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公开(公告)号：US11185572B2
公开(公告)日：2021-11-30
申请号：US16047129
申请日：2018-07-27
Inventor： Avinoam Kadouri , Avihay Bar-Ilan , Eldad Melamed , Daniel Offen , Ofer Sadan , Merav Bahat-Stromza
Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.
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公开(公告)号：US09717761B2
公开(公告)日：2017-08-01
申请号：US14359623
申请日：2012-11-21
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Sandu Pitaru , Javier Ganz , Daniel Offen , Eldad Melamed
IPC: C12N5/00 , A61K35/30 , C12N5/0793 , C12N5/079 , A61K35/12
CPC classification number: A61K35/30 , A61K2035/124 , C12N5/0619 , C12N5/0622 , C12N2500/38 , C12N2500/90 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/13 , C12N2501/135 , C12N2501/41 , C12N2501/415 , C12N2501/999 , C12N2506/097
Abstract: The present invention provides methods and uses of neural cells differentiated from adult stem cells of the oral mucosa for cell therapy of neurological and psychiatric diseases and disorders. Methods for direction of differentiation of oral mucosal stem cells into neuronal or neuron supporting cells are also provided.
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公开(公告)号：US20150086517A1
公开(公告)日：2015-03-26
申请号：US14556281
申请日：2014-12-01
Inventor： Avinoam Kadouri , Avihay Bar-Ilan , Eldad Melamed , Daniel Offen , Ofer Sadan , Merav Bahat-Stromza
IPC: A61K38/18
CPC classification number: A61K38/185 , A61K35/12 , A61K35/28 , C12N5/0618 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0669 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2506/1353
Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.
Abstract translation: 公开了一种分离的人细胞，其包含至少一种间充质干细胞表型和分泌性脑源性神经营养因子（BDNF），其中BDNF的基础分泌比间充质干细胞中BDNF的基础分泌高至少五倍 。 还公开了生产方法及其用途。
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公开(公告)号：US10744162B2
公开(公告)日：2020-08-18
申请号：US16353680
申请日：2019-03-14
Inventor： Daniel Offen , Michal Dadon-Nachum , Tali Ben-Zur , Eldad Melamed , David Yaffe
Abstract: An isolated muscle progenitor cell being MyoD positive, CD34 negative and CD45 negative is disclosed. The muscle progenitor cell is genetically modified to express at least one neurotrophic factor. In addition, cell populations are disclosed, comprising at least four subpopulations of muscle cells each being genetically modified to express a different neurotrophic factor, wherein said neurotrophic factor is selected from the group consisting of glial derived neurotrophic factor (GDNF), insulin growth factor (IGF-1), vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF). Uses of the cell populations are also disclosed.
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公开(公告)号：US09879225B2
公开(公告)日：2018-01-30
申请号：US14173846
申请日：2014-02-06
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Daniel Offen , Merav Bahat-Stromza , Eldad Melamed
CPC classification number: C12N5/0669 , C12N5/0622 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/40 , C12N2506/1353
Abstract: An isolated human cell and populations thereof is provided comprising at least one astrocytic phenotype and at least one mesenchymal stem cell phenotype, wherein the mesenchymal stem cell phenotype is not an astrocytic phenotype.
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Patent Agency Ranking
公开(公告)号：US09474787B2
公开(公告)日：2016-10-25
申请号：US14556281
申请日：2014-12-01
Inventor： Avinoam Kadouri , Avihay Bar-Ilan , Eldad Melamed , Daniel Offen , Ofer Sadan , Merav Bahat-Stromza
CPC classification number: A61K38/185 , A61K35/12 , A61K35/28 , C12N5/0618 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0669 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2506/1353
Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.
Abstract translation: 公开了一种分离的人细胞，其包含至少一种间充质干细胞表型和分泌性脑源性神经营养因子（BDNF），其中BDNF的基础分泌比间充质干细胞中BDNF的基础分泌高至少五倍 。 还公开了生产方法及其用途。
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公开(公告)号：US08900574B2
公开(公告)日：2014-12-02
申请号：US14164286
申请日：2014-01-27
Inventor： Avinoam Kadouri , Avihay Bar-Ilan , Eldad Melamed , Daniel Offen , Ofer Sadan , Merav Bahat-Stromza
CPC classification number: A61K38/185 , A61K35/12 , A61K35/28 , C12N5/0618 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0669 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2506/1353
Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.
Abstract translation: 公开了一种分离的人细胞，其包含至少一种间充质干细胞表型和分泌性脑源性神经营养因子（BDNF），其中BDNF的基础分泌比间充质干细胞中BDNF的基础分泌高至少五倍 。 还公开了生产方法及其用途。
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8.发明申请ISOLATED CELLS AND POPULATIONS COMPRISING SAME FOR THE TREATMENT OF CNS DISEASES 有权分离细胞和包含相同的人类用于治疗CNS疾病公开(公告)号：US20140154222A1
公开(公告)日：2014-06-05
申请号：US14173846
申请日：2014-02-06
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Daniel OFFEN , Merav Bahat-Stromza , Eldad Melamed
IPC: C12N5/077
CPC classification number: C12N5/0669 , C12N5/0622 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/40 , C12N2506/1353
Abstract: An isolated human cell and populations thereof is provided comprising at least one astrocytic phenotype and at least one mesenchymal stem cell phenotype, wherein the mesenchymal stem cell phenotype is not an astrocytic phenotype.
Abstract translation: 提供分离的人细胞及其群体，其包含至少一种星形细胞表型和至少一种间充质干细胞表型，其中间质干细胞表型不是星形细胞表型。
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公开(公告)号：US10052363B2
公开(公告)日：2018-08-21
申请号：US15261959
申请日：2016-09-11
Inventor： Avinoam Kadouri , Avihay Bar-Ilan , Eldad Melamed , Daniel Offen , Ofer Sadan , Merav Bahat-Stromza
CPC classification number: A61K38/185 , A61K35/12 , A61K35/28 , C12N5/0618 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0669 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2506/1353
Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.
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10.发明申请公开(公告)号：US20140335059A1
公开(公告)日：2014-11-13
申请号：US14359623
申请日：2012-11-21
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Sandu Pitaru , Javier Ganz , Daniel Offen , Eldad Melamed
CPC classification number: A61K35/30 , A61K2035/124 , C12N5/0619 , C12N5/0622 , C12N2500/38 , C12N2500/90 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/13 , C12N2501/135 , C12N2501/41 , C12N2501/415 , C12N2501/999 , C12N2506/097
Abstract: The present invention provides methods and uses of neural cells differentiated from adult stem cells of the oral mucosa for cell therapy of neurological and psychiatric diseases and disorders. Methods for direction of differentiation of oral mucosal stem cells into neuronal or neuron supporting cells are also provided.
Abstract translation: 本发明提供了从口腔粘膜的成体干细胞分化的神经细胞用于神经和精神疾病和病症的细胞治疗的方法和用途。 还提供了将口腔粘膜干细胞分化为神经元或神经元支持细胞的方向的方法。
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