公开(公告)号：US20050077418A1

公开(公告)日：2005-04-14

申请号：US10676168

申请日：2003-09-30

申请人： Peter Werner ,  James Armstrong ,  Larry Hougum ,  Daniel Koziczkowski ,  Thomas Simon

发明人： Peter Werner ,  James Armstrong ,  Larry Hougum ,  Daniel Koziczkowski ,  Thomas Simon

IPC分类号： B65H19/18 ,  B65H19/16

CPC分类号： B65H19/1868 ,  B65H19/1821 ,  B65H2301/46412 ,  B65H2511/142 ,  B65H2511/512 ,  B65H2513/10 ,  B65H2513/11 ,  B65H2515/31 ,  B65H2701/1311 ,  B65H2701/1313 ,  B65H2220/01 ,  B65H2220/03 ,  B65H2220/02

摘要： A system and method for splicing reeled media using operational feedback. According to certain embodiments, the method of operating a media production system involves sensing speed parameters of first and second reeled media, tracking an unwinding parameter of the first reeled media, and positionally tracking a leading end position of the second reeled media. The method also involves controlling splicing between the first and second reeled media based at least partially on the speed parameters, the unwinding parameter, and the leading end position.

摘要翻译： 使用操作反馈拼接卷绕介质的系统和方法。 根据某些实施例，操作介质生产系统的方法包括感测第一和第二卷绕介质的速度参数，跟踪第一卷绕介质的展开参数，以及位置跟踪第二卷绕介质的前端位置。 该方法还包括至少部分地基于速度参数，展开参数和前端位置来控制第一和第二卷绕介质之间的拼接。

公开(公告)号：US20110110719A1

公开(公告)日：2011-05-12

申请号：US12867236

申请日：2009-02-11

申请人： Thomas Simon

发明人： Thomas Simon

IPC分类号： E02B5/02 ,  E02B5/00

CPC分类号： E03F3/046

摘要： Embodiments of the present invention include a drainage channel comprising a first barrier for containment and a second barrier for containment. In one embodiment, the second barrier comprises a liner and a support. In a further embodiment, the support substantially secures at least a portion of the second barrier in the first barrier.

摘要翻译： 本发明的实施例包括排水通道，其包括用于容纳的第一屏障和用于容纳的第二屏障。 在一个实施例中，第二屏障包括衬里和支撑件。 在另一实施例中，支撑件基本上固定第一屏障中的第二屏障的至少一部分。

公开(公告)号：US20080096927A1

公开(公告)日：2008-04-24

申请号：US11660195

申请日：2005-08-19

申请人： Thomas Simon ,  Alise Reicin ,  Richard Hunt

发明人： Thomas Simon ,  Alise Reicin ,  Richard Hunt

IPC分类号： A61K31/4439 ,  A61K31/365 ,  A61K31/444 ,  A61P19/00 ,  A61P9/00

CPC分类号： A61K45/06 ,  A61K31/4152 ,  A61K31/4439 ,  A61K2300/00

摘要： The invention encompasses a pharmaceutical composition comprising a therapeutically effective amount of a cyclooxygenase-2 selective inhibitor selected from rofecoxib and etoricoxib or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of a proton pump inhibitor selected from the group consisting of: omeprazole, lansoprazole, rabeprazole, pantoprazole, and esomeprazole, or a pharmaceutically acceptable salt of any of the aforementioned, in combination with a pharmaceutically acceptable carrier. The invention also encompasses a method for treating a cyclooxygenase-2 mediated disease or condition in a human patient at risk of a thrombotic cardiovascular event, wherein the patient is on aspirin therapy to reduce the risk of the thrombotic cardiovascular event, comprising administering to the patient this pharmaceutical composition.

摘要翻译： 本发明包括药物组合物，其包含治疗有效量的选自罗非昔布和依托昔康的环加氧酶-2选择性抑制剂或其药学上可接受的盐，以及治疗有效量的选自以下的质子泵抑制剂：奥美拉唑，兰索拉唑 ，雷贝拉唑，泮托拉唑和艾美拉唑，或任何上述药学上可接受的盐与药学上可接受的载体组合。 本发明还包括用于治疗患有血栓性心血管事件危险的人类患者中环氧合酶-2介导的疾病或病症的方法，其中所述患者服用阿司匹林治疗以降低血栓性心血管事件的风险，包括给予患者 该药物组合物。

