公开(公告)号：US5159194A

公开(公告)日：1992-10-27

申请号：US756290

申请日：1991-09-06

申请人： Philip Marriott ,  Anthony M. Jones ,  Robert S. Taylor

发明人： Philip Marriott ,  Anthony M. Jones ,  Robert S. Taylor

IPC分类号： G01N27/62 ,  H01J49/02 ,  H01J49/30

CPC分类号： H01J49/022

摘要： A method of mass spectrometry and a mass spectrometer for the analysis of a sample, the mass spectrometer comprising means for producing ions from the sample and a magnetic sector for analyzing the ions, wherein the magnetic field of the magnetic sector is generated by passage of a magnet current controlled by a digital control signal representative of a sequence of integers generated by a computer. According to the invention, means are provided for generating the magnet current in exponential relation to the sequence of integers. In contrast to prior spectrometers, the invention provides peak switching and mass selection across the mass range with a constant number of integer steps per mass peak, thereby facilitating the digital selection of any particular mass peak, particularly those at low mass.

公开(公告)号：USRE45386E1

公开(公告)日：2015-02-24

申请号：US14032096

申请日：2013-09-19

申请人： Philip Marriott

发明人： Philip Marriott

IPC分类号： H01J49/00 ,  H01J49/26 ,  B01D59/44

CPC分类号： H01J49/421 ,  H01J49/0045 ,  H01J49/04 ,  H01J49/105 ,  H01J49/22

摘要： The present invention relates to inductively coupled plasma mass spectrometry (ICPMS) in which a collision cell is employed to selectively remove unwanted artefact ions from an ion beam by causing them to interact with a reagent gas. The present invention provides a first evacuated chamber (6) at high vacuum located between an expansion chamber (3) and a second evacuated chamber (20) containing the collision cell (24). The first evacuated chamber (6) includes a first ion optical device (17). The collision cell (24) contains a second ion optical device (25). The provision of the first evacuated chamber (5) reduces the gas load on the collision cell (24), by minimising the residual pressure within the collision cell (24) that is attributable to the gas load from the plasma source (1). This serves to minimise the formation, or re-formation, of unwanted artefact ions in the collision cell (24).

摘要翻译： 电感耦合等离子体质谱法（ICPMS）本发明涉及电感耦合等离子体质谱法（ICPMS），其中使用碰撞电池通过使其与反应气体相互作用来选择性地从离子束中去除不需要的伪影离子。 本发明提供了一种位于膨胀室（3）和包含碰撞室（24）的第二抽空室（20）之间的高真空的第一真空室（6）。 第一真空室（6）包括第一离子光学装置（17）。 碰撞单元（24）包含第二离子光学装置（25）。 通过最小化由于来自等离子体源（1）的气体负载引起的碰撞室（24）内的残余压力，第一真空室（5）的设置减少了碰撞室（24）上的气体负荷。 这用于最小化碰撞池（24）中不想要的伪影离子的形成或重新形成。

公开(公告)号：US20110290996A1

公开(公告)日：2011-12-01

申请号：US13111588

申请日：2011-05-19

申请人： Philip Neil Shaw ,  Philip Marriott

发明人： Philip Neil Shaw ,  Philip Marriott

IPC分类号： G01N1/38 ,  H01J49/02

CPC分类号： G01N1/38 ,  G01N1/10 ,  Y10T436/25625 ,  Y10T436/2575

摘要： The present invention provides a pump device 50 which is usable to dilute a sample 52 before analysis. A first pump 54 pumps the sample to a mixing region 58 where it mixes with a diluent 66. A second pump 64 pumps the diluted sample to the analysis instrument. The flow of the diluent to the mixer is equal to the difference of the flow of the sample to the mixer and the flow of the diluted sample to the instrument. Pumps 54 and 64 are independently controllable by a controller unit which is arranged so that data from the instrument can be used to determine the dilution factor of the sample. Thus, the controller can control this dilution factor in real time, upon receipt of such data from the instrument, by change either one of (or both) the pump's flow rate.

