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    Molded protein material in form of pellet for sensor
    2.
    发明授权
    Molded protein material in form of pellet for sensor 有权
    用于传感器的颗粒形式的成型蛋白质材料

    公开(公告)号：US08137927B2

    公开(公告)日：2012-03-20

    申请号：US11122172

    申请日：2005-05-04

    申请人： Rajiv Shah ,  Bahar Reghabi ,  Rudy Montalvo ,  Yanan Zhang

    发明人： Rajiv Shah ,  Bahar Reghabi ,  Rudy Montalvo ,  Yanan Zhang

    IPC分类号： C12Q1/26 ,  C12Q1/54 ,  C12N11/02 ,  C12M1/34

    CPC分类号： C07K1/1077 ,  C12Q1/54 ,  Y10S435/817

    摘要： A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.

    摘要翻译： 一种用于配制和固定由该方法形成的蛋白质和蛋白质基质的方法。 蛋白质基质制备方法产生物理和化学稳定的蛋白质基质，其具有低溶胀，非浸出，高活性和高机械强度性质。 该方法包括将蛋白质混合物交联并硬化，并使用模具将蛋白质形成所需的形状和尺寸。

    Method and apparatus for enhancing the integrity of an implantable sensor device
    3.
    发明授权
    Method and apparatus for enhancing the integrity of an implantable sensor device 有权
    用于增强可植入传感器装置完整性的方法和装置

    公开(公告)号：US07162289B2

    公开(公告)日：2007-01-09

    申请号：US10335574

    申请日：2002-12-31

    申请人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

    发明人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

    IPC分类号： A61B5/00 ,  A61B5/05 ,  C12M1/00 ,  C12Q1/00

    CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B5/686 ,  A61B2562/02 ,  G01N33/5438 ,  Y10T29/49002 ,  Y10T29/49007 ,  Y10T29/49128 ,  Y10T29/49155

    摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.

    摘要翻译： 一种用于增强可植入传感器的完整性的方法和装置。 形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。 传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。 可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。 通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。 涂层可沉积在传感器引线的表面上，提供加强和润滑。

    Method of forming a molded protein matrix for a sensor
    4.
    发明授权
    Method of forming a molded protein matrix for a sensor 有权
    形成用于传感器的模制蛋白质基质的方法

    公开(公告)号：US08187851B2

    公开(公告)日：2012-05-29

    申请号：US12179502

    申请日：2008-07-24

    申请人： Rajiv Shah ,  Bahar Reghabi ,  Rudy Montalvo ,  Yanan Zhang

    发明人： Rajiv Shah ,  Bahar Reghabi ,  Rudy Montalvo ,  Yanan Zhang

    IPC分类号： C12N11/02 ,  C12Q1/54 ,  C12Q1/26 ,  C12M1/34

    CPC分类号： C07K1/1077 ,  C12Q1/54 ,  Y10S435/817

    摘要： A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.

    摘要翻译： 一种用于配制和固定由该方法形成的蛋白质和蛋白质基质的方法。 蛋白质基质制备方法产生物理和化学稳定的蛋白质基质，其具有低溶胀，非浸出，高活性和高机械强度性质。 该方法包括将蛋白质混合物交联并硬化，并使用模具将蛋白质形成所需的形状和尺寸。

    Method of forming a molded protein matrix for use in a sensor
    5.
    发明授权
    Method of forming a molded protein matrix for use in a sensor 有权
    形成用于传感器的模制蛋白质基质的方法

    公开(公告)号：US07435569B2

    公开(公告)日：2008-10-14

    申请号：US10911172

    申请日：2004-08-03

    申请人： Rajiv Shah ,  Bahar Reghabi ,  Rudy Montalvo ,  Yanan Zhang

    发明人： Rajiv Shah ,  Bahar Reghabi ,  Rudy Montalvo ,  Yanan Zhang

    IPC分类号： C12N11/02 ,  C12Q1/54 ,  C12Q1/26 ,  C12M1/34

    CPC分类号： C07K1/1077 ,  C12Q1/54 ,  Y10S435/817

    摘要： A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.

    摘要翻译： 一种用于配制和固定由该方法形成的蛋白质和蛋白质基质的方法。 蛋白质基质制备方法产生物理和化学稳定的蛋白质基质，其具有低溶胀，非浸出，高活性和高机械强度性质。 该方法包括将蛋白质混合物交联并硬化，并使用模具将蛋白质形成所需的形状和尺寸。

    Sensor containing molded solidified protein
    8.
    发明授权
    Sensor containing molded solidified protein 有权
    含有成型凝固蛋白的传感器

    公开(公告)号：US07192766B2

    公开(公告)日：2007-03-20

    申请号：US10033723

    申请日：2001-12-27

    申请人： Rajiv Shah ,  Bahar Reghabi ,  Rudy Montalvo ,  Yanan Zhang

    发明人： Rajiv Shah ,  Bahar Reghabi ,  Rudy Montalvo ,  Yanan Zhang

    IPC分类号： C12M1/34 ,  C12Q1/54 ,  C12Q1/26 ,  C12N11/02

    CPC分类号： C07K1/1077 ,  C12Q1/54 ,  Y10S435/817

    摘要： A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.

    摘要翻译： 一种用于配制和固定由该方法形成的蛋白质和蛋白质基质的方法。 蛋白质基质制备方法产生物理和化学稳定的蛋白质基质，其具有低溶胀，非浸出，高活性和高机械强度性质。 该方法包括将蛋白质混合物交联并硬化，并使用模具将蛋白质形成所需的形状和尺寸。

    Method and apparatus for enhancing the integrity of an implantable sensor device
    9.
    发明申请
    Method and apparatus for enhancing the integrity of an implantable sensor device 有权
    用于增强可植入传感器装置完整性的方法和装置

    公开(公告)号：US20050049641A1

    公开(公告)日：2005-03-03

    申请号：US10928863

    申请日：2004-08-26

    申请人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

    发明人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

    IPC分类号： A61B5/00 ,  A61N1/00 ,  C12Q1/68

    CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B5/686 ,  A61B2562/02 ,  G01N33/5438 ,  Y10T29/49002 ,  Y10T29/49007 ,  Y10T29/49128 ,  Y10T29/49155

    摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.

    摘要翻译： 一种用于增强可植入传感器的完整性的方法和装置。 形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。 传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。 可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。 通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。 涂层可沉积在传感器引线的表面上，提供加强和润滑。