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公开(公告)号：US20090179638A1
公开(公告)日：2009-07-16
申请号：US12278071
申请日：2007-02-01
IPC分类号： G01V3/00 , C07D513/04 , C07F5/02 , G01N33/68 , G01N33/566
CPC分类号： G01N33/6896 , G01N2500/02
摘要： Disclosed is an assay for identifying compounds that modulate a neuronal apoptotic pathway, the assay comprises: a) contacting HSP90 protein with a probe to form a probe: HSP90 complex, the probe being displaceable by a test compound; b) measuring a signal from the probe so as to establish a reference level; c) incubating the probe:HSP90 complex with the test compound; d) measuring the signal from the probe; e) comparing the signal from step d) with the reference level, a modulation of the signal indicating that the test compound binds to HSP90. Also disclosed is a probe which is labeled with a detectable label and/or an affinity tag.
摘要翻译： 公开了用于鉴定调节神经元凋亡途径的化合物的测定法，该测定包括：a）使HSP90蛋白与探针接触以形成探针：HSP90复合物，所述探针可被测试化合物置换; b）测量来自探针的信号，以便建立参考水平; c）将探针：HSP90复合物与测试化合物孵育; d）测量探头的信号; e）将来自步骤d）的信号与参考水平进行比较，指示测试化合物与HSP90结合的信号的调制。 还公开了用可检测标记和/或亲和标签标记的探针。
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公开(公告)号：US20100155681A1
公开(公告)日：2010-06-24
申请号：US12445844
申请日：2007-10-08
IPC分类号： G02B6/46
CPC分类号： G02B6/4464 , H02G1/086
摘要： A blowing head for installing an optical fibre unit into a tube, including driving means for driving the optical fibre unit into the tube, the driving means having a plurality of driving surfaces, wherein one or more attic plurality of the driving surfaces are resiliently biased with a predetermined force toward the other driving surface or surfaces, and wherein in use the optical fibre unit moves between the plurality of driving surfaces.
摘要翻译： 一种用于将光纤单元安装到管中的吹头，包括用于将光纤单元驱动到管中的驱动装置，所述驱动装置具有多个驱动表面，其中驱动表面的一个或多个顶板多个被弹性偏压， 朝向其他驱动表面的预定力，并且其中在使用中，光纤单元在多个驱动表面之间移动。
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公开(公告)号：US20100046895A1
公开(公告)日：2010-02-25
申请号：US12594449
申请日：2008-03-31
IPC分类号： G02B6/44
CPC分类号： G02B6/4464 , G02B6/4485 , H02G1/086
摘要： Apparatus for installing a cable into a tube with the assistance of a fluid drag acting on the cable within the tube, the apparatus including:—installation means for driving the cable into the tube, wherein in use the cable is resistant to being conveyed to the installation means, and—reduction means for reducing the conveyance resistance of the cable.
摘要翻译： 用于在作用在管内的电缆上的流体阻力的情况下将电缆安装到管中的装置，该装置包括：用于将电缆驱动到管中的安装装置，其中在使用中电缆抵抗被传送到 用于降低电缆的输送阻力的安装装置和减速装置。
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公开(公告)号：US5557703A
公开(公告)日：1996-09-17
申请号：US464092
申请日：1995-06-05
CPC分类号： C03C25/1065 , G02B6/443 , G02B6/4438 , G02B6/4464
摘要： An optical fibre package suitable for installation using a fibre blowing process includes at least one optical fibre, an inner coating about said fibre, and an outer resin coating about said inner coating, said resin coating including a significant plurality of particulate inclusions at least 10 .mu.m across, wherein the concentration of the particulate inclusions is significantly greater at the outer surface of the resin coating than at the inner limit of the resin coating. The inclusions may be hollow glass microspheres or mica flakes. The relative absence of significant particulate inclusions at the inner limit of the resin coating improves the mechanical particulate of the fibre package relative to similar known packages. The presence of significant inclusions at the outer surface of the resin coating tends, during a blowing process, to increase viscous drag effects and to reduce friction between the package and the duct into which the package is blown, thereby enhancing blowability.