摘要翻译： 本发明提供一种泵装置50，其可用于在分析之前稀释样品52。 第一泵54将样品泵送到混合区域58，在混合区域58中与稀释剂66混合。第二泵64将稀释的样品泵送到分析仪器。 稀释剂到混合器的流动等于样品与混合器的流动量和稀释样品流到仪器的流量。 泵54和64可由控制器单元独立控制，所述控制器单元布置成使得来自仪器的数据可用于确定样品的稀释因子。 因此，控制器可以通过改变泵的流量（或两者）中的一个（或两者）从仪器接收到这样的数据来实时地控制该稀释因子。

公开(公告)号：US20060151690A1

公开(公告)日：2006-07-13

申请号：US11299250

申请日：2005-12-09

申请人： Philip Marriott

发明人： Philip Marriott

IPC分类号： H01J49/00

CPC分类号： H01J49/421 ,  H01J49/0045 ,  H01J49/04 ,  H01J49/105 ,  H01J49/22

摘要： The present invention relates to inductively coupled plasma mass spectrometry (ICPMS) in which a collision cell is employed to selectively remove unwanted artefact ions from an ion beam by causing them to interact with a reagent gas. The present invention provides a first evacuated chamber (6) at high vacuum located between an expansion chamber (3) and a second evacuated chamber (20) containing the collision cell (24). The first evacuated chamber (6) includes a first ion optical device (17). The collision cell (24) contains a second ion optical device (25). The provision of the first evacuated chamber (6) reduces the gas load on the collision cell (24), by minimising the residual pressure within the collision cell (24) that is attributable to the gas load from the plasma source (1). This serves to minimise the formation, or re-formation, of unwanted artefact ions in the collision cell (24).

摘要翻译： 电感耦合等离子体质谱法（ICPMS）本发明涉及电感耦合等离子体质谱法（ICPMS），其中使用碰撞电池通过使其与反应气体相互作用来选择性地从离子束中去除不需要的伪影离子。 本发明提供了一种位于膨胀室（3）和包含碰撞室（24）的第二抽空室（20）之间的高真空的第一真空室（6）。 第一真空室（6）包括第一离子光学装置（17）。 碰撞单元（24）包含第二离子光学装置（25）。 通过最小化由于来自等离子体源（1）的气体负载引起的碰撞室（24）内的残余压力，第一抽真空室（6）的设置减少了碰撞室（24）上的气体负荷。 这用于最小化碰撞池（24）中不想要的伪影离子的形成或重新形成。

公开(公告)号：US20060104827A1

公开(公告)日：2006-05-18

申请号：US10524706

申请日：2003-08-14

申请人： Philip Shaw ,  Philip Marriott

发明人： Philip Shaw ,  Philip Marriott

IPC分类号： F04B3/00 ,  F04B5/00

CPC分类号： G01N35/1097 ,  G01N1/38 ,  G01N35/08

摘要： A pumping apparatus (50) which isolates a sample (52) from a pump (72), thereby circumventing the so-called “memory effect” problem. The sample is pumped into an intermediary, or buffer region (64) using a first pump (54). The sample is displaced from this buffer region by pumping a second fluid (74) into the buffer region using a second pump (72). When the sample is displaced from the buffer region it proceeds to a mixer (78) where it can be diluted before analysis. The second pump is required to operate with a high degree of accuracy so that the sample is diluted by a consistent amount. Preferably, the second pump is a highly accurate piston pump.

摘要翻译： 一种泵送装置（50），其将样品（52）与泵（72）隔离，从而绕过所谓的“记忆效应”问题。 使用第一泵（54）将样品泵入中间或缓冲区（64）。 通过使用第二泵（72）将第二流体（74）泵送到缓冲区域中，使样品从该缓冲区域移位。 当样品从缓冲区域移位时，它进入混合器（78），在混合器（78）中可以在分析之前进行稀释。 第二个泵需要高精度的操作，以使样品以一致的量稀释。 优选地，第二泵是高精度的活塞泵。

