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公开(公告)号：US08394969B2
公开(公告)日：2013-03-12
申请号：US12563782
申请日：2009-09-21
申请人： Brett C. Bookser , Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka
发明人： Brett C. Bookser , Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka
IPC分类号： A61K31/4184 , C07D235/26 , C07D235/28 , C07D235/30
CPC分类号： C07D235/26 , C07D235/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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2.发明申请公开(公告)号：US20110263533A1
公开(公告)日：2011-10-27
申请号：US13124898
申请日：2009-10-12
申请人： Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka , Brett C. Bookser
发明人： Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka , Brett C. Bookser
IPC分类号： A61K31/675 , C07F9/40 , C07F9/6574 , A61P35/00 , A61P3/04 , A61P3/06 , A61P9/12 , C07F9/6506 , A61P3/10
CPC分类号： C07F9/65068 , C07F9/65583 , C07F9/657181
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, Metabolic Syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖，高胆固醇血症和高血压。
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3.发明申请公开(公告)号：US20100081643A1
公开(公告)日：2010-04-01
申请号：US12563782
申请日：2009-09-21
申请人： BRETT C. BOOKSER , Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka
发明人： BRETT C. BOOKSER , Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka
IPC分类号： A61K31/4184 , C07D235/26 , C07D403/12 , C07D401/12 , C07D413/10 , A61K31/397 , A61K31/44 , A61K31/5025 , A61K31/4439 , A61P3/00 , A61P9/00
CPC分类号： C07D235/26 , C07D235/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。
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公开(公告)号：US08410284B2
公开(公告)日：2013-04-02
申请号：US13124898
申请日：2009-10-12
申请人： Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka , Brett C. Bookser
发明人： Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka , Brett C. Bookser
IPC分类号： A61K31/675 , C07F9/00 , C07F9/6506
CPC分类号： C07F9/65068 , C07F9/65583 , C07F9/657181
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, Metabolic Syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖，高胆固醇血症和高血压。
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5.发明申请公开(公告)号：US20110195964A1
公开(公告)日：2011-08-11
申请号：US13125329
申请日：2009-10-19
申请人： Qun Dang , De Michael Chung , Tony S. Gibson , Daniel K. Cashion , HongJian Jiang , Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka
发明人： Qun Dang , De Michael Chung , Tony S. Gibson , Daniel K. Cashion , HongJian Jiang , Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka
IPC分类号： A61K31/5377 , C07D235/28 , A61K31/4184 , A61P3/10 , A61P3/04 , A61P3/06 , A61P35/00 , A61P9/12 , C07D405/10 , C07D401/10 , A61K31/4439 , A61K31/454 , C07D413/10 , C07D403/10 , A61K31/497
CPC分类号： C07D235/28 , C07D235/26 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D417/04
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖，高胆固醇血症和高血压。
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公开(公告)号：US08563746B2
公开(公告)日：2013-10-22
申请号：US13125329
申请日：2009-10-19
申请人： Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion , Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka
发明人： Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion , Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka
IPC分类号： A61K31/4184 , A61K31/5377 , A61K31/497 , C07D235/26 , C07D235/28 , C07D401/10 , C07D401/06 , C07D409/04 , C07D403/10 , C07D413/10 , C07D413/14 , C07D417/04
CPC分类号： C07D235/28 , C07D235/26 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D417/04
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。
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公开(公告)号：US08329914B2
公开(公告)日：2012-12-11
申请号：US13125345
申请日：2009-10-22
申请人： Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka , Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion
发明人： Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka , Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion
IPC分类号： A61K31/675 , A61K31/4184 , C07F9/06 , C07D235/06 , C07D235/24
CPC分类号： C07F9/65068 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4412 , A61K45/06 , C07F9/65583 , C07F9/65742 , A61K2300/00
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。
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公开(公告)号：US20110218174A1
公开(公告)日：2011-09-08
申请号：US13125345
申请日：2009-10-22
申请人： Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka , Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion
发明人： Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka , Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion
IPC分类号： A61K31/675 , C07F9/6506 , C07F9/6533 , C07F9/6574 , A61P35/00 , A61P3/10 , A61P3/00 , A61P3/04 , A61P9/12 , A61P3/06
CPC分类号： C07F9/65068 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4412 , A61K45/06 , C07F9/65583 , C07F9/65742 , A61K2300/00
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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9.发明授权Phenyl carboxamide compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease 失效用作治疗阿尔茨海默病的β-分泌酶抑制剂的苯基甲酰胺化合物公开(公告)号：US07449599B2
公开(公告)日：2008-11-11
申请号：US11579049
申请日：2005-05-09
申请人： Craig A. Coburn , Thomas G. Steele , Joseph P. Vacca , David Allen Annis, Jr. , Gergely M. Makara , Huw M. Nash , Praveen K. Tadikonda , Tong Wang
发明人： Craig A. Coburn , Thomas G. Steele , Joseph P. Vacca , David Allen Annis, Jr. , Gergely M. Makara , Huw M. Nash , Praveen K. Tadikonda , Tong Wang
IPC分类号： C07C233/05 , C07C233/65 , C07C305/18 , C07C255/50 , A61K31/16 , A61K31/255 , A61K31/275
CPC分类号： C07C235/84 , C07C255/57 , C07C309/67
摘要： The present invention is directed to phenyl carboxamide compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
摘要翻译： 本发明涉及作为β-分泌酶的抑制剂并且可用于治疗其中涉及β-分泌酶的疾病如阿尔茨海默氏病的苯甲酰胺化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及β-分泌酶的疾病中的用途。
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