公开(公告)号：US06572749B1

公开(公告)日：2003-06-03

申请号：US09912154

申请日：2001-07-23

申请人： Phillip H. Paul ,  David J. Rakestraw ,  Don W. Arnold ,  Kenneth R. Hencken ,  Joseph S. Schoeniger ,  David W. Neyer

发明人： Phillip H. Paul ,  David J. Rakestraw ,  Don W. Arnold ,  Kenneth R. Hencken ,  Joseph S. Schoeniger ,  David W. Neyer

IPC分类号： B05B500

CPC分类号： G01N30/32 ,  F04B19/006 ,  G01N2030/285 ,  G01N2030/326

摘要： An electrokinetic high pressure hydraulic pump for manipulating fluids in capillary-based system. The pump uses electro-osmotic flow to provide a high pressure hydraulic system, having no moving mechanical parts, for pumping and/or compressing fluids, for providing valve means and means for opening and closing valves, for controlling fluid flow rate, and manipulating fluid flow generally and in capillary-based systems (microsystems), in particular. The compact nature of the inventive high pressure hydraulic pump provides the ability to construct a micro-scale or capillary-based HPLC system that fulfills the desire for small sample quantity, low solvent consumption, improved efficiency, the ability to run samples in parallel, and field portability. Control of pressure and solvent flow rate is achieved by controlling the voltage applied to an electrokinetic pump.

摘要翻译： 一种电动高压液压泵，用于在毛细管系统中操纵流体。 泵使用电渗流提供高压液压系统，没有移动的机械部件，用于泵送和/或压缩流体，用于提供阀装置和用于打开和关闭阀门的装置，用于控制流体流速和操纵流体 特别是在毛细管系统（微系统）中流动。 本发明的高压液压泵的紧凑特性提供构建基于微量或基于毛细管的HPLC系统的能力，其满足对小样品量，低溶剂消耗，提高的效率，并行运行样品的能力的需求，以及 现场可携带性。 通过控制施加到电动泵的电压来实现压力和溶剂流​​速的控制。

公开(公告)号：US06833068B2

公开(公告)日：2004-12-21

申请号：US10341870

申请日：2003-01-13

申请人： Phillip H. Paul ,  Don W. Arnold ,  David W. Neyer

发明人： Phillip H. Paul ,  Don W. Arnold ,  David W. Neyer

IPC分类号： B01D1508

CPC分类号： B01J20/283 ,  B01J20/285 ,  B01L3/502746 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0487 ,  G01N30/10 ,  G01N30/16 ,  G01N30/466 ,  G01N30/6095 ,  G01N2030/162 ,  G01N2030/285 ,  G01N2030/324

摘要： Apparatus for eliminating siphoning, “dead” regions, and fluid concentration gradients in microscale analytical devices. In its most basic embodiment, the present invention affords passive injection control for both electric field-driven and pressure-driven systems by providing additional fluid flow channels or auxiliary channels disposed on either side of a sample separation column. The auxiliary channels are sized such that volumetric fluid flow rate through these channels, while sufficient to move the sample away from the sample injection region in a timely fashion, is less than that through the sample separation channel or chromatograph.

公开(公告)号：US06277257B1

公开(公告)日：2001-08-21

申请号：US09271687

申请日：1999-03-18

申请人： Phillip H. Paul ,  David J. Rakestraw ,  Don W. Arnold ,  Kenneth R. Hencken ,  Joseph S. Schoeniger ,  David W. Neyer

发明人： Phillip H. Paul ,  David J. Rakestraw ,  Don W. Arnold ,  Kenneth R. Hencken ,  Joseph S. Schoeniger ,  David W. Neyer

