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1.发明申请公开(公告)号：US20080247998A1
公开(公告)日：2008-10-09
申请号：US10584303
申请日：2005-07-14
CPC分类号： A61L27/3873 , A61L27/3834 , A61L27/3895 , C12N5/0663 , C12N2502/1329
摘要： A method of creating an atrioventricular bypass tract for a heart comprises growing mesenchymal stem cells into a strip with two ends, attaching one end of the strip onto the atrium of the heart, and attaching the other end of the strip to the ventricle of the heart, to create a tract connecting the atrium to the ventricle to provide a path for electrical signals generated by the sinus node to propagate across the tract and excite the ventricle.
摘要翻译： 为心脏产生房室旁路的方法包括将间充质干细胞生长成具有两端的条带，将条带的一端附接到心脏的心房上，并将带的另一端附接到心脏的心室 ，以产生将心房连接到心室的路径，以提供由窦房结产生的电信号通过道路传播并激发心室的路径。
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2.发明授权公开(公告)号：US08435509B2
公开(公告)日：2013-05-07
申请号：US13109804
申请日：2011-05-17
CPC分类号： A61L27/3873 , A61L27/3834 , A61L27/3895 , C12N5/0663 , C12N2502/1329
摘要： The invention provides a method of creating an atrioventricular bypass tract for a heart comprising growing mesenchymal stem cells into a strip with two ends, and attaching one end of the strip onto the atrium of the heart, and attaching the other end of the strip to the ventricle of the heart. By this attachment, a tract is created that connects the atrium to the ventricle to provide a path for electrical signals generated by the sinus node to propagate across the tract and excite the ventricle.
摘要翻译： 本发明提供了一种创建心脏的房室旁路的方法，包括将间充质干细胞生长成具有两端的条带，并将条带的一端附接到心脏的心房上，并将带的另一端附接到 心脏心室。 通过该附件，产生将心房连接到心室的管道，以提供由窦房结产生的电信号通过管道传播并激励心室的路径。
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3.发明申请Biological bypass bridge with sodium channels, calcium channels and/or potassium channels to compensate for conduction block in the heart 有权具有钠通道，钙通道和/或钾通道的生物旁路桥以补偿心脏中的传导阻滞公开(公告)号：US20070053886A1
公开(公告)日：2007-03-08
申请号：US11490760
申请日：2006-07-21
申请人： Michael Rosen , Peter Brink , Ira Cohen , Richard Robinson , Peter Danilo
发明人： Michael Rosen , Peter Brink , Ira Cohen , Richard Robinson , Peter Danilo
CPC分类号： A61N1/0587 , C12N5/0663 , C12N2502/1329 , C12N2510/00
摘要： This invention provides a bypass bridge comprising a tract of gap junction-coupled cells having a first end and a second end, both ends capable of being attached to two selected sites in a heart so as to allow the conduction of a pacemaker and/or electrical signal/current across the tract between the two sites, wherein the cells functionally express a sodium channel. The invention also provides related methods of making the bypass bridge, methods of implanting same in a heart, and methods of treating a disorder associated with an impaired conduction in a subject's heart.
摘要翻译： 本发明提供了一种旁路桥，其包括一段具有第一端和第二端的间隙连接耦合的电池，两端能够连接到心脏中的两个选定位置，以允许起搏器和/或电气 在两个位点之间的通道之间的信号/电流，其中细胞在功能上表达钠通道。 本发明还提供了制造旁路桥的相关方法，在心脏中植入其的方法，以及治疗与受试者心脏中的传导受损有关的障碍的方法。
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