摘要翻译： 适用于使用纤维吹制方法安装的光纤包装包括至少一根光纤，围绕所述纤维的内涂层和围绕所述内涂层的外树脂涂层，所述树脂涂层包括至少10微米的显着多个颗粒夹杂物 m，其中在树脂涂层的外表面上的颗粒夹杂物的浓度明显大于树脂涂层的内部极限。 夹杂物可以是中空玻璃微球或云母片。 相对于相似的已知包装，在树脂涂层的内部极限处相对不存在显着的颗粒夹杂物改善了纤维包装的机械颗粒。 在吹塑过程中，在树脂涂层的外表面存在显着的夹杂物，从而增加粘性阻力效应，并减少包装与包装被吹入的管道之间的摩擦，从而提高吹塑性。
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公开(公告)号：US20090242860A1
公开(公告)日：2009-10-01
申请号：US12295778
申请日：2007-04-02
申请人： Philip A. Barker , Nitzan Gonen
发明人： Philip A. Barker , Nitzan Gonen
IPC分类号： H02G1/08
CPC分类号： G02B6/4464
摘要： A method of installing a cable into a conduit, the conduit having more than one bore size, comprising the steps of—introducing air to flow in a direction into and through the conduit, and—changing an air pressure level of the air within the conduit from a first pressure level to a second pressure level by either venting a part of the air from the conduit or adding to the air within the conduit.
摘要翻译： 一种将电缆安装到管道中的方法，该导管具有多于一个的孔径，包括以下步骤：引入空气沿着进入和穿过导管的方向流动，并且改变导管内的空气的空气压力水平 从第一压力水平到第二压力水平，通过从导管排出一部分空气或者增加管道内的空气。
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6.发明申请Lgi, lingo and p75ntr family members: novel modulators of neuronal growth 失效Lgi，lingo和p75ntr家族成员：神经元生长的新型调节剂公开(公告)号：US20090221479A1
公开(公告)日：2009-09-03
申请号：US11920522
申请日：2006-05-16
CPC分类号： G01N33/5058 , A61K38/17 , G01N33/5026 , G01N2500/02
摘要： The present invention relates to a novel method to promote regeneration or repair of the central or peripheral nervous system following injury The present invention concerns the use of a leucine-rich, glioma-inactivated protein (LGIn), or an analog or derivative thereof, to promote the regeneration or remyelination of neurons after injury to the central nervous system LGIns are endogenous proteins secreted by central neurons that promote regeneration of neurons after injury to the central nervous system The present invention includes an assay to measure the interaction of LGIn with LINGOn and p75NTRn as well as to identify factors that enhance or disrupt these interactions The invention further includes cell lines capable of expressing LGIn, LINGOn and p75NTRn molecules, as well as the proteins purified from these cells.
摘要翻译： 本发明涉及一种在损伤后促进中枢或周围神经系统的再生或修复的新方法。本发明涉及富含亮氨酸的神经胶质瘤失活的蛋白质（LGIn）或其类似物或衍生物用于 促进神经元在中枢神经系统损伤后的再生或再髓鞘化LGIns是中枢神经元分泌的内源性蛋白质，其促进中枢神经系统损伤后神经元的再生。本发明包括测定LGIn与LINGOn和p75NTRn的相互作用的测定 以及鉴定增强或破坏这些相互作用的因素本发明还包括能够表达LGIn，LINGOn和p75NTRn分子的细胞系，以及从这些细胞纯化的蛋白质。
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公开(公告)号：US09762039B2
公开(公告)日：2017-09-12
申请号：US12295750
申请日：2007-04-02
申请人： Philip A. Barker , Graham A Laidler
发明人： Philip A. Barker , Graham A Laidler
IPC分类号： H02G1/08 , G01R27/28 , F16L7/00 , F16L55/48 , G01N29/024 , G01N29/22 , G02B6/44 , F16L101/50
CPC分类号： H02G1/08 , F16L7/00 , F16L55/48 , F16L2101/50 , G01N29/024 , G01N29/222 , G01N2291/012 , G01N2291/02836 , G01N2291/044 , G01N2291/056 , G02B6/4464 , G02B6/447 , H02G1/081 , H02G1/086
摘要： A method for use in connection with installing a cable into a conduit having a first conduit end and a second conduit end, comprising the steps of —providing the cable with a metallic attribute, —providing within or proximate to the conduit, sensing means for sensing the metallic attribute, —introducing the cable into the first conduit end and driving it towards the second conduit end and —detecting that the sensing means has sensed the metallic attribute by sensing a change in inductance levels of the sensing means.
