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    PROCESS FOR THE PREPARATION OF PYRIDINE COMPOUNDS
    1.
    发明申请
    PROCESS FOR THE PREPARATION OF PYRIDINE COMPOUNDS 失效
    制备吡啶化合物的方法

    公开(公告)号：US20070249662A1

    公开(公告)日：2007-10-25

    申请号：US11737852

    申请日：2007-04-20

    申请人： Pietro ALLEGRINI ,  Marcello Rasparini ,  Gabriele Razzetti ,  Roberto Rossi ,  Gianpiero Ventimiglia

    发明人： Pietro ALLEGRINI ,  Marcello Rasparini ,  Gabriele Razzetti ,  Roberto Rossi ,  Gianpiero Ventimiglia

    IPC分类号： A61K31/4439 ,  A61K31/4745 ,  C07D471/02 ,  C07D403/02

    CPC分类号： C07D471/04 ,  C07D401/12

    摘要： A process for preparation of a compound of formula (I), both as the isomeric mixture and individual isomers, wherein Q is ═CR8— or ═N—; each R1, R2, R3, R4 is independently selected from hydrogen, halogen, hydroxy; nitro; C1-C6 alkyl optionally substituted with hydroxy; alkylthio C1-C6; C1-C6 alkoxy optionally substituted with halogen or C1-C6 alkoxy; phenyl-C1-C6 alkyl; phenyl-C1-C6 alkoxy; and —N(RaRb) wherein each Ra and Rb is independently hydrogen or C1-C6 alkyl or Ra and Rb, taken together with the nitrogen atom they are linked to, form a saturated heterocyclic ring; andeach R5, R6, R7, R8 is independently selected from hydrogen, halogen, hydroxy; C1-C6 alkyl optionally substituted with hydroxy; alkylthio C1-C6; C1-C6 alkoxy optionally substituted with halogen; C1-C6 alkyl-carbonyl, C1-C6 alkoxy-carbonyl, and oxazol-2-yl; comprising converting a compound of formula (IV), to said compound of formula (I), in the presence of a catalyst, if necessary in an organic solvent.

    摘要翻译： 制备式（I）化合物的方法，均为异构体混合物和各异构体，其中Q为-CR 8 - 或-N-; 每个R 1，R 2，R 3，R 4，R 4独立地选自氢，卤素，羟基; 硝基 任选被羟基取代的C 1 -C 6烷基; 烷硫基C 1 -C 6烷基; 任选被卤素或C 1 -C 6烷氧基取代的C 1 -C 6烷氧基; 苯基-C 1 -C 6烷基; 苯基-C 1 -C 6烷氧基; 和-N（RaRb），其中每个R a和R b独立地是氢或C 1 -C 6烷基或R a和R b与它们所连接的氮原子一起 形成饱和杂环; 并且每个R 5，R 6，R 7，R 8和R 8独立地选自氢，卤素，羟基 ; 任选被羟基取代的C 1 -C 6烷基; 烷硫基C 1 -C 6烷基; 任选被卤素取代的C 1 -C 6烷氧基; C 1 -C 6烷基 - 羰基，C 1 -C 6烷氧基 - 羰基和恶唑-2（C 1 -C 6） - 基; 包括在催化剂存在下，如果需要在有机溶剂中将式（Ⅳ）化合物转化为所述式（Ⅳ）化合物。

    Process for the preparation of pyridine compounds
    2.
    发明授权
    Process for the preparation of pyridine compounds 失效
    吡啶化合物的制备方法

    公开(公告)号：US07605268B2

    公开(公告)日：2009-10-20

    申请号：US11737852

    申请日：2007-04-20

    申请人： Pietro Allegrini ,  Marcello Rasparini ,  Gabriele Razzetti ,  Roberto Rossi ,  Gianpiero Ventimigla

    发明人： Pietro Allegrini ,  Marcello Rasparini ,  Gabriele Razzetti ,  Roberto Rossi ,  Gianpiero Ventimigla

    IPC分类号： C07D401/12

    CPC分类号： C07D471/04 ,  C07D401/12

    摘要： A process for preparation of a compound of formula (I), both as the isomeric mixture and individual isomers, wherein Q is ═CR8— or ═N—; each R1, R2, R3, R4 is independently selected from hydrogen, halogen, hydroxy; nitro; C1-C6 alkyl optionally substituted with hydroxy; alkylthio C1-C6; C1-C6 alkoxy optionally substituted with halogen or C1-C6 alkoxy; phenyl-C1-C6 alkyl; phenyl-C1-C6 alkoxy; and —N(RaRb) wherein each Ra and Rb is independently hydrogen or C1-C6 alkyl or Ra and Rb, taken together with the nitrogen atom they are linked to, form a saturated heterocyclic ring; and each R5, R6, R7, R8 is independently selected from hydrogen, halogen, hydroxy; C1-C6 alkyl optionally substituted with hydroxy; alkylthio C1-C6; C1-C6 alkoxy optionally substituted with halogen; C1-C6 alkyl-carbonyl, C1-C6 alkoxy-carbonyl, and oxazol-2-yl; comprising converting a compound of formula (IV), to said compound of formula (I), in the presence of a catalyst, if necessary in an organic solvent.

    摘要翻译： 制备式（I）化合物的方法，均为异构体混合物和各异构体，其中Q为-CR8-或-N-; 每个R 1，R 2，R 3，R 4独立地选自氢，卤素，羟基; 硝基 任选被羟基取代的C 1 -C 6烷基; 烷硫基C1-C6; 任选被卤素或C 1 -C 6烷氧基取代的C 1 -C 6烷氧基; 苯基-C 1 -C 6烷基; 苯基-C 1 -C 6烷氧基; 和-N（RaRb），其中每个R a和R b独立地是氢或C 1 -C 6烷基或R a和R b与它们连接的氮原子一起形成饱和杂环; 并且每个R 5，R 6，R 7，R 8独立地选自氢，卤素，羟基; 任选被羟基取代的C 1 -C 6烷基; 烷硫基C1-C6; 任选被卤素取代的C 1 -C 6烷氧基; C 1 -C 6烷基 - 羰基，C 1 -C 6烷氧羰基和恶唑-2-基; 包括在催化剂存在下，如果需要在有机溶剂中将式（Ⅳ）化合物转化为所述式（Ⅳ）化合物。