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1.发明授权Process for the preparation of (2,2)-paracyclophane and derivatives thereof 失效（2,2） - 对环磷烷及其衍生物的制备方法
公开(公告)号：US4734533A
公开(公告)日：1988-03-29
申请号：US940772
申请日：1986-12-12
IPC分类号： B01J31/00 , B01J31/02 , C07B61/00 , C07C1/00 , C07C1/32 , C07C13/70 , C07C17/00 , C07C17/26 , C07C17/263 , C07C25/18 , C07C67/00 , C07C13/28
CPC分类号： C07C1/323 , C07C17/263 , C07C2103/92
摘要： Process for the preparation of (2,2)-paracyclophane or derivatives thereof by the Hofmann elimination of p.-methylbenzyltrimethylammonium hydroxide or derivatives thereof, in an aqueous solution of an alkali metal hydroxide, wherein said elimination is carried out in the presence of a ketone of the formula:Ch.sub.3 --CO--CH.sub.2 --R (I)wherein R is hydrogen, a halogen, or an alkyl-carboxylic group.
摘要翻译： 在碱金属氢氧化物的水溶液中通过霍夫曼消除对甲基苄基三甲基氢氧化铵或其衍生物来制备（2,2） - 对环烷烃或其衍生物的方法，其中所述消除在 酮，其具有式：Ch 3 -CO-CH 2 -R（I）其中R是氢，卤素或烷基 - 羧基。
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公开(公告)号：US4675462A
公开(公告)日：1987-06-23
申请号：US924274
申请日：1986-10-29
IPC分类号： B01J23/70 , B01J27/00 , B01J27/055 , B01J27/122 , B01J27/128 , B01J31/00 , B01J31/04 , C07B61/00 , C07C1/00 , C07C1/32 , C07C13/70 , C07C67/00 , C07C2/72
CPC分类号： C07C1/323 , C07C2103/92
摘要： A process for the preparation of (2,2)-paracyclophane by conversion of p.methylbenzyltrimethylammonium halide to the corresponding hydroxide and by Hofmann elimination from p.methylbenzyltrimethylammonium hydroxide, wherein both reactions are carried out in the same aqueous solution of an alkaline hydroxide and in the presence of a copper or iron compound.
摘要翻译： 通过将对甲基苄基三甲基铵卤化物转化为相应的氢氧化物并通过从甲基苄基三甲基氢氧化铵中去除霍夫曼消除来制备（2,2） - 对环烷酸的方法，其中两个反应在碱性氢氧化物的相同水溶液中进行， 在铜或铁化合物的存在下。
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3.发明授权Process for the preparation of tricyclo 8.2.2.2 hexadeca 4,6,10,12,13,15 hexaene chlorinated in the benzene rings 失效制备三环的方法8.2.2.2十六碳四氢呋喃4,6,10,12,13,15六氯在苯环中氯化
公开(公告)号：US4886923A
公开(公告)日：1989-12-12
申请号：US245325
申请日：1988-09-16
IPC分类号： B01J27/10 , B01J23/745 , B01J31/02 , B01J31/04 , B01J31/26 , B01J31/28 , B01J31/30 , C07B61/00 , C07C17/00 , C07C17/12 , C07C25/18 , C07C25/22 , C07C67/00
CPC分类号： C07C17/12
摘要： A process for the chlorination of the benzene rings of tricyclo 8.2.2.2 hexadeca 4,6,10,12,13,15 hexane (or (2,2)-paracyclophane) having the formula (I): ##STR1## by gaseous chlorine, by operating in the presence of at least one metal chloride as a catalyst, and at least one co-catalyst having the formula V:R--OH (V)whereinR=hydrocarbon or alkylcarboxylic radical with linear or branched chain, containing from 1 to 6 carbon atoms is taught.
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公开(公告)号：US5043483A
公开(公告)日：1991-08-27
申请号：US276634
申请日：1988-11-28
CPC分类号： C07C37/14
摘要： Process for the alkylation of phenols comprising reacting a phenol with a vinyl-aromatic hydrocarbon in the presence of an acidic catalyst and of a solvent.
