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公开(公告)号：US20090020502A1
公开(公告)日：2009-01-22
申请号：US12238023
申请日：2008-09-25
IPC分类号： H01B13/008
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
摘要翻译： 具有电极元件的电化学生物传感器具有光滑，高质量的边缘。 这些光滑边缘限定电极，电极迹线和接触垫之间的间隙。 由于本发明实现了显着的边缘平滑度，所以间隙可以相当小，这在测试精度，速度和可以包装到单个生物传感器中的不同功能的数量方面提供显着的优点。 此外，本发明提供了一种新颖的生物传感器制造方法，其中可以以纳秒为单位形成本发明的生物传感器的整个电极图案，而不考虑电极图案的复杂性或必须烧蚀的导电材料的量 形成它们
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公开(公告)号：US08287703B2
公开(公告)日：2012-10-16
申请号：US12238023
申请日：2008-09-25
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
摘要翻译： 具有电极元件的电化学生物传感器具有光滑，高质量的边缘。 这些光滑边缘限定电极，电极迹线和接触垫之间的间隙。 由于本发明实现了显着的边缘平滑度，所以间隙可以相当小，这在测试精度，速度和可以包装到单个生物传感器中的不同功能的数量方面提供显着的优点。 此外，本发明提供了一种新颖的生物传感器制造方法，其中可以以纳秒为单位形成本发明的生物传感器的整个电极图案，而不考虑电极图案的复杂性或必须烧蚀的导电材料的量 形成它们
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公开(公告)号：US08551308B2
公开(公告)日：2013-10-08
申请号：US12238101
申请日：2008-09-25
IPC分类号： G01N27/327 , C12Q1/25 , H05K3/00
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
摘要翻译： 具有电极元件的电化学生物传感器具有光滑，高质量的边缘。 这些光滑边缘限定电极，电极迹线和接触垫之间的间隙。 由于本发明实现了显着的边缘平滑度，所以间隙可以相当小，这在测试精度，速度和可以包装到单个生物传感器中的不同功能的数量方面提供显着的优点。 此外，本发明提供了一种新颖的生物传感器制造方法，其中可以以纳秒为单位形成本发明的生物传感器的整个电极图案，而不考虑电极图案的复杂性或必须烧蚀的导电材料的量 形成它们
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公开(公告)号：US20090056120A1
公开(公告)日：2009-03-05
申请号：US12238101
申请日：2008-09-25
IPC分类号： G01N27/26
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
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公开(公告)号：US07867369B2
公开(公告)日：2011-01-11
申请号：US10871843
申请日：2004-06-18
申请人： Raghbir S. Bhullar , Harvey B. Buck, Jr. , Brian S. Hill , Paul Douglas Walling , Terry A. Beaty , David W. Burke , Eric R. Diebold
发明人： Raghbir S. Bhullar , Harvey B. Buck, Jr. , Brian S. Hill , Paul Douglas Walling , Terry A. Beaty , David W. Burke , Eric R. Diebold
IPC分类号： G01N27/327
CPC分类号： C12M1/00 , C12Q1/001 , G01N27/3272
摘要： A biosensor having multiple electrical functionalities located both within and outside of the measurement zone in which a fluid sample is interrogated. Incredibly small and complex electrical patterns with high quality edges provide electrical functionalities in the biosensor and also provide the electrical wiring for the various other electrical devices provided in the inventive biosensor. In addition to a measurement zone with multiple and various electrical functionalities, biosensors of the present invention may be provided with a user interface zone, a digital device zone and/or a power generation zone. The inventive biosensors offer improved ease of use and performance, and decrease the computational burden and associated cost of the instruments that read the biosensors by adding accurate yet cost-effective functionalities to the biosensors themselves.