IPC分类号： B01D6144

CPC分类号： G01N30/32 ,  F04B19/006 ,  G01N2030/285 ,  G01N2030/326

摘要： An electrokinetic high pressure hydraulic pump for manipulating fluids in capillary-based systems. The pump uses electro-osmotic flow to provide a high pressure hydraulic system, having no moving mechanical parts, for pumping and/or compressing fluids, for providing valve means and means for opening and closing valves, for controlling fluid flow rate, and manipulating fluid flow generally and in capillary-based systems (Microsystems), in particular. The compact nature of the inventive high pressure hydraulic pump provides the ability to construct a micro-scale or capillary-based HPLC system that fulfills the desire for small sample quantity, low solvent consumption, improved efficiency, the ability to run samples in parallel, and field portability. Control of pressure and solvent flow rate is achieved by controlling the voltage applied to an electrokinetic pump.

摘要翻译： 一种电动高压液压泵，用于在毛细管系统中操纵流体。 泵使用电渗流提供高压液压系统，没有移动的机械部件，用于泵送和/或压缩流体，用于提供阀装置和用于打开和关闭阀门的装置，用于控制流体流速和操纵流体 特别是在毛细管系统（Microsystems）中通常流动。 本发明的高压液压泵的紧凑特性提供构建基于微量或基于毛细管的HPLC系统的能力，其满足对小样品量，低溶剂消耗，提高的效率，并行运行样品的能力的需求，以及 现场可携带性。 通过控制施加到电动泵的电压来实现压力和溶剂流​​速的控制。

公开(公告)号：US06290909B1

公开(公告)日：2001-09-18

申请号：US09548475

申请日：2000-04-13

申请人： Phillip H. Paul ,  Don W. Arnold ,  David W. Neyer

发明人： Phillip H. Paul ,  Don W. Arnold ,  David W. Neyer

IPC分类号： G01N3002

CPC分类号： G01N30/22 ,  G01N30/6095 ,  G01N2030/285 ,  Y10T436/2575

摘要： Apparatus and method for driving a sample, having a well-defined volume, under pressure into a chromatography column. A conventional high pressure sampling valve is replaced by a sample injector composed of a pair of injector components connected in series to a common junction. The injector components are containers of porous dielectric material constructed so as to provide for electroosmotic flow of a sample into the junction. At an appropriate time, a pressure pulse from a high pressure source, that can be an electrokinetic pump, connected to the common junction, drives a portion of the sample, whose size is determined by the dead volume of the common junction, into the chromatographic column for subsequent separation and analysis. The apparatus can be fabricated on a substrate for microanalytical applications.

摘要翻译： 用于在压力下将具有明确定义的体积的样品驱动到色谱柱中的装置和方法。 传统的高压取样阀被由一对与公共接头串联连接的一对注射器部件组成的样品注射器代替。 注射器组件是多孔电介质材料的容器，其被构造成提供样品的电渗流入结点。 在适当的时间，连接到公共接头的来自高压源（可以是电动泵）的压力脉冲将一部分样品（其尺寸由公共接头的死体积确定）驱动到色谱中 色谱柱用于随后的分离和分析。 该装置可以在用于微量分析应用的基板上制造。

公开(公告)号：US07875159B2

公开(公告)日：2011-01-25

申请号：US11684500

申请日：2007-03-09

申请人： Deon S. Anex ,  Phillip H. Paul ,  David W. Neyer

发明人： Deon S. Anex ,  Phillip H. Paul ,  David W. Neyer

IPC分类号： F04F99/00

CPC分类号： F04B19/006 ,  F04B17/00 ,  F04B19/00 ,  F04B43/043

摘要： An electrokinetic pump achieves high and low flow rates without producing significant gaseous byproducts and without significant evolution of the pump fluid. A first feature of the pump is that the electrodes in the pump are capacitive with a capacitance of at least 10−4 Farads/cm2. A second feature of the pump is that it is configured to maximize the potential across the porous dielectric material. The pump can have either or both features.

