公开(公告)号：US08867032B2

公开(公告)日：2014-10-21

申请号：US13634620

申请日：2011-03-22

申请人： Pol Van Dorpe ,  Kristof Lodewijks ,  Masahiko Shioi ,  Jian Ye

发明人： Pol Van Dorpe ,  Kristof Lodewijks ,  Masahiko Shioi ,  Jian Ye

IPC分类号： G01J3/44 ,  B82Y30/00 ,  B82Y15/00 ,  G01N21/65 ,  G01N21/64 ,  G01N21/55 ,  B22F1/00

CPC分类号： G01N21/658 ,  B22F2001/0029 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/553 ,  G01N21/554 ,  G01N21/648 ,  Y10S977/773 ,  Y10T428/25

摘要： A substrate is described that is suitable for surface enhanced optical detection. The substrate comprises an electrically conductive layer The substrate further comprises at least one nanoparticle comprising an electrically conductive portion. The electrically conductive portion may provide an opening to an underlying material. Such at least one nanoparticles may be a nanoring, a nanodisc, or a non-spherical nanoshell. The substrate further comprises a dielectric spacer for spacing the electrically conductive layer from the at least one nanoparticles. The dielectric spacer is a dielectric material substantially only present under the at least one nanoparticle, leaving the electrically conductive layer uncovered from dielectric material at positions away from the nanoparticles. The at least one nanoparticle and the dielectric spacer are interfaced along a first major surface and the at least one nanoparticle comprises an upstanding surface not in line with an upstanding surface of the dielectric spacer.

摘要翻译： 描述了适用于表面增强光学检测的衬底。 衬底包括导电层。衬底还包括至少一个包含导电部分的纳米颗粒。 导电部分可以提供到下面的材料的开口。 这样的至少一种纳米颗粒可以是纳米级，纳米型或非球形纳米壳。 衬底还包括用于将导电层与至少一种纳米颗粒间隔开的介质间隔物。 电介质间隔物是基本上只存在于至少一个纳米颗粒下的电介质材料，留下导电层在远离纳米颗粒的位置处不与电介质材料覆盖。 所述至少一个纳米颗粒和电介质间隔物沿着第一主表面接合，并且所述至少一个纳米颗粒包括不与所述电介质间隔物的直立表面一致的直立表面。

公开(公告)号：US20130003058A1

公开(公告)日：2013-01-03

申请号：US13634620

申请日：2011-03-22

申请人： Pol Van Dorpe ,  Kristof Lodewijks ,  Masahiko Shioi ,  Jian Ye

发明人： Pol Van Dorpe ,  Kristof Lodewijks ,  Masahiko Shioi ,  Jian Ye

IPC分类号： G01J3/44 ,  B32B5/16 ,  B05D5/12 ,  B05D3/10 ,  B82Y30/00

CPC分类号： G01N21/658 ,  B22F2001/0029 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/553 ,  G01N21/554 ,  G01N21/648 ,  Y10S977/773 ,  Y10T428/25

摘要： A substrate is described that is suitable for surface enhanced optical detection. The substrate comprises an electrically conductive layer (110), such as for example a gold layer. It furthermore comprises at least one nanoparticle (1404) comprising an electrically conductive portion. The electrically conductive portion in some embodiments provides an opening to an underlying material. Such at least one nanoparticles (1404) thus may for example be a nanoring, a nanodisc, or a non-spherical nanoshell. The substrate furthermore comprises a dielectric spacer (1406) for spacing the electrically conductive layer from the at least one nanoparticles. The dielectric spacer (1406) is a dielectric material substantially only present under the at least one nanoparticle (1404), leaving the electrically conductive layer (110) uncovered from dielectric material at positions away from the nanoparticles (1404). The at least one nanoparticle (1404) and the dielectric spacer (1406) are interfaced along a first major surface (1402) and the at least one nanoparticle (1404) comprises an upstanding surface not in line with an upstanding surface of the dielectric spacer (1406).

