公开(公告)号：US08983168B2

公开(公告)日：2015-03-17

申请号：US13460172

申请日：2012-04-30

申请人： Ping Chen ,  Chao He ,  Gary Ross

发明人： Ping Chen ,  Chao He ,  Gary Ross

IPC分类号： G06K9/00

CPC分类号： G06T7/0006 ,  G06T2207/30108 ,  G07D7/2016 ,  G07D7/2075

摘要： A method of categorizing defects in a media item. The method comprising the steps of: receiving a binarised image of the media item, where the binarised image comprises a plurality of pixels, each pixel having either a potential defect intensity or a non-defect intensity; and identifying one or more blobs comprising contiguous pixels each having a potential defect intensity. For each identified blob, the method involves comparing a size of the blob with a damage threshold; ignoring the blob if the blob size is smaller than the damage threshold; and for each identified blob having a size exceeding or equaling the damage threshold, categorizing the identified blob.

摘要翻译： 对媒体项目中的缺陷进行分类的方法。 该方法包括以下步骤：接收媒体项目的二进制化图像，其中二进制化图像包括多个像素，每个像素具有潜在缺陷强度或非缺陷强度; 以及识别包括各自具有潜在缺陷强度的连续像素的一个或多个斑点。 对于每个识别的斑点，该方法涉及将斑块的大小与损伤阈值进行比较; 如果斑点大小小于损伤阈值，则忽略斑点; 并且对于具有超过或等于损伤阈值的大小的每个识别的斑点，对所识别的斑点进行分类。

公开(公告)号：US08805025B2

公开(公告)日：2014-08-12

申请号：US13436078

申请日：2012-03-30

申请人： Ping Chen ,  Chao He ,  Gary Ross

发明人： Ping Chen ,  Chao He ,  Gary Ross

IPC分类号： G06T7/00 ,  G07D11/00

CPC分类号： G07D7/187

摘要： A method of detecting staining on a media item is described. An example method includes receiving an image of the media item, including a plurality of pixels having different intensity values within a range of intensity values, applying central weighting to the received image, applying a threshold to each pixel in the centrally-weighted image to transform each pixel to a binary value, comparing a pixel in the evaluation image with a pixel in a binary reference image to create a difference image including (i) a stain pixel at each spatial location in which a pixel in the evaluation image has a low intensity pixel and the corresponding pixel in the binary reference image has a high intensity pixel, and (ii) a non-stain pixel at all other spatial locations. The media item is identified as stained in the event that the difference image meets a staining criterion.

摘要翻译： 描述了在媒体项目上检测染色的方法。 一种示例性方法包括接收媒体项目的图像，包括在强度值范围内具有不同强度值的多个像素，对接收到的图像应用中央加权，向中央加权图像中的每个像素应用阈值以变换 每个像素为二进制值，将评估图像中的像素与二进制参考图像中的像素进行比较，以产生差分图像，其包括（i）评估图像中的像素具有低强度的每个空间位置处的污点像素 像素和二进制参考图像中的对应像素具有高强度像素，以及（ii）所有其它空间位置处的非污点像素。 在差异图像满足染色标准的情况下，媒体项目被识别为染色。

公开(公告)号：US20130287264A1

公开(公告)日：2013-10-31

申请号：US13460172

申请日：2012-04-30

申请人： Ping Chen ,  Chao He ,  Gary Ross

发明人： Ping Chen ,  Chao He ,  Gary Ross

IPC分类号： G06K9/36

CPC分类号： G06T7/0006 ,  G06T2207/30108 ,  G07D7/2016 ,  G07D7/2075

摘要： A method of categorising defects in a media item. The method comprising the steps of: receiving a binarised image of the media item, where the binarised image comprises a plurality of pixels, each pixel having either a potential defect intensity or a non-defect intensity; and identifying one or more blobs comprising contiguous pixels each having a potential defect intensity. For each identified blob, the method involves comparing a size of the blob with a damage threshold; ignoring the blob if the blob size is smaller than the damage threshold; and for each identified blob having a size exceeding or equalling the damage threshold, categorising the identified blob.