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公开(公告)号：US20110025467A1
公开(公告)日：2011-02-03
申请号：US12934879
申请日：2009-03-26
IPC分类号： H04Q5/22
CPC分类号： G02B6/447 , G06K7/0008 , G06K7/10336
摘要： A records component reader comprising a member comprising a front-facing surface and a rear-facing surface, a transceiver disposed on the front-facing surface, for projecting a reading field enabling an interrogation to be sent to the records component and a response to be received from the records component, the transceiver being arranged in use to adaptably curve about a surface of an item including a records component, and shielding means for confining the sending of the interrogation and the receipt of the response within the reading field.
摘要翻译： 一种记录组件读取器，包括包括前向表面和后向表面的构件，设置在前侧表面上的收发器，用于将读取区域投射到能够将询问发送到记录组件的响应， 收发器被布置在使用中以适应性地围绕包括记录部件的物品的表面曲线，以及屏蔽装置，用于限制询问的发送和响应的接收在读取区域内。
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公开(公告)号：US5555335A
公开(公告)日：1996-09-10
申请号：US170287
申请日：1994-04-01
CPC分类号： C03C25/1065 , G02B6/443 , G02B6/4438 , G02B6/4464
摘要： An optical fibre package suitable for installation using a fibre blowing process includes at least one optical fibre, an inner coating about said fibre, and an outer resin coating about said inner coating, said resin coating including a significant plurality of particulate inclusions at least 10 .mu.m across, wherein the concentration of the particulate inclusions is significantly greater at the outer surface of the resin coating than at the inner limit of the resin coating. The inclusions may be hollow glass microspheres or mica flakes. The relative absence of significant particulate inclusions at the inner limit of the resin coating improves the mechanical performance of the fibre package relative to similar known packages. The presence of significant inclusions at the outer surface of the resin coating tends, during a blowing process, to increase viscous drag effects and to reduce friction between the package and the duct into which the package is blown, thereby enhancing blowability.
摘要翻译： PCT No.PCT / GB92 / 01190 Sec。 371日期1994年04月1日 102（e）1994年4月1日PCT PCT 1992年7月1日PCT公布。 出版物WO93 / 0151200 日期1993年1月21日适用于使用纤维吹制法的安装的光纤包装包括至少一根光纤，围绕所述纤维的内涂层和围绕所述内涂层的外树脂涂层，所述树脂涂层包括显着的多个颗粒 夹杂物至少10微米，其中在树脂涂层的外表面上的颗粒夹杂物的浓度明显大于树脂涂层的内部极限。 夹杂物可以是中空玻璃微球或云母片。 相对于类似的已知包装，在树脂涂层的内部极限处相对不存在显着的颗粒夹杂物改善了纤维包装的机械性能。 在吹塑过程中，在树脂涂层的外表面存在显着的夹杂物，从而增加粘性阻力效应，并减少包装与包装被吹入的管道之间的摩擦，从而提高吹塑性。
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10.发明授权LGI, LINGO and p75NTR family members: novel modulators of neuronal growth 失效LGI，LINGO和p75NTR家族成员：神经元生长的新型调节剂公开(公告)号：US08309517B2
公开(公告)日：2012-11-13
申请号：US11920522
申请日：2006-05-16
IPC分类号： A61K38/00
CPC分类号： G01N33/5058 , A61K38/17 , G01N33/5026 , G01N2500/02
摘要： The present invention relates to a novel method to promote regeneration or repair of the central or peripheral nervous system following injury The present invention concerns the use of a leucine-rich, glioma-inactivated protein (LGIn), or an analog or derivative thereof, to promote the regeneration or remyelination of neurons after injury to the central nervous system LGIns are endogenous proteins secreted by central neurons that promote regeneration of neurons after injury to the central nervous system The present invention includes an assay to measure the interaction of LGIn with LINGOn and p75NTRn as well as to identify factors that enhance or disrupt these interactions The invention further includes cell lines capable of expressing LGIn, LINGOn and p75NTRn molecules, as well as the proteins purified from these cells.
摘要翻译： 本发明涉及一种在损伤后促进中枢或周围神经系统的再生或修复的新方法。本发明涉及富含亮氨酸的神经胶质瘤失活的蛋白质（LGIn）或其类似物或衍生物用于 促进神经元在中枢神经系统损伤后的再生或再髓鞘化LGIns是中枢神经元分泌的内源性蛋白质，其促进中枢神经系统损伤后神经元的再生。本发明包括测定LGIn与LINGOn和p75NTRn的相互作用的测定 以及鉴定增强或破坏这些相互作用的因素本发明还包括能够表达LGIn，LINGOn和p75NTRn分子的细胞系，以及从这些细胞纯化的蛋白质。
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