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    METHOD FOR ESTIMATING THE PHYSIOLOGICAL PARAMETERS DEFINING THE EDEMA INDUCED UPON INFUSION OF FLUID FROM AN INTRAPARENCHYMALLY PLACED CATHETER
    1.
    发明申请
    METHOD FOR ESTIMATING THE PHYSIOLOGICAL PARAMETERS DEFINING THE EDEMA INDUCED UPON INFUSION OF FLUID FROM AN INTRAPARENCHYMALLY PLACED CATHETER 有权
    估计生理参数的方法，该参数定义了从浸润式放置导管输入的流体引起的EDEMA

    公开(公告)号：US20120046538A1

    公开(公告)日：2012-02-23

    申请号：US13241936

    申请日：2011-09-23

    申请人： Raghu Raghavan ,  Martin Brady

    发明人： Raghu Raghavan ,  Martin Brady

    IPC分类号： A61B5/055

    CPC分类号： A61K49/06 ,  A61M2005/14292 ,  G01R33/5601 ,  G01R33/56341

    摘要： A method for estimating the physiological parameters defining the edema induced upon infusion of fluid from an intraparenchymally placed catheter including; acquisition of patient-specific medical data; estimation of pertinent tissue microstructure based on the patient-specific medical data and/or generalized information derived or drawn from one or more of the following: experience, literature, modeling, studies, research, analysis; acquisition of information about delivery parameters, and/or delivery device geometry, and/or fluid properties, such as: delivery device trajectory, flow rate, pressure, catheter diameter, catheter profile, fluid viscosity, fluid molecular size; and computing a field of values of predicted extracellular volume fraction over the tissue region using the information obtained above. According to a further aspect, a method of infusing or planning and/or monitoring an infusion of a contrast agent such that the distribution of such agent can be detected by medical data acquisition and observing and/or measuring the backflow length along the catheter track.

    摘要翻译： 一种估计生理参数的方法，所述生理参数限定了从实施静脉内放置的导管输注流体时引起的水肿，包括： 获取患者特定的医疗数据; 基于患者特异性医学数据和/或从以下一个或多个导出或得出的一般化信息估计相关组织微结构：经验，文献，建模，研究，研究，分析; 获取关于递送参数的信息和/或递送装置几何形状和/或流体性质，例如：递送装置轨迹，流速，压力，导管直径，导管轮廓，流体粘度，流体分子尺寸; 以及使用上面获得的信息计算组织区域上预测的细胞外体积分数值的一个领域。 根据另一方面，一种输注或规划和/或监测造影剂的输注的方法，使得可以通过医学数据采集来检测这种药剂的分布，并且观察和/或测量沿导管轨迹的回流长度。

    METHOD FOR ESTIMATING THE PHYSIOLOGICAL PARAMETERS DEFINING THE EDEMA INDUCED UPON INFUSION OF FLUID FROM AN INTRAPARENCHYMALLY PLACED CATHETER
    3.
    发明申请
    METHOD FOR ESTIMATING THE PHYSIOLOGICAL PARAMETERS DEFINING THE EDEMA INDUCED UPON INFUSION OF FLUID FROM AN INTRAPARENCHYMALLY PLACED CATHETER 审中-公开
    估计生理参数的方法，该参数定义了从浸润式放置导管输入的流体引起的EDEMA

    公开(公告)号：US20080292160A1

    公开(公告)日：2008-11-27

    申请号：US12121103

    申请日：2008-05-15

    申请人： Raghu Raghavan ,  Martin Brady

    发明人： Raghu Raghavan ,  Martin Brady

    IPC分类号： A61B5/00

    CPC分类号： A61K49/06 ,  A61M2005/14292 ,  G01R33/5601 ,  G01R33/56341

    摘要： A method for estimating the physiological parameters defining the edema induced upon infusion of fluid from an intraparenchymally placed catheter including; a) acquisition of patient-specific medical data; b) estimation of pertinent tissue microstructure based on the patient-specific medical data and/or generalized information derived or drawn from one or more of the following: experience, literature, modeling, studies, research, analysis; c) acquisition of information about delivery parameters, and/or delivery device geometry, and/or fluid properties, such as: delivery device trajectory, flow rate, pressure, catheter diameter, catheter profile, fluid viscosity, fluid molecular size; and d) computing a field of values of predicted extracellular volume fraction over the tissue region using the information obtained in (b) and (c). According to a further aspect, a method of infusing or planning and/or monitoring an infusion of a contrast agent such that the distribution of such agent can be detected by means of medical data acquisition (e.g. MRI, CT, x-ray, ultrasound, SPECT, PET) and observing and/or measuring the backflow length along the catheter track.