摘要翻译： 对媒体项目中的缺陷进行分类的方法。 该方法包括以下步骤：接收媒体项目的二进制化图像，其中二进制化图像包括多个像素，每个像素具有潜在缺陷强度或非缺陷强度; 以及识别包括各自具有潜在缺陷强度的连续像素的一个或多个斑点。 对于每个识别的斑点，该方法涉及将斑块的大小与损伤阈值进行比较; 如果斑点大小小于损伤阈值，则忽略斑点; 并且对于具有超过或等于损伤阈值的大小的每个识别的斑点，对所识别的斑点进行分类。

公开(公告)号：US20130259301A1

公开(公告)日：2013-10-03

申请号：US13436078

申请日：2012-03-30

申请人： Ping Chen ,  Chao He ,  Gary Ross

发明人： Ping Chen ,  Chao He ,  Gary Ross

IPC分类号： G06K9/68

CPC分类号： G07D7/187

摘要： A method of detecting staining on a media item is described. An example method includes receiving an image of the media item, including a plurality of pixels having different intensity values within a range of intensity values, applying central weighting to the received image, applying a threshold to each pixel in the centrally-weighted image to transform each pixel to a binary value, comparing a pixel in the evaluation image with a pixel in a binary reference image to create a difference image including (i) a stain pixel at each spatial location in which a pixel in the evaluation image has a low intensity pixel and the corresponding pixel in the binary reference image has a high intensity pixel, and (ii) a non-stain pixel at all other spatial locations. The media item is identified as stained in the event that the difference image meets a staining criterion.

摘要翻译： 描述了在媒体项目上检测染色的方法。 一种示例性方法包括接收媒体项目的图像，包括在强度值范围内具有不同强度值的多个像素，对接收到的图像应用中央加权，向中央加权图像中的每个像素应用阈值以变换 每个像素为二进制值，将评估图像中的像素与二进制参考图像中的像素进行比较，以产生差分图像，其包括（i）评估图像中的像素具有低强度的每个空间位置处的污点像素 像素和二进制参考图像中的对应像素具有高强度像素，以及（ii）所有其它空间位置处的非污点像素。 在差异图像满足染色标准的情况下，媒体项目被识别为染色。

公开(公告)号：US20180354957A1

公开(公告)日：2018-12-13

申请号：US16058299

申请日：2018-08-08

申请人： Konstantin Petrukhin ,  Christopher Cioffi ,  Graham Johnson ,  Rando Allikmets ,  Emily Freeman ,  Ping Chen ,  Michael Conlon ,  Lei Zhu

发明人： Konstantin Petrukhin ,  Christopher Cioffi ,  Graham Johnson ,  Rando Allikmets ,  Emily Freeman ,  Ping Chen ,  Michael Conlon ,  Lei Zhu

IPC分类号： C07D487/04 ,  C07D471/04

CPC分类号： C07D487/04 ,  C07D471/04

摘要： The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; and B is a substituted or unsubstituted heterobicycle, wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20180222919A1

公开(公告)日：2018-08-09

申请号：US15944334

申请日：2018-04-03

申请人： Konstantin Petrukhin ,  Christopher Cioffi ,  Graham Johnson ,  Nicoleta Dobri ,  Emily Freeman ,  Ping Chen ,  Michael Conlon ,  Lei Zhu

发明人： Konstantin Petrukhin ,  Christopher Cioffi ,  Graham Johnson ,  Nicoleta Dobri ,  Emily Freeman ,  Ping Chen ,  Michael Conlon ,  Lei Zhu

IPC分类号： C07D498/04 ,  C07D213/79 ,  C07D213/80 ,  C07D231/56 ,  C07D237/24 ,  C07C233/56 ,  C07D249/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052 ,  C07D239/28

CPC分类号： C07D498/04 ,  C07C233/56 ,  C07D213/79 ,  C07D213/80 ,  C07D231/56 ,  C07D237/24 ,  C07D239/28 ,  C07D249/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052

摘要： The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is alkyl; A is absent or present, and when present is —C(O)— or —C(O)NH—; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is —C(O)—, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US08756810B2

公开(公告)日：2014-06-24

申请号：US13355029

申请日：2012-01-20

申请人： Ping Chen ,  Shu-Chun Yu

发明人： Ping Chen ,  Shu-Chun Yu

IPC分类号： B21D53/02 ,  B23P19/02 ,  F28D15/02

CPC分类号： F28D15/0275 ,  F28F2275/02 ,  F28F2275/12 ,  Y10T29/4935 ,  Y10T29/49353 ,  Y10T29/49364 ,  Y10T29/49393 ,  Y10T29/49885 ,  Y10T29/49945

摘要： A board-shaped heat dissipating device includes a board body having a plane face with a recess formed thereon, a heat conducting element fitted in the recess, at least one groove formed on any one of the board body and the heat conducting element, and at least one heat pipe pressed into the groove to flush with an open side of the groove. After the heat pipe is pressed into the groove and the heat conducting element is firmly fitted in the recess, portions of the heat conducting element that are higher than the plane face are removed through a cut operation, so that the heat conducting element is flush with the plane face of the board body to reduce the space occupied by the heat dissipating device. With the above arrangements, the problem of thermal resistance can be avoided and upgraded overall heat dissipation efficiency can be achieved.