公开(公告)号：US20050127283A1

公开(公告)日：2005-06-16

申请号：US10497396

申请日：2003-05-13

申请人： Philip Marriott

发明人： Philip Marriott

IPC分类号： G01N27/62 ,  H01J49/42 ,  H01J49/00

CPC分类号： H01J49/4215 ,  H01J49/004

摘要： A mass filter apparatus for filtering a beam of ions is described. The apparatus comprises an ion beam source and first and second mass filter stages in series to receive the ion beam. A vacuum system maintains the first and second filter stages at substantially the same operating pressure, below 10−3 torr. The first mass filter stage transmits only ions having a sub-range of mass-to-charge ratios including a selected mass-to-charge ratio. The second filter transmits only ions of the selected mass-to-charge ratio. The second mass filter can achieve high accuracy detection without being subjected to problems such as build-up of material on quadrupole rods, resulting in a distorted electric field close to the rods. The first mass filter acts as a coarse filter, typically transmitting 1% of ions received from the ion source. Thus, the detection accuracy and lifetime of mass spectrometers embodying this invention are greatly improved.

摘要翻译： 描述了用于过滤离子束的质量过滤装置。 该装置包括离子束源和用于接收离子束的串联的第一和第二质量过滤器级。 真空系统将第一和第二过滤器级保持在基本相同的操作压力，低于10 -3乇。 第一质量过滤器级仅传送具有包括所选质量 - 电荷比的质荷比的子范围的离子。 第二过滤器仅传输所选质量 - 电荷比的离子。 第二质量过滤器可以实现高精度检测，而不会受到诸如在四极杆上的材料堆积等问题，导致靠近杆的电场变形。 第一个质量过滤器用作粗过滤器，通常传输从离子源接收的离子的1％。 因此，体现本发明的质谱仪的检测精度和寿命大大提高。

公开(公告)号：US07339163B2

公开(公告)日：2008-03-04

申请号：US11807132

申请日：2007-05-25

申请人： Philip Marriott

发明人： Philip Marriott

IPC分类号： H01J49/00 ,  B01D59/44

CPC分类号： H01J49/421 ,  H01J49/0045 ,  H01J49/04 ,  H01J49/105 ,  H01J49/22

摘要： The present invention relates to inductively coupled plasma mass spectrometry (ICPMS) in which a collision cell is employed to selectively remove unwanted artifact ions from an ion beam by causing them to interact with a reagent gas. The present invention provides a first evacuated chamber (6) at high vacuum located between an expansion chamber (3) and a second evacuated chamber (20) containing the collision cell (24). The first evacuated chamber (6) includes a first ion optical device (17). The collision cell (24) contains a second ion optical device (25). The provision of the first evacuated chamber (6) reduces the gas load on the collision cell (24), by minimising the residual pressure within the collision cell (24) that is attributable to the gas load from the plasma source (1). This serves to minimise the formation, or re-formation, of unwanted artifact ions in the collision cell (24).

摘要翻译： 本发明涉及电感耦合等离子体质谱法（ICPMS），其中使用碰撞电池通过使其与反应气体相互作用来选择性地从离子束中去除不需要的伪影离子。 本发明提供了一种位于膨胀室（3）和包含碰撞室（24）的第二抽空室（20）之间的高真空的第一真空室（6）。 第一真空室（6）包括第一离子光学装置（17）。 碰撞单元（24）包含第二离子光学装置（25）。 通过最小化由于来自等离子体源（1）的气体负载引起的碰撞室（24）内的残余压力，第一抽真空室（6）的设置减少了碰撞室（24）上的气体负荷。 这用于使碰撞单元（24）中的不想要的人造物离子的形成或重新形成最小化。

公开(公告)号：US07273996B2

公开(公告)日：2007-09-25

申请号：US11293336

申请日：2005-12-01

申请人： Philip Marriott ,  Jonathan Herbert Bradford ,  Jim Stringer ,  Timothy Alan Whitechurch

发明人： Philip Marriott ,  Jonathan Herbert Bradford ,  Jim Stringer ,  Timothy Alan Whitechurch

