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    Methods for manufacture of valve flaps for cardiac valve prostheses
    1.
    发明授权
    Methods for manufacture of valve flaps for cardiac valve prostheses 失效
    用于制造心脏瓣膜假体瓣瓣的方法

    公开(公告)号：US4624822A

    公开(公告)日：1986-11-25

    申请号：US634085

    申请日：1984-07-25

    申请人： Pietro Arru ,  Gioacchino Bona ,  Maria Curcio ,  Franco Vallana

    发明人： Pietro Arru ,  Gioacchino Bona ,  Maria Curcio ,  Franco Vallana

    IPC分类号： A61F2/00 ,  A61F2/24 ,  A61L27/08 ,  A61L27/36 ,  B29C51/10

    CPC分类号： A61L27/507 ,  A61F2/2415 ,  A61L27/08 ,  A61L27/3683 ,  A61F2220/0075 ,  A61F2310/00161 ,  Y10S623/901

    摘要： Sheets of incompletely fixed biological tissue comprising portions for defining valve flaps of a cardiac valve prosthesis are mounted on forming means which can separate in a substantially fluid-tight manner the opposite faces of such portions. These opposite faces are subjected to a fluid pressure difference which produces deformation of the portions towards a conformation substantially identical with the conformation of the valve flaps when mounted in the prosthesis. The biological tissue is finally fixed while the portions defining the valve flaps of the prosthesis are maintained in the said conformation. The sheets of biological tissue are then separated from the forming means to be subsequently mounted in the frame of the prosthesis.

    摘要翻译： 包括用于限定心脏瓣膜假体的瓣膜的部分的不完全固定的生物组织的片材被安装在形成装置上，该装置可以以基本上流体密封的方式分离这些部分的相对面。 这些相对的面受到流体压力差，当安装在假体中时，该压力差导致部分朝向与瓣瓣的构象基本相同的构象的变形。 生物组织最后被固定，而限定假体瓣瓣的部分保持在所述构型中。 然后将生物组织片与成形装置分离，随后安装在假体的框架中。

    Cyclically deformable haemocompatible and biocompatible devices coated with biocompatible carbonaceous material
    3.
    发明授权
    Cyclically deformable haemocompatible and biocompatible devices coated with biocompatible carbonaceous material 失效
    用生物相容性碳质材料涂覆的可循环变形的血液兼容性和生物相容性装置

    公开(公告)号：US5423886A

    公开(公告)日：1995-06-13

    申请号：US110419

    申请日：1993-08-23

    申请人： Pietro Arru ,  Stefano Rinaldi ,  Marco Santi ,  Franco Vallana

    发明人： Pietro Arru ,  Stefano Rinaldi ,  Marco Santi ,  Franco Vallana

    IPC分类号： A61F2/24 ,  A61M1/10 ,  A61F2/06

    CPC分类号： A61F2/2412 ,  A61M1/10

    摘要： There are disclosed devices for conditioning a blood flow which include at least one element with portions which are exposed to the blood and are deformable cyclically at a frequency comparable to the frequency of the heartbeat, in which the cyclically deformable portions have a continuous coating of biocompatible carbonaceous material comprised of carbon crystals having a density of greater than 2.1 grams per cubic centimeter applied by sputtering directly on and completely covering at least those portions of the device which are exposed to the blood.

    摘要翻译： 已经公开了用于调节血流的装置，其包括至少一个元件，其具有暴露于血液的部分并且以与心跳频率相当的频率周期性变形，其中可循环变形部分具有生物相容性的连续涂层 碳质材料由具有大于2.1克/立方厘米密度的碳晶体组成，通过溅射直接溅射并完全覆盖暴露于血液的装置的至少那些部分。

    Method for making prosthesis of polymeric material coated with biocompatible carbon
    4.
    发明授权
    Method for making prosthesis of polymeric material coated with biocompatible carbon 失效
    制造涂有生物相容性碳的聚合材料假体的方法

    公开(公告)号：US5133845A

    公开(公告)日：1992-07-28

    申请号：US479651

    申请日：1990-02-14

    申请人： Franco Vallana ,  Pietro Arru

    发明人： Franco Vallana ,  Pietro Arru

    IPC分类号： A61F2/00 ,  A61L27/30 ,  C23C14/06 ,  C23C14/35

    CPC分类号： A61L27/303 ,  C23C14/0605 ,  C23C14/355 ,  A61F2310/00574

    摘要： A prosthetic device includes a turbostratic biocompatible carbon film firmly adherent to a substrate and having a density of at least 2.1 g/cm.sup.3. The carbon preferably is very thin, e.g., less than about one micron. The thin carbon biocompatible film covers at least that portion of the substrate which will be in contact with body tissue and/or fluids to insure against physiological rejection and degradation of the prosthetic device. The carbon can be deposited on a variety of substrates, including low temperature substrates, in situ, without adversely affecting the mechanical properties of the substrate. The prosthetic device of the invention is formed by triode sputtering vacuum deposition at a relatively low temperature to achieve the desired results with respect to the deposited carbon and the substrate and with respect to the required adherence therebetween.