    摘要翻译： 一种估计生理参数的方法，所述生理参数限定了从实施静脉内放置的导管输注流体时引起的水肿，包括： a）获取患者特定的医疗数据; b）基于患者特定的医学数据和/或从以下一个或多个中得出或得出的一般化信息来估计相关的组织微结构：经验，文献，建模，研究，研究，分析; c）获取关于递送参数和/或递送装置几何形状和/或流体特性的信息，例如：递送装置轨迹，流速，压力，导管直径，导管轮廓，流体粘度，流体分子尺寸; 以及d）使用（b）和（c）中获得的信息计算组织区域上预测的细胞外体积分数的值的场。 根据另一方面，一种输注或规划和/或监测造影剂的输注的方法，使得可以通过医学数据采集（例如MRI，CT，X射线，超声波， SPECT，PET），并观察和/或测量沿着导管轨道的回流长度。

    Delivery of materials into margins of tissue cavities
    4.
    发明授权
    Delivery of materials into margins of tissue cavities 有权

    公开(公告)号：US09757543B2

    公开(公告)日：2017-09-12

    申请号：US14229876

    申请日：2014-03-29

    申请人： Raghu Raghavan ,  Martin Brady

    发明人： Raghu Raghavan ,  Martin Brady

    IPC分类号： A61M31/00 ,  A61M37/00 ,  A61M25/10

    CPC分类号： A61M25/10 ,  A61M2025/105 ,  A61M2025/1086

    摘要： Surgery is performed on a patient with a novel device by: excising tissue from tissue mass within a patient to create a cavity within the tissue mass; inserting a novel device of this invention into the cavity; shaping a flexible expandable component of the device to adjust dimensions on the flexible expandable component; providing a liquid into the component through the liquid input port; and controlling pressure or flow rate of the liquid in the component to move the liquid through the multiple openings and into the cavity. The device has a liquid inlet port, an exterior surface having length, width and depth, and multiple openings in the surface distributed throughout the length, width and depth to act as liquid delivery ports; the exterior surface of the liquid delivery device being shapeable by internal pneumatic pressure or hydraulic pressure to better fit inside dimensions of a surgical cavity; the multiple openings deliver the liquid through the multiple openings.

    Brain tissue classification
    5.
    发明授权
    Brain tissue classification 有权
    脑组织分类

    公开(公告)号：US09101282B2

    公开(公告)日：2015-08-11

    申请号：US11534383

    申请日：2006-09-22

    申请人： Andreas Hartlep ,  Christoph Pedain ,  Martin Brady ,  Raghu Raghavan

    发明人： Andreas Hartlep ,  Christoph Pedain ,  Martin Brady ,  Raghu Raghavan

    IPC分类号： A61B5/055 ,  G01R33/56 ,  A61B5/00 ,  G06T7/00

    CPC分类号： A61B5/055 ,  A61B5/0042 ,  A61B5/4064 ,  A61B5/7264 ,  A61B2576/026 ,  G01R33/5608 ,  G06T7/12 ,  G06T2207/10088 ,  G06T2207/30016

    摘要： A medical imaging processing method includes: using an imaging method to acquire at least first and second data sets of a region of interest of a patient's body, with at least one image acquisition parameter being changed so that first and second data sets yield different contrast levels relating to different substance and/or tissue types, and wherein the at least one acquisition parameter used to obtain the first data set is selected to enhance the contrast between one of the substance and/or tissue types relative to other substance and/or tissue types, and the at least one acquisition parameter used to obtain the second data set is selected to enhance the contrast between a different one of the substance and/or tissue types relative other substance and/or tissue types, thereby to optimize the contrast between at least three different substance and/or tissue types; and processing the two data sets to identify the different tissue types and/or boundaries therebetween.