公开(公告)号：US20050215611A1

公开(公告)日：2005-09-29

申请号：US10513085

申请日：2003-05-09

申请人： Richard Hunt ,  Thomas Simon

发明人： Richard Hunt ,  Thomas Simon

IPC分类号： A61K31/415

CPC分类号： A61K31/415

摘要： The present invention encompasses a method for treating a chronic cyclooxygenase-2 mediated disease or condition and reducing the risk of a thrombotic cardiovascular event in a human patient in need of such treatment and at risk of a thrombotic cardiovascular event comprising orally concomitantly or sequentially administering to said patient a cyclooxygenase-2 selective inhibitor in an amount effective to treat the cyclooxygenase-2 mediated disease or condition and nitric oxide releasing aspirin in an amount effective to reduce the risk of the thrombotic cardiovascular event while maintaining a high level of upper gastrointestinal safety and tolerability. The invention also encompasses a method for treating a chronic cyclooxygenase-2 mediated disease or condition and reducing the risk of a thrombotic cardiovascular event in a human patient in need of such treatment and at risk of a thrombotic cardiovascular event comprising orally concomitantly or sequentially administering to said patient a nitric oxide releasing-cyclooxygenase-2 selective inhibitor in an amount effective to treat the cyclooxygenase-2 mediated disease or condition and aspirin in an amount effective to reduce the risk of the thrombotic cardiovascular event while maintaining a high level of upper gastrointestinal safety and tolerability. Pharmaceutical compositions are also encompassed.

摘要翻译： 本发明包括一种治疗慢性环氧合酶-2介导的疾病或病症并减少需要这种治疗的人类患者血栓性心血管事件的风险并且具有血栓性心血管事件的风险的方法，包括口服伴随地或依次给予 所述患者以有效治疗环氧合酶-2介导的疾病或病症和一氧化氮释放阿司匹林的量的环氧合酶-2选择性抑制剂的量有效降低血栓形成心血管事件的风险，同时保持高水平的上消化道安全性， 耐受性 本发明还包括一种治疗慢性环氧合酶-2介导的疾病或病症并降低需要这种治疗的人类患者血栓性心血管事件的风险并且具有血栓性心血管事件的风险的方法，其包括口服同时或依次给予 所述患者以有效治疗环氧合酶-2介导的疾病或病症和阿司匹林的量的一氧化氮释放 - 环氧合酶-2选择性抑制剂，其量可有效降低血栓形成心血管事件的风险，同时保持高水平的上消化道安全性 和耐受性。 也包括药物组合物。

公开(公告)号：US5667794A

公开(公告)日：1997-09-16

申请号：US710078

申请日：1996-09-11

申请人： Thomas Simon ,  Roger Berlin

发明人： Thomas Simon ,  Roger Berlin

IPC分类号： A61K31/426 ,  A61K33/00

CPC分类号： A61K31/426

摘要： A method for treating a patient suffering from heartburn and having no substantial esophageal erosion, comprising administering to the patient a composition comprising an amount of famotidine between about 5 mg and 10 mg. In one embodiment, the amount of famotidine is about 5 mg. In another embodiment, the amount of famotidine is about 10 mg.A method for treating a patient suffering from heartburn and having no substantial esophageal erosion, comprising administering to the patient a composition comprising an amount of famotidine between about 5 mg and 10 mg, and an antacid. In one embodiment, the amount of famotidine is about 5 mg. In another embodiment, the amount of famotidine is about 10 mg.

摘要翻译： 一种治疗患有胃灼热并且没有实质性食管侵蚀的患者的方法，包括向患者施用包含约5mg至10mg的法莫替丁的组合物。 在一个实施方案中，法莫替丁的量为约5mg。 在另一个实施方案中，法莫替丁的量为约10mg。 一种治疗患有胃灼热并且没有实质性食管侵蚀的患者的方法，包括向患者施用包含约5mg至10mg的法莫替丁的组合物和抗酸剂。 在一个实施方案中，法莫替丁的量为约5mg。 在另一个实施方案中，法莫替丁的量为约10mg。

公开(公告)号：US20050272978A1

公开(公告)日：2005-12-08

申请号：US11148036

申请日：2005-06-08

申请人： Rainer Brunnen ,  Thomas Simon

发明人： Rainer Brunnen ,  Thomas Simon

IPC分类号： A61B1/005 ,  A61B1/008

CPC分类号： A61B1/0055 ,  A61B1/0011 ,  A61B1/008

摘要： A bendable portion, which is arranged at the distal end of an insertion tube of an endoscope, comprises a plurality of tube segments, each of said tube segments having connecting means that cooperate with the connecting means of the adjacent tube segment, as well as control wires that can control the bending of the bendable portion. The respective connecting means of a tube segment are provided such that they axially protrude from the faces of the tube segment and are located within the mantle of the tube segment and such that they do not exceed the thickness of the mantle. The connecting means, which are provided on the respective faces of adjacent tube segments and which are located opposite each other, complement each other in the manner of a hinge-type connection.

