公开(公告)号：US20130122517A1

公开(公告)日：2013-05-16

申请号：US13811743

申请日：2011-06-30

申请人： Tanja Henzler ,  Karl Holschuh ,  Johann Bauer ,  Thomas Herget ,  Michael Hartmann ,  Oliver Poetz ,  Thomas Joos

发明人： Tanja Henzler ,  Karl Holschuh ,  Johann Bauer ,  Thomas Herget ,  Michael Hartmann ,  Oliver Poetz ,  Thomas Joos

IPC分类号： G01N21/64

CPC分类号： G01N21/6428 ,  B82Y15/00 ,  G01N33/54346 ,  G01N33/588

摘要： The present invention relates to a method and kit for performing assays like immunoassays. The assays are performed by using two different types of magnetic beads.

摘要翻译： 本发明涉及用于进行如免疫测定法的测定的方法和试剂盒。 通过使用两种不同类型的磁珠来进行测定。

公开(公告)号：US08084457B2

公开(公告)日：2011-12-27

申请号：US10572043

申请日：2004-09-15

申请人： Axel Choidas ,  Alexander Backes ,  Matt Cotten ,  Ola Engkvist ,  Beatrice Felber ,  Achim Freisleben ,  Klaus Godl ,  Zoltán Greff ,  Peter Habenberger ,  Doris Hafenbradl ,  Christian Hartung ,  Thomas Herget ,  Edmund Hoppe ,  Bert Klebl ,  Andrea Missio ,  Gerhard Müller ,  Wilfried Schwab ,  Birgit Zech ,  Jose Bravo ,  John Harris ,  Joelle Le ,  Jackie Macritchie ,  Vladimir Savic ,  Brad Sherborne ,  Don Simpson

发明人： Axel Choidas ,  Alexander Backes ,  Matt Cotten ,  Ola Engkvist ,  Beatrice Felber ,  Achim Freisleben ,  Klaus Godl ,  Zoltán Greff ,  Peter Habenberger ,  Doris Hafenbradl ,  Christian Hartung ,  Thomas Herget ,  Edmund Hoppe ,  Bert Klebl ,  Andrea Missio ,  Gerhard Müller ,  Wilfried Schwab ,  Birgit Zech ,  Jose Bravo ,  John Harris ,  Joelle Le ,  Jackie Macritchie ,  Vladimir Savic ,  Brad Sherborne ,  Don Simpson

IPC分类号： A01N43/54 ,  C07D239/42 ,  C07D401/04 ,  C07D239/00 ,  C07D239/02

CPC分类号： C04B35/632 ,  C07D239/42 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.

摘要翻译： 本发明涉及4,6-二取代的氨基嘧啶衍生物和/或其药学上可接受的盐，这些衍生物作为药物活性剂的用途，特别是用于预防和/或治疗感染性疾病，包括机会性疾病，朊病毒疾病，免疫学 疾病，自身免疫疾病，双相和临床疾病，心血管疾病，细胞增殖性疾病，糖尿病，炎症，移植排斥，勃起功能障碍，神经变性疾病和中风，以及含有所述4,6-二取代氨基嘧啶衍生物和 /或其药学上可接受的盐。 此外，本发明涉及所述4,6-二取代氨基嘧啶衍生物作为蛋白激酶的抑制剂和包含至少一种固定化形式的所述4,6-二取代氨基嘧啶衍生物的介质和使用所述培养基 用于富集，纯化和/或消除与固定的4,6-二取代氨基嘧啶衍生物结合的核苷酸结合蛋白。

公开(公告)号：US06262338B1

公开(公告)日：2001-07-17

申请号：US08903325

申请日：1997-07-17

申请人： Peter Schreier ,  Thomas Herget ,  Jeff Schell

发明人： Peter Schreier ,  Thomas Herget ,  Jeff Schell

IPC分类号： C12N1529

CPC分类号： C07K14/415 ,  C12N9/14 ,  C12N9/2442 ,  C12N15/8279 ,  C12Y302/01014

摘要： The present invention relates to DNA isolated from Arachis hypogaea which encodes or hybridizes to DNA which encodes a protein that repels pests. Such DNA is useful in the transformation of vectors, host organisms and plants and for the production of plants which exhibit an increased resistance to pests.

摘要翻译： 本发明涉及从编织消除有害生物的蛋白质的DNA编码或杂交的花生链球菌分离的DNA。 这样的DNA可用于转化载体，宿主生物和植物以及用于产生对害虫具有增加抗性的植物。

公开(公告)号：US20110027126A1

公开(公告)日：2011-02-03

申请号：US12934436

申请日：2009-03-13

申请人： Tanja Henzler ,  Thomas Herget

发明人： Tanja Henzler ,  Thomas Herget

IPC分类号： B01J19/00

CPC分类号： G01N33/54393

摘要： The present invention relates to a method for a long term storage of substrate-coupled beads prepared for biological reactions, preferably enzymatic reactions. Suitable beads for this method may be inorganic or organic. Preferably polystyrene beads are used for this method.

