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公开(公告)号：US09458442B2
公开(公告)日：2016-10-04
申请号：US14459876
申请日：2014-08-14
申请人： Ping Jiang , H. Michael Shepard , Lei Huang
发明人： Ping Jiang , H. Michael Shepard , Lei Huang
IPC分类号： C07K14/81 , C12N9/26 , A61K38/47 , G01N33/574 , G01N33/566 , G01N33/68 , A61K47/10 , C07K14/47
CPC分类号： C12N9/2474 , A61K38/47 , A61K47/10 , C07K14/47 , C07K2319/00 , C07K2319/30 , C07K2319/735 , G01N33/566 , G01N33/574 , G01N33/57488 , G01N33/6893 , G01N2333/705 , G01N2400/40 , G01N2800/52
摘要： Methods and diagnostic agents for identification of subjects for cancer treatment with an anti-hyaluronan agent, such as a hyaluronan-degrading enzyme, are provided. Diagnostic agents for the detection and quantification of hyaluronan in a biological sample and monitoring cancer treatment with an anti-hyaluronan agent, for example a hyaluronan-degrading enzyme, are provided. Combinations and kits for use in practicing the methods also are provided.
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2.发明申请COMPANION DIAGNOSTIC FOR ANTI-HYALURONAN AGENT THERAPY AND METHODS OF USE THEREOF 有权抗血小板药物治疗的联合诊断方法及其使用方法公开(公告)号：US20140348817A1
公开(公告)日：2014-11-27
申请号：US14459876
申请日：2014-08-14
申请人： Ping Jiang , H. Michael Shepard , Lei Huang
发明人： Ping Jiang , H. Michael Shepard , Lei Huang
IPC分类号： C12N9/26 , C07K14/47 , G01N33/574 , A61K47/10
CPC分类号： C12N9/2474 , A61K38/47 , A61K47/10 , C07K14/47 , C07K2319/00 , C07K2319/30 , C07K2319/735 , G01N33/566 , G01N33/574 , G01N33/57488 , G01N33/6893 , G01N2333/705 , G01N2400/40 , G01N2800/52
摘要： Methods and diagnostic agents for identification of subjects for cancer treatment with an anti-hyaluronan agent, such as a hyaluronan-degrading enzyme, are provided. Diagnostic agents for the detection and quantification of hyaluronan in a biological sample and monitoring cancer treatment with an anti-hyaluronan agent, for example a hyaluronan-degrading enzyme, are provided. Combinations and kits for use in practicing the methods also are provided.
摘要翻译： 提供了用透明质酸药物如透明质酸降解酶进行癌症治疗的受试者鉴别的方法和诊断剂。 提供用于检测和定量生物样品中透明质酸的诊断剂，并用抗透明质酸药物（例如透明质酸降解酶）监测癌症治疗。 还提供了用于实施方法的组合和试剂盒。
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3.发明授权Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof 有权抗透明质酸药物治疗的伴随诊断及其使用方法公开(公告)号：US08846034B2
公开(公告)日：2014-09-30
申请号：US13694071
申请日：2012-10-24
申请人： Ping Jiang , H. Michael Shepard , Lei Huang
发明人： Ping Jiang , H. Michael Shepard , Lei Huang
IPC分类号： C07K14/81 , G01N33/574 , A61K38/47 , G01N33/566 , G01N33/68
CPC分类号： C12N9/2474 , A61K38/47 , A61K47/10 , C07K14/47 , C07K2319/00 , C07K2319/30 , C07K2319/735 , G01N33/566 , G01N33/574 , G01N33/57488 , G01N33/6893 , G01N2333/705 , G01N2400/40 , G01N2800/52
摘要： Methods and diagnostic agents for identification of subjects for cancer treatment with an anti-hyaluronan agent, such as a hyaluronan-degrading enzyme, are provided. Diagnostic agents for the detection and quantification of hyaluronan in a biological sample and monitoring cancer treatment with an anti-hyaluronan agent, for example a hyaluronan-degrading enzyme, are provided. Combinations and kits for use in practicing the methods also are provided.
