公开(公告)号：US08663563B2

公开(公告)日：2014-03-04

申请号：US13311307

申请日：2011-12-05

Applicant: Cagri Savran ,  Chun-Li Chang ,  Zhenwen Ding ,  Babak Ziaie ,  Andrew Ellington ,  Venkata Naga Lakshmi Rekha Patchigolla

Inventor： Cagri Savran ,  Chun-Li Chang ,  Zhenwen Ding ,  Babak Ziaie ,  Andrew Ellington ,  Venkata Naga Lakshmi Rekha Patchigolla

IPC: G01B11/02

CPC classification number: G01B11/14 ,  B82Y35/00

Abstract: A reflective diffractometric hydrogel sensor includes an upper layer, including a microfluidic chamber formed from a substantially transparent material and configured to contain a solution, a reflective diffraction grating positioned within the microfluidic chamber, the diffraction grating including a plurality of hydrogel strips configured to change in dimension in response to a stimulus, each hydrogel strip having a top surface coated with a reflective material and a bottom surface in contact with the upper layer substrate, and a reflective surface below the reflective diffraction grating wherein when a coherent light is incident upon and reflected from the upper layer at an angle substantially normal to the upper layer an interference diffraction pattern results, including a first diffraction mode, a light intensity of which indicates the relative distance between the top surfaces of the plurality of hydrogel strips and the reflective surface.

Abstract translation: 反射衍射水凝胶传感器包括上层，包括由基本上透明的材料形成的微流体室，并且被构造为容纳溶液，位于微流体室内的反射衍射光栅，衍射光栅包括多个水凝胶条，其被配置为在 每个水凝胶条具有涂覆有反射材料的顶表面和与上层基底接触的底表面，以及反射衍射光栅下方的反射表面，其中当相干光入射并反射时 导致基本垂直于上层的角度从上层开始产生干涉衍射图案，其包括第一衍射模式，其第一衍射模式的光强表示多个水凝胶条带的顶表面与反射表面之间的相对距离。

公开(公告)号：US20130053699A1

公开(公告)日：2013-02-28

申请号：US13221145

申请日：2011-08-30

Applicant: Wen-Hong Wu ,  Chung-Hsing Chang ,  Han-Chao Chang ,  Chun-Li Chang ,  Kuo-Cheng Huang ,  Din-Ping Tsai ,  Hsin-Su Yu

Inventor： Wen-Hong Wu ,  Chung-Hsing Chang ,  Han-Chao Chang ,  Chun-Li Chang ,  Kuo-Cheng Huang ,  Din-Ping Tsai ,  Hsin-Su Yu

IPC: A61B6/00

CPC classification number: A61B5/0071 ,  A61B5/7425 ,  A61N5/062

Abstract: An apparatus for performing photodynamic diagnosis and photodynamic therapy on a target region that is pre-given with a photosensitizer precursor includes a display unit, an excitation light source operable to irradiate the target region with exciting light so as to excite emission of fluorescence from the target region as a result of fluorescence response of the photosensitizer precursor, an image capturing unit operable to capture a white light image and a fluorescent image of the target region, an image processing unit operable to superimpose the white light image and the fluorescent image into a synthesized image and to provide at least one of the white light image, the fluorescent image and the synthesized image thereto for display on the display unit, and a curing light source operable to irradiate a specified portion of the target region with curing light for treating the specified portion.