摘要翻译： 本发明涉及一种用于生物反应制备的底物偶联珠的长期储存方法，优选酶反应。 用于该方法的合适的珠可以是无机的或有机的。 优选地，该方法使用聚苯乙烯珠。

公开(公告)号：US20070191344A1

公开(公告)日：2007-08-16

申请号：US10572043

申请日：2004-09-15

申请人： Axel Choidas ,  Alexander Backes ,  Matt Cotten ,  Ola Engkvist ,  Beatrice Felber ,  Achim Freisleben ,  Klaus Godl ,  Zoltan Greff ,  Peter Habenberger ,  Doris Hafenbradl ,  Christian Hartung ,  Thomas Herget ,  Edmund Hoppe ,  Bert Klebl ,  Andrea Missio ,  Gerhard Muller ,  Wilfried Schwab ,  Birgit Zech ,  Jose Bravo ,  John Harris ,  Joelle Le ,  Jackie Macritchie ,  Vladimir Savic ,  Brad Sherborne ,  Don Simpson

发明人： Axel Choidas ,  Alexander Backes ,  Matt Cotten ,  Ola Engkvist ,  Beatrice Felber ,  Achim Freisleben ,  Klaus Godl ,  Zoltan Greff ,  Peter Habenberger ,  Doris Hafenbradl ,  Christian Hartung ,  Thomas Herget ,  Edmund Hoppe ,  Bert Klebl ,  Andrea Missio ,  Gerhard Muller ,  Wilfried Schwab ,  Birgit Zech ,  Jose Bravo ,  John Harris ,  Joelle Le ,  Jackie Macritchie ,  Vladimir Savic ,  Brad Sherborne ,  Don Simpson

IPC分类号： A61K31/55 ,  A61K31/506 ,  C07D403/02

CPC分类号： C04B35/632 ,  C07D239/42 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.

摘要翻译： 本发明涉及4,6-二取代的氨基嘧啶衍生物和/或其药学上可接受的盐，这些衍生物作为药物活性剂的用途，特别是用于预防和/或治疗感染性疾病，包括机会性疾病，朊病毒疾病，免疫学 疾病，自身免疫疾病，双相和临床疾病，心血管疾病，细胞增殖性疾病，糖尿病，炎症，移植排斥，勃起功能障碍，神经变性疾病和中风，以及含有所述4,6-二取代氨基嘧啶衍生物和 /或其药学上可接受的盐。 此外，本发明涉及所述4,6-二取代氨基嘧啶衍生物作为蛋白激酶的抑制剂和包含至少一种固定化形式的所述4,6-二取代氨基嘧啶衍生物的介质和使用所述培养基 用于富集，纯化和/或消除与固定的4,6-二取代氨基嘧啶衍生物结合的核苷酸结合蛋白。

公开(公告)号：US20070123537A1

公开(公告)日：2007-05-31

申请号：US10595307

申请日：2004-10-05

申请人： Thomas Herget

发明人： Thomas Herget

IPC分类号： A61K31/517 ,  C07D405/14 ,  C07D403/02 ,  C07D239/94

CPC分类号： C07D215/44

摘要： The present invention relates to phenyl-quinazolinyl-amine derivatives and pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising at least one of these derivatives and/or pharmaceutically salts thereof, as well as the use of these derivatives for the prophylaxis and/or treatment of herpesviral induced infections, including opportunistic infections, especially for the prophylaxis and/or treatment of infections and diseases induced by HCMV.

摘要翻译： 本发明涉及苯基 - 喹唑啉基 - 胺衍生物及其药学上可接受的盐以及包含这些衍生物和/或其药学上的至少一种的药物组合物，以及这些衍生物用于预防和/或治疗疱疹病毒 诱发的感染，包括机会性感染，特别是预防和/或治疗由HCMV引起的感染和疾病。

公开(公告)号：US20060151574A1

公开(公告)日：2006-07-13

申请号：US10536950

申请日：2003-12-01

申请人： Thomas Herget ,  Bert Klebl

发明人： Thomas Herget ,  Bert Klebl

IPC分类号： A47J36/02

CPC分类号： A61K38/212 ,  A61K9/0014 ,  A61K9/2866 ,  A61K31/00 ,  A61K31/203 ,  A61K31/593 ,  A61K33/04 ,  A61K38/215 ,  A61K38/217 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates generally to chemical compounds and substances which are effective against Hepatitis C virus (HCV) infections. Moreover, the present invention relates to compositions comprising said compounds and/or substances, to methods for preventing HCV infections as well use of the compounds and/or substances for the preparation of compositions useful for the prophylaxis and/or treatment of HCV infections. Useful compounds and substances according to the invention are selenium, selenium salts, Vitamin D3 and retinoids, like all trans retinoic acid and salts thereof, C1-C alkyl amides of all trans retinoic acid and salts thereof, C1-C10 alkyl esters of all trans retinoic acid and salts thereof, 9-cis retinoic acid and salts thereof, C1-C10 alkyl amides of 9-cis retinoic acid and salts thereof, C1-C10 alkyl esters of 9-cis retinoic acid and salts thereof, (E)-4-[2(5,6,7,8-tetrahydro-5,5,8,8-tetra methyl-2-naphthalenyl-1-propenyl)benzoic acid (TTNPB), (4-[5,6,7,8-tetrahydro5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid (AM-580), N-(4-hydroxyphenyl)retinamide (4-HPR), and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (AHPN).