摘要翻译： 电动泵实现高和低流速，而不产生显着的气体副产物并且没有泵流体的显着演变。 泵的第一个特征是泵中的电极是容性为至少10-4法拉/ cm2的电容。 泵的第二个特征是其被配置为使跨越多孔介电材料的电势最大化。 泵可以具有两个或两个特征。

公开(公告)号：US20080173545A1

公开(公告)日：2008-07-24

申请号：US11766678

申请日：2007-06-21

申请人： Deon S. Anex ,  Phillip H. Paul ,  David W. Neyer

发明人： Deon S. Anex ,  Phillip H. Paul ,  David W. Neyer

IPC分类号： B01J19/08

CPC分类号： F04B19/006 ,  F04B17/00 ,  F04B19/00 ,  F04B43/043

摘要： An electrokinetic pump achieves high and low flow rates without producing significant gaseous byproducts and without significant evolution of the pump fluid. A first feature of the pump is that the electrodes in the pump are capacitive with a capacitance of at least 10−4 Farads cm2. A second feature of the pump is that it is configured to maximize the potential across the porous dielectric material. The pump can have either or both features.

摘要翻译： 电动泵实现高和低流速，而不产生显着的气体副产物并且没有泵流体的显着演变。 泵的第一特征在于泵中的电极是电容性的，具有至少10 -4欧向平方厘米的电容。 泵的第二个特征是其被配置为使跨越多孔介电材料的电势最大化。 泵可以具有两个或两个特征。

公开(公告)号：US20110114492A1

公开(公告)日：2011-05-19

申请号：US13013484

申请日：2011-01-25

申请人： Deon S. Anex ,  Phillip H. Paul ,  David W. Neyer

发明人： Deon S. Anex ,  Phillip H. Paul ,  David W. Neyer

IPC分类号： F04F99/00

CPC分类号： F04B19/006 ,  F04B17/00 ,  F04B19/00 ,  F04B43/043

摘要： An electrokinetic pump achieves high and low flow rates without producing significant gaseous byproducts and without significant evolution of the pump fluid. A first feature of the pump is that the electrodes in the pump are capacitive with a capacitance of at least 10−4 Farads/cm2. A second feature of the pump is that it is configured to maximize the potential across the porous dielectric material. The pump can have either or both features.

摘要翻译： 电动泵实现高和低流速，而不产生显着的气体副产物并且没有泵流体的显着演变。 泵的第一个特征是泵中的电极是容性为至少10-4法拉/ cm2的电容。 泵的第二个特征是其被配置为使跨越多孔介电材料的电势最大化。 泵可以具有两个或两个特征。

公开(公告)号：US07517440B2

公开(公告)日：2009-04-14

申请号：US11112867

申请日：2005-04-21

申请人： Deon S. Anex ,  Phillip H. Paul ,  David W. Neyer ,  Edwin J. Hlavka

发明人： Deon S. Anex ,  Phillip H. Paul ,  David W. Neyer ,  Edwin J. Hlavka

IPC分类号： B01D57/02 ,  B01D59/42 ,  C25B9/12 ,  C25B15/04

CPC分类号： A61M5/14276 ,  A61M5/14248 ,  A61M5/1483 ,  A61M5/1723 ,  A61M2005/14513 ,  A61M2205/52 ,  A61M2230/201 ,  F04B19/006 ,  F04B43/043 ,  Y10T137/0318 ,  Y10T137/0357 ,  Y10T137/0368 ,  Y10T137/0379 ,  Y10T137/218

摘要： A method of pumping fluid including the steps of providing an electrokinetic pump comprising a pair of double-layer capacitive electrodes having a capacitance of at least 10−2 Farads/cm2 and being connectable to a power source, a porous dielectric material disposed between the electrodes and a reservoir containing pump fluid; connecting the electrodes to a power source; and moving pump fluid out of the reservoir substantially without the occurrence of Faradaic processes in the pump. The invention also includes an electrokinetic pump system having a pair of double-layer capacitive electrodes having a capacitance of at least 10−2 Farads/cm2; a porous dielectric material disposed between the electrodes; a reservoir containing pump fluid; and a power source connected to the electrodes; the electrodes, dielectric material and power source being adapted to move the pump fluid out of the reservoir substantially without the occurrence of Faradaic processes in the pump.

