Asymmetric Liposomes for the Highly Efficient Encapsulation of Nucleic Acids and Hydrophilic Anionic Compounds, and Method for Preparing Same
    4.
    发明申请
    Asymmetric Liposomes for the Highly Efficient Encapsulation of Nucleic Acids and Hydrophilic Anionic Compounds, and Method for Preparing Same 有权
    用于高效包封核酸和亲水阴离子化合物的不对称脂质体及其制备方法

    公开(公告)号:US20130149374A1

    公开(公告)日:2013-06-13

    申请号:US13697705

    申请日:2010-11-12

    IPC分类号: A61K9/127 A61K31/713

    摘要: The present invention relates to asymmetric liposomes for high encapsulation efficiency of nucleic acids and hydrophilic anionic compounds, and to a method for preparing same, and specifically, to asymmetric liposomes consisting of a cationic lipid having a small head group as an internal lipid and a neutral or PEGylated lipid having a big head group as an external lipid, wherein nucleic acids and/or anionic compounds are encapsulated in the internal lipid. According to the present invention, asymmetric liposomes, in which nucleic acids and hydrophilic anionic compounds are encapsulated with high efficiency, may be prepared, and thus the same may be used for various purposes, such as gene therapy, and the delivery of hydrophilic anionic drugs which are difficult to prepare as prodrugs, and drug delivery, imaging, etc. can be carried out by encapsulating a fluorescent contrast agent in the liposome.

    摘要翻译: 本发明涉及用于核酸和亲水性阴离子化合物的高包封效率的不对称脂质体及其制备方法,具体涉及由具有小头基团作为内部脂质和中性的阳离子脂质组成的不对称脂质体 或具有大头基的聚乙二醇化脂质作为外部脂质,其中核酸和/或阴离子化合物包封在内部脂质中。 根据本发明,可以制备其中核酸和亲水性阴离子化合物以高效率包封的不对称脂质体,因此可以用于各种目的,例如基因治疗和递送亲水性阴离子药物 其难以作为前药制备,并且药物递送,成像等可以通过将荧光对比剂包封在脂质体中来进行。

    Asymmetric liposomes for the highly efficient encapsulation of nucleic acids and hydrophilic anionic compounds, and method for preparing same
    5.
    发明授权
    Asymmetric liposomes for the highly efficient encapsulation of nucleic acids and hydrophilic anionic compounds, and method for preparing same 有权
    用于高效包封核酸和亲水性阴离子化合物的不对称脂质体及其制备方法

    公开(公告)号:US09326940B2

    公开(公告)日:2016-05-03

    申请号:US13697705

    申请日:2010-11-12

    摘要: The present invention relates to asymmetric liposomes for high encapsulation efficiency of nucleic acids and hydrophilic anionic compounds, and to a method for preparing same, and specifically, to asymmetric liposomes consisting of a cationic lipid having a small head group as an internal lipid and a neutral or PEGylated lipid having a big head group as an external lipid, wherein nucleic acids and/or anionic compounds are encapsulated in the internal lipid. According to the present invention, asymmetric liposomes, in which nucleic acids and hydrophilic anionic compounds are encapsulated with high efficiency, may be prepared, and thus the same may be used for various purposes, such as gene therapy, and the delivery of hydrophilic anionic drugs which are difficult to prepare as prodrugs, and drug delivery, imaging, etc. can be carried out by encapsulating a fluorescent contrast agent in the liposome.

    摘要翻译: 本发明涉及用于核酸和亲水性阴离子化合物的高包封效率的不对称脂质体及其制备方法,具体涉及由具有小头基团作为内部脂质和中性的阳离子脂质组成的不对称脂质体 或具有大头基的聚乙二醇化脂质作为外部脂质,其中核酸和/或阴离子化合物包封在内部脂质中。 根据本发明,可以制备其中核酸和亲水性阴离子化合物以高效率包封的不对称脂质体,因此可以用于各种目的,例如基因治疗和递送亲水性阴离子药物 其难以作为前药制备,并且药物递送,成像等可以通过将荧光对比剂包封在脂质体中来进行。

    PRODUCTION METHOD FOR HIGH-PURITY CALCITE AND AMMONIUM SULPHATE BY USING GYPSUM
    7.
    发明申请
    PRODUCTION METHOD FOR HIGH-PURITY CALCITE AND AMMONIUM SULPHATE BY USING GYPSUM 有权
    通过使用GYPSUM的高纯度计算和硫酸铵的生产方法

    公开(公告)号:US20140161692A1

    公开(公告)日:2014-06-12

    申请号:US14232833

    申请日:2012-07-13

    IPC分类号: C22B26/20

    摘要: Provided is a recycling method for producing calcite and ammonium sulfate having a high purity of at least 95% and generated by means of a carbonation reaction for fixing carbon dioxide inside the crystal structure of a mineral, and in which waste gypsum is reacted with carbon dioxide, which is a greenhouse gas, such that the carbon dioxide is fixed as a stable mineral, and high-purity calcite and ammonium sulfate are produced as resultant products.

    摘要翻译: 本发明提供一种生产高纯度至少95%的方解石和硫酸铵的回收方法,通过碳酸化反应产生,用于将二氧化碳固定在矿物晶体结构内部,其中废石膏与二氧化碳反应 作为温室气体,使得二氧化碳被固定为稳定的矿物质,并且生产高纯度方解石和硫酸铵作为所得产物。