公开(公告)号：US08507498B2

公开(公告)日：2013-08-13

申请号：US12451039

申请日：2008-04-24

申请人： Philipp Wabnitz ,  Heike Schauerte ,  Hans Allgeier ,  Martin Augustin ,  Lutz Zeitlmann ,  Michael A. Pleiss ,  Gabriele Stumm ,  Anke Mueller ,  Axel Choidas ,  Bert Klebl ,  Gerhard Mueller ,  Wilfried Schwab ,  Joelle Le ,  Jackie Macritchie ,  Don Simpson

发明人： Philipp Wabnitz ,  Heike Schauerte ,  Hans Allgeier ,  Martin Augustin ,  Lutz Zeitlmann ,  Michael A. Pleiss ,  Gabriele Stumm ,  Anke Mueller ,  Axel Choidas ,  Bert Klebl ,  Gerhard Mueller ,  Wilfried Schwab ,  Joelle Le ,  Jackie Macritchie ,  Don Simpson

IPC分类号： A01N43/54 ,  C07D239/42 ,  C07D401/04

CPC分类号： C07D239/42 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： The present invention relates to inhibitors of general Formula (I) of cyclin-dependent kinases and therapeutic applications thereof. Furthermore, the invention relates to compounds for preventing and/or treating any type of pain, inflammatory disorders, immunological diseases, proliferative diseases, infectious diseases, cardiovascular diseases and neurodegenerative diseases.

摘要翻译： 本发明涉及细胞周期蛋白依赖性激酶的通式（I）的抑制剂及其治疗应用。 此外，本发明涉及用于预防和/或治疗任何类型的疼痛，炎症性疾病，免疫疾病，增殖性疾病，感染性疾病，心血管疾病和神经变性疾病的化合物。

公开(公告)号：US20110306602A1

公开(公告)日：2011-12-15

申请号：US12451039

申请日：2008-04-24

申请人： Philipp Wabnitz ,  Heike Schauerte ,  Hans Allgeier ,  Lutz Zeitlmann ,  Anke Mueller ,  Martin Augustin ,  Michael A. Pleiss ,  Gabriele Stumm ,  Axel Choidas ,  Bert Klebl ,  Gerhard Mueller ,  Wilfried Schwab ,  Joelle Le ,  Jackie Macritchie ,  Don Simpson

发明人： Philipp Wabnitz ,  Heike Schauerte ,  Hans Allgeier ,  Lutz Zeitlmann ,  Anke Mueller ,  Martin Augustin ,  Michael A. Pleiss ,  Gabriele Stumm ,  Axel Choidas ,  Bert Klebl ,  Gerhard Mueller ,  Wilfried Schwab ,  Joelle Le ,  Jackie Macritchie ,  Don Simpson

IPC分类号： A61K31/55 ,  C07D405/12 ,  C07D409/12 ,  C07D401/12 ,  C07D413/12 ,  C07D403/12 ,  C07D417/12 ,  C07D401/10 ,  C07D413/10 ,  C07D403/10 ,  A61K31/505 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/506 ,  A61P29/00 ,  A61P37/00 ,  A61P35/00 ,  A61P31/00 ,  A61P9/00 ,  A61P25/28 ,  C07D239/42

CPC分类号： C07D239/42 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： The present invention relates to inhibitors of general Formula (I) of cyclin-dependent kinases and therapeutic applications thereof. Furthermore, the invention relates to compounds for preventing and/or treating any type of pain, inflammatory disorders, immunological diseases, proliferative diseases, infectious diseases, cardiovascular diseases and neurodegenerative diseases.

摘要翻译： 本发明涉及细胞周期蛋白依赖性激酶的通式（I）的抑制剂及其治疗应用。 此外，本发明涉及用于预防和/或治疗任何类型的疼痛，炎症性疾病，免疫疾病，增殖性疾病，感染性疾病，心血管疾病和神经变性疾病的化合物。

公开(公告)号：US20070191344A1

公开(公告)日：2007-08-16

申请号：US10572043

申请日：2004-09-15

申请人： Axel Choidas ,  Alexander Backes ,  Matt Cotten ,  Ola Engkvist ,  Beatrice Felber ,  Achim Freisleben ,  Klaus Godl ,  Zoltan Greff ,  Peter Habenberger ,  Doris Hafenbradl ,  Christian Hartung ,  Thomas Herget ,  Edmund Hoppe ,  Bert Klebl ,  Andrea Missio ,  Gerhard Muller ,  Wilfried Schwab ,  Birgit Zech ,  Jose Bravo ,  John Harris ,  Joelle Le ,  Jackie Macritchie ,  Vladimir Savic ,  Brad Sherborne ,  Don Simpson

