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公开(公告)号：US20090203018A1
公开(公告)日：2009-08-13
申请号：US12360819
申请日：2009-01-27
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6823 , C12Q2527/107 , C12Q2537/163 , C12Q2561/109
摘要： The present invention provides methods, compositions, and kits for detecting the presence or absence of target sequences in a sample, where the sample also contains interfering sequences that are similar or identical to the target sequences. In particular, the present invention provides blocker oligonucleotides that at least partially inhibit the formation of invasive cleavage structures with the interfering sequences but do not substantially inhibit the formation of invasive cleavage structures with the target sequences.
摘要翻译： 本发明提供用于检测样品中靶序列存在或不存在的方法，组合物和试剂盒，其中样品还含有与靶序列相似或相同的干扰序列。 特别地，本发明提供了阻断型寡核苷酸，该阻断剂寡核苷酸至少部分地抑制了具有干扰序列形成侵入性切割结构，但基本上不抑制靶序列形成侵入性切割结构。
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公开(公告)号：US07932039B2
公开(公告)日：2011-04-26
申请号：US12360819
申请日：2009-01-27
CPC分类号： C12Q1/6827 , C12Q1/6823 , C12Q2527/107 , C12Q2537/163 , C12Q2561/109
摘要： The present invention provides methods, compositions, and kits for detecting the presence or absence of target sequences in a sample, where the sample also contains interfering sequences that are similar or identical to the target sequences. In particular, the present invention provides blocker oligonucleotides that at least partially inhibit the formation of invasive cleavage structures with the interfering sequences but do not substantially inhibit the formation of invasive cleavage structures with the target sequences.
摘要翻译： 本发明提供用于检测样品中靶序列存在或不存在的方法，组合物和试剂盒，其中样品还含有与靶序列相似或相同的干扰序列。 特别地，本发明提供了阻断型寡核苷酸，该阻断剂寡核苷酸至少部分地抑制了具有干扰序列形成侵入性切割结构，但基本上不抑制靶序列形成侵入性切割结构。
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公开(公告)号：US20130149697A1
公开(公告)日：2013-06-13
申请号：US13768794
申请日：2013-02-15
申请人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert W. Kwiatkowski, JR. , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
发明人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert W. Kwiatkowski, JR. , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708 , C12Q2561/109
摘要： The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of HPV sequences. The present invention also provides compositions, methods and kits for screening sets of HPV sequences in a single reaction container.
摘要翻译： 本发明提供用于检测和表征HPV序列的组合物和方法。 更具体地，本发明提供了使用侵入性切割结构测定法（例如INVADER测定法）筛选核酸样品（例如来自患者）以存在HPV序列集合中的任何一个的组合物，方法和试剂盒。 本发明还提供了用于在单个反应容器中筛选HPV序列的组合物，方法和试剂盒。
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公开(公告)号：US08389245B2
公开(公告)日：2013-03-05
申请号：US11857942
申请日：2007-09-19
申请人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert W. Kwiatkowski, Jr. , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
发明人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert W. Kwiatkowski, Jr. , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
IPC分类号： C12P19/34
CPC分类号： C12Q1/708 , C12Q2561/109
摘要： The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of HPV sequences. The present invention also provides compositions, methods and kits for screening sets of HPV sequences in a single reaction container.
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公开(公告)号：US07527948B2
公开(公告)日：2009-05-05
申请号：US10951241
申请日：2004-09-27
申请人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert W. Kwiatkowski, Jr. , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
发明人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert W. Kwiatkowski, Jr. , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
CPC分类号： C12Q1/708 , C12Q2561/109
摘要： The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of HPV sequences. The present invention also provides compositions, methods and kits for screening sets of HPV sequences in a single reaction container.
摘要翻译： 本发明提供用于检测和表征HPV序列的组合物和方法。 更具体地，本发明提供了使用侵入性切割结构测定法（例如INVADER测定法）筛选核酸样品（例如来自患者）以存在HPV序列集合中的任何一个的组合物，方法和试剂盒。 本发明还提供了用于在单个反应容器中筛选HPV序列的组合物，方法和试剂盒。
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公开(公告)号：US20080176215A1
公开(公告)日：2008-07-24
申请号：US11857942
申请日：2007-09-19
申请人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert W. Kwiatkowski , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
发明人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert W. Kwiatkowski , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708 , C12Q2561/109
摘要： The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of HPV sequences. The present invention also provides compositions, methods and kits for screening sets of HPV sequences in a single reaction container.
