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    Substituted [1,4]-diazepanes as CXCR3 antagonists and their use in the treatment of inflammatory disorders
    7.
    发明申请
    Substituted [1,4]-diazepanes as CXCR3 antagonists and their use in the treatment of inflammatory disorders 审中-公开
    取代的[1,4] - 二氮杂环己烷作为CXCR3拮抗剂及其在治疗炎性疾病中的应用

    公开(公告)号：US20080312215A1

    公开(公告)日：2008-12-18

    申请号：US11427175

    申请日：2006-06-28

    申请人： Andrew G. Cole ,  Marc-Raleigh Brescia ,  Ian Henderson

    发明人： Andrew G. Cole ,  Marc-Raleigh Brescia ,  Ian Henderson

    IPC分类号： A61K31/551 ,  C07D243/08 ,  A61P19/02 ,  A61P1/00

    CPC分类号： C07D295/185 ,  C07D295/155 ,  C07D295/215

    摘要： CXCR3 inhibitors of formula are disclosed. Inhibition of CXCR3 activation is useful for treating disorders resulting from CXCR3-associated T-cell mediated function, such as inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis and diabetes, as well as in the prevention of allograft rejection. N-ethyl-1,4-diazepane-1-carboxamides in which R1 is substituted or unsubstituted arylalkyl and R3 is substituted or unsubstituted aryl are particularly preferred.

    摘要翻译： 公开了CXCR3抑制剂。 CXCR3激活的抑制可用于治疗由与CXCR3相关的T细胞介导的功能（例如炎性肠病，多发性硬化症，类风湿性关节炎和糖尿病）以及预防同种异体移植排斥引起的疾病。 其中R 1为取代或未取代的芳烷基，且R 3为取代或未取代的芳基的N-乙基-1,4-二氮杂环庚烷-1-甲酰胺是特别优选的。