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5.发明授权Process for producing a silane or siloxane compound containing a cycloalkyl ring 失效制备含有环烷基环的硅烷或硅氧烷化合物的方法
公开(公告)号：US4956484A
公开(公告)日：1990-09-11
申请号：US163948
申请日：1988-03-03
CPC分类号： C07F7/0801 , C07F7/1892
摘要： A process for producing a silane or siloxane compound containing at least one cycloalkyl ring by hydrogenation of a corresponding derivative containing at least one aromatic ring in the presence of a Raney nickel catalyst modified with chromium.
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6.发明授权
公开(公告)号：US4912243A
公开(公告)日：1990-03-27
申请号：US186349
申请日：1988-04-26
CPC分类号： C07F7/0889 , C07F7/0801 , C07F7/1892
摘要： A process of producing a silanic or siloxanic compound containing at least one cycloalkyl ring by hydrogenation of a corresponding compound containing at least one aromatic ring, in solution, in the presence of a catalyst comprising palladium, supported on active carbon and at a pressure equal to or higher than 10 bar.
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7.发明授权Process of producing a silanic or siloxanic compound containing at least one cycloalkyl ring 失效制备含有至少一个环烷基环的硅烷基或硅氧烷化合物的方法
公开(公告)号：US4977291A
公开(公告)日：1990-12-11
申请号：US408400
申请日：1989-09-15
CPC分类号： C07F7/083 , C07F7/0801 , C07F7/0889 , C07F7/1892
摘要： A process of producing a silanic or siloxanic compound containing at least one cycloalkyl ring by the hydrogenation of a corresponding compound containing at least one aromatic ring, in the presence of a Raney nickel catalyst having a granulometry comprised essentially between 10 and 150 micrometers and a surface area of at least 80 m.sup.2 /g.
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公开(公告)号：US4853488A
公开(公告)日：1989-08-01
申请号：US179250
申请日：1988-04-08
申请人： Raffaele Ungarelli , Loris Sogli
发明人： Raffaele Ungarelli , Loris Sogli
IPC分类号： C07C17/26 , B01J31/02 , C07B61/00 , C07C1/00 , C07C1/32 , C07C13/70 , C07C17/00 , C07C17/263 , C07C25/18 , C07C67/00
CPC分类号： C07C1/323 , C07C2103/92
摘要： Process for the preparation of (2,2)-paracyclophane or derivatives thereof by the Hofmann elimination of p-methylbenzyl-trimethylammonium hydroxide or derivatives thereof, in an aqueous solution of an alkali metal hydroxide, wherein said elimination is carried out in the presence of a compound of the formula (I):(R).sub.m --A--(X).sub.n (I)wherein A represents an aromatic group, X an electron donor group, R hydrogen or an alkyl group containing from 1 to 4 carbon atoms, n is an integer from 1 to 6, and m is zero or an integer from 1 up to a value such that the sum m+n is equal to the number of substitutable positions in the aromatic group.
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公开(公告)号：US6005101A
公开(公告)日：1999-12-21
申请号：US17860
申请日：1998-02-03
申请人： Loris Sogli , Davide Longoni , Giovanni Pozzi , Enrico Siviero , Daniele Mario Terrassan , Ermanno Bernasconi , Francisco Salto
发明人： Loris Sogli , Davide Longoni , Giovanni Pozzi , Enrico Siviero , Daniele Mario Terrassan , Ermanno Bernasconi , Francisco Salto
IPC分类号： C07D501/04 , C07D501/00 , C07D501/14 , C07D501/16 , C07D501/20 , C07D501/24 , C07D501/26 , C07D501/28 , C07D501/59
CPC分类号： C07D501/00
摘要： A compound having the following general formula (I): ##STR1## where R is a hydrogen atom; a linear or branched C.sub.1 -C.sub.4 alkyl group, unsubstituted or substituted by at least a phenyl group or at least a hydrogen atom; a benzyl group substituted by at least a linear or branched C.sub.1 -C.sub.4 alkyl or alkoxy group or a nitro group; a silyl substituted by at least a linear or branched, unsubstituted or substituted C.sub.1 -C.sub.4 alkyl group; n is 0 or 1; and Y is a radical of formula ##STR2## wherein A is H, OH, Cl, CH.sub.2, CH.sub.2 X, where X is F, Cl, Br, I, OH or OR' and R' is COCH.sub.3 or a linear or branched, unsubstituted or substituted C.sub.1 -C.sub.4 alkyl group and - - - represents a single or a double bond, with the proviso that when n=0 and R is H, R' is not a methyl group.