摘要翻译： 本发明提供用于检测和表征HPV序列的组合物和方法。 更具体地，本发明提供了使用侵入性切割结构测定法（例如INVADER测定法）筛选核酸样品（例如来自患者）以存在HPV序列集合中的任何一个的组合物，方法和试剂盒。 本发明还提供了用于在单个反应容器中筛选HPV序列的组合物，方法和试剂盒。
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公开(公告)号：US20070111200A1
公开(公告)日：2007-05-17
申请号：US10951241
申请日：2004-09-27
申请人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert Kwiatkowski , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
发明人： Angela Hudson , Tamara Sander , Poonam Agarwal , Michelle Garsha , Hon Ip , Robert Kwiatkowski , Vecheslav Elagin , Marilyn Olson-Munoz , Michelle Curtis , Sarah Olson , Ilse Tyler
CPC分类号： C12Q1/708 , C12Q2561/109
摘要： The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of HPV sequences. The present invention also provides compositions, methods and kits for screening sets of HPV sequences in a single reaction container.
摘要翻译： 本发明提供用于检测和表征HPV序列的组合物和方法。 更具体地，本发明提供了使用侵入性切割结构测定法（例如INVADER测定法）筛选核酸样品（例如来自患者）以存在HPV序列集合中的任何一个的组合物，方法和试剂盒。 本发明还提供了用于在单个反应容器中筛选HPV序列的组合物，方法和试剂盒。
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公开(公告)号：US07482127B2
公开(公告)日：2009-01-27
申请号：US11592458
申请日：2006-11-03
CPC分类号： C12Q1/6827 , C12Q1/6823 , C12Q2527/107 , C12Q2537/163 , C12Q2561/109
摘要： The present invention provides methods, compositions, and kits for detecting the presence or absence of target sequences in a sample, where the sample also contains interfering sequences that are similar or identical to the target sequences. In particular, the present invention provides blocker oligonucleotides that at least partially inhibit the formation of invasive cleavage structures with the interfering sequences but do not substantially inhibit the formation of invasive cleavage structures with the target sequences.
摘要翻译： 本发明提供用于检测样品中靶序列存在或不存在的方法，组合物和试剂盒，其中样品还含有与靶序列相似或相同的干扰序列。 特别地，本发明提供了阻断性寡核苷酸，该阻断剂寡核苷酸至少部分地抑制了具有干扰序列形成侵入性切割结构，但基本上不抑制靶序列形成侵入性切割结构。
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公开(公告)号：US20070202517A1
公开(公告)日：2007-08-30
申请号：US11592458
申请日：2006-11-03
申请人： Poonam Agarwal , Robert Kwiatkowski
发明人： Poonam Agarwal , Robert Kwiatkowski
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6823 , C12Q2527/107 , C12Q2537/163 , C12Q2561/109
摘要： The present invention provides methods, compositions, and kits for detecting the presence or absence of target sequences in a sample, where the sample also contains interfering sequences that are similar or identical to the target sequences. In particular, the present invention provides blocker oligonucleotides that at least partially inhibit the formation of invasive cleavage structures with the interfering sequences but do not substantially inhibit the formation of invasive cleavage structures with the target sequences.
摘要翻译： 本发明提供用于检测样品中靶序列存在或不存在的方法，组合物和试剂盒，其中样品还含有与靶序列相似或相同的干扰序列。 特别地，本发明提供了阻断型寡核苷酸，该阻断剂寡核苷酸至少部分地抑制了具有干扰序列形成侵入性切割结构，但基本上不抑制靶序列形成侵入性切割结构。
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公开(公告)号：US20060147938A1
公开(公告)日：2006-07-06
申请号：US10713653
申请日：2003-11-14
申请人： Molly Accola , Susan Wigdal , Andrea Mast , Christian Bartholomay , Robert Kwiatkowski , Vincent Tevere , Hon Ip , Kathleen Carroll , Patrick Peterson , Poonam Agarwal , Nancy Jarvis , Jeff Hall , Robert Roeven
发明人： Molly Accola , Susan Wigdal , Andrea Mast , Christian Bartholomay , Robert Kwiatkowski , Vincent Tevere , Hon Ip , Kathleen Carroll , Patrick Peterson , Poonam Agarwal , Nancy Jarvis , Jeff Hall , Robert Roeven
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/16
摘要： The present invention provides compositions and methods for the detection and characterization of mutations associated with cystic fibrosis. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of a collection of mutations in the CFTR gene associated with cystic fibrosis. The present invention also provides compositions, methods and kits for screening sets of CFTR alleles in a single reaction container.
摘要翻译： 本发明提供了用于检测和表征与囊性纤维化相关的突变的组合物和方法。 更具体地，本发明提供了组合物，方法和试剂盒，其用于使用侵入性切割结构测定法（例如INVADER测定法）筛选核酸样品，例如来自患者，以存在CFTR基因中的任何突变集合 与囊性纤维化有关。 本发明还提供用于筛选单个反应容器中的CFTR等位基因组的组合物，方法和试剂盒。
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