摘要翻译： 本发明一般涉及对丙型肝炎病毒（HCV）感染有效的化合物和物质。 此外，本发明涉及包含所述化合物和/或物质的组合物，用于预防HCV感染的方法以及化合物和/或物质用于制备用于预防和/或治疗HCV感染的组合物的用途。 根据本发明的有用的化合物和物质是硒，硒盐，维生素D 3和类维生素A，如所有反式视黄酸及其盐，C 1 -C 3烷基酰胺 全反式视黄酸及其盐，全反式视黄酸的C 1 -C 10烷基酯及其盐，9-顺式视黄酸及其盐，C

公开(公告)号：US20080194574A1

公开(公告)日：2008-08-14

申请号：US10596508

申请日：2004-12-16

申请人： Jan Eike Eikhoff ,  Mark Richard Ashton ,  Stephen Martin Courtney ,  Christopher John Yarnold ,  Maurizio Varrone ,  Pui Leng Loke ,  Thomas Herget ,  Wilfried Schwab ,  Doris Hafenbradl

发明人： Jan Eike Eikhoff ,  Mark Richard Ashton ,  Stephen Martin Courtney ,  Christopher John Yarnold ,  Maurizio Varrone ,  Pui Leng Loke ,  Thomas Herget ,  Wilfried Schwab ,  Doris Hafenbradl

IPC分类号： A61K31/4985 ,  C07D487/04 ,  C07D241/10 ,  A61K31/4965 ,  A61P31/00 ,  A61P37/00 ,  A61P25/16 ,  A61P25/28

CPC分类号： C07D401/04 ,  C07D241/20 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14

摘要： The present invention relates to pyrazine derivatives according to the general formula (I) and pharmaceutically acceptable salts thereof and their use as pharmaceutical compounds as well as the use of these compounds for the preparation of a pharmaceutical composition for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases, stroke and especially for the treatment of herpesviral induced infections, including opportunistic infections as well as infections and diseases caused by human cytomegalovirus (HCMV).

摘要翻译： 本发明涉及根据通式（I）的吡嗪衍生物及其药学上可接受的盐及其作为药物化合物的用途，以及这些化合物在制备用于预防和/或治疗感染性疾病的药物组合物中的用途 疾病，包括机会性疾病，朊病毒疾病，免疫疾病，自身免疫性疾病，双相和临床病症，心血管疾病，细胞增殖性疾病，糖尿病，炎症，移植排斥，勃起功能障碍，神经变性疾病，中风，特别是治疗疱疹病毒诱导的感染 ，包括机会性感染以及由巨细胞病毒（HCMV）引起的感染和疾病。

公开(公告)号：US07341717B2

公开(公告)日：2008-03-11

申请号：US10723719

申请日：2003-11-26

申请人： Thomas Herget ,  Matthew Cotten ,  Sabine Obert ,  Bert Klebl

发明人： Thomas Herget ,  Matthew Cotten ,  Sabine Obert ,  Bert Klebl

IPC分类号： A61K48/00 ,  C12Q1/70

CPC分类号： A61K31/00 ,  A61K38/215 ,  A61K38/217 ,  A61K48/00 ,  A61K2039/505 ,  C12N9/0065 ,  C12N2501/24 ,  C12Q1/28 ,  C12Y111/01009 ,  G01N33/573 ,  G01N33/5767 ,  G01N2333/18 ,  G01N2333/908 ,  G01N2500/04 ,  A61K2300/00

摘要： The present invention relates to the human cellular protein glutathione peroxidase-gastrointestinal as a target for medical intervention against Hepatitis C virus (HCV) infections. Furthermore, the present invention relates to a method for the detection of compounds useful for prophylaxis and/or treatment of Hepatitis C virus infections and a method for detecting Hepatitis C virus infections in an individual or in cells. Also compositions, compounds, nucleic acid molecules (such as aptamers), mono- or polyclonal antibodies are disclosed which are effective for the treatment of HCV infections, and methods for prophylaxis and/or treatment of Hepatitis C virus infections or for the regulation of Hepatitis C virus production are disclosed.

摘要翻译： 本发明涉及人类细胞蛋白谷胱甘肽过氧化物酶 - 胃肠道作为针对丙型肝炎病毒（HCV）感染的医疗干预的靶标。 此外，本发明涉及检测可用于预防和/或治疗丙型肝炎病毒感染的化合物的方法和检测个体或细胞中丙型肝炎病毒感染的方法。 还公开了对治疗HCV感染有效的组合物，化合物，核酸分子（例如适体），单克隆或多克隆抗体，以及用于预防和/或治疗丙型肝炎病毒感染或调节肝炎的方法 C病毒生产被披露。