摘要翻译： 具有位于测量区域内和外部的多个电功能的生物传感器，其中询问流体样品。 具有高质量边缘的难以置信的小且复杂的电气图案在生物传感器中提供电功能，并且还为本发明的生物传感器中提供的各种其它电气装置提供电线。 除了具有多个和各种电功能的测量区域之外，本发明的生物传感器可以设置有用户界面区域，数字设备区域和/或发电区域。 本发明的生物传感器提供了改进的易用性和性能，并且通过向生物传感器本身添加准确而成本有效的功能来降低读取生物传感器的仪器的计算负担和相关成本。
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公开(公告)号：US08222044B2
公开(公告)日：2012-07-17
申请号：US13297501
申请日：2011-11-16
IPC分类号： G01N21/75
CPC分类号： G01N27/3272 , Y10T156/1052
摘要： A test strip with a sample receiving chamber having a novel flared portion that terminates in a sample receiving opening. The flared portion provides a reservoir from which sample fluid can be drawn into the capillary or sample receiving chamber. The wider opening provided by the present invention is easier to “target” with a sample fluid. In preferred embodiments, the hydrophilic reagent layer extends to the dosing end or side of the test strip and further promotes wicking of the sample into the sample receiving chamber and thus reduces dose hesitation. In other preferred embodiments, a tapered dosing end is provided on the test strip in combination with the flared portion, and this combination create a test strip that will draw sample fluid into the sample receiving chamber regardless of where along the dosing edge of the test strip the fluid sample makes contact.
摘要翻译： 具有样品接收室的测试条具有终止于样品接收开口的新颖的扩口部分。 扩口部分提供储存器，样品流体可从该储存器吸入毛细管或样品接收室。 本发明提供的更宽的开口更容易用样品流体“目标”。 在优选的实施方案中，亲水试剂层延伸到测试条的计量端或侧，并进一步促进样品的芯吸到样品接收室中，从而减少剂量犹豫。 在其它优选实施例中，在测试条上与锥形部分结合地提供锥形剂量端，并且该组合产生测试条，其将样品流体吸入样品接收室，而不管沿着测试条的计量边缘的哪里 流体样品接触。
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公开(公告)号：US08071030B2
公开(公告)日：2011-12-06
申请号：US10872027
申请日：2004-06-18
IPC分类号： G01N33/48
CPC分类号： G01N27/3272 , Y10T156/1052
摘要： A test strip with a sample receiving chamber having a novel flared portion that terminates in a sample receiving opening. The flared portion provides a reservoir from which sample fluid can be drawn into the capillary or sample receiving chamber. The wider opening provided by the present invention is easier to “target” with a sample fluid. In preferred embodiments, the hydrophilic reagent layer extends to the dosing end or side of the test strip and further promotes wicking of the sample into the sample receiving chamber and thus reduces dose hesitation. In other preferred embodiments, a tapered dosing end is provided on the test strip in combination with the flared portion, and this combination create a test strip that will draw sample fluid into the sample receiving chamber regardless of where along the dosing edge of the test strip the fluid sample makes contact.
摘要翻译： 具有样品接收室的测试条具有终止于样品接收开口的新颖的扩口部分。 扩口部分提供储存器，样品流体可从该储存器吸入毛细管或样品接收室。 本发明提供的更宽的开口更容易用样品流体“目标”。 在优选的实施方案中，亲水试剂层延伸到测试条的计量端或侧，并进一步促进样品的芯吸到样品接收室中，从而减少剂量犹豫。 在其它优选实施例中，在测试条上与锥形部分结合地提供锥形剂量端，并且该组合产生测试条，其将样品流体吸入样品接收室，而不管沿着测试条的计量边缘的哪里 流体样品接触。
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公开(公告)号：US20120055626A1
公开(公告)日：2012-03-08
申请号：US13297501
申请日：2011-11-16
CPC分类号： G01N27/3272 , Y10T156/1052
摘要： A test strip with a sample receiving chamber having a novel flared portion that terminates in a sample receiving opening. The flared portion provides a reservoir from which sample fluid can be drawn into the capillary or sample receiving chamber. The wider opening provided by the present invention is easier to “target” with a sample fluid. In preferred embodiments, the hydrophilic reagent layer extends to the dosing end or side of the test strip and further promotes wicking of the sample into the sample receiving chamber and thus reduces dose hesitation. In other preferred embodiments, a tapered dosing end is provided on the test strip in combination with the flared portion, and this combination create a test strip that will draw sample fluid into the sample receiving chamber regardless of where along the dosing edge of the test strip the fluid sample makes contact.
