公开(公告)号：US20110098593A1

公开(公告)日：2011-04-28

申请号：US12913686

申请日：2010-10-27

申请人： Philip Low ,  Yu M. Chi ,  Siddharth Joshi ,  Christopher Uebelher ,  Yvon A. Dubois ,  Kevin Liu

发明人： Philip Low ,  Yu M. Chi ,  Siddharth Joshi ,  Christopher Uebelher ,  Yvon A. Dubois ,  Kevin Liu

IPC分类号： A61B5/0476

CPC分类号： A61B5/0006 ,  A61B5/0416 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/6803 ,  A61B5/6831

摘要： An assembly and system for collection and assessment of physiological data is provided. The assembly includes a physiological data acquisition module that may be used in combination with a head harness for the collection, recordation, storage and transmission of quality physiological data. The assembly integrates easy to use, self-applied electrodes in a user-friendly system resulting in less data artifacts than commonly seen in conventional methods and techniques for collecting physiological data. The assembly and system captures high-quality physiological data for display, storage, processing and analysis.

摘要翻译： 提供了用于收集和评估生理数据的组装和系统。 组件包括生理数据采集模块，其可以与头带组合使用，用于收集，记录，存储和传输质量生理数据。 该组件将易于使用的自应用电极集成在用户友好的系统中，导致比用于收集生理数据的常规方法和技术中常见的更少的数据伪影。 组装和系统捕获高质量的生理数据进行显示，存储，处理和分析。

公开(公告)号：US20070150691A1

公开(公告)日：2007-06-28

申请号：US11318868

申请日：2005-12-27

申请人： Ajith Illendula ,  Philip Low

发明人： Ajith Illendula ,  Philip Low

IPC分类号： G06F12/00

CPC分类号： G06F12/0246

摘要： Example methods and apparatus to share a thread to reclaim memory space in non-volatile memory file systems are disclosed. A disclosed example method includes associating a memory reclaim thread with first and second flash memory volumes to reclaim memory space in the first and second flash memory volumes and reclaiming the memory space in at least one of the first and second flash memory volumes via the memory reclaim thread.

摘要翻译： 公开了共享线程以回收非易失性存储器文件系统中的存储器空间的示例方法和装置。 所公开的示例性方法包括将存储器回收线程与第一和第二闪存存储器卷相关联以回收第一和第二闪存存储器卷中的存储器空间并且经由存储器回收回收至少一个第一和第二闪存存储器卷中的存储器空间 线。

公开(公告)号：US20100330702A1

公开(公告)日：2010-12-30

申请号：US12601986

申请日：2008-05-29

申请人： Cagri Savran ,  Philip Low ,  David Thompson ,  Walter Henne ,  Derek Doornweerd ,  Chun-Li Chang ,  Ghanashyam Acharya ,  David Brownholland

发明人： Cagri Savran ,  Philip Low ,  David Thompson ,  Walter Henne ,  Derek Doornweerd ,  Chun-Li Chang ,  Ghanashyam Acharya ,  David Brownholland

IPC分类号： G01N33/543 ,  G01N30/00

CPC分类号： G01N33/54386 ,  C12Q1/6804 ,  G01N21/4788 ,  G01N33/54393

摘要： Systems and methods for rapid and ultrasensitive detection of target hiomolecules in a sample are presented. The detection of biomolecules is achieved through a synergistic use of immunoseparation and diffractomctry, and the formation of antibody-biomolecule-ligand sandwich complexes that form diffraction gratings. Characteristic diffraction patterns are then produced upon illumination of the diffraction gratings with light. The diffraction patterns can he used to detect very low amounts of biomolecules present in the sample.

摘要翻译： 介绍了样品中目标高分子快速和超灵敏检测的系统和方法。 生物分子的检测通过免疫分离和衍射的协同使用以及形成衍射光栅的抗体 - 生物分子 - 配体夹心复合物的形成来实现。 然后在用光照射衍射光栅时产生特征衍射图案。 他可以使用衍射图来检测样品中存在的非常低量的生物分子。

公开(公告)号：US20060067946A1

公开(公告)日：2006-03-30

申请号：US11274973

申请日：2005-11-16

申请人： Philip Low ,  Yingjuan Lu

发明人： Philip Low ,  Yingjuan Lu

IPC分类号： A61K39/385

CPC分类号： A61K39/39 ,  A61K39/385 ,  A61K39/39541 ,  A61K47/551 ,  A61K2039/55511 ,  A61K2039/55522 ,  A61K2039/55533 ,  A61K2039/6081 ,  A61K2300/00

