公开(公告)号：US10786349B2

公开(公告)日：2020-09-29

申请号：US15559582

申请日：2016-03-21

Applicant: Massachusetts Eye and Ear Infirmary ,  President and Fellows of Harvard College

Inventor： Aaron K. Remenschneider ,  Elliot Kozin ,  Nicole Black ,  Michael J. McKenna ,  Daniel J. Lee ,  Jennifer Lewis ,  John Rosowski ,  David Kolesky ,  Mark A. Skylar-Scott ,  Alexander D. Valentine

IPC: A61F2/18 ,  A61L27/26 ,  A61L27/38 ,  A61L27/54

Abstract: This disclosure features artificial tympanic membrane graft devices and two-component bilayer graft devices that include a scaffold having a plurality of ribs made of a first material and a plurality of spaces between the ribs filled or made with the first material, a different, second material, a combination of the first and a second materials, or a combination of a second material and one or more other different materials. The bilayer graft devices have two components or layers. One component, e.g., the underlay graft device, can include a projection, and the second component, e.g., the overlay graft device, can include an opening that corresponds to the projection (or vice versa) so that the opening and the projection can secure the two layers together in a “lock and key” manner. This disclosure also features methods of making, using, and implanting the three-dimensional artificial tympanic membrane and bilayer graft devices.

公开(公告)号：US10946588B2

公开(公告)日：2021-03-16

申请号：US16081812

申请日：2017-03-03

Applicant: President and Fellows of Harvard College

Inventor： Jennifer A. Lewis ,  Mark Andrew Skylar-Scott ,  Jochen Mueller ,  David Kolesky

IPC: B29C64/393 ,  G05B19/4099 ,  B33Y30/00 ,  B29C64/209 ,  B29C67/00 ,  B29C64/112 ,  G06F30/00 ,  B29C64/118 ,  G06F119/18 ,  B33Y10/00 ,  B33Y50/02

Abstract: A present disclosure relates to a system for automatic design and manufacturing of 3D printing units and 3D products. The system is configured to obtain specification of a target structure corresponding to a 3D product; automatically determine a design and a printing path of a 3D printing unit based on the specification of the target structure, wherein the 3D printing unit is a micronozzle unit configured to print the target structure of the 3D product; automatically determine a manufacturing procedure to print the 3D printing unit based on the specification of the target structure; and instruct a 3D printer to print the 3D printing unit according to the manufacturing procedure and the printing path of the 3D printing unit.

公开(公告)号：US20190070786A1

公开(公告)日：2019-03-07

申请号：US16081812

申请日：2017-03-03

Applicant: President and Fellows of Harvard College

Inventor： Jennifer A. Lewis ,  Mark Andrew Skylar-Scott ,  Jochen Mueller ,  David Kolesky

IPC: B29C64/393 ,  B29C64/118 ,  B29C64/209 ,  G05B19/4099 ,  G06F17/50

Abstract: A present disclosure relates to a system for automatic design and manufacturing of 3D printing units and 3D products. The system is configured to obtain specification of a target structure corresponding to a 3D product; automatically determine a design and a printing path of a 3D printing unit based on the specification of the target structure, wherein the 3D printing unit is a micronozzle unit configured to print the target structure of the 3D product; automatically determine a manufacturing procedure to print the 3D printing unit based on the specification of the target structure; and instruct a 3D printer to print the 3D printing unit according to the manufacturing procedure and the printing path of the 3D printing unit.

公开(公告)号：US20180042718A1

公开(公告)日：2018-02-15

申请号：US15559582

申请日：2016-03-21

Applicant: Massachusetts Eye and Ear Infirmary ,  President and Fellows of Harvard College

Inventor： Aaron K. Remenschneider ,  Elliott Kozin ,  Nicole Black ,  Michael J. McKenna ,  Daniel J. Lee ,  Jennifer Lewis ,  John Rosowski ,  David Kolesky ,  Mark A. Skylar-Scott ,  Alexander D. Valentine

IPC: A61F2/18 ,  A61L27/54 ,  A61L27/38 ,  A61L27/26

CPC classification number: A61F2/18 ,  A61F2002/183 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2250/0067 ,  A61L27/26 ,  A61L27/3839 ,  A61L27/54 ,  A61L2430/14

Abstract: This disclosure features artificial tympanic membrane graft devices and two-component bilayer graft devices that include a scaffold having a plurality of ribs made of a first material and a plurality of spaces between the ribs filled or made with the first material, a different, second material, a combination of the first and a second materials, or a combination of a second material and one or more other different materials. The bilayer graft devices have two components or layers. One component, e.g., the under-lay graft device, can include a projection, and the second component, e.g., the overlay graft device, can include an opening that corresponds to the projection (or vice versa) so that the opening and the projection can secure the two layers together in a “lock and key” manner. This disclosure also features methods of making, using, and implanting the three-dimensional artificial tympanic membrane and bilayer graft devices.