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公开(公告)号：US20220299415A1
公开(公告)日：2022-09-22
申请号：US17834542
申请日：2022-06-07
Inventor： Laura Elizabeth Downie , Leslie Yeo , Amarin George McDonnell
IPC: G01N11/02 , G01N33/487 , G01N29/14 , G01N29/02 , G01N29/24 , A61B5/00 , G01N13/02 , G01N29/00 , A61B8/00
Abstract: A method for evaluating Dry Eye Disease (“DED”) in a human or animal subject is provided. Thread thinning dynamics of a tear sample of the subject are determined using an acoustically-driven microfluidic extensional rheometry instrument. At least one physical parameter value of the tear sample is calculated based at least in part on the determined thread thinning dynamics. DED is evaluated based at least in part on the at least one calculated physical parameter value of the tear sample. A device for evaluating Dry Eye Disease (DED) in a human or animal subject is also provided. The device includes an acoustically-driven microfluidic extensional rheometry instrument and a processing device configured to evaluate DED based at least in part on the calculated at least one physical parameter value of the tear sample.
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公开(公告)号：US20210100963A1
公开(公告)日：2021-04-08
申请号：US17044454
申请日：2019-04-05
Applicant: Royal Melbourne Institute of Technology
Inventor： Amarin McDonnell , Amgad Rezk , Leslie Yeo
IPC: A61M11/00 , B05B17/06 , H01L41/187 , B06B1/06
Abstract: A nebuliser for nebulising liquid droplets includes a housing; at least one piezoelectric substrate accommodated within the housing and having a transducer surface upon which is located at least one electroacoustic transducer for generating acoustic wave energy within the substrate, and an opposing non-transducer surface; and a liquid supply system for supplying a liquid to at least one of the transducer and non-transducer surfaces. The liquid supply system includes a reservoir for accommodating the liquid, and at least one relatively rigid supply conduit in contact with the substrate for supplying the liquid from the reservoir to the substrate.
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公开(公告)号：US10404232B2
公开(公告)日：2019-09-03
申请号：US15029433
申请日：2014-09-30
Applicant: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY
Inventor： Amgad Rezk , Leslie Yeo , James Friend
Abstract: A piezoelectric actuation platform (1) including piezoelectric substrate (3) formed from a single crystal piezoelectric material, and at least one simple electrode (5) in contact with the piezoelectric substrate for applying an electrical signal to the substrate such that a lamb or surface acoustic wave can be generated within said substrate.
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公开(公告)号：US20180141073A1
公开(公告)日：2018-05-24
申请号：US15573609
申请日：2016-05-13
Applicant: Royal Melbourne Institute of Technology
Inventor： James Tan , Amgad Rezk , Heba Ahmed , Leslie Yeo
CPC classification number: B05B17/0615 , B05B7/0012 , B05B17/0661 , B05B17/0684 , B06B1/0644 , B08B3/12
Abstract: A device, comprising: an electroacoustic transducer on a substrate; a power supply to supply electromagnetic wave energy to the electroacoustic transducer; and a source of a substance that is movable to the substrate; wherein the electroacoustic transducer and the substrate are configured to generate acoustic wave energy that is used to move the substance from the source to the substrate, and to manipulate the substance on the substrate.
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公开(公告)号：US20210177737A1
公开(公告)日：2021-06-17
申请号：US16758988
申请日：2018-10-26
Applicant: Royal Melbourne Institute of Technology
Inventor： Shwathy Ramesan , Amgad Rezk , Leslie Yeo
Abstract: An intracellular delivery device (1) including, a piezoelectric substrate (3) having a working surface (8), at least one interdigitated transducer (5) located on and in contact with the working surface (8), and a receptacle (11) located on the working surface for accommodating cells to be targeted for intracellular delivery therein, wherein an alternating signal applied to the interdigitated transducer generates acoustic wave energy through the piezoelectric substrate that can be transferred to the accommodated cells.
