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1.发明授权Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties 有权用荧光部分标记的单一蛋白质分子的高灵敏度检测方法公开(公告)号：US07572640B2
公开(公告)日：2009-08-11
申请号：US11784211
申请日：2007-04-04
IPC分类号： G01N21/76
CPC分类号： G01N21/6428 , C07K16/18 , C07K16/22 , C07K16/244 , C07K16/248 , C07K16/2803 , C07K16/2875 , G01N1/28 , G01N15/1459 , G01N27/447 , G01N33/582 , G01N33/68 , G01N35/1095 , G01N2015/1438 , G01N2035/1034 , Y10T436/13
摘要： Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.
摘要翻译： 公开了用于分子的高灵敏度检测的方法，试剂盒和组合物。 方法，试剂盒和组合物可用于测定样品中分子的浓度为1飞摩尔，1 attomolar或更低的水平。 方法，试剂盒和组合物还允许在宽范围内测定浓度，例如7-log范围，而不需要样品稀释。
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公开(公告)号：US20080171352A1
公开(公告)日：2008-07-17
申请号：US11830762
申请日：2007-07-30
CPC分类号： G01N21/6428 , C07K16/18 , C07K16/22 , C07K16/244 , C07K16/248 , C07K16/2803 , C07K16/2875 , G01N1/28 , G01N15/1459 , G01N27/447 , G01N33/582 , G01N33/68 , G01N35/1095 , G01N2015/1438 , G01N2035/1034 , Y10T436/13
摘要： Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.
摘要翻译： 公开了用于分子的高灵敏度检测的方法，试剂盒和组合物。 方法，试剂盒和组合物可用于测定样品中分子的浓度为1飞摩尔，1 attomolar或更低的水平。 方法，试剂盒和组合物还允许在宽范围内测定浓度，例如7-log范围，而不需要样品稀释。
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公开(公告)号：US20090234202A1
公开(公告)日：2009-09-17
申请号：US12398175
申请日：2009-03-04
申请人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Sara Agee
发明人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Sara Agee
CPC分类号： G01N33/577 , A61B5/00 , A61B5/0402 , A61B5/412 , A61B5/415 , A61B5/418 , A61B5/7264 , A61B5/7275 , G01N21/6428 , G01N33/582 , G01N33/6863 , G01N33/6869 , G01N33/6872 , G01N33/6887 , G01N33/6896 , G01N33/74 , G01N33/92 , G01N2333/4712 , G01N2333/475 , Y02A90/26 , Y10T436/143333
摘要： The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnI) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.
摘要翻译： 本发明公开了使用分子的高灵敏度检测来检测和监测受试者的状况的方法。 本发明提供了一种用于检测或监测受试者状况的方法，包括检测来自受试者的第一样品中的第一标记物并检测第二标志物，其中第一标记物包含生物标志物，例如心肌肌钙蛋白I（cTnI） 或血管内皮生长因子（VEGF），并且其中第一标记物的检测限小于约10pg / ml。 第二标记可以是生物标志物，生理学标记，分子标记或遗传标记。
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公开(公告)号：US08343728B2
公开(公告)日：2013-01-01
申请号：US12902182
申请日：2010-10-12
申请人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Alan Wu
发明人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Alan Wu
IPC分类号： G01N33/53
CPC分类号： G01N33/68 , G01N21/6428 , G01N21/6486 , G01N33/582 , G01N33/6887 , G01N33/6893 , G01N2333/47 , G01N2800/32 , G01N2800/324 , G01N2800/325 , G01N2800/50
摘要： The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
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公开(公告)号：US20110111524A1
公开(公告)日：2011-05-12
申请号：US12902182
申请日：2010-10-12
申请人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Alan Wu
发明人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Alan Wu
IPC分类号： G01N33/566
