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公开(公告)号:US08846710B2
公开(公告)日:2014-09-30
申请号:US11884982
申请日:2006-02-22
申请人: Tushar A. Kshirsagar , Bryon A. Merrill , Scott E. Langer , Kyle J. Lindstrom , Sarah C. Slania , Gregory J. Marszalek , Joshua R. Wurst , Karl J. Manske , Shri Niwas , Gregory D. Lundquist, Jr. , Philip D. Heppner , George W. Griesgraber , Michael E. Danielson
发明人: Tushar A. Kshirsagar , Bryon A. Merrill , Scott E. Langer , Kyle J. Lindstrom , Sarah C. Slania , Gregory J. Marszalek , Joshua R. Wurst , Karl J. Manske , Shri Niwas , Gregory D. Lundquist, Jr. , Philip D. Heppner , George W. Griesgraber , Michael E. Danielson
IPC分类号: A61K31/4745 , C07D471/04 , C07D471/14
CPC分类号: A61K31/4745 , C07D471/04 , C07D471/14 , Y02A50/409 , Y02A50/411 , Y02A50/481
摘要: A method of preferentially inducing IFN-α biosynthesis in an animal comprising administering certain imidazo[4,5-c] ring compounds with a hydroxymethyl or hydroxyethyl substituent at the 2-position or pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of using these compounds a immunomodulators for treatment of diseases including viral and neoplastic diseases comprising preferentially inducing IFN-α biosynthesis in an animal are disclosed.
摘要翻译: 一种在动物中优先诱导IFN-α生物合成的方法,其包括在2-位上给予某些咪唑并[4,5-c]环化合物与羟甲基或羟乙基取代基或含有化合物,中间体,制备方法和 公开了使用这些化合物的免疫调节剂用于治疗包括病毒和肿瘤疾病在内的疾病的方法,其包括在动物中优先诱导IFN-α生物合成。
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公开(公告)号:US07897597B2
公开(公告)日:2011-03-01
申请号:US10595103
申请日:2004-08-27
申请人: Kyle J. Lindstrom , Hugues M. H. Martin , Bryon A. Merrill , Michael J. Rice , Joshua R. Wurst , Chad A. Haraldson , Tushar A. Kshirsagar , Philip D. Heppner , Shri Niwas , George W. Griesgraber , Matthew R. Radmer
发明人: Kyle J. Lindstrom , Hugues M. H. Martin , Bryon A. Merrill , Michael J. Rice , Joshua R. Wurst , Chad A. Haraldson , Tushar A. Kshirsagar , Philip D. Heppner , Shri Niwas , George W. Griesgraber , Matthew R. Radmer
IPC分类号: A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/02
CPC分类号: C07D471/04
摘要: Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy or hydroxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译: 在6,7,8或9位含有芳氧基或芳基亚烷基氧基或羟基取代基的咪唑并喹啉化合物含有这些化合物作为免疫调节剂的化合物,中间体和使用方法,用于调节动物中的细胞因子生物合成 公开了包括病毒和肿瘤疾病在内的疾病的治疗。
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公开(公告)号:US07678918B2
公开(公告)日:2010-03-16
申请号:US11999602
申请日:2007-12-06
申请人: John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
发明人: John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC分类号: C07D411/02
CPC分类号: C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
摘要: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.