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Patent Agency Ranking
公开(公告)号：US12275039B2
公开(公告)日：2025-04-15
申请号：US16771947
申请日：2018-12-11
Applicant: Royal Melbourne Institute of Technology
Inventor： Leslie Yeo , Amgad Rezk , Shwathy Ramesan
Abstract: An apparatus, including at least one piezoelectric chip having a working surface, and an opposing at least substantially parallel transducer surface; and at least one interdigital transducer applied to the transducer surface of the chip for generating acoustic energy within the chip in response to an application of an electrical signal to the interdigital transducer; wherein the working surface of the chip is, when in use, in contact with a fluid receptacle to thereby acoustically actuate fluid accommodated within said fluid receptacle, the chip being directly in contact with the receptacle or in contact with a fluid coupling medium that is in contact with the receptacle.
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公开(公告)号：US11857992B2
公开(公告)日：2024-01-02
申请号：US15573609
申请日：2016-05-13
Applicant: Royal Melbourne Institute of Technology
Inventor： James Tan , Amgad Rezk , Heba Ahmed , Leslie Yeo
CPC classification number: B05B17/0615 , B05B7/0012 , B05B17/0684 , B06B1/0644 , B08B3/12 , B05B17/0661
Abstract: A device, comprising: an electroacoustic transducer on a substrate; a power supply to supply electromagnetic wave energy to the electroacoustic transducer; and a source of a substance that is movable to the substrate; wherein the electroacoustic transducer and the substrate are configured to generate acoustic wave energy that is used to move the substance from the source to the substrate, and to manipulate the substance on the substrate.
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公开(公告)号：US11707429B2
公开(公告)日：2023-07-25
申请号：US16758988
申请日：2018-10-26
Applicant: Royal Melbourne Institute of Technology
Inventor： Shwathy Ramesan , Amgad Rezk , Leslie Yeo
CPC classification number: A61K9/0009 , C12N5/0068 , B06B1/06 , C12N2521/10
Abstract: An intracellular delivery device (1) including, a piezoelectric substrate (3) having a working surface (8), at least one interdigitated transducer (5) located on and in contact with the working surface (8), and a receptacle (11) located on the working surface for accommodating cells to be targeted for intracellular delivery therein, wherein an alternating signal applied to the interdigitated transducer generates acoustic wave energy through the piezoelectric substrate that can be transferred to the accommodated cells.
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公开(公告)号：US20200158611A1
公开(公告)日：2020-05-21
申请号：US16327063
申请日：2017-08-24
Inventor： Laura Elizabeth Downie , Leslie Yeo , Amarin George McDonnell
IPC: G01N11/02 , G01N33/487
Abstract: A method for evaluating Dry Eye Disease (“DED”) in a human or animal subject is provided. Thread thinning dynamics of a tear sample of the subject are determined using an acoustically-driven microfluidic extensional rheometry instrument. At least one physical parameter value of the tear sample is calculated based at least in part on the determined thread thinning dynamics. DED is evaluated based at least in part on the at least one calculated physical parameter value of the tear sample. A device for evaluating Dry Eye Disease (DED) in a human or animal subject is also provided. The device includes an acoustically-driven microfluidic extensional rheometry instrument and a processing device configured to evaluate DED based at least in part on the calculated at least one physical parameter value of the tear sample.
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公开(公告)号：US12140516B2
公开(公告)日：2024-11-12
申请号：US17834542
申请日：2022-06-07
Inventor： Laura Elizabeth Downie , Leslie Yeo , Amarin George McDonnell
IPC: G01N11/02 , A61B5/00 , A61B8/00 , G01N13/02 , G01N29/00 , G01N29/02 , G01N29/14 , G01N29/24 , G01N33/487
Abstract: A method for evaluating Dry Eye Disease (“DED”) in a human or animal subject is provided. Thread thinning dynamics of a tear sample of the subject are determined using an acoustically-driven microfluidic extensional rheometry instrument. At least one physical parameter value of the tear sample is calculated based at least in part on the determined thread thinning dynamics. DED is evaluated based at least in part on the at least one calculated physical parameter value of the tear sample. A device for evaluating Dry Eye Disease (DED) in a human or animal subject is also provided. The device includes an acoustically-driven microfluidic extensional rheometry instrument and a processing device configured to evaluate DED based at least in part on the calculated at least one physical parameter value of the tear sample.
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