CPC分类号： G01N33/68 , G01N21/6428 , G01N21/6486 , G01N33/582 , G01N33/6887 , G01N33/6893 , G01N2333/47 , G01N2800/32 , G01N2800/324 , G01N2800/325 , G01N2800/50
摘要： The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
摘要翻译： 本发明提供了用于敏感检测心肌肌钙蛋白的方法，组合物，试剂盒和系统。 这些方法，组合物，试剂盒和系统在涉及释放心肌肌钙蛋白的病症中的诊断，预后和测定方法中是有用的。
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公开(公告)号：US20100297672A9
公开(公告)日：2010-11-25
申请号：US12062412
申请日：2008-04-03
申请人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Alan H.B. Wu
发明人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Alan H.B. Wu
IPC分类号： G01N33/53 , G01N33/536
CPC分类号： G01N33/68 , G01N21/6428 , G01N21/6486 , G01N33/582 , G01N33/6887 , G01N33/6893 , G01N2333/47 , G01N2800/32 , G01N2800/324 , G01N2800/325 , G01N2800/50
摘要： The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
摘要翻译： 本发明提供了用于敏感检测心肌肌钙蛋白的方法，组合物，试剂盒和系统。 这些方法，组合物，试剂盒和系统在涉及释放心肌肌钙蛋白的病症中的诊断，预后和测定方法中是有用的。
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公开(公告)号：US07838250B1
公开(公告)日：2010-11-23
申请号：US12062412
申请日：2008-04-03
申请人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Alan Wu
发明人： Philippe J. Goix , Robert Puskas , John Todd , Richard A. Livingston , Douglas Held , Alan Wu
IPC分类号： G01N33/53
CPC分类号： G01N33/68 , G01N21/6428 , G01N21/6486 , G01N33/582 , G01N33/6887 , G01N33/6893 , G01N2333/47 , G01N2800/32 , G01N2800/324 , G01N2800/325 , G01N2800/50
摘要： The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
摘要翻译： 本发明提供用于敏感检测心肌肌钙蛋白的方法，组合物，试剂盒和系统。 这些方法，组合物，试剂盒和系统在涉及释放心肌肌钙蛋白的病症中的诊断，预后和测定方法中是有用的。
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8.发明授权Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry 有权使用荧光光谱法测定血液样品中特定蛋白质的分析方法公开(公告)号：US09040305B2
公开(公告)日：2015-05-26
申请号：US11767196
申请日：2007-06-22
CPC分类号： G01N33/582
摘要： The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles, e.g., protein molecules, or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.
摘要翻译： 本发明包括分析器和分析仪系统，其包括单个粒子分析仪，使用分析仪和分析仪系统分析样品的方法，用于单个粒子，例如蛋白质分子，或用于多个粒子（复用），基于 使用系统的分析器或分析器系统，以及用于存储在本发明的分析器和分析器系统中有用的参数的电子介质。
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公开(公告)号：US08685711B2
公开(公告)日：2014-04-01
申请号：US12731500
申请日：2010-03-25
IPC分类号： C12M1/34
CPC分类号： G01N21/6428 , G01N33/533 , G01N33/54306 , G01N33/582 , G01N33/68 , G01N2201/06113 , G01N2201/062
摘要： Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.
摘要翻译： 公开了用于分子的高灵敏度检测的方法，试剂盒和组合物。 方法，试剂盒和组合物可用于测定样品中分子的浓度为1飞摩尔，1 attomolar或更低的水平。 方法，试剂盒和组合物还允许在宽范围内测定浓度，例如7-log范围，而不需要样品稀释。
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公开(公告)号：US20100329929A1
公开(公告)日：2010-12-30
申请号：US12731500
申请日：2010-03-25
IPC分类号： G01N30/00
CPC分类号： G01N21/6428 , G01N33/533 , G01N33/54306 , G01N33/582 , G01N33/68 , G01N2201/06113 , G01N2201/062
摘要： Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.
摘要翻译： 公开了用于分子的高灵敏度检测的方法，试剂盒和组合物。 方法，试剂盒和组合物可用于测定样品中分子的浓度为1飞摩尔，1 attomolar或更低的水平。 方法，试剂盒和组合物还允许在宽范围内测定浓度，例如7-log范围，而不需要样品稀释。
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