    摘要翻译： 医疗成像处理方法包括：使用成像方法来获取患者身体的至少一个感兴趣区域的数据集，其中至少一个图像获取参数被改变，使得第一和第二数据组产生不同的对比度 涉及不同的物质和/或组织类型，并且其中用于获得第一数据集的至少一个采集参数被选择以增强物质和/或组织类型之一相对于其他物质和/或组织类型之间的对比度 ，并且选择用于获得第二数据集的至少一个采集参数以增强物质和/或组织类型之间的不同物质与其他物质和/或组织类型之间的对比度，从而优化至少 三种不同的物质和/或组织类型; 并且处理两个数据集以识别其间的不同组织类型和/或边界。

    MARGIN DETERMINATION/TUMOR CELL MIGRATION
    7.
    发明申请
    MARGIN DETERMINATION/TUMOR CELL MIGRATION 审中-公开
    标记确定/肿瘤细胞迁移

    公开(公告)号：US20090270712A1

    公开(公告)日：2009-10-29

    申请号：US12423228

    申请日：2009-04-14

    申请人： Raghu Raghavan ,  Martin Brady ,  Maria Inmaculada Rodriguez-Ponce

    发明人： Raghu Raghavan ,  Martin Brady ,  Maria Inmaculada Rodriguez-Ponce

    IPC分类号： A61M37/00 ,  A61B6/00 ,  A61B19/00

    CPC分类号： A61M5/1723 ,  A61B5/055 ,  A61B34/10 ,  A61B90/36 ,  A61M2005/14292 ,  A61M2210/0693 ,  G01R33/281 ,  G01R33/5608

    摘要： A method for identifying target regions in a tissue for local drug delivery, wherein functional and/or structural anatomical data such as edema and/or resection cavity is captured by an imaging system, and wherein the anatomical data is evaluated by segmentation techniques such as region-growing-based methods with computer assistance to determine a margin around a resection cavity and/or the volume of edema, the margin and/or the volume of edema being the target tissue for local drug delivery.

    摘要翻译： 一种用于识别用于局部药物递送的组织中的目标区域的方法，其中由成像系统捕获功能和/或结构解剖学数据，例如水肿和/或切除腔，并且其中所述解剖数据通过分割技术（例如区域 计算机辅助的基于成长的方法来确定切除腔周围的边缘和/或水肿体积，水肿的边缘和/或体积是用于局部药物递送的目标组织。

    Brain tissue classification
    8.
    发明申请
    Brain tissue classification 有权
    脑组织分类

    公开(公告)号：US20070167788A1

    公开(公告)日：2007-07-19

    申请号：US11534383

    申请日：2006-09-22

    申请人： Andreas Hartlep ,  Christoph Pedain ,  Martin Brady ,  Raghu Raghavan

    发明人： Andreas Hartlep ,  Christoph Pedain ,  Martin Brady ,  Raghu Raghavan

    IPC分类号： A61B8/00

    CPC分类号： A61B5/055 ,  A61B5/0042 ,  A61B5/4064 ,  A61B5/7264 ,  A61B2576/026 ,  G01R33/5608 ,  G06T7/12 ,  G06T2207/10088 ,  G06T2207/30016

    摘要： A medical imaging processing method includes: using an imaging method to acquire at least first and second data sets of a region of interest of a patient's body, with at least one image acquisition parameter being changed so that first and second data sets yield different contrast levels relating to different substance and/or tissue types, and wherein the at least one acquisition parameter used to obtain the first data set is selected to enhance the contrast between one of the substance and/or tissue types relative to other substance and/or tissue types, and the at least one acquisition parameter used to obtain the second data set is selected to enhance the contrast between a different one of the substance and/or tissue types relative other substance and/or tissue types, thereby to optimize the contrast between at least three different substance and/or tissue types: and processing the two data sets to identify the different tissue types and/or boundaries therebetween.

    摘要翻译： 医疗成像处理方法包括：使用成像方法来获取患者身体的至少一个感兴趣区域的数据集，其中至少一个图像获取参数被改变，使得第一和第二数据组产生不同的对比度 涉及不同的物质和/或组织类型，并且其中用于获得第一数据集的至少一个采集参数被选择以增强物质和/或组织类型之一相对于其他物质和/或组织类型之间的对比度 ，并且选择用于获得第二数据集的至少一个采集参数以增强物质和/或组织类型之间的不同物质与其他物质和/或组织类型之间的对比度，从而优化至少 三种不同的物质和/或组织类型：并处理两个数据集以识别其间的不同组织类型和/或边界。