公开(公告)号：US20220095979A1

公开(公告)日：2022-03-31

申请号：US17453636

申请日：2021-11-04

申请人： RECOR MEDICAL, INC.

发明人： Jin Shimada ,  Harry Puryear ,  Gregory Brucker

IPC分类号： A61B5/24 ,  A61B5/20 ,  A61B5/00 ,  A61B18/14 ,  A61B18/18

摘要： Certain embodiments described herein relate to a system for use in analyzing neural activity of nerves surrounding a biological lumen. The system includes a probe body, electrodes, a stimulator, and an amplifier. The stimulator delivers electrical stimulation via a first pair of the electrodes, supported by the probe body, to test for an evoked neural response by nerves surrounding the biological lumen. The amplifier includes a pair of input terminals, an output terminal, and a ground reference terminal. A second pair of the electrodes is electrically coupled to the pair of input terminals of the amplifier, to thereby enable the amplifier to produce the sensed signal indicative of the evoked neural response. A remaining one of the electrodes, which is not included in the first and the second pairs of the electrodes, is electrically coupled to the ground reference terminal of the amplifier.

公开(公告)号：US11510731B2

公开(公告)日：2022-11-29

申请号：US15943354

申请日：2018-04-02

申请人： ReCor Medical, Inc.

发明人： Harry A. Puryear ,  Jin Shimada

IPC分类号： A61B18/14 ,  A61B18/00 ,  A61B5/24

摘要： Systems and methods provide interface to a patient's autonomic nerves via an interior lumen wall of a blood vessel. Systems can include a probe having at least one electrode for receiving electrical signals from the interior of the lumen wall. The system can include processing components for extracting the signals from noise within the patient's body. Systems can include stimulation electrodes for providing stimulation and eliciting action potentials within the patient and destructive processes for destroying nervous function. The effect of nerve destruction on the propagation of action potentials can be effectively used as a feedback mechanism for determining the amount of nervous function destruction in the patient.

公开(公告)号：US11642061B2

公开(公告)日：2023-05-09

申请号：US16517180

申请日：2019-07-19

申请人： RECOR MEDICAL, INC.

发明人： Jin Shimada ,  Harry A. Puryear

IPC分类号： A61B5/24 ,  A61B5/00 ,  A61B18/14 ,  A61B5/20 ,  A61N1/18 ,  A61B18/18 ,  A61B18/00 ,  A61B18/12 ,  A61B18/16

CPC分类号： A61B5/24 ,  A61B5/201 ,  A61B5/4836 ,  A61B5/725 ,  A61B18/1492 ,  A61B18/1815 ,  A61N1/18 ,  A61B2018/00023 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/126 ,  A61B2018/1253 ,  A61B2018/1407 ,  A61B2018/1467 ,  A61B2018/162 ,  A61B2018/1861 ,  A61B2562/028

摘要： An intraluminal microneurography probe has a probe body configured to be introduced into an artery near an organ of a body without preventing the flow of blood through the artery. An expandable sense electrode and an expandable stimulation electrode are fixed to the probe body at one end of each electrode such that movement of the other end toward the fixed end causes the sense electrode to expand from the probe body toward a wall of the artery. A ground electrode is configured to couple to the body, and a plurality of electrical connections are operable to electrically couple the electrodes to electrical circuitry. The sense electrode is operable to measure sympathetic nerve activity in response to excitation of the stimulation electrode. A radio frequency ablation element is located between the expandable sense electrode and expandable stimulation electrode, and is operable to ablate nerves proximate to the artery.

公开(公告)号：US20230071433A1

公开(公告)日：2023-03-09

申请号：US18049406

申请日：2022-10-25

申请人： ReCor Medical, Inc.

发明人： Harry A. Puryear ,  Jin Shimada

IPC分类号： A61B18/14

摘要： Systems and methods provide interface to a patient's autonomic nerves via an interior lumen wall of a blood vessel. Systems can include a probe having at least one electrode for receiving electrical signals from the interior of the lumen wall. The system can include processing components for extracting the signals from noise within the patient's body. Systems can include stimulation electrodes for providing stimulation and eliciting action potentials within the patient and destructive processes for destroying nervous function. The effect of nerve destruction on the propagation of action potentials can be effectively used as a feedback mechanism for determining the amount of nervous function destruction in the patient.

公开(公告)号：US11197716B2

公开(公告)日：2021-12-14

申请号：US15996978

申请日：2018-06-04

申请人： RECOR MEDICAL, INC.

发明人： Harry A. Puryear ,  Jin Shimada

IPC分类号： A61B5/24 ,  A61B18/14 ,  A61B18/00

摘要： Systems and methods provide interface to a patient's autonomic nerves via an interior lumen wall of a blood vessel. Systems can include a probe having at least one electrode for receiving electrical signals from the interior of the lumen wall. The system can include processing components for extracting the signals from noise within the patient's body. Systems can include stimulation electrodes for providing stimulation and eliciting action potentials within the patient and destructive processes for destroying nervous function. The effect of nerve destruction on the propagation of action potentials can be effectively used as a feedback mechanism for determining the amount of nervous function destruction in the patient.