    摘要翻译： 假体装置包括牢固粘附于基底并具有至少2.1g / cm 3密度的渗透生物相容性碳膜。 碳优选非常薄，例如小于约1微米。 薄碳生物相容膜至少覆盖将与身体组织接触的基底部分和/或流体，以确保假体装置的生理排斥和降解。 碳可以原位沉积在各种基材上，包括低温基材，而不会不利地影响基材的机械性能。 本发明的假体装置通过三极管在相对较低的温度下溅射真空沉积来形成，以便相对于沉积的碳和基底以及相对于它们之间所需的粘附获得期望的结果。

    Method and apparatus for forming prosthetic device having a biocompatible carbon film thereon
    5.
    发明授权
    Method and apparatus for forming prosthetic device having a biocompatible carbon film thereon 失效
    用于形成其上具有生物相容性碳膜的假体装置的方法和装置

    公开(公告)号：US5084151A

    公开(公告)日：1992-01-28

    申请号：US480094

    申请日：1990-02-14

    申请人： Franco Vallana ,  Pietro Arru

    发明人： Franco Vallana ,  Pietro Arru

    IPC分类号： A61F2/00 ,  A61F2/30 ,  C23C14/06 ,  C23C14/20 ,  C23C14/35

    CPC分类号： A61F2/30767 ,  C23C14/0605 ,  C23C14/205 ,  C23C14/355 ,  A61F2/3094 ,  A61F2310/00574

    摘要： A prosthetic device which includes a biocompatible carbon film firmly adherent to a substrate. The carbon preferably is turbostratic and is preferably very thin, e.g., less than about one micron. The thin carbon biocompatible film is dense and covers at least that portion of the substrate which will be in contact with body tissue and/or fluids to insure against physiological rejection and degradation of the prosthetic device. The carbon can be deposited on a variety of substrates, including low temperature substrates, in situ, without adversely affecting the mechanical properties of the substrate. The prosthetic device of the invention is formed by triode sputtering vacuum deposition at a relatively low temperature to achieve the desired results with respect to the deposited carbon and the substrate and with respect to the required adherence therebetween.

    摘要翻译： 一种假体装置，其包括牢固地粘附于基底的生物相容性碳膜。 碳优选是涡流式的，并且优选非常薄，例如小于约1微米。 薄碳生物相容性膜是致密的并且至少覆盖将与身体组织和/或流体接触的基底部分，以确保假体装置的生理排斥和降解。 碳可以原位沉积在各种基材上，包括低温基材，而不会不利地影响基材的机械性能。 本发明的假体装置通过三极管在相对较低的温度下溅射真空沉积来形成，以便相对于沉积的碳和基底以及相对于它们之间所需的粘附获得期望的结果。

    Prosthetic device having a biocompatible carbon film thereon and a method of and apparatus for forming such device
    6.
    发明授权
    Prosthetic device having a biocompatible carbon film thereon and a method of and apparatus for forming such device 失效
    在其上具有生物相容性碳膜的假体装置及其形成方法和装置

    公开(公告)号：US5387247A

    公开(公告)日：1995-02-07

    申请号：US462849

    申请日：1990-01-03

    申请人： Franco Vallana ,  Pietro Arru

    发明人： Franco Vallana ,  Pietro Arru

    IPC分类号： A61F2/00 ,  A61F2/30 ,  A61L29/10 ,  C23C14/06 ,  C23C14/20 ,  C23C14/35 ,  A61F2/54 ,  A61F2/68

    CPC分类号： C23C14/355 ,  A61F2/0077 ,  A61F2/30767 ,  A61L29/103 ,  C23C14/0605 ,  C23C14/205 ,  A61B17/06166 ,  A61F2/08 ,  A61F2/24 ,  A61F2/2803 ,  A61F2/3094 ,  A61F2/82 ,  A61F2240/001 ,  A61F2310/00574

    摘要： A prosthetic device which includes a biocompatible carbon film firmly adherent to a substrate. The carbon preferably is turbostratic and is preferably very thin, e.g., less than about one micron. The thin carbon biocompatible film is dense and covers at least that portion of the substrate which will be in contact with body tissue and/or fluids to insure against physiological rejection and degradation of the prosthetic device. The carbon can be deposited on a variety of substrates, including low temperature substrates, in situ, without adversely affecting the mechanical properties of the substrate. The prosthetic device of the invention is formed by triode sputtering vacuum deposition at a relatively low temperature to achieve the desired results with respect to the deposited carbon and the substrate and with respect to the required adherence therebetween.

