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公开(公告)号：US20120270857A1
公开(公告)日：2012-10-25
申请号：US13384050
申请日：2010-06-30
申请人： Peter R. Guzzo , David D. Manning , William Earley
发明人： Peter R. Guzzo , David D. Manning , William Earley
IPC分类号： C07D487/06 , A61P1/00 , A61K31/439 , A61P25/32 , A61P29/00 , A61K31/55 , A61P25/22 , A61P25/28 , A61P25/16 , A61P35/00 , A61P25/08 , A61K31/5517 , A61P25/18
CPC分类号： C07D513/06 , A61K31/439 , A61K31/55 , A61K31/5517 , A61K45/06 , C07D453/02 , C07D487/04 , C07D513/04
摘要： Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.
摘要翻译： 公开了新的5-HT 3受体调节剂。 这些化合物用于治疗各种疾病，包括化疗诱发的恶心和呕吐，术后恶心呕吐和肠易激综合征。 制备这些化合物的方法也在本发明中描述。
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公开(公告)号：US08710046B2
公开(公告)日：2014-04-29
申请号：US13384050
申请日：2010-06-30
申请人： Peter R. Guzzo , David D. Manning , William Earley
发明人： Peter R. Guzzo , David D. Manning , William Earley
IPC分类号： C07D487/04 , C07D403/04 , A61K31/5517 , A61P25/00
CPC分类号： C07D513/06 , A61K31/439 , A61K31/55 , A61K31/5517 , A61K45/06 , C07D453/02 , C07D487/04 , C07D513/04
摘要： Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.
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3.发明授权Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin 有权芳基和杂芳基取代的四氢苯并氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取公开(公告)号：US07956050B2
公开(公告)日：2011-06-07
申请号：US11487884
申请日：2006-07-17
申请人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
发明人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
IPC分类号： A61P25/00 , A61K31/55 , C07D223/16
CPC分类号： C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
摘要翻译： 本发明的化合物由以下芳基 - 和杂芳基取代的四氢苯并吖庚因和具有式I（AE）和式（II）的二氢苯并氮杂衍生物表示：其中指定为*的碳原子为R或S构型， X和R 1 -R 9如本文所定义。
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4.发明授权Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin 有权芳基和杂芳基取代的四氢苯并氮杂及其用于阻断去甲肾上腺素，多巴胺和5-羟色胺的再摄取公开(公告)号：US08791101B2
公开(公告)日：2014-07-29
申请号：US12917066
申请日：2010-11-01
申请人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
发明人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
IPC分类号： A61K31/55 , C07D401/04
CPC分类号： C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
摘要翻译： 本发明的化合物由以下芳基 - 和杂芳基取代的四氢苯并吖庚因和具有式I（AE）和式（II）的二氢苯并氮杂衍生物表示：其中指定为*的碳原子为R或S构型， X和R 1 -R 9如本文所定义。
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5.发明申请ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN 有权ARYL-和HETEROARYL取代的四氢苯并噻吩并用于阻断肾上腺素，多巴胺和丝氨酸蛋白酶公开(公告)号：US20110046114A1
公开(公告)日：2011-02-24
申请号：US12917066
申请日：2010-11-01
申请人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
发明人： Bruce F. Molino , Shuang Liu , Aruna Sambandam , Peter R. Guzzo , Min Hu , Congxiang Zha , Kassoum Nacro , David D. Manning , Matthew L. Isherwood , Kristen N. Fleming , Wenge Cui , Richard E. Olson
CPC分类号： C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
摘要翻译： 本发明的化合物由以下芳基 - 和杂芳基取代的四氢苯并吖庚因和具有式I（AE）和式（II）的二氢苯并氮杂衍生物表示：其中指定为*的碳原子为R或S构型， X和R 1 -R 9如本文所定义。
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公开(公告)号：US08501729B2
公开(公告)日：2013-08-06
申请号：US13372967
申请日：2012-02-14
IPC分类号： C07D471/06 , C07D487/06 , C07D519/00 , A61K31/55 , A61P25/00
CPC分类号： A61K31/55 , A61K31/437 , A61K31/439 , C07D451/14 , C07D453/02 , C07D471/06 , C07D487/06 , C07D519/00
摘要： Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.
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公开(公告)号：US08450307B2
公开(公告)日：2013-05-28
申请号：US11628569
申请日：2005-06-06
申请人： Bruce J. Sargent , Henry Pauls , Judd M. Berman , Jailall Ramnauth , Peter Sampson , Andras Toro , Fernando J. Martin , Matthew D. Surman , Helene Y. Decornez , David D. Manning
发明人： Bruce J. Sargent , Henry Pauls , Judd M. Berman , Jailall Ramnauth , Peter Sampson , Andras Toro , Fernando J. Martin , Matthew D. Surman , Helene Y. Decornez , David D. Manning
IPC分类号： C07D401/12 , C07D405/12 , C07D409/12 , C07D498/04 , A61K31/551 , A61K31/5365
CPC分类号： C07D498/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D471/14
摘要： In part, the present invention is directed to antibacterial compounds.
摘要翻译： 部分地，本发明涉及抗菌化合物。
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公开(公告)号：US20100093705A1
公开(公告)日：2010-04-15
申请号：US11628569
申请日：2005-06-06
申请人： Bruce J. Sargent , Henry Pauls , Judd M. Berman , Jailall Ramnauth , Peter Sampson , Andras Toro , Fernando J. Martin , Matthew D. Surman , Helene Y. Decornez , David D. Manning
发明人： Bruce J. Sargent , Henry Pauls , Judd M. Berman , Jailall Ramnauth , Peter Sampson , Andras Toro , Fernando J. Martin , Matthew D. Surman , Helene Y. Decornez , David D. Manning
IPC分类号： A61K31/551 , C07D471/04 , C07D223/16 , C07D491/02 , A61K31/4375 , A61P31/04
CPC分类号： C07D498/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D471/14
摘要： In part, the present invention is directed to antibacterial compounds.
摘要翻译： 部分地，本发明涉及抗菌化合物。
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公开(公告)号：US20120219641A1
公开(公告)日：2012-08-30
申请号：US13372967
申请日：2012-02-14
IPC分类号： A61K31/4745 , A61K31/55 , A61K33/00 , A61K31/496 , A61K31/5513 , A61K38/31 , A61P25/18 , A61P25/16 , A61P25/00 , A61P1/00 , A61P1/08 , A61P25/14 , A61P25/28 , A61P25/30 , C07D519/00
CPC分类号： A61K31/55 , A61K31/437 , A61K31/439 , C07D451/14 , C07D453/02 , C07D471/06 , C07D487/06 , C07D519/00
摘要： Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.
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公开(公告)号：US08124600B2
公开(公告)日：2012-02-28
申请号：US12473940
申请日：2009-05-28
IPC分类号： C07D471/06 , C07D487/06 , C07D519/00 , A61P25/00
CPC分类号： A61K31/55 , A61K31/437 , A61K31/439 , C07D451/14 , C07D453/02 , C07D471/06 , C07D487/06 , C07D519/00
摘要： Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.
摘要翻译： 公开了新的5-HT 3受体调节剂。 这些化合物用于治疗各种疾病，包括化疗诱发的恶心和呕吐，术后恶心呕吐和肠易激综合征。 制备这些化合物的方法也在本发明中描述。
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