发明人： Axel Choidas ,  Alexander Backes ,  Matt Cotten ,  Ola Engkvist ,  Beatrice Felber ,  Achim Freisleben ,  Klaus Godl ,  Zoltan Greff ,  Peter Habenberger ,  Doris Hafenbradl ,  Christian Hartung ,  Thomas Herget ,  Edmund Hoppe ,  Bert Klebl ,  Andrea Missio ,  Gerhard Muller ,  Wilfried Schwab ,  Birgit Zech ,  Jose Bravo ,  John Harris ,  Joelle Le ,  Jackie Macritchie ,  Vladimir Savic ,  Brad Sherborne ,  Don Simpson

IPC分类号： A61K31/55 ,  A61K31/506 ,  C07D403/02

CPC分类号： C04B35/632 ,  C07D239/42 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.

摘要翻译： 本发明涉及4,6-二取代的氨基嘧啶衍生物和/或其药学上可接受的盐，这些衍生物作为药物活性剂的用途，特别是用于预防和/或治疗感染性疾病，包括机会性疾病，朊病毒疾病，免疫学 疾病，自身免疫疾病，双相和临床疾病，心血管疾病，细胞增殖性疾病，糖尿病，炎症，移植排斥，勃起功能障碍，神经变性疾病和中风，以及含有所述4,6-二取代氨基嘧啶衍生物和 /或其药学上可接受的盐。 此外，本发明涉及所述4,6-二取代氨基嘧啶衍生物作为蛋白激酶的抑制剂和包含至少一种固定化形式的所述4,6-二取代氨基嘧啶衍生物的介质和使用所述培养基 用于富集，纯化和/或消除与固定的4,6-二取代氨基嘧啶衍生物结合的核苷酸结合蛋白。

公开(公告)号：US08084457B2

公开(公告)日：2011-12-27

申请号：US10572043

申请日：2004-09-15

申请人： Axel Choidas ,  Alexander Backes ,  Matt Cotten ,  Ola Engkvist ,  Beatrice Felber ,  Achim Freisleben ,  Klaus Godl ,  Zoltán Greff ,  Peter Habenberger ,  Doris Hafenbradl ,  Christian Hartung ,  Thomas Herget ,  Edmund Hoppe ,  Bert Klebl ,  Andrea Missio ,  Gerhard Müller ,  Wilfried Schwab ,  Birgit Zech ,  Jose Bravo ,  John Harris ,  Joelle Le ,  Jackie Macritchie ,  Vladimir Savic ,  Brad Sherborne ,  Don Simpson

发明人： Axel Choidas ,  Alexander Backes ,  Matt Cotten ,  Ola Engkvist ,  Beatrice Felber ,  Achim Freisleben ,  Klaus Godl ,  Zoltán Greff ,  Peter Habenberger ,  Doris Hafenbradl ,  Christian Hartung ,  Thomas Herget ,  Edmund Hoppe ,  Bert Klebl ,  Andrea Missio ,  Gerhard Müller ,  Wilfried Schwab ,  Birgit Zech ,  Jose Bravo ,  John Harris ,  Joelle Le ,  Jackie Macritchie ,  Vladimir Savic ,  Brad Sherborne ,  Don Simpson

IPC分类号： A01N43/54 ,  C07D239/42 ,  C07D401/04 ,  C07D239/00 ,  C07D239/02

CPC分类号： C04B35/632 ,  C07D239/42 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.

摘要翻译： 本发明涉及4,6-二取代的氨基嘧啶衍生物和/或其药学上可接受的盐，这些衍生物作为药物活性剂的用途，特别是用于预防和/或治疗感染性疾病，包括机会性疾病，朊病毒疾病，免疫学 疾病，自身免疫疾病，双相和临床疾病，心血管疾病，细胞增殖性疾病，糖尿病，炎症，移植排斥，勃起功能障碍，神经变性疾病和中风，以及含有所述4,6-二取代氨基嘧啶衍生物和 /或其药学上可接受的盐。 此外，本发明涉及所述4,6-二取代氨基嘧啶衍生物作为蛋白激酶的抑制剂和包含至少一种固定化形式的所述4,6-二取代氨基嘧啶衍生物的介质和使用所述培养基 用于富集，纯化和/或消除与固定的4,6-二取代氨基嘧啶衍生物结合的核苷酸结合蛋白。