摘要翻译： 提供了用透明质酸药物如透明质酸降解酶进行癌症治疗的受试者鉴别的方法和诊断剂。 提供用于检测和定量生物样品中透明质酸的诊断剂，并用抗透明质酸药物（例如透明质酸降解酶）监测癌症治疗。 还提供了用于实施方法的组合和试剂盒。
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4.发明申请COMPANION DIAGNOSTIC FOR ANTI-HYALURONAN AGENT THERAPY AND METHODS OF USE THEREOF 有权抗血小板药物治疗的联合诊断方法及其使用方法公开(公告)号：US20150218544A9
公开(公告)日：2015-08-06
申请号：US14459876
申请日：2014-08-14
申请人： Ping Jiang , H. Michael Shepard , Lei Huang
发明人： Ping Jiang , H. Michael Shepard , Lei Huang
IPC分类号： C12N9/26 , C07K14/47 , G01N33/574 , A61K47/10
CPC分类号： C12N9/2474 , A61K38/47 , A61K47/10 , C07K14/47 , C07K2319/00 , C07K2319/30 , C07K2319/735 , G01N33/566 , G01N33/574 , G01N33/57488 , G01N33/6893 , G01N2333/705 , G01N2400/40 , G01N2800/52
摘要： Methods and diagnostic agents for identification of subjects for cancer treatment with an anti-hyaluronan agent, such as a hyaluronan-degrading enzyme, are provided. Diagnostic agents for the detection and quantification of hyaluronan in a biological sample and monitoring cancer treatment with an anti-hyaluronan agent, for example a hyaluronan-degrading enzyme, are provided. Combinations and kits for use in practicing the methods also are provided.
摘要翻译： 提供了用透明质酸药物如透明质酸降解酶进行癌症治疗的受试者鉴别的方法和诊断剂。 提供用于检测和定量生物样品中透明质酸的诊断剂，并用抗透明质酸药物（例如透明质酸降解酶）监测癌症治疗。 还提供了用于实施方法的组合和试剂盒。
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5.发明申请Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof 有权抗透明质酸药物治疗的伴随诊断及其使用方法公开(公告)号：US20130202583A1
公开(公告)日：2013-08-08
申请号：US13694071
申请日：2012-10-24
申请人： Ping Jiang , H. Michael Shepard , Lei Huang
发明人： Ping Jiang , H. Michael Shepard , Lei Huang
CPC分类号： C12N9/2474 , A61K38/47 , A61K47/10 , C07K14/47 , C07K2319/00 , C07K2319/30 , C07K2319/735 , G01N33/566 , G01N33/574 , G01N33/57488 , G01N33/6893 , G01N2333/705 , G01N2400/40 , G01N2800/52
摘要： Methods and diagnostic agents for identification of subjects for cancer treatment with an anti-hyaluronan agent, such as a hyaluronan-degrading enzyme, are provided. Diagnostic agents for the detection and quantification of hyaluronan in a biological sample and monitoring cancer treatment with an anti-hyaluronan agent, for example a hyaluronan-degrading enzyme, are provided. Combinations and kits for use in practicing the methods also are provided.
摘要翻译： 提供了用透明质酸药物如透明质酸降解酶进行癌症治疗的受试者鉴别的方法和诊断剂。 提供用于检测和定量生物样品中透明质酸的诊断剂，并用抗透明质酸药物（例如透明质酸降解酶）监测癌症治疗。 还提供了用于实施方法的组合和试剂盒。
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6.发明申请Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof 审中-公开有条件的活性抗表皮生长因子受体抗体及其使用方法公开(公告)号：US20140170159A9
公开(公告)日：2014-06-19
申请号：US13815553
申请日：2013-03-08
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K39/39558 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92 , A61K39/00
摘要： Provided herein are modified anti-EGFR antibodies and nucleic acid molecules encoding modified anti-EGFR antibodies. Also provided are methods of treatment and uses using modified anti-EGFR antibodies.
摘要翻译： 本文提供了修饰的抗EGFR抗体和编码修饰的抗EGFR抗体的核酸分子。 还提供了使用修饰的抗EGFR抗体的治疗和使用的方法。
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7.发明申请Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof 审中-公开有条件的活性抗表皮生长因子受体抗体及其使用方法公开(公告)号：US20130266579A1
公开(公告)日：2013-10-10
申请号：US13815553
申请日：2013-03-08
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K39/39558 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92 , A61K39/00
摘要： Provided herein are modified anti-EGFR antibodies and nucleic acid molecules encoding modified anti-EGFR antibodies. Also provided are methods of treatment and uses using modified anti-EGFR antibodies.