摘要翻译： 描述了适用于表面增强光学检测的衬底。 衬底包括导电层（110），例如金层。 它还包括至少一个包含导电部分的纳米颗粒（1404）。 在一些实施例中，导电部分为下层材料提供开口。 因此，这样的至少一种纳米颗粒（1404）可以例如是纳米级，纳米棒状或非球形纳米壳。 衬底还包括用于将导电层与至少一种纳米颗粒间隔开的电介质间隔物（1406）。 电介质间隔物（1406）是基本上仅存在于至少一个纳米颗粒（1404）下面的电介质材料，留下导电层（110）在远离纳米颗粒（1404）的位置处不与电介质材料覆盖。 至少一个纳米颗粒（1404）和电介质间隔物（1406）沿着第一主表面（1402）接合，并且所述至少一个纳米颗粒（1404）包括不与介电间隔物的直立表面 1406）。

公开(公告)号：US20110001976A1

公开(公告)日：2011-01-06

申请号：US12828775

申请日：2010-07-01

申请人： Masaru MINAMIGUCHI ,  Tatsurou Kawamura ,  Masahiko Shioi ,  Atsushi Matsubara

发明人： Masaru MINAMIGUCHI ,  Tatsurou Kawamura ,  Masahiko Shioi ,  Atsushi Matsubara

IPC分类号： G01N21/55

CPC分类号： G01N21/554 ,  G01N21/553 ,  G01N21/648 ,  G01N21/658 ,  G01N33/54373

摘要： The present invention provides an apparatus for biogenic substance concentration measurement including: a cell including therein a first region, a second region, and a test solution retention space; a light source; a polarizing plate; and a photoreceiver, in which a plurality of first metallic nanorods each having a first antibody on a surface thereof are immobilized on the first region, a plurality of second metallic nanorods each having a second antibody on a surface thereof are immobilized on the second region, the respective long axes of the plurality of first metallic nanorods are aligned in the same direction, the respective long axes of the plurality of second metallic nanorods are aligned in the same direction, the long-axis direction of the first metallic nanorod is orthogonal to the long-axis direction of the second metallic nanorod, and at least one of the polarizing plate and the cell is capable of rotation with an optical axis as the rotation axis.

摘要翻译： 本发明提供一种用于生物源物质浓度测量的装置，包括：包含第一区域，第二区域和测试溶液保留空间的单元; 光源; 偏振片; 以及光接收器，其中在其表面上分别具有第一抗体的多个第一金属纳米棒固定在第一区域上，在其表面上分别具有第二抗体的多个第二金属纳米棒被固定在第二区域上， 多个第一金属纳米棒的各自的长轴在同一方向上排列，多个第二金属纳米棒的各个长轴在相同的方向上排列，第一金属纳米棒的长轴方向与 第二金属纳米棒的长轴方向，并且偏振板和单元中的至少一个能够以光轴作为旋转轴旋转。

公开(公告)号：US08548545B2

公开(公告)日：2013-10-01

申请号：US13458544

申请日：2012-04-27

申请人： Tatsurou Kawamura ,  Masaru Minamiguchi ,  Masahiko Shioi

发明人： Tatsurou Kawamura ,  Masaru Minamiguchi ,  Masahiko Shioi

IPC分类号： A61B5/1455

CPC分类号： A61B5/14532 ,  A61B5/1455

摘要： One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating a substantially-parallel light from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate a reflected light; inclining the light source and calculating the concentration of the biogenic substance on the basis of the difference of signals before and after the inclination.

摘要翻译： 本发明的目的之一是提供具有改进的测量精度的生物源物质浓度测量方法。 本发明的一个实施例提供了一种测量生物体中包含的生物体的浓度的方法，所述方法包括制备测量装置的步骤，其中测量装置包括光源，滤光器和光接收器 ; 通过皮肤表面上的位置将来自光源的基本上平行的光照射到植入皮肤的颗粒上，产生反射光; 基于倾斜前后的信号差，倾斜光源并计算生物来源物质的浓度。

公开(公告)号：US20120029326A1

公开(公告)日：2012-02-02

申请号：US13267625

申请日：2011-10-06

申请人： Tatsurou KAWAMURA ,  Masahiko Shioi ,  Masaru Minamiguchi

发明人： Tatsurou KAWAMURA ,  Masahiko Shioi ,  Masaru Minamiguchi

IPC分类号： A61B5/1455

CPC分类号： G01N21/658 ,  A61B5/14532 ,  A61B5/14558 ,  A61B5/6861

摘要： The object of the present invention is to provide a method for measuring concentration of a biological substance contained in a living body in which deterioration of the accuracy due to the reflected light and the interruption component is suppressed. Linear-polarized light is emitted to a particle chip implanted in the skin with modulating its modulating direction continuously. A surface enhanced Raman scattering light of the biological substance generated on the particle chip. A concentration of the biological substance is calculated based on the received signal. The receiving signal satisfy the following equation (III). [Math. 3] R(t)=Am·sin(t)+D  (III) R(t): received signal Am: amplitude t: time D: a constant number

