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公开(公告)号：US20250032997A1
公开(公告)日：2025-01-30
申请号：US18781201
申请日：2024-07-23
Applicant: Repligen Corporation
Inventor： Michael Bransby , Philip Yuen , Derek Carroll
Abstract: The present invention relates to hollow fiber tangential flow depth filtration media adapted for perfusion bioprocessing, and related TFDF filtration units, bioprocessing systems, and methods, including methods for perfusion cell culture. The hollow fiber elements of the present invention combine a relatively thin porous wall with a relatively low porosity to provide filtration media resistant to fouling during perfusion culture.
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公开(公告)号：US11958018B2
公开(公告)日：2024-04-16
申请号：US17091616
申请日：2019-05-28
Applicant: REPLIGEN CORPORATION
Inventor： Michael Bransby , Derek Carroll , Philip Yuen , Ralf Kuriyel
CPC classification number: B01D63/06 , B01D61/147 , B01D63/02 , B01D65/08 , C12M33/14 , B01D2315/10 , B01D2321/20
Abstract: The disclosure provides tangential flow depth filtration (TFDF) systems which exhibit improved filter fluxes and process capacities and reduced fouling characteristics. The TFDF systems of the disclosure optionally utilize tubular depth filters (TDF). Methods are provided which include the passage of a non-laminar flow through at least a portion of a length of a TDF in a TFDF system.
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3.发明授权公开(公告)号：US11680239B2
公开(公告)日：2023-06-20
申请号：US16730516
申请日：2019-12-30
Applicant: Repligen Corporation
Inventor： Michael Bransby , Derek Carroll , Philip Yuen
CPC classification number: C12M25/10 , B01D63/04 , B01D69/081 , B01D71/26 , C12M21/08 , C12M29/10 , B01D2239/0428 , B01D2239/1216 , B01D2239/1225
Abstract: This disclosure relates to the use of a hydrophobic hollow fiber filter for the filtration of cell cultures and other biological perfusions, due to its resistance to fouling, as well as the ability to filter solutions with a high solid content. A hydrophobic hollow fiber filter may be used within a filter housing in conjunction with a process vessel and a traditional separation system. When the system is used with alternating tangential flow or tangential flow filtration, the hydrophobic hollow fiber filter results in more effective filtration of the filtrate, leading to greater concentration of the retentate, even in solution containing high levels of solids.
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公开(公告)号：US20220193614A1
公开(公告)日：2022-06-23
申请号：US17559792
申请日：2021-12-22
Applicant: Repligen Corporation
Inventor： Bao Le , Philip Yuen
Abstract: Devices, systems, and methods for continually degassing/venting a feedstream within a filtration system. The filtration system may include a filter device utilizing hollow fiber filters to filter the feedstream. Additional venting hollow fiber filters vent gas from the filtration system to outside the filtration system. The venting hollow fiber filters may have ends which expose the interior lumens thereof to outside the filter unit to vent gases which pass through the walls of the hollow fiber filters. Degassed permeate thus flows through the filtering hollow fiber filters.
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5.发明授权公开(公告)号：US11339364B2
公开(公告)日：2022-05-24
申请号：US16171867
申请日：2018-10-26
Applicant: Repligen Corporation
Inventor： Michael Bransby , Philip Yuen
Abstract: A micro alternating tangential flow (microATF) perfusion filter includes a hollow cylinder having a proximal end and a distal end. The proximal end is connected in series to a permeate chamber, followed by a retentate chamber. The proximal end either (i) terminates in or at the permeate chamber, or (ii) terminates in or at the retentate chamber. The portion of the proximal end within the permeate chamber, in a case of (ii), possesses at least one opening allowing fluid communication between an inside of the hollow cylinder and the permeate chamber. The microATF perfusion filter further includes an inlet, positioned over the retentate chamber, for communication with a source of positive or negative pressure, and an outlet, positioned in a wall of the permeate chamber, which can be connected to a check valve, which, in turn, can be connected to a hydrophobic fluid vent filter.
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Patent Agency Ranking
公开(公告)号：US20240238731A1
公开(公告)日：2024-07-18
申请号：US18605090
申请日：2024-03-14
Applicant: REPLIGEN CORPORATION
Inventor： Michael Bransby , Derek Carroll , Philip Yuen , Ralf Kuriyel
CPC classification number: B01D63/06 , B01D61/147 , B01D63/02 , B01D65/08 , C12M33/14 , B01D2315/10 , B01D2321/20
Abstract: The disclosure provides tangential flow depth filtration (TFDF) systems which exhibit improved filter fluxes and process capacities and reduced fouling characteristics. The TFDF systems of the disclosure optionally utilize tubular depth filters (TDF). Methods are provided which include the passage of a non-laminar flow through at least a portion of a length of a TDF in a TFDF system.
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7.发明授权公开(公告)号：US11946033B2
公开(公告)日：2024-04-02
申请号：US17729022
申请日：2022-04-26
Applicant: Repligen Corporation
Inventor： Michael Bransby , Philip Yuen
CPC classification number: C12M29/10 , B01D61/147 , B01D61/18 , C12M29/04 , C12M33/14 , B01D61/146 , B01D2311/16 , B01D2315/10
Abstract: A micro alternating tangential flow (microATF) perfusion filter includes a hollow cylinder having a proximal end and a distal end. The proximal end is connected in series to a permeate chamber, followed by a retentate chamber. The proximal end either (i) terminates in or at the permeate chamber, or (ii) terminates in or at the retentate chamber. The portion of the proximal end within the permeate chamber, in a case of (ii), possesses at least one opening allowing fluid communication between an inside of the hollow cylinder and the permeate chamber. The microATF perfusion filter further includes an inlet, positioned over the retentate chamber, for communication with a source of positive or negative pressure, and an outlet, positioned in a wall of the permeate chamber, which can be connected to a check valve, which, in turn, can be connected to a hydrophobic fluid vent filter.
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公开(公告)号：US20220080359A1
公开(公告)日：2022-03-17
申请号：US17091616
申请日：2019-05-28
Applicant: REPLIGEN CORPORATION
Inventor： Michael Bransby , Derek Carroll , Philip Yuen , Ralf Kuriyel
Abstract: The disclosure provides tangential flow depth filtration (TFDF) systems which exhibit improved filter fluxes and process capacities and reduced fouling characteristics. The TFDF systems of the disclosure optionally utilize tubular depth filters (TDF). Methods are provided which include the passage of a non-laminar flow through at least a portion of a length of a TDF in a TFDF system.
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公开(公告)号：US20220323910A1
公开(公告)日：2022-10-13
申请号：US17719850
申请日：2022-04-13
Applicant: Repligen Corporation
Inventor： Michael Bransby , Philip Yuen , Rene Daniel Jean-Marie Gantier , David Bianchi , Jonathan Kuhlmann
Abstract: The present disclosure relates to hollow fiber tangential flow filter units, including hollow fiber tangential flow depth filter units, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.
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公开(公告)号：US12220665B2
公开(公告)日：2025-02-11
申请号：US18605090
申请日：2024-03-14
Applicant: REPLIGEN CORPORATION
Inventor： Michael Bransby , Derek Carroll , Philip Yuen , Ralf Kuriyel
Abstract: The disclosure provides tangential flow depth filtration (TFDF) systems which exhibit improved filter fluxes and process capacities and reduced fouling characteristics. The TFDF systems of the disclosure optionally utilize tubular depth filters (TDF). Methods are provided which include the passage of a non-laminar flow through at least a portion of a length of a TDF in a TFDF system.
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