公开(公告)号：US20070078319A1

公开(公告)日：2007-04-05

申请号：US11606837

申请日：2006-11-30

申请人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

发明人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

IPC分类号： A61B5/05 ,  A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B5/686 ,  A61B2562/02 ,  G01N33/5438 ,  Y10T29/49002 ,  Y10T29/49007 ,  Y10T29/49128 ,  Y10T29/49155

摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.

公开(公告)号：US20050049641A1

公开(公告)日：2005-03-03

申请号：US10928863

申请日：2004-08-26

申请人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

发明人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

IPC分类号： A61B5/00 ,  A61N1/00 ,  C12Q1/68

CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B5/686 ,  A61B2562/02 ,  G01N33/5438 ,  Y10T29/49002 ,  Y10T29/49007 ,  Y10T29/49128 ,  Y10T29/49155

摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.

摘要翻译： 一种用于增强可植入传感器的完整性的方法和装置。 形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。 传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。 可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。 通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。 涂层可沉积在传感器引线的表面上，提供加强和润滑。

公开(公告)号：US07162289B2

公开(公告)日：2007-01-09

申请号：US10335574

申请日：2002-12-31

申请人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

发明人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

IPC分类号： A61B5/00 ,  A61B5/05 ,  C12M1/00 ,  C12Q1/00

CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B5/686 ,  A61B2562/02 ,  G01N33/5438 ,  Y10T29/49002 ,  Y10T29/49007 ,  Y10T29/49128 ,  Y10T29/49155

摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.

摘要翻译： 一种用于增强可植入传感器的完整性的方法和装置。 形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。 传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。 可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。 通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。 涂层可沉积在传感器引线的表面上，提供加强和润滑。

公开(公告)号：US07912525B2

公开(公告)日：2011-03-22

申请号：US11606837

申请日：2006-11-30

申请人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

发明人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

IPC分类号： A61B5/00 ,  A61B5/05

CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B5/686 ,  A61B2562/02 ,  G01N33/5438 ,  Y10T29/49002 ,  Y10T29/49007 ,  Y10T29/49128 ,  Y10T29/49155

摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.

摘要翻译： 一种用于增强可植入传感器的完整性的方法和装置。 形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。 传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。 可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。 通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。 涂层可沉积在传感器引线的表面上，提供加强和润滑。

公开(公告)号：US07552522B2

公开(公告)日：2009-06-30

申请号：US10928863

申请日：2004-08-26

申请人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

发明人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

IPC分类号： G01R3/00

CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B5/686 ,  A61B2562/02 ,  G01N33/5438 ,  Y10T29/49002 ,  Y10T29/49007 ,  Y10T29/49128 ,  Y10T29/49155

摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.

摘要翻译： 一种用于增强可植入传感器的完整性的方法和装置。 形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。 传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。 可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。 通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。 涂层可沉积在传感器引线的表面上，提供加强和润滑。

公开(公告)号：US20070079836A1

公开(公告)日：2007-04-12

申请号：US11610269

申请日：2006-12-13

申请人： Bahar Reghabi ,  Rajiv Shah ,  Eunjoo Jin ,  Rebecca Gottlieb ,  Michael Miller ,  Nannette Van Antwerp ,  Bradley Enegren ,  William Van Antwerp ,  John Mastrototaro

发明人： Bahar Reghabi ,  Rajiv Shah ,  Eunjoo Jin ,  Rebecca Gottlieb ,  Michael Miller ,  Nannette Van Antwerp ,  Bradley Enegren ,  William Van Antwerp ,  John Mastrototaro

IPC分类号： A61B19/00

CPC分类号： A61B5/14532 ,  A61B5/076 ,  A61B5/14503 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61M39/0208

摘要： A reusable analyte sensor site for use with a replaceable analyte sensor for determining a level of an analyte includes a site housing and a resealable insertion site coupled to one end of the site housing. Preferably, the site housing is formed to have an interior cavity, and includes an outer membrane made of a material selected to promote vascularization and having a first pore size, and an inner membrane made of a material selected to be free of tissue ingress. Also, the site housing permits the analyte to pass through the site housing to the interior cavity to permit measurement by the replaceable analyte sensor. The resealable insertion site is provided for inserting the replaceable analyte sensor into the interior cavity of the site housing.

摘要翻译： 与用于确定分析物水平的可更换分析物传感器一起使用的可重复使用的分析物传感器位点包括与站点外壳的一端连接的现场外壳和可重新密封的插入位置。 优选地，所述部位壳体形成为具有内部空腔，并且包括由选择用于促进血管形成并具有第一孔径的材料制成的外膜和由选择为不具有组织进入的材料制成的内膜。 此外，现场外壳允许分析物通过现场外壳进入内腔，以允许通过可更换的分析物传感器进行测量。 可重新密封的插入位置用于将可更换的分析物传感器插入到现场外壳的内部空腔中。

公开(公告)号：US20050272989A1

公开(公告)日：2005-12-08

申请号：US10861837

申请日：2004-06-04

申请人： Rajiv Shah ,  Bahar Reghabi ,  Rebecca Gottlieb ,  Udo Hoss ,  John Mastrototaro

发明人： Rajiv Shah ,  Bahar Reghabi ,  Rebecca Gottlieb ,  Udo Hoss ,  John Mastrototaro

IPC分类号： A61B5/00 ,  C12Q1/00 ,  C12Q1/26 ,  G01N27/30 ,  G01N33/49 ,  A61B5/05 ,  G01N27/26 ,  G01N33/50

CPC分类号： C12Q1/006 ,  A61B5/14532 ,  A61B5/1486 ,  C12Q1/005 ,  C12Q1/26 ,  G01N33/4905

摘要： Embodiments of the invention provide analyte sensors having stabilized coating compositions and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having stabilized glucose oxidase coatings.

摘要翻译： 本发明的实施方案提供了具有稳定的涂料组合物的分析物传感器和用于制造和使用这种传感器 示例性实施方案包括具有稳定的葡萄糖氧化酶涂层的电化学葡萄糖传感器。

公开(公告)号：US07247138B2

公开(公告)日：2007-07-24

申请号：US10365279

申请日：2003-02-12

申请人： Bahar Reghabi ,  Rajiv Shah ,  Eunjoo Jin ,  Rebecca Gottlieb ,  Michael E. Miller ,  Nannette M. Van Antwerp ,  Bradley J. Enegren ,  William P. Van Antwerp ,  John J. Mastrototaro

发明人： Bahar Reghabi ,  Rajiv Shah ,  Eunjoo Jin ,  Rebecca Gottlieb ,  Michael E. Miller ,  Nannette M. Van Antwerp ,  Bradley J. Enegren ,  William P. Van Antwerp ,  John J. Mastrototaro

IPC分类号： A61B5/00 ,  A61B19/00 ,  A61M5/32

CPC分类号： A61B5/14532 ,  A61B5/076 ,  A61B5/14503 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61M39/0208

摘要： A reusable analyte sensor site for use with a replaceable analyte sensor for determining a level of an analyte includes a site housing material and a resealable insertion site coupled to one end of the site housing material. Preferably, the site housing material is formed to have an interior cavity with an opening. The site housing material is selected to promote tissue ingrowth and vascularization, and yet be free of tissue ingress. Also, the site housing material permits the analyte to pass through the site housing material to