摘要翻译： 具有以下通式（I）的化合物：其中R是氢原子; 直链或支链C 1 -C 4烷基，未被取代或被至少一个苯基或至少一个氢原子取代; 被至少一个直链或支链的C 1 -C 4烷基或烷氧基或硝基取代的苄基; 由至少一个直链或支链的未取代或取代的C 1 -C 4烷基取代的甲硅烷基; n为0或1; 并且Y是下式的基团，其中A是H，OH，Cl，CH 2，CH 2 X，其中X是F，Cl，Br，I，OH或OR'，R'是COCH 3或直链或支链，未取代或取代的C1 -C4烷基和+ E，未 - - + EE表示单键或双键，条件是当n = 0且R为H时，R'不为甲基。
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10.发明授权Process for the preparation of intermediates useful in the synthesis of cephalosporins 失效制备可用于合成头孢菌素的中间体的方法
公开(公告)号：US5660711A
公开(公告)日：1997-08-26
申请号：US569631
申请日：1995-12-08
申请人： Derek Walker , Junning Lee , Charles R. Martin , Haiyan Zhang , Loris Sogli , Ermanno Bernasconi , Vinod Parakkal Menon
发明人： Derek Walker , Junning Lee , Charles R. Martin , Haiyan Zhang , Loris Sogli , Ermanno Bernasconi , Vinod Parakkal Menon
IPC分类号： C07D501/00 , C07D501/04 , C07D501/12 , C07D501/14 , C07D501/18 , C07D501/22 , C07D501/24 , C07D501/59 , C25B3/04 , C25B3/00
CPC分类号： C07D501/00 , Y02P20/55
摘要： A process is described for preparing 3-exomethylene cephalosporanic acid derivatives for use in the synthesis of cephalosporin antibiotics such as ceftibuten. The process comprises electrochemical reduction of a compound of the formula (IV) ##STR1## wherein: R.sup.3 is CH.sub.3 C(O)--; ##STR2## is an optional sulfoxide group; n is 2 or 3; R.sup.1 is H and R is H or NHR.sup.2, where R.sup.2 is H or a protecting group selected from C.sub.6 H.sub.5 CH.sub.2 OC(O)--, C.sub.6 H.sub.5 C(O)-- or C.sub.1 -C.sub.6 alkoxy-C(O)--; or wherein R and R.sup.1 together with the carbon atom to which they are attached comprise --C(O)--, and produces the desired 3-exomethylene compounds with low levels of the corresponding 3-methyl tautomers.
摘要翻译： 描述了一种用于制备用于合成头孢菌素类抗生素如头孢他啶的3-异亚甲基头孢菌酸衍生物的方法。 该方法包括电化学还原式（IV）化合物其中：R3是CH 3 C（O） - ;
是一个可选的亚砜基团; n为2或3; R1为H且R为H或NHR2，其中R2为H或选自C6H5CH2OC（O） - ，C6H5C（O） - 或C1-C6烷氧基-C（O） - 的保护基）。 或其中R和R 1与它们所连接的碳原子一起包含-C（O） - 并且产生具有低水平的相应3-甲基互变异构体的所需3-异丙烯基化合物。
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