    摘要翻译： 一种假体装置，其包括牢固地粘附于基底的生物相容性碳膜。 碳优选是涡流式的，并且优选非常薄，例如小于约1微米。 薄碳生物相容性膜是致密的并且至少覆盖将与身体组织和/或流体接触的基底部分，以确保假体装置的生理排斥和降解。 碳可以原位沉积在各种基材上，包括低温基材，而不会不利地影响基材的机械性能。 本发明的假体装置通过三极管在相对较低的温度下溅射真空沉积来形成，以便相对于沉积的碳和基底以及相对于它们之间所需的粘附获得期望的结果。

    Prosthesis of polymeric material coated with biocompatible carbon
    7.
    发明授权
    Prosthesis of polymeric material coated with biocompatible carbon 失效
    用生物相容性碳涂覆的聚合材料的假体

    公开(公告)号：US5370684A

    公开(公告)日：1994-12-06

    申请号：US931431

    申请日：1992-08-18

    申请人： Franco Vallana ,  Pietro Arru ,  Marco Santi

    发明人： Franco Vallana ,  Pietro Arru ,  Marco Santi

    IPC分类号： A61F20060101 ,  A61F2/00 ,  A61L27/30 ,  C23C14/06 ,  C23C14/35 ,  A61F2/06 ,  A61F2/02

    CPC分类号： A61L27/303 ,  C23C14/0605 ,  C23C14/355 ,  A61F2310/00574 ,  Y10S623/90

    摘要： A prosthetic device which includes a turbostratic biocompatible carbon film firmly adherent to a substrate and having a density of at least 2.1 g/cm.sup.3. The carbon preferably is very thin, e.g. , less than about one micron. The thin carbon biocompatible film covers at least that portion of the substrate which will be in contact with body tissue and/or fluids to insure against physiological rejection and degradation of the prosthetic device. The carbon can be deposited on a variety of substrates, including low temperature substrates, in situ, without adversely affecting the mechanical properties of the substrate. The prosthetic device of the invention is formed by triode sputtering vacuum deposition at a relatively low temperature to achieve the desired results with respect to the deposited carbon and the substrate and with respect to the required adherence therebetween.

    摘要翻译： 一种假体装置，其包括牢固粘附于基底并具有至少2.1g / cm 3的密度的渗透生物相容性碳膜。 碳优选非常薄，例如。 ，小于约1微米。 薄碳生物相容膜至少覆盖将与身体组织接触的基底部分和/或流体，以确保假体装置的生理排斥和降解。 碳可以原位沉积在各种基材上，包括低温基材，而不会不利地影响基材的机械性能。 本发明的假体装置通过三极管在相对较低的温度下溅射真空沉积来形成，以便相对于沉积的碳和基底以及相对于它们之间所需的粘附获得期望的结果。

    Method for activating a pyrocarbon electrode tip
    8.
    发明授权
    Method for activating a pyrocarbon electrode tip 失效
    激活焦碳电极尖端的方法

    公开(公告)号：US4495039A

    公开(公告)日：1985-01-22

    申请号：US405784

    申请日：1982-08-06

    申请人： Osvaldo Cerise ,  Pietro Arru ,  Franco Vallana

    发明人： Osvaldo Cerise ,  Pietro Arru ,  Franco Vallana

    IPC分类号： A61N1/05 ,  C25B11/12

    CPC分类号： A61N1/05

    摘要： A pyrocarbon tip for a cardiac stimulator electrode is subjected to an anodic electrolytic treatment in which a strong, concentrated acid with oxidizing properties, or a mixture of two or more such acids, is used as the electrolyte. The treatment is carried out with a voltage greater than 1 V, preferably between 1 and 20 V, and with a current density greater than 3 mA/mm.sup.2, preferably between 30 and 40 mA/mm.sup.2. Pyrocarbon tips treated in this manner have very low bias voltages in use.

    摘要翻译： 将用于心脏刺激器电极的焦碳碳尖端进行阳极电解处理，其中使用具有氧化性能的强酸浓缩酸或两种或更多种这种酸的混合物作为电解质。 处理以大于1V，优选1至20V的电压和大于3mA / mm 2的电流密度，优选在30至40mA / mm 2之间进行。 以这种方式处理的焦碳尖端在使用中具有非常低的偏压。