摘要翻译： 具有样品接收室的测试条具有终止于样品接收开口的新颖的扩口部分。 扩口部分提供储存器，样品流体可从该储存器吸入毛细管或样品接收室。 本发明提供的更宽的开口更容易用样品流体“目标”。 在优选的实施方案中，亲水试剂层延伸到测试条的计量端或侧，并进一步促进样品的芯吸到样品接收室中，从而减少剂量犹豫。 在其它优选实施例中，在测试条上与锥形部分结合地提供锥形剂量端，并且该组合产生测试条，其将样品流体吸入样品接收室，而不管沿着测试条的计量边缘的哪里 流体样品接触。
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公开(公告)号：US08775095B2
公开(公告)日：2014-07-08
申请号：US12818781
申请日：2010-06-18
CPC分类号： A61B5/14532 , A61B5/4842
摘要： Methods for decentralized monitoring of a progression of a diabetic state of a patient include contemporaneously obtaining an initial set of venous blood samples and an initial set of capillary blood samples after a standardized metabolic challenge from the patient in a centralized setting, wherein the diabetic state is diagnosed using the initial set of venous blood samples and a first test baseline is established by correlating the initial set of capillary blood samples with the initial set of venous blood samples, implementing a therapy, performing decentralized testing after reaching a target event, wherein a status test is obtained from a status set of capillary blood samples obtained from the patient after a subsequent standardized metabolic challenge, and comparing the status test with the first test baseline to determine an effectiveness of the therapy.
摘要翻译： 用于分散监测患者糖尿病状态进展的方法包括同时获得一组初始静脉血样本和在集中式设置中来自患者的标准化代谢攻击之后的初始毛细血管样本组，其中所述糖尿病状态为 使用初始静脉血样本进行诊断并通过将初始毛细血管样本集与初始静脉血样品集合相关联来实现，实施治疗，在达到目标事件之后进行分散测试，其中状态 在随后的标准化代谢攻击之后，从患者获得的毛细血管血样的状态集获得测试，并将状态测试与第一测试基线进行比较以确定治疗的有效性。
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公开(公告)号：US20110313673A1
公开(公告)日：2011-12-22
申请号：US12818781
申请日：2010-06-18
CPC分类号： A61B5/14532 , A61B5/4842
摘要： Methods for decentralized monitoring of a progression of a diabetic state of a patient include contemporaneously obtaining an initial set of venous blood samples and an initial set of capillary blood samples after a standardized metabolic challenge from the patient in a centralized setting, wherein the diabetic state is diagnosed using the initial set of venous blood samples and a first test baseline is established by correlating the initial set of capillary blood samples with the initial set of venous blood samples, implementing a therapy, performing decentralized testing after reaching a target event, wherein a status test is obtained from a status set of capillary blood samples obtained from the patient after a subsequent standardized metabolic challenge, and comparing the status test with the first test baseline to determine an effectiveness of the therapy.
摘要翻译： 用于分散监测患者糖尿病状态进展的方法包括同时获得一组初始静脉血样本和在集中式设置中来自患者的标准化代谢攻击之后的初始毛细血管样本组，其中所述糖尿病状态为 使用初始静脉血样本进行诊断并通过将初始毛细血管样本集与初始静脉血样品集合相关联来实现，实施治疗，在达到目标事件之后进行分散测试，其中状态 在随后的标准化代谢攻击之后，从患者获得的毛细血管血样的状态集获得测试，并将状态测试与第一测试基线进行比较以确定治疗的有效性。
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