Abstract translation: 用于对预先给予光敏剂前体的目标区进行光动力学诊断和光动力学治疗的装置包括显示单元，激发光源，其可操作以用激发光照射目标区域，以激发来自目标的荧光的发射 区域，作为光敏剂前体的荧光响应的结果，可操作以捕获白色光图像和目标区域的荧光图像的图像捕获单元，可操作以将白色光图像和荧光图像叠加到合成的区域中的图像处理单元 并且提供白光图像，荧光图像和合成图像中的至少一个以在显示单元上显示;以及固化光源，其可操作以用固化光照射目标区域的指定部分，以处理指定的 一部分。

公开(公告)号：US20140024049A1

公开(公告)日：2014-01-23

申请号：US14001963

申请日：2012-04-05

Applicant: Cagri A. Savran ,  Philip S. Low ,  Chun-Li Chang

Inventor： Cagri A. Savran ,  Philip S. Low ,  Chun-Li Chang

IPC: G01N27/74

CPC classification number: B01L3/502761 ,  B01L3/50273 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/0877 ,  B01L2400/043 ,  G01N27/745 ,  G01N33/54326 ,  G01N33/574 ,  G01N33/57434 ,  G01N33/57492 ,  G01N2001/4016

Abstract: A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target cells bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target cells from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target cells bound to magnetic beads on the surface of the plate. The microfluidic detection system includes a pump flowing the fluid through the detector component at high flow rates of milliliters per minute for high throughput detection of target cells.

Abstract translation: 用于微米尺寸实体（例如生物细胞）的微流体检测系统包括结合有多个开口的板的检测器部件，该板分离两个室，一个与包含与磁珠结合的靶细胞的流体源连通。 这些开口的尺寸设置成总是允许磁珠通过其进入下部的一个室，并且进一步的尺寸设计成总是防止靶细胞从上部的一个室中通过。 检测器部件还包括磁铁，该磁体定位成将未结合的磁珠拉过开口并捕获与板表面上的磁珠结合的靶细胞。 微流体检测系统包括泵以高分子量/分钟的速度流过检测器部件，用于目标细胞的高通量检测。

公开(公告)号：US20130321773A1

公开(公告)日：2013-12-05

申请号：US13488623

申请日：2012-06-05

Applicant: Cheng-Chung Lee ,  Yu-Ting Li ,  Wen-Hong Wu ,  Chun-Li Chang

Inventor： Cheng-Chung Lee ,  Yu-Ting Li ,  Wen-Hong Wu ,  Chun-Li Chang

IPC: A61B3/10

CPC classification number: A61B3/10 ,  A61B3/1035

Abstract: An optometric automatic test device and method for a lens are provided to perform image capturing and reading with an image analysis technique, perform automatic focusing by automated control technology rather than by the test worker's operation, and enable two tests, namely refractive power test and astigmatism test, to be performed on eyeglass lenses automatically, so as to greatly reduce the errors caused by the test worker's operation and enhance test efficiency.

Abstract translation: 提供了一种用于镜头的验光自动测试装置和方法，用图像分析技术进行图像采集和读取，通过自动化控制技术而不是测试人员的操作执行自动对焦，并且可以进行两个测试，即屈光力测试和散光 测试，自动执行眼镜镜片，大大减少测试人员操作造成的错误，提高测试效率。

公开(公告)号：US20120170050A1

公开(公告)日：2012-07-05

申请号：US13311307

申请日：2011-12-05

Applicant: Cagri Savran ,  Chun-Li Chang ,  Zhenwen Ding ,  Babak Ziaie ,  Andrew Ellington ,  Venkata Naga Lakshmi Rekha Patchigolla

Inventor： Cagri Savran ,  Chun-Li Chang ,  Zhenwen Ding ,  Babak Ziaie ,  Andrew Ellington ,  Venkata Naga Lakshmi Rekha Patchigolla

IPC: G01B11/02

CPC classification number: G01B11/14 ,  B82Y35/00

Abstract: A reflective diffractometric hydrogel sensor includes an upper layer, including a microfluidic chamber formed from a substantially transparent material and configured to contain a solution, a reflective diffraction grating positioned within the microfluidic chamber, the diffraction grating including a plurality of hydrogel strips configured to change in dimension in response to a stimulus, each hydrogel strip having a top surface coated with a reflective material and a bottom surface in contact with the upper layer substrate, and a reflective surface below the reflective diffraction grating wherein when a coherent light is incident upon and reflected from the upper layer at an angle substantially normal to the upper layer an interference diffraction pattern results, including a first diffraction mode, a light intensity of which indicates the relative distance between the top surfaces of the plurality of hydrogel strips and the reflective surface.