摘要翻译： 一种板状散热装置，包括具有形成在其上的凹部的平面的板主体，嵌合在凹部中的导热元件，形成在板主体和导热元件中的任一个上的至少一个槽， 至少一个热管被压入槽中以与槽的开放侧齐平。 在热管被压入槽中并且导热元件牢固地装配在凹部中之后，通过切割操作去除导热元件高于平面的部分，使得导热元件与 板体的平面减少了散热装置占用的空间。 通过上述布置，可以避免热阻的问题，并且可以提高总的散热效率。

公开(公告)号：US20140128339A1

公开(公告)日：2014-05-08

申请号：US14054424

申请日：2013-10-15

申请人： Vinay Girijavallabhan ,  Stephane Bogen ,  Quang T. Truong ,  Ping Chen ,  Angela Kerekes ,  Frank Bennett ,  Sara Esposite ,  Qingmei Hong ,  Ian Davies

发明人： Vinay Girijavallabhan ,  Stephane Bogen ,  Quang T. Truong ,  Ping Chen ,  Angela Kerekes ,  Frank Bennett ,  Sara Esposite ,  Qingmei Hong ,  Ian Davies

IPC分类号： C07H19/06 ,  A61K45/06 ,  A61K31/7072 ,  C07H19/10 ,  A61K31/7068

CPC分类号： C07H19/06 ,  A61K31/7068 ,  A61K31/7072 ,  A61K45/06 ,  C07H19/067 ,  C07H19/073 ,  C07H19/10

摘要： The present invention relates to 2′-Methyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R, R1, R2 and R3, are as defined herein. The present invention also relates to compositions comprising at least one 2′-Methyl Substituted Nucleoside Derivative, and methods of using the 2′-Methyl Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.

摘要翻译： 本发明涉及式（I）的2'-甲基取代的核苷衍生物及其药学上可接受的盐，其中R，R 1，R 2和R 3如本文所定义。 本发明还涉及包含至少一种2'-甲基取代的核苷衍生物的组合物，以及使用2'-甲基取代的核苷衍生物治疗或预防患者HCV感染的方法。

公开(公告)号：US20140080884A1

公开(公告)日：2014-03-20

申请号：US14118998

申请日：2012-06-25

申请人： Itzia Arroyo ,  Davida Krueger ,  Ping Chen ,  Aaron Moment ,  Tesfaye Biftu ,  Faye Sheen ,  Yanfeng Zhang

发明人： Itzia Arroyo ,  Davida Krueger ,  Ping Chen ,  Aaron Moment ,  Tesfaye Biftu ,  Faye Sheen ,  Yanfeng Zhang

IPC分类号： C07D487/04

CPC分类号： C07D487/04 ,  A61K31/4162 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/513 ,  C07B2200/13 ,  Y02P20/55

摘要： Novel crystalline forms of (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine are potent inhibitors of dipeptidyl peptidase-IV and are useful for the treatment of non-insulin dependent (Type 2) diabetes mellitus. The invention also relates to pharmaceutical compositions containing these novel forms, processes to prepare these forms and their pharmaceutical compositions as well as uses thereof for the treatment of Type 2 diabetes.

摘要翻译： （2R，3S，5R）-2-（2,5-二氟苯基）-5- [2-（甲基磺酰基）-2,6-二氢吡咯并[3,4-c]吡唑-5（4H） - 吡啶-3-基]四氢-2H-吡喃-3-胺是二肽基肽酶-IV的有效抑制剂，可用于治疗非胰岛素依赖型（2型）糖尿病。 本发明还涉及含有这些新型形式的药物组合物，制备这些形式的方法及其药物组合物及其用于治疗2型糖尿病的用途。

公开(公告)号：US08653008B2

公开(公告)日：2014-02-18

申请号：US12664023

申请日：2008-06-11

申请人： Olav Martin Selle ,  Amare Mebratu ,  Harry Montgomerie ,  Ping Chen ,  Thomas Hagen

发明人： Olav Martin Selle ,  Amare Mebratu ,  Harry Montgomerie ,  Ping Chen ,  Thomas Hagen

IPC分类号： C09K8/52 ,  E21B43/26 ,  C09K8/38 ,  C09K8/70 ,  C09K8/94

CPC分类号： C09K8/52 ,  C09K8/38 ,  C09K8/528 ,  C09K8/536 ,  C09K8/70 ,  C09K8/703 ,  C09K8/94 ,  E21B37/06 ,  Y10S507/927

摘要： A method for delivering a scale treatment agent to a hydrocarbon producing system. The method includes the steps of contacting the system with a foam comprising the scale treatment agent, and shutting the scale treatment agent in the system for at least 0.5 hour.

摘要翻译： 一种将规模处理剂递送到烃生产系统的方法。 该方法包括以下步骤：使系统与包含刻度处理剂的泡沫体接触，并且将系统中的刻度处理剂封闭至少0.5小时。