摘要： A method and pharmaceutical composition are provided for enhancing the endogenous immune response-mediated elimination of a population of pathogenic cells in a host animal wherein the pathogenic cells preferentially express, uniquely express, or overexpress a binding site for a particular ligand. The invention comprises administering the ligand conjugated to an immunogen to a host animal harboring the population of pathogenic cells. Antibodies, preexisting or administered to the host animal to establish a passive immunity, directed against the immunogen bind to the ligand-immunogen conjugate resulting in elimination of the pathogenic cells by the host's immune response. At least one additional therapeutic factor is administered selected from the group consisting of a cell killing agent, a tumor penetration enhancer, a chemotherapeutic agent, antimicrobial agent, a cytotoxic immune cell, and a compound capable of stimulating an endogenous immune response wherein the compound does not bind to the ligand-immunogen conjugate.

公开(公告)号：US20050244336A1

公开(公告)日：2005-11-03

申请号：US11022088

申请日：2004-12-23

申请人： Philip Low

发明人： Philip Low

IPC分类号： A61B20060101 ,  A61K39/395 ,  A61K49/00 ,  G01N33/50 ,  G01N33/53 ,  G01N33/92

CPC分类号： A61K49/0043 ,  A61K49/0041 ,  A61K49/0052 ,  A61K49/006 ,  A61K51/0474 ,  A61K51/0497 ,  G01N33/5061 ,  G01N33/92 ,  G01N2800/323

摘要： The invention relates to a method of identifying/monitoring active atherosclerotic plaques associated with blood vessel walls wherein the plaques comprise activated macrophages having accessible binding sites for a ligand. The method comprises the steps of administering to a patient being evaluated for atherosclerosis an effective amount of a composition comprising a conjugate of a ligand and a chromophore capable of emitting light under predetermined conditions, allowing sufficient time for the ligand conjugate to bind to the activated macrophages, subjecting the blood vessels to the predetermined conditions using a catheter-based device, and identifying active plaques by detecting light emitted by the chromophore using a catheter-based device or by using an external imaging technique. The invention also relates to a similar method wherein a chemical moiety capable of emitting radiation is conjugated to the ligand.

摘要翻译： 本发明涉及鉴定/监测与血管壁相关的活动性动脉粥样硬化斑块的方法，其中斑块包含具有可配位结合位点的活化巨噬细胞。 该方法包括以下步骤：向被评估动脉粥样硬化的患者施用有效量的包含配体和能够在预定条件下发光的发色团的缀合物的组合物，允许配体缀合物足够的时间结合活化的巨噬细胞 使用基于导管的装置对血管进行预定条件，并且使用基于导管的装置或通过使用外部成像技术检测由发色团发出的光来识别活性斑块。 本发明还涉及一种类似的方法，其中能够发射辐射的化学部分与配体缀合。

公开(公告)号：US08073534B2

公开(公告)日：2011-12-06

申请号：US11431425

申请日：2006-05-09

申请人： Philip Low

发明人： Philip Low

IPC分类号： A61B5/04

CPC分类号： G06K9/00536 ,  A61B5/048 ,  A61B5/4812 ,  A61B5/4815 ,  A61B5/7203 ,  A61B5/726 ,  A61B5/7264 ,  A61B5/7267

摘要： Determining low power frequency range information from spectral data. Raw signal data can be adjusted to increase dynamic range for power within low power frequency ranges as compared to higher-power frequency ranges to determine adjusted source data valuable for acquiring low power frequency range information. Low power frequency range information can be used in the analysis of a variety of raw signal data. For example, low power frequency range information within electroencephalography data for a subject from a period of sleep can be used to determine sleep states. Similarly, automated full-frequency spectral electroencephalography signal analysis can be useful for customized analysis including assessing sleep quality, detecting pathological conditions, and determining the effect of medication on sleep states.