IPC分类号： B23K9/00

CPC分类号： H05H1/30

摘要： An inductively coupled plasma alignment apparatus having a coil 10 for generating an inductively coupled plasma in a gas, the coil having a first axis 100; a torch 20 passing at least partially through the coil, the torch having a second axis 200; and an adjustment mechanism 80, 110 for adjusting the position of the torch with respect to the coil so as to alter the relative configuration of the first and second axes. The adjustment mechanism may adjust an angle and/or a distance between the second axis and the first axis. The second axis may be held substantially parallel to the first axis, while the adjustment mechanism adjusts a distance between the second axis and the first axis. The coil is preferably maintained substantially fixed in position with respect to a sampling aperture for sampling photons or ions from the plasma.

公开(公告)号：US07211788B2

公开(公告)日：2007-05-01

申请号：US10497396

申请日：2003-05-13

申请人： Philip Marriott

发明人： Philip Marriott

IPC分类号： H01J49/00

CPC分类号： H01J49/4215 ,  H01J49/004

摘要： A mass filter apparatus for filtering a beam of ions is described. The apparatus comprises an ion beam source and first and second mass filter stages in series to receive the ion beam. A vacuum system maintains the first and second filter stages at substantially the same operating pressure, below 10−3 torr. The first mass filter stage transmits only ions having a sub-range of mass-to-charge ratios including a selected mass-to-charge ratio. The second filter transmits only ions of the selected mass-to-charge ratio.The second mass filter can achieve high accuracy detection without being subjected to problems such as build-up of material on quadrupole rods, resulting in a distorted electric field close to the rods. The first mass filter acts as a coarse filter, typically transmitting 1% of ions received from the ion source. Thus, the detection accuracy and lifetime of mass spectrometers embodying this invention are greatly improved.

摘要翻译： 描述了用于过滤离子束的质量过滤装置。 该装置包括离子束源和用于接收离子束的串联的第一和第二质量过滤器级。 真空系统将第一和第二过滤器级保持在基本相同的操作压力，低于10 -3乇。 第一质量过滤器级仅传送具有包括所选质量 - 电荷比的质荷比的子范围的离子。 第二过滤器仅传输所选质量 - 电荷比的离子。 第二质量过滤器可以实现高精度检测，而不会受到诸如在四极杆上的材料堆积等问题，导致靠近杆的电场变形。 第一个质量过滤器用作粗过滤器，通常传输从离子源接收的离子的1％。 因此，体现本发明的质谱仪的检测精度和寿命大大提高。

公开(公告)号：US08758703B2

公开(公告)日：2014-06-24

申请号：US13111588

申请日：2011-05-19

申请人： Philip Neil Shaw ,  Philip Marriott

发明人： Philip Neil Shaw ,  Philip Marriott

IPC分类号： F04B53/00

CPC分类号： G01N1/38 ,  G01N1/10 ,  Y10T436/25625 ,  Y10T436/2575

摘要： The present invention provides a pump device 50 which is usable to dilute a sample 52 before analysis. A first pump 54 pumps the sample to a mixing region 58 where it mixes with a diluent 66. A second pump 64 pumps the diluted sample to the analysis instrument. The flow of the diluent to the mixer is equal to the difference of the flow of the sample to the mixer and the flow of the diluted sample to the instrument. Pumps 54 and 64 are independently controllable by a controller unit which is arranged so that data from the instrument can be used to determine the dilution factor of the sample. Thus, the controller can control this dilution factor in real time, upon receipt of such data from the instrument, by change either one of (or both) the pump's flow rate.

摘要翻译： 本发明提供一种泵装置50，其可用于在分析之前稀释样品52。 第一泵54将样品泵送到混合区域58，在混合区域58中与稀释剂66混合。第二泵64将稀释的样品泵送到分析仪器。 稀释剂到混合器的流动等于样品与混合器的流动量和稀释样品流到仪器的流量。 泵54和64可由控制器单元独立控制，所述控制器单元布置成使得来自仪器的数据可用于确定样品的稀释因子。 因此，控制器可以通过改变泵的流量（或两者）中的一个（或两者）从仪器接收到这样的数据来实时地控制该稀释因子。