摘要翻译： 本发明的目的是提供一种用于测量生物体中包含的生物体的浓度的方法，其中抑制了由反射光和中断成分引起的精度的劣化。 线性偏振光通过调制其调制方向连续地发射到植入皮肤中的粒子碎片。 颗粒上产生生物物质的表面增强拉曼散射光。 基于接收到的信号计算生物物质的浓度。 接收信号满足下式（III）。 [数学。 3] R（t）= Am·sin（t）+ D（III）R（t）：接收信号Am：幅度t：时间D：常数

公开(公告)号：US20090316137A1

公开(公告)日：2009-12-24

申请号：US11915889

申请日：2007-03-08

申请人： Masahiko Shioi

发明人： Masahiko Shioi

IPC分类号： G01N21/35 ,  G01J3/00

CPC分类号： A61B5/1075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/6817 ,  G01J1/04 ,  G01J1/0448 ,  G01J1/0451 ,  G01J2003/1213 ,  G01N21/35

摘要： A device for measuring the concentration of a biological constituent based on infrared radiation emitted by a subject's eardrum with the influence of the eardrum's thickness taken into account is provided.The biological constituent concentration measuring device includes: a detecting section for detecting infrared radiation emitted by an eardrum; an acquisition section for acquiring thickness information about the thickness of the eardrum; and a computing section for figuring out the concentration of the biological constituent based on the infrared radiation detected and the thickness information acquired. The infrared radiation emitted by the eardrum is subject to the influence of the subject's eardrum thickness. Therefore, by calculating the biological constituent concentration based on not only the infrared radiation detected but also the eardrum thickness information, the biological constituent concentration can be measured highly accurately.

摘要翻译： 提供了一种用于根据所考虑的鼓膜厚度的影响来测量基于被检体耳膜发射的红外辐射的生物成分浓度的装置。 所述生物体成分浓度测定装置包括：检测部，其检测由鼓膜发射的红外线辐射; 用于获取关于所述鼓膜厚度的厚度信息的获取部分; 以及计算部，用于基于所检测的红外辐射和获取的厚度信息来计算生物成分的浓度。 由鼓膜发射的红外辐射受到受试者耳膜厚度的影响。 因此，通过不仅检测出红外辐射而且基于鼓膜厚度信息计算生物成分浓度，所以可以高精度地测定生物成分浓度。

公开(公告)号：US20090270698A1

公开(公告)日：2009-10-29

申请号：US12067917

申请日：2006-10-19

申请人： Masahiko Shioi ,  Yoshiko Miyamoto ,  Shinji Uchida

发明人： Masahiko Shioi ,  Yoshiko Miyamoto ,  Shinji Uchida

IPC分类号： A61B5/1455

CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B5/6817

摘要： A bioinformation measurement device that enables further accurate bioinformation measurement is provided. The device includes an insertion portion 104 to be inserted in an ear cavity 200; a first light inlet 105 and a second light inlet 106 provided at the insertion portion 104, for introducing the infrared light irradiated from the ear cavity 200 to the insertion portion 104; an optical guide path provided in the insertion portion 104 for guiding the first infrared light introduced from the first light inlet 105 and the second infrared light introduced from the second light inlet 106; a dispersive element for dispersing the first infrared light and the second infrared light guided by the optical guide path; an infrared ray detector 108 for detecting the first infrared light and the second infrared light dispersed by the dispersive element; and a computing unit for computing bioinformation based on the intensities of the first infrared light and the second infrared light detected by the infrared ray detector 108.

摘要翻译： 提供了能够进一步精确的生物信息测量的生物信息测量装置。 该装置包括插入耳孔200中的插入部分104; 设置在插入部104处的第一光入口105和第二光入口106，用于将从耳腔200照射的红外光引入插入部104; 设置在插入部104中用于引导从第一光入口105引入的第一红外光和从第二光入口106引入的第二红外光的光导路径; 用于分散由光导路引导的第一红外光和第二红外线的色散元件; 用于检测由色散元件分散的第一红外光和第二红外光的红外线检测器108; 以及计算单元，用于基于由红外线检测器108检测到的第一红外光和第二红外光的强度来计算生物信息。

公开(公告)号：US20090030295A1

公开(公告)日：2009-01-29

申请号：US12281809

申请日：2007-03-08

申请人： Masahiko Shioi ,  Shinji Uchida ,  Yoshiko Miyamoto

发明人： Masahiko Shioi ,  Shinji Uchida ,  Yoshiko Miyamoto

IPC分类号： A61B5/1455

CPC分类号： A61B5/1455 ,  A61B1/227 ,  A61B5/14532 ,  A61B5/6817 ,  G01N21/35

摘要： A biological constituent concentration measuring device that can measure a biological constituent concentration highly accurately using a radiation that has come from an eardrum is provided.A measuring device for measuring concentration of a biological constituent includes: an image capturing section for capturing an image of an eardrum; a processing section for generating tilt information concerning tilt of the eardrum based on a first image capturing information obtained by capturing an image of a first area of the eardrum and a second image capturing information obtained by capturing an image of a second area of the eardrum, which is different from the first area; an infrared sensor for sensing infrared radiation that has been radiated from the eardrum; and a computing section for calculating the concentration of a biological constituent based on the infrared radiation sensed and the tilt information.