摘要翻译： 一种泵送流体的方法，包括以下步骤：提供电动泵，其包括具有至少10-2法拉/ cm 2的电容并可连接到电源的一对双层电容电极，设置在电极之间的多孔介电材料 和含有泵流体的储存器; 将电极连接到电源; 并将泵流体从储存器中移出基本上不会在泵中发生法拉第过程。 本发明还包括具有一对电容至少为10-2法拉/ cm2的双层电容电极的电动泵系统; 设置在电极之间的多孔电介质材料; 包含泵液的储存器; 以及连接到所述电极的电源; 电极，电介质材料和电源适于将泵流体基本上移出储存器，而不会在泵中发生法拉第过程。

公开(公告)号：US07235164B2

公开(公告)日：2007-06-26

申请号：US10273723

申请日：2002-10-18

申请人： Deon S. Anex ,  Phillip H. Paul ,  David W. Neyer

发明人： Deon S. Anex ,  Phillip H. Paul ,  David W. Neyer

IPC分类号： C25B9/00 ,  H22K44/00

CPC分类号： F04B19/006 ,  F04B17/00 ,  F04B19/00 ,  F04B43/043

摘要： An electrokinetic pump achieves high and low flow rates without producing significant gaseous byproducts and without significant evolution of the pump fluid. A first feature of the pump is that the electrodes in the pump are capacitive with a capacitance of at least 10−4 Farads/cm2. A second feature of the pump is that it is configured to maximize the potential across the porous dielectric material. The pump can have either or both features.

摘要翻译： 电动泵实现高和低流速，而不产生显着的气体副产物并且没有泵流体的显着演变。 泵的第一特征是泵中的电极是电容性的，具有至少10 -4欧拉/ cm 2的电容。 泵的第二个特征是其被配置为使跨越多孔介电材料的电势最大化。 泵可以具有两个或两个特征。

公开(公告)号：US08795493B2

公开(公告)日：2014-08-05

申请号：US12567482

申请日：2009-09-25

申请人： David W. Neyer ,  Phillip H. Paul ,  Don Wesley Arnold ,  Christopher G. Bailey

发明人： David W. Neyer ,  Phillip H. Paul ,  Don Wesley Arnold ,  Christopher G. Bailey

IPC分类号： G05D7/06

CPC分类号： G01N30/32 ,  B01D61/56 ,  G01N2030/324 ,  G01N2030/326 ,  G05D7/0694 ,  G05D11/132 ,  Y10T137/85978 ,  Y10T137/85986 ,  Y10T137/86027 ,  G01N30/34 ,  G01N2030/285

摘要： A flow controller which uses a combination of hydrostatic pressure and electroosmotic flow to control the flow of a fluid. A driving fluid (1204) whose flow rate is dependent on both hydrostatic pressures and electroosmotic flow can be used (a) directly as a working fluid in an operable device, for example a chromatograph, or (b) to displace a working fluid (1203) from a storage container (625) into an operable device (1301), or both (a) and (b). The driving fluid (1204) can be composed of one or more fluids. Part or all the driving fluid (1204) is passed through an electroosmotic device (100) so as to increase or decrease the flow rate induced by hydrostatic pressure.

摘要翻译： 流量控制器，其使用静水压力和电渗流量的组合来控制流体的流动。 其流量取决于流体静力压力和电渗流量的驱动流体（1204）可以（a）直接用作可操作装置（例如色谱仪）中的工作流体，或（b）将工作流体（1203） ）从存储容器（625）移动到可操作装置（1301）或（a）和（b）中。 驱动流体（1204）可以由一种或多种流体组成。 部分或全部驱动流体（1204）通过电渗装置（100），以增加或减少由静水压力引起的流速。