摘要翻译： 本文提供了修饰的抗EGFR抗体和编码修饰的抗EGFR抗体的核酸分子。 还提供了使用修饰的抗EGFR抗体的治疗和使用的方法。
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公开(公告)号：US09913822B2
公开(公告)日：2018-03-13
申请号：US13815804
申请日：2013-03-15
IPC分类号： A61K47/48 , A61K31/56 , A61K31/7068 , A61K31/337 , A61K38/47 , A61K31/37 , A61K31/42 , A61K31/573 , A61K31/706 , A61K31/7076 , A61K31/7088 , C12N9/06 , C12N9/26 , A61K45/06 , A61K9/00 , A61K47/60 , A61K47/56 , A61K47/64
CPC分类号： A61K31/337 , A61K9/0019 , A61K31/37 , A61K31/42 , A61K31/56 , A61K31/573 , A61K31/706 , A61K31/7068 , A61K31/7076 , A61K31/7088 , A61K38/47 , A61K45/06 , A61K47/48215 , A61K47/48284 , A61K47/56 , A61K47/60 , A61K47/643 , C12N9/003 , C12N9/2474 , C12Y105/01003 , C12Y302/01035 , A61K2300/00
摘要： Provided herein is combination therapy containing an anti-hyaluronan agent, such as a polymer-conjugated hyaluronan-degrading enzyme, and a tumor-targeted taxane, and optionally a further chemotherapeutic agent such as a nucleoside analog. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers.
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公开(公告)号：US20130302275A1
公开(公告)日：2013-11-14
申请号：US13694731
申请日：2012-12-28
申请人： Ge Wei , H. Michael Shepard , Qiping Zhao , Robert James Connor
发明人： Ge Wei , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC分类号： C12N9/26
CPC分类号： C12N9/2474 , A61K9/0019 , A61K38/00 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , C12Q1/34 , C12Y302/01035 , G01N2333/926 , G01N2333/928 , Y02A50/463 , A61K2300/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.
摘要翻译： 提供了修饰的PH20透明质酸酶多肽，包括表现出增加的稳定性和/或增加的活性的修饰的多肽。 还提供了组合物及其制剂和用途。
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10.发明授权Organ-specific targeting of cationic amphiphile / DNA complexes for gene therapy 失效用于基因治疗的阳离子两亲物/ DNA复合物的器官特异性靶向公开(公告)号：US06331524B1
公开(公告)日：2001-12-18
申请号：US08835213
申请日：1997-04-07
申请人： Ronald K. Scheule , Rebecca G. Bagley , Simon J. Eastman , Seng H. Cheng , John Marshall , David J. Harris , Edward R. Lee , Craig S. Siegel , Chau-Dung Chang , S. Catherine Hubbard , Duane E. Johnson , Daniel C. Maneval , H. Michael Shepard , Richard J. Gregory
发明人： Ronald K. Scheule , Rebecca G. Bagley , Simon J. Eastman , Seng H. Cheng , John Marshall , David J. Harris , Edward R. Lee , Craig S. Siegel , Chau-Dung Chang , S. Catherine Hubbard , Duane E. Johnson , Daniel C. Maneval , H. Michael Shepard , Richard J. Gregory
IPC分类号： A61K4800
CPC分类号： C07J41/0055 , A61K9/1272 , A61K47/54 , A61K47/542 , A61K47/543 , A61K47/554 , A61K48/00 , C07J41/0005 , C07J41/0061 , C07J43/003 , C12N15/88
摘要： Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. The amphiphiles contain lipophilic groups derived from steroids, from mono or dialkylamines, or from alkyl or acyl groups; and cationic groups, protonatable at physiological pH, derived from amines, alkylamines or polyalkylamines. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile. Novel and highly effective plasmid constructs are also disclosed, including those that are particularly effective at providing gene therapy for clinical conditions complicated by inflammation. Additionally, targeting of organs for gene therapy by intravenous administration of therapeutic compositions is described.
摘要翻译： 提供了新的阳离子两亲物，其促进生物活性（治疗性）分子进入细胞。 两亲物含有衍生自类固醇的单亲或二烷基胺或烷基或酰基的亲脂基团; 和在生理pH下可质子化的阳离子基团，衍生自胺，烷基胺或多烷基胺。 还提供了通常通过使一种或多种阳离子两亲物的分散体与治疗分子接触而制备的治疗组合物。 根据本发明的实践可以递送到细胞中的治疗分子包括DNA，RNA和多肽。 本发明治疗组合物的代表性用途包括提供基因治疗以及向细胞递送反义多核苷酸或生物活性多肽。 关于基因治疗的治疗组合物，通常以与阳离子两亲物络合的质粒的形式提供DNA。 还公开了新型和高效的质粒构建体，包括在为炎症复杂的临床病症提供基因治疗方面特别有效的质粒构建体。 另外，描述了通过静脉内施用治疗组合物靶向用于基因治疗的器官。
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