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公开(公告)号：US20170002016A1
公开(公告)日：2017-01-05
申请号：US15125615
申请日：2015-03-16
Applicant: RaQualia Pharma Inc.
Inventor： Yuji SHISHIDO , Masashi OHMI , Kazuo ANDO
IPC: C07D491/056 , A61K31/422 , A61K31/423 , C07D413/06 , C07D403/06 , A61K31/4184 , C07D403/14 , A61K31/497 , C07D401/14 , A61K31/4439 , C07D417/14 , A61K31/427 , A61K31/4725 , A61K31/4709 , A61K31/4545 , C07D417/06 , C07D235/02 , C07D403/10 , C07D471/04 , C07D401/12 , C07D403/12 , A61K31/506 , A61K31/501 , A61K31/444 , A61K31/517 , A61K31/502 , A61K31/437 , A61K31/519 , C07D487/04 , C07D409/10 , A61K31/498 , C07D491/048 , A61K31/4355 , A61K31/4985 , A61K31/5025 , C07D413/10 , C07D263/52 , C07D405/14 , A61K31/538 , C07D413/14
CPC classification number: C07D491/056 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/427 , A61K31/435 , A61K31/4355 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/538 , C07D235/02 , C07D235/06 , C07D263/52 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/10 , C07D409/14 , C07D413/06 , C07D413/10 , C07D413/14 , C07D417/06 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048
Abstract: The present invention relates to azaspiro derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor.
Abstract translation: 本发明涉及式（I）的azaspiro衍生物或其药学上可接受的盐或其前药，其制备方法，含有它们的药物组合物及其用于治疗通过TRPM8受体介导的各种病症的用途。
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Patent Agency Ranking
公开(公告)号：US20230339934A1
公开(公告)日：2023-10-26
申请号：US17921203
申请日：2021-04-30
Applicant: RaQualia Pharma Inc.
Inventor： Yuji SHISHIDO , Tadashi INOUE , Tatsuya YAMAGISHI , Kazuo ANDO , Yutaka FUKUMOTO , Ryohei MAGARA
IPC: C07D471/04 , C07D487/04
CPC classification number: C07D471/04 , C07D487/04
Abstract: This invention relates to pyrimidin-4(3H)-one derivatives that act as modulators of the TRPV4 receptor. The present invention also relates to processes for the preparation of novel pyrimidin-4(3H)-one derivatives and to their use in the treatment of a wide range of diseases, syndromes, and disorders, in particular for the treatment of inflammatory, pain, and urological diseases or disorders.
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公开(公告)号：US20200230123A1
公开(公告)日：2020-07-23
申请号：US16642706
申请日：2018-08-31
Applicant: RaQualia Pharma Inc. , XuanZhu Pharma Co., Ltd.
Inventor： Kiyoshi KAWAMURA , Tatsuya YAMAGISHI , Yuji SHISHIDO , Mikio MORITA , Ryuichi YAMAGUCHI , Masashi OHMI
IPC: A61K31/4433 , A61K31/4418 , A61K31/4545 , C07D213/647 , C07D213/64 , C07D401/12 , C07D405/12 , C07D401/04 , A61K31/4965 , C07D241/18 , C07D239/34 , A61K31/505 , A61K31/18 , A61K31/415 , A61K31/42 , C07D231/12 , C07D261/08 , C07C311/51 , C07D401/10 , A61P29/00
Abstract: The present invention relates to biaryloxy derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channel is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.
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公开(公告)号：US20200016135A1
公开(公告)日：2020-01-16
申请号：US16301691
申请日：2018-06-20
Applicant: RaQualia Pharma Inc.
Inventor： Tatsuya YAMAGISHI , Mikio MORITA , Yuji SHISHIDO , Ryuichi YAMAGUCHI , Norikazu GAJA
IPC: A61K31/444 , C07D213/81 , C07D401/12 , C07D239/28 , A61K31/506 , A61K31/44 , A61K31/4709 , A61K31/505
Abstract: The present invention relates to amide derivatives which have blocking activities of voltage gated sodium channels as the Nav1.7 and Nav1.8 channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.
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公开(公告)号：US20180339993A1
公开(公告)日：2018-11-29
申请号：US16050514
申请日：2018-07-31
Applicant: RaQualia Pharma Inc.
Inventor： Yuji SHISHIDO , Masashi OHMI , Kazuo ANDO
IPC: C07D491/056 , A61K31/538 , C07D235/06 , A61K31/423 , A61K31/4355 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/506 , A61K31/519 , C07D413/10 , C07D235/02 , A61K31/517 , A61K31/435 , A61K31/422 , A61K31/4178 , C07D491/048 , C07D263/52 , C07D487/04 , C07D471/04 , C07D417/14 , C07D417/10 , C07D417/06 , C07D413/06 , C07D409/14 , C07D409/10 , C07D403/14 , C07D403/10 , C07D403/06 , C07D401/12 , A61K31/437 , A61K31/427 , C07D413/14 , C07D405/14 , C07D401/14 , C07D403/12 , A61K31/4184
Abstract: The present invention relates to azaspiro derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor,
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公开(公告)号：US20180305341A1
公开(公告)日：2018-10-25
申请号：US15758932
申请日：2016-09-12
Applicant: RAQUALIA PHARMA INC.
Inventor： Yuji SHISHIDO , Masashi OHMI
IPC: C07D403/12 , C07D403/10 , C07D471/04
CPC classification number: C07D403/12 , A61K31/4184 , A61K31/437 , A61K31/501 , A61K45/06 , C07D403/10 , C07D471/04 , A61K2300/00
Abstract: The present invention relates to imidazolinone derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor.
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