摘要翻译： 布置在内窥镜的插入管的远端的可弯曲部分包括多个管段，每个管段具有与相邻管段的连接装置配合的连接装置，以及控制 可以控制可弯曲部分的弯曲的导线。 管段的相应的连接装置设置成使得它们从管段的表面轴向地突出并且位于管段的罩内，并且使得它们不超过套管的厚度。 设置在相邻管段的相应表面上并且彼此相对定位的连接装置以铰链式连接的方式相互补充。

公开(公告)号：US5569607A

公开(公告)日：1996-10-29

申请号：US407997

申请日：1995-03-22

申请人： Thomas Simon ,  Ingo Kaiser ,  Carsten Carstensen

发明人： Thomas Simon ,  Ingo Kaiser ,  Carsten Carstensen

IPC分类号： G01N1/28 ,  G02B21/34 ,  G01N21/03

CPC分类号： G02B21/34 ,  Y10T436/112499

摘要： Slide for the microscopic evaluation of liquid specimens comprising a base plate, at least one evaluation chamber and a cover foil. The evaluation chambers have a specimen application zone and an evaluation area. A capillary gap is located between the evaluation zone and the cover foil. An improved slide compared to known devices was achieved by using a foil to cover the evaluation chambers and by spacers which ensure a defined thickness of the capillary gap.

摘要翻译： 滑动用于对包括基板，至少一个评估室和盖箔的液体试样的显微评价。 评估室具有试样应用区和评价区。 毛细管间隙位于评估区和覆盖箔之间。 通过使用箔来覆盖评估室和通过确保毛细管间隙的确定厚度的间隔物，实现了与已知装置相比的改进的载玻片。

公开(公告)号：US20060082421A1

公开(公告)日：2006-04-20

申请号：US11293703

申请日：2005-12-02

申请人： Thomas Simon ,  Rajeevan Amirtharajah ,  John Benham

发明人： Thomas Simon ,  Rajeevan Amirtharajah ,  John Benham

IPC分类号： H01P5/12

CPC分类号： H01P5/185 ,  H04L25/0266

摘要： A controller sends signals to an electromagnetic coupler associated with a bus. The signals are arranged to set a coupling strength of the coupler.

公开(公告)号：US20050039066A1

公开(公告)日：2005-02-17

申请号：US10918209

申请日：2004-08-13

申请人： Thomas Simon ,  Rajeevan Amirtharajah

发明人： Thomas Simon ,  Rajeevan Amirtharajah

IPC分类号： H04J3/06 ,  H04L7/00 ,  G06F1/12

CPC分类号： H04L7/0008 ,  H04J3/0682

摘要： Calibrating return time includes determining clock calibration information based on clock signals local to a master device and return clock signals corresponding to each of at least two slave devices, storing clock calibration information with respect to each of the slave devices with which the master device will communicate using a bus, and, after the clock calibration information has been stored, resynchronizing data signals that are received from each of the slave devices based on the corresponding stored clock calibration information.

摘要翻译： 校准返回时间包括基于主设备本地的时钟信号确定时钟校准信息，以及对应于至少两个从设备中的每一个的返回时钟信号，存储关于主设备将与之通信的每个从设备的时钟校准信息 使用总线，并且在存储了时钟校准信息之后，基于相应的存储的时钟校准信息重新同步从每个从设备接收的数据信号。

公开(公告)号：US5854267A

公开(公告)日：1998-12-29

申请号：US459182

申请日：1995-06-02

申请人： Roger Berlin ,  Thomas N. Gates ,  Thomas Simon

发明人： Roger Berlin ,  Thomas N. Gates ,  Thomas Simon

IPC分类号： A61K31/425

CPC分类号： A61K31/425

摘要： A method for preventing heartburn episodes in a patient susceptible to suffering heartburn episodes following ingestion of heartburn-inducing food or beverage, comprising administering to the patient, 30 minutes prior to consumption by the patient of the food or beverage, a composition comprising an amount of famotidine of 10 mg.

摘要翻译： 一种用于在摄取引起胃灼热的食物或饮料之后，易于患有胃灼热发作的患者中的胃灼热发作的方法，包括在患者食用食物或饮料之前30分钟向患者施用包含一定量的 法莫替丁10mg。