摘要翻译： 提供了可以使用来自鼓膜的辐射高精度地测量生物成分浓度的生物成分浓度测量装置。 用于测量生物成分浓度的测量装置包括：用于捕获鼓膜图像的图像捕获部分; 基于通过拍摄耳膜的第一区域的图像获得的第一图像拍摄信息和通过拍摄鼓膜的第二区域的图像而获得的第二图像拍摄信息，生成关于耳膜倾斜的倾斜信息的处理部分， 这与第一个区域不同; 用于感测已经从鼓膜辐射的红外辐射的红外传感器; 以及计算部分，用于基于所感测的红外辐射和倾斜信息计算生物成分的浓度。

公开(公告)号：US08735170B2

公开(公告)日：2014-05-27

申请号：US13483790

申请日：2012-05-30

申请人： Masaru Minamiguchi ,  Tatsurou Kawamura ,  Masahiko Shioi ,  Atsushi Matsubara

发明人： Masaru Minamiguchi ,  Tatsurou Kawamura ,  Masahiko Shioi ,  Atsushi Matsubara

IPC分类号： G01N33/566 ,  G01N33/551 ,  G01N33/553 ,  G01N21/64

CPC分类号： G01N33/551 ,  G01N21/21 ,  G01N21/553 ,  G01N21/648 ,  G01N33/553

摘要： A biogenic substance concentration measuring apparatus includes an optical measuring apparatus for measuring optical properties of a first substrate and a second substrate by using a cell for biogenic substance concentration measurement that includes: the first substrate on which a plurality of first metallic nanorods, each of which is modified with a substance that bonds specifically to a test substance, are immobilized such that the long axes thereof are aligned in the same direction; and the second substrate on which a plurality of second metallic nanorods, each of which is modified with a blocking substance, are immobilized such that the long axes thereof are aligned perpendicularly to the long axes of the first metallic nanorods on the first substrate, and calculates a biogenic substance concentration with high accuracy from the optical properties.

摘要翻译： 一种生物来源物质浓度测量装置，包括：用于通过使用生物源物质浓度测量用的细胞测量第一基板和第二基板的光学特性的光学测量装置，其包括：第一基板，多个第一金属纳米棒， 用特异性结合试验物质的物质进行了改性，被固定成使其长轴在同一方向上排列; 并且其上固定有多个第二金属纳米棒的第二基板，每个第二金属纳米棒被阻挡物质改性，使得其长轴垂直于第一基板上的第一金属纳米棒的长轴取向，并且计算 一种具有高精度的光学性质的生物物质浓度。

公开(公告)号：US07333186B2

公开(公告)日：2008-02-19

申请号：US11081088

申请日：2005-03-16

申请人： Kiyoko Oshima ,  Shinji Uchida ,  Masahiko Shioi

发明人： Kiyoko Oshima ,  Shinji Uchida ,  Masahiko Shioi

IPC分类号： G01N33/48 ,  A61B5/00

CPC分类号： A61B5/14532

摘要： In order to precisely determine a stable measuring region appropriate for a measurement of biological information, and to measure a concentration of a specific component, i.e. biological information, without inconsistency, a biological information measuring device is provided with, a measuring region determining means for determining a measuring region in between an eponychium and a distal interphalangeal joint; an information detector for applying a light to measuring region; a light source for entering a light to information detector; a light detector for detecting a light which exits from the information detector; and a processor for measuring specific component based on information obtained from light detector.

摘要翻译： 为了精确地确定适于测量生物信息的稳定测量区域，并且测量特定成分（即生物信息）的浓度而不一致，生物信息测量装置具有：测量区域确定装置，用于确定 一个测量区域在一个eponychium和一个远端指间关节之间; 用于将光施加到测量区域的信息检测器; 用于将光线输入信息检测器的光源; 用于检测从所述信息检测器退出的光的光检测器; 以及基于从光检测器获得的信息来测量特定分量的处理器。