摘要翻译： 从频谱数据确定低功率频率范围信息。 与较高功率频率范围相比，可以调整原始信号数据以增加低功率频率范围内的功率的动态范围，以确定用于获取低功率频率范围信息的有价值的调整的源数据。 低功率频率范围信息可用于分析各种原始信号数据。 例如，可以使用从睡眠期间的对象的脑电图数据内的低功率频率范围信息来确定睡眠状态。 类似地，自动全频谱脑电图信号分析可用于定制分析，包括评估睡眠质量，检测病理状况以及确定药物对睡眠状态的影响。

公开(公告)号：US20110218454A1

公开(公告)日：2011-09-08

申请号：US13129185

申请日：2009-11-16

申请人： Philip Low

发明人： Philip Low

IPC分类号： A61B5/0476

CPC分类号： A61B5/0476 ,  A61B5/4809 ,  A61B5/4812

摘要： Traditional analysis of sleep patterns requires several channels of data. This analysis can be useful for customized analysis including assessing sleep quality, detecting pathological conditions, determining the effect of medication on sleep states and identifying biomarkers, and drug dosages or reactions.

摘要翻译： 睡眠模式的传统分析需要多个数据通道。 该分析可用于定制分析，包括评估睡眠质量，检测病理状况，确定药物对睡眠状态的影响和鉴定生物标志物，以及药物剂量或反应。

公开(公告)号：US20070276231A1

公开(公告)日：2007-11-29

申请号：US11793459

申请日：2005-12-23

申请人： Philip Low ,  Bindu Varghese ,  Iontcho Vlahov

发明人： Philip Low ,  Bindu Varghese ,  Iontcho Vlahov

IPC分类号： A61B6/00

CPC分类号： C07B59/005 ,  A61B6/037 ,  A61K51/04 ,  A61K51/0459 ,  C07B59/002

摘要： The invention relates to compositions and methods to diagnose/monitor, using positron emission tomography, pathogenic disease states wherein the pathogenic cells uniquely express, preferentially express, or overexpress vitamin receptors. In an illustrative embodiment, vitamins, or analogs thereof, conjugated to a radiophore are used to diagnose/monitor disease states extra-corporeally using positron emission tomography. The disease states that can be diagnosed/monitored in accordance with the invention are cancer and disease states involving activated macrophages, such as disease states involving an inflammatory response.

摘要翻译： 本发明涉及使用正电子发射断层扫描来诊断/监测致病性疾病的组合物和方法，其中致病细胞独特地表达，优先表达或过度表达维生素受体。 在说明性实施例中，使用与放射线相结合的维生素或其类似物来诊断/监测使用正电子发射层析成像的体外疾病状态。 可以根据本发明诊断/监测的疾病状态是涉及活化的巨噬细胞的癌症和疾病状态，例如涉及炎症反应的疾病状态。

公开(公告)号：US20070231266A1

公开(公告)日：2007-10-04

申请号：US11648223

申请日：2006-12-29

申请人： Philip Low ,  Mary Turk

发明人： Philip Low ,  Mary Turk

IPC分类号： A61K51/00 ,  A61K49/00

CPC分类号： A61K51/0482 ,  A61K9/127 ,  A61K47/646 ,  A61K47/6849 ,  A61K51/1027

摘要： The invention relates to a method of treating or monitoring/diagnosing a disease state mediated by activated macrophages. The method comprises the step of administering to a patient suffering from a macrophage mediated disease state an effective amount of a composition comprising a conjugate or complex of the general formula Ab-X where the group Ab comprises a ligand capable of binding to activated macrophages, and when the conjugate is being used for treatment of the disease state, the group X comprises an immunogen, a cytotoxin, or a compound capable of altering macrophage function, and when the conjugate is being used for monitoring/diagnosing the disease state, X comprises an imaging agent. The method is useful for treating a patient suffering from a disease selected from the group consisting of rheumatoid arthritis, ulcerative colitis, Crohn's disease, inflammation, infections, osteomyelitis, atherosclerosis, organ transplant rejection, pulmonary fibrosis, sarcoidosis, and systemic sclerosis.

摘要翻译： 本发明涉及一种治疗或监测/诊断由活化的巨噬细胞介导的疾病状态的方法。 该方法包括向患有巨噬细胞介导的疾病状态的患者施用有效量的组合物的步骤，所述组合物包含通式为“？in-line-formula description =”In-Line Formulas“end =” 导线“>> -X <？in-line-formula description =”In-line Formulas“end =”tail“？>其中组A 能够结合活化的巨噬细胞的配体，当缀合物用于治疗疾病状态时，组X包含免疫原，细胞毒素或能够改变巨噬细胞功能的化合物，当缀合物用于 监测/诊断疾病状态，X包括成像剂。 该方法可用于治疗患有选自类风湿性关节炎，溃疡性结肠炎，克罗恩病，炎症，感染，骨髓炎，动脉粥样硬化，器官移植排斥，肺纤维化，结节病和系统性硬化症的疾病的患者。