独的A，B和C肽链; 和所有这些基因的等同物。 提供了涉及重组DNA技术的肽的合成方法。
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7.发明授权Molecular cloning and characterization of a gene sequence coding for human relaxin 失效编码人类松弛素的基因序列的分子克隆和表征
公开(公告)号：US4871670A
公开(公告)日：1989-10-03
申请号：US863819
申请日：1986-05-12
IPC分类号： A61K38/22 , A61P13/02 , A61P15/00 , C07H21/04 , C07K1/113 , C07K14/00 , C07K14/41 , C07K14/575 , C07K14/64 , C07K19/00 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/12 , C12P19/34 , C12P21/00 , C12P21/02 , C12R1/19
CPC分类号： C07K14/64 , Y10S930/30
摘要： Genes and DNA transfer vectors for the expression of human preprorelaxin; sub-units thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Methods for synthesis of the peptides involving recombinant DNA techniques.
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8.发明授权Molecular cloning and characterization of a further gene sequence coding for human relaxin 失效编码人类松弛素的另一个基因序列的分子克隆和表征
公开(公告)号：US5023321A
公开(公告)日：1991-06-11
申请号：US21885
申请日：1987-03-04
IPC分类号： C07K14/64
CPC分类号： C07K14/64 , Y10S530/851 , Y10S530/853
摘要： Genes and DNA transfer vectors for the expression of human preprorelaxin; sub-units thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Methods for synthesis of the peptides involving recombinant DNA techniques.
摘要翻译： 用于表达人类前释放蛋白的基因和DNA转移载体; 亚单位，包括人prorelaxin表达的基因和转移载体及其各自的A，B和C肽链; 和所有这些基因的等同物。 涉及重组DNA技术的肽的合成方法。
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公开(公告)号：US20120171115A1
公开(公告)日：2012-07-05
申请号：US13383836
申请日：2010-12-23
IPC分类号： C07K16/00 , C07K16/18 , A61K39/395 , C12N15/13 , C12N15/63 , C12P21/02 , C12N1/21 , C07K17/00 , C12N5/02 , G01N33/53 , A61K49/00 , A61K49/16 , C12N1/19 , C12N5/10 , C07K16/22
CPC分类号： C07K16/30 , A61K47/60 , A61K49/0002 , C07K16/3092 , C07K16/32 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2319/21
摘要： The present invention provides an isolated protein comprising an immunoglobulin variable region comprising at least two cysteine residues positioned within framework region (FR) 2 and/or at least two cysteine residues positioned within framework region (FR3), wherein if at least two of the cysteine residues in FR2 and/or FR3 are not conjugated to a compound then an intra-framework disulphide bond is capable of forming between the cysteine residues. Preferably the protein comprises an immunoglobulin heavy chain variable region (VH) and an immunoglobulin light chain variable region (VL), wherein at least one of the variable regions comprises the two cysteine residues. The present invention also provides conjugates of the protein and another compound.
摘要翻译： 本发明提供了分离的蛋白质，其包含免疫球蛋白可变区，其包含位于框架区（FR）2内的至少两个半胱氨酸残基和/或位于框架区（FR3）内的至少两个半胱氨酸残基），其中如果半胱氨酸 FR2和/或FR3中的残基不与化合物缀合，则骨架内二硫键能够在半胱氨酸残基之间形成。 优选地，蛋白质包含免疫球蛋白重链可变区（VH）和免疫球蛋白轻链可变区（VL），其中至少一个可变区包含两个半胱氨酸残基。 本发明还提供了蛋白质和另一种化合物的缀合物。
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公开(公告)号：US09290577B2
公开(公告)日：2016-03-22
申请号：US13383578
申请日：2010-07-02
申请人： Peter J. Hudson , Paul R. Sanders , Debra Tamvakis , Fabio Turatti , Michael P. Wheatcroft , David Leong
发明人： Peter J. Hudson , Paul R. Sanders , Debra Tamvakis , Fabio Turatti , Michael P. Wheatcroft , David Leong
CPC分类号： C07K16/30 , A61K47/6879 , A61K51/10 , A61K51/1093 , A61K2039/505 , C07K16/3092 , C07K16/32 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2319/31
摘要： The present invention provides an isolated protein comprising an immunoglobulin variable region comprising at least two cysteine residues positioned within framework region 1 such that if at least two of the cysteine residues are not conjugated to another compound a disulphide bond forms between the cysteine residues. Preferably the protein comprises an immunoglobulin heavy chain variable region and an immunoglobulin light chain variable region, wherein at least one of the variable regions comprises the two cysteine residues. The present invention also provides a protein that binds to TAG72. The present invention also provides conjugates of the protein and another compound.
摘要翻译： 本发明提供了分离的蛋白质，其包含免疫球蛋白可变区，其包含位于框架区1内的至少两个半胱氨酸残基，使得如果至少两个半胱氨酸残基不与另一化合物缀合，则在半胱氨酸残基之间形成二硫键。 优选地，蛋白质包含免疫球蛋白重链可变区和免疫球蛋白轻链可变区，其中至少一个可变区包含两个半胱氨酸残基。 本发明还提供了结合TAG72的蛋白质。 本发明还提供了蛋白质和另一种化合物的缀合物。
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