公开(公告)号：US3714163A

公开(公告)日：1973-01-30

申请号：US3714163D

申请日：1970-08-20

Applicant: ROUSSEL UCLAF

Inventor： CLEMENCE F ,  LE MARTRET O

IPC: C07D473/08 ,  C07H19/16 ,  C07D57/48 ,  C07D57/52

CPC classification number: C07D473/08 ,  C07H19/16

Abstract: As a new compound Beta -(theophylline ethyl) monosulfite having the formula

AND SALTS THEREOF WITH INORGANIC AND ORGANIC BASES, THEIR PROCESS OF PREPARATION AND AS AN ANTIBACTERIAL AGENT, THE TETRACYCLINE SALT OF Beta -(THEOPHYLLINE ETHYL) MONOSULFITE.

Abstract translation: 作为具有下式的新型化合物β-（茶碱乙基）亚硫酸氢盐，其无机和有机物基质，它们的制备方法和抗菌剂，β-（乙酸乙酯）单体的四氢化萘盐。

公开(公告)号：US3853875A

公开(公告)日：1974-12-10

申请号：US26278572

申请日：1972-06-14

Applicant: ROUSSEL UCLAF

Inventor： CLEMENCE F ,  LE MARTRET O

IPC: A61K31/495 ,  A61P9/08 ,  A61P9/12 ,  A61P25/02 ,  A61P43/00 ,  C07D277/56 ,  C07D295/08 ,  C07D295/088 ,  C07D91/32

CPC classification number: C07D295/088 ,  A61K31/495 ,  C07D277/56 ,  C07D295/08 ,  Y10S514/929

Abstract: X1 and X2, identical or different, representing hydrogen, a chlorine, bromine or iodine atom, an alkyl radical containing from 1 to 6 carbon atoms, an alkyloxy radical containing from 1 to 6 carbon atoms or a tribalogenomethyl group, or R represents a heterocycle containing a maximum of 6 links and capable of bearing 1 or more heteroatoms, as well as the salts of these compounds with a mineral or organic acid, and the process of preparation. These compounds have an adrenolytic and peripheral vasodilatatory activity.

wherein n represents the whole numbers 0, 1, 2, 3, 4 or 5, n'' represents the whole numbers 1, 2, 3, 4 or 5, m represents the whole numbers 0, 1, 2, 3, 4 or 5 and R represents a substituted or unsubstituted phenyl radical of general formula:

New esters of 2-alkyl thiazole 5-carboxylic acid of formula I:

Abstract translation: 式I的2-烷基噻唑5-羧酸的新酯：

公开(公告)号：US3778504A

公开(公告)日：1973-12-11

申请号：US3778504D

申请日：1971-10-08

Applicant: ROUSSEL UCLAF

Inventor： CLEMENCE F ,  LE MARTRET O

IPC: C07D213/82 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18 ,  C07D307/68 ,  C07D333/38 ,  A61K27/00

CPC classification number: C07D213/82 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18 ,  C07D307/68 ,  C07D333/38

Abstract: BENZIMIDAZOLES OF THE FORMULA

1-(2-R-PHENYL),2-R1,5-X'',6-X-BENZIMIDAZOLE

WHEREIN X AND X'' MAY BE DIFFERENT AND ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HALOGEN, ALKYL, ALKOXY, TRIHALOMETHYL AND NITRO, R IS SELECTED FROM THE GROUP CONSISTING OF -COOH-, -COOR'', AND

-CO-N(-A)-B

R'' IS SELECTED FROM THE GROUP CONSISTING OF ALIPHATIC AND HYDROXYLATED RESIDUE OF A GLYCOL, A AND B ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND OPTIONALLY SUBSTITUTED ALIPHATIC AND R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALIPHATIC HYDROCARBON, UNSUBSTITUTED AND POLYSUBSTITUTED ARYL, ARYLALIPHATIC, A THIENYL, A B-PYRIDYL AND A FURYL WITH THE PROVISO THAT WHEN R1 IS PHENYL, X'' AND X ARE OTHER THAN HALOGEN, ALKOXY AND TRIFLUOROMETHYL WHICH COMPOUNDS POSSESS ANTI-INFLAMMATORY AND ANTIVIRAL ACTIVITY AND A NOVEL PROCESS FOR THEIR PREPARATION.

公开(公告)号：US3817999A

公开(公告)日：1974-06-18

申请号：US18461971

申请日：1971-09-28

Applicant: ROUSSEL UCLAF

Inventor： CLEMENCE F ,  LE MARTRET O

IPC: C07D295/192 ,  C07D87/34

CPC classification number: C07D295/192

Abstract: An amide of 2-hydroxy-3-methoxy-5-allyl-benzoic acid of the formula

WHEREIN R is selected from the group consisting of hydrogen, alkyl of 1 to 7 carbon atoms and acyl of an organic carboxylic acid of 1 to 18 carbon atoms, R1 and R2 taken together with the nitrogen atom form a heterocyclic which may contain another heteroatom, which products possess outstanding choleretic properties far superior to dehydrocholic acid.

D R A W I N G

Abstract translation: 式WHEREIN R的2-羟基-3-甲氧基-5-烯丙基 - 苯甲酸的酰胺选自氢，1至7个碳原子的烷基和1至18个碳的有机羧酸的酰基 原子，R 1和R 2与氮原子一起形成可以含有另一个杂原子的杂环，该产物具有优于脱氢胆酸的优异的胆固醇性质。

公开(公告)号：US3808213A

公开(公告)日：1974-04-30

申请号：US19356071

申请日：1971-10-28

Applicant: ROUSSEL UCLAF

Inventor： CLEMENCE F ,  LE MARTRET O

IPC: C07C57/72 ,  C07D211/56 ,  C07D295/185 ,  C07D51/70 ,  C07C103/22

CPC classification number: C07D295/185 ,  C07C57/72 ,  C07D211/56

Abstract: A COMPOUND SELECTED FROM THE GROUP CONSISTING OF ACETAMIDES OF THE FORMULA

CH*C-CH2-C(-C6H5)2-CO-N(-R)-CH(-R1)-CH2-N(-R2)-R3

WHEREIN R IS SELECTED FROM THE GROUP CONISTING OF HYDROGEN AND ALKYL OF 1 TO 4 CARBON ATOMS, R1 IS HYDROGEN, R2 IS ALKYL OF 1 TO 4 CARBON ATOMS AND R3 IS SELECTED FROM THE GROUP CONSISTING OF ALKYL OF 1 TO 4 CARBON ATOMS, ARYL AND ARALKYL OR THE GROUP

-N
MAY FORM A 6-MEMBERED NITROGEN-CONTAINING HETEROCYCLIC OR THE GROUP

-CH
MAY FROM A 6-MEMBERED NITROGEN-CONTAINING HETEROCYCLIC OR THE GROUP

-N(-R2-R3-)

MAY FORM A 5- TO 6-MEMBERED, NITROGEN-CONTAINING HETEROCYCLIC OPTIONALLY CONTAINING ANOTHER HETERO-ATOM AND THEIR NON-TOXIC, PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS WHICH HAVE INTENSE ANALGESIC ACTIVITY AND ACT AS POTENTIALIZERS FOR NEURO-SEDATIVES AND THEIR PREPARATION AND INTERMEDIATES THEREOF.