公开(公告)号：US20180326077A1

公开(公告)日：2018-11-15

申请号：US15310416

申请日：2015-05-12

Applicant: Purdue Research Foundation

Inventor： Alyssa Panitch ,  Rebecca Scott ,  Kinam Park ,  James Wodicka

IPC: A61K47/42 ,  A61K47/61 ,  C08B37/02 ,  C07K14/47 ,  A61K47/54 ,  C08B37/00 ,  C08B37/08 ,  A61P9/14 ,  A61P9/10 ,  A61P29/00 ,  C07D487/04

CPC classification number: A61K47/42 ,  A61K47/545 ,  A61K47/61 ,  A61P9/10 ,  A61P9/14 ,  A61P29/00 ,  C07D487/04 ,  C07K14/4725 ,  C08B37/0021 ,  C08B37/0069 ,  C08B37/0072

Abstract: The invention relates to peptide conjugates that can bind to endothelial cells, and that are useful for reducing the incidence and severity of endothelial dysfunction in mammals.

公开(公告)号：US10772931B2

公开(公告)日：2020-09-15

申请号：US15306656

申请日：2015-04-24

Applicant: Purdue Research Foundation

Inventor： Alyssa Panitch ,  Rebecca Scott

IPC: A61K38/16 ,  A61K45/06 ,  A61K38/17 ,  A61K38/14 ,  A61K47/61 ,  A61K9/00

Abstract: Compositions and methods are provided for treating a patient suffering from a disease associated with endothelial dysfunction by administering to the patient a pharmaceutical composition containing an effective amount of a synthetic collagen binding peptidoglycan.

公开(公告)号：US10828370B2

公开(公告)日：2020-11-10

申请号：US15310416

申请日：2015-05-12

Applicant: Purdue Research Foundation

Inventor： Alyssa Panitch ,  Rebecca Scott ,  Kinam Park ,  James Wodicka

IPC: A61K38/08 ,  A61K47/42 ,  C07D487/04 ,  C08B37/02 ,  C08B37/00 ,  C08B37/08 ,  A61K47/61 ,  A61K47/54 ,  A61P9/10 ,  A61P29/00 ,  A61P9/14 ,  C07K14/47

Abstract: The invention relates to peptide conjugates that can bind to endothelial cells, and that are useful for reducing the incidence and severity of endothelial dysfunction in mammals.

公开(公告)号：US20170043023A1

公开(公告)日：2017-02-16

申请号：US15306656

申请日：2015-04-24

Applicant: Purdue Research Foundation

Inventor： Alyssa Panitch ,  Rebecca Scott

IPC: A61K47/48 ,  A61K38/16

CPC classification number: A61K38/16 ,  A61K9/0019 ,  A61K38/14 ,  A61K38/1709 ,  A61K45/06 ,  A61K47/61

Abstract: Compositions and methods are provided for treating a patient suffering from a disease associated with endothelial dysfunction by administering to the patient a pharmaceutical composition containing an effective amount of a synthetic collagen binding peptidoglycan.

Abstract translation: 提供了通过向患者施用含有有效量的合成胶原结合肽聚糖的药物组合物来治疗患有与内皮功能障碍相关疾病的患者的组合物和方法。