Abstract translation: 反射衍射水凝胶传感器包括上层，包括由基本上透明的材料形成的微流体室，并且被构造为容纳溶液，位于微流体室内的反射衍射光栅，衍射光栅包括多个水凝胶条，其被配置为在 每个水凝胶条具有涂覆有反射材料的顶表面和与上层基底接触的底表面，以及反射衍射光栅下方的反射表面，其中当相干光入射并反射时 导致基本垂直于上层的角度从上层开始产生干涉衍射图案，其包括第一衍射模式，其第一衍射模式的光强表示多个水凝胶条带的顶表面与反射表面之间的相对距离。

公开(公告)号：US20100330702A1

公开(公告)日：2010-12-30

申请号：US12601986

申请日：2008-05-29

Applicant: Cagri Savran ,  Philip Low ,  David Thompson ,  Walter Henne ,  Derek Doornweerd ,  Chun-Li Chang ,  Ghanashyam Acharya ,  David Brownholland

Inventor： Cagri Savran ,  Philip Low ,  David Thompson ,  Walter Henne ,  Derek Doornweerd ,  Chun-Li Chang ,  Ghanashyam Acharya ,  David Brownholland

IPC: G01N33/543 ,  G01N30/00

CPC classification number: G01N33/54386 ,  C12Q1/6804 ,  G01N21/4788 ,  G01N33/54393

Abstract: Systems and methods for rapid and ultrasensitive detection of target hiomolecules in a sample are presented. The detection of biomolecules is achieved through a synergistic use of immunoseparation and diffractomctry, and the formation of antibody-biomolecule-ligand sandwich complexes that form diffraction gratings. Characteristic diffraction patterns are then produced upon illumination of the diffraction gratings with light. The diffraction patterns can he used to detect very low amounts of biomolecules present in the sample.

Abstract translation: 介绍了样品中目标高分子快速和超灵敏检测的系统和方法。 生物分子的检测通过免疫分离和衍射的协同使用以及形成衍射光栅的抗体 - 生物分子 - 配体夹心复合物的形成来实现。 然后在用光照射衍射光栅时产生特征衍射图案。 他可以使用衍射图来检测样品中存在的非常低量的生物分子。

公开(公告)号：US09341621B2

公开(公告)日：2016-05-17

申请号：US12601986

申请日：2008-05-29

Applicant: Cagri Savran ,  Philip Low ,  David Thompson ,  Walter Henne ,  Derek Doorneweerd ,  Chun-Li Chang ,  Ghanashyam Acharya ,  David Brownholland

Inventor： Cagri Savran ,  Philip Low ,  David Thompson ,  Walter Henne ,  Derek Doorneweerd ,  Chun-Li Chang ,  Ghanashyam Acharya ,  David Brownholland

IPC: G01N33/53 ,  G01N33/543 ,  C12Q1/68 ,  G01N21/47

CPC classification number: G01N33/54386 ,  C12Q1/6804 ,  G01N21/4788 ,  G01N33/54393

Abstract: Systems and methods for rapid and ultrasensitive detection of target biomolecules in a sample are presented. The detection of biomolecules is achieved through a synergistic use of immunoseparation and diffractometry, and the formation of antibody-biomolecule-ligand sandwich complexes that form diffraction gratings. Characteristic diffraction patterns are then produced upon illumination of the diffraction gratings with light. The diffraction patterns can be used to detect very low amounts of biomolecules present in the sample.

Abstract translation: 提出了用于样品中目标生物分子的快速和超灵敏检测的系统和方法。 通过免疫分离和衍射的协同使用以及形成衍射光栅的抗体 - 生物分子 - 配体夹心复合体的形成来实现生物分子的检测。 然后在用光照射衍射光栅时产生特征衍射图案。 衍射图可用于检测样品中存在的非常低量的生物分子。