摘要翻译: 咪唑并吡啶和四氢咪唑并吡啶化合物诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。 该化合物显示抗病毒和抗肿瘤性质。 公开了制备可用于制备化合物的化合物和中间体的方法。
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公开(公告)号:US06969722B2
公开(公告)日:2005-11-29
申请号:US10772170
申请日:2004-02-04
IPC分类号: A61K31/4745 , C07D471/02 , C07D471/04 , A61K31/437
CPC分类号: C07D471/04
摘要: Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号:US06949646B2
公开(公告)日:2005-09-27
申请号:US11004674
申请日:2004-12-03
申请人: John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
发明人: John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC分类号: A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/4745 , A61K31/522 , A61P7/00 , A61P17/00 , A61P29/00 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07D213/00 , C07D233/00 , C07D257/00 , C07D401/04 , C07D471/04 , C07D471/14 , C07D471/22 , C07D519/00
CPC分类号: C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
摘要: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
摘要翻译: 咪唑并吡啶和四氢咪唑并吡啶化合物诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。 该化合物显示抗病毒和抗肿瘤性质。 还公开了制备可用于制备化合物的化合物和中间体的方法。
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公开(公告)号:US06903113B2
公开(公告)日:2005-06-07
申请号:US10771639
申请日:2004-02-04
IPC分类号: C07D471/04 , A61K31/437
CPC分类号: C07D471/04
摘要: Imidazopyridine compounds that contain urea or thiourea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译: 在1位含有脲或硫脲官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成,并且可用于治疗各种病症,包括病毒性疾病和肿瘤性疾病。
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公开(公告)号:US08871782B2
公开(公告)日:2014-10-28
申请号:US10595230
申请日:2004-10-01
申请人: Kyle J. Lindstrom , Bryon A. Merrill , Chad A. Haraldson , Michael J. Rice , Tushar A. Kshirsagar , Philip D. Heppner , Joshua R. Wurst , Shri Niwas , Sarah C. Johannessen
发明人: Kyle J. Lindstrom , Bryon A. Merrill , Chad A. Haraldson , Michael J. Rice , Tushar A. Kshirsagar , Philip D. Heppner , Joshua R. Wurst , Shri Niwas , Sarah C. Johannessen
IPC分类号: A61K31/437 , C07D471/06 , C07D471/04
CPC分类号: C07D471/04 , A61K31/4745 , C07D413/14 , C07D519/00 , Y02A50/409 , Y02A50/411 , Y02A50/463
摘要: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.
摘要翻译: 含有6,7,8或9位烷氧基取代基的咪唑并喹啉化合物含有化合物,中间体,制备方法,以及这些化合物作为免疫调节剂的用途,用于诱导或抑制动物中的细胞因子生物合成, 在包括病毒和肿瘤的疾病的治疗中。
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公开(公告)号:US08263594B2
公开(公告)日:2012-09-11
申请号:US13008453
申请日:2011-01-18
申请人: Kyle J. Lindstrom , Hugues M. H. Martin , Bryon A. Merrill , Michael J. Rice , Joshua R. Wurst , Chad A. Haraldson , Philip D. Heppner , Shri Niwas , Matthew R. Radmer
发明人: Kyle J. Lindstrom , Hugues M. H. Martin , Bryon A. Merrill , Michael J. Rice , Joshua R. Wurst , Chad A. Haraldson , Philip D. Heppner , Shri Niwas , Matthew R. Radmer
IPC分类号: A61K31/5377 , A61K31/437 , A61K31/497 , C07D471/04 , C07D413/14 , A61P31/12 , A61P35/00
CPC分类号: C07D471/04
摘要: Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
摘要翻译: 含有芳香氧基或芳基亚烷氧基取代基的6,7,8或9位的咪唑并喹啉化合物含有这些化合物作为免疫调节剂的化合物,中间体和使用方法,用于调节动物中的细胞因子生物合成和治疗 公开了包括病毒和肿瘤疾病在内的疾病。
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公开(公告)号:US07897609B2
公开(公告)日:2011-03-01
申请号:US11570703
申请日:2005-06-17
申请人: Shri Niwas , Bryon A. Merrill , Philip D. Heppner , Tushar A. Kshirsagar , Gregory D. Lundquist, Jr. , David T. Amos , Kyle J. Lindstrom
发明人: Shri Niwas , Bryon A. Merrill , Philip D. Heppner , Tushar A. Kshirsagar , Gregory D. Lundquist, Jr. , David T. Amos , Kyle J. Lindstrom
IPC分类号: C07D215/38 , A61K31/02
CPC分类号: C07D471/14
摘要: Imidazonaphthyridine ring systems substituted with an aryl substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译: 公开了用芳基取代基取代的咪唑并萘啶环体系,含有这些化合物的药物组合物,以及这些化合物作为免疫调节剂的用途,用于诱导动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。
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公开(公告)号:US07335773B2
公开(公告)日:2008-02-26
申请号:US11276074
申请日:2006-02-13
申请人: John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
发明人: John F. Gerster , Kyle J. Lindstrom , Stephen L. Crooks , Philip D. Heppner , Gregory J. Marszalek , Peter V. Maye , Bryon A. Merrill , John W. Mickelson , Michael J. Rice
IPC分类号: C07D471/02
CPC分类号: C07D471/04 , A61K31/4745 , A61K45/06 , C07D471/14 , A61K2300/00
摘要: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.
摘要翻译: 咪唑并吡啶和四氢咪唑并吡啶化合物诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。 该化合物显示抗病毒和抗肿瘤性质。 公开了制备可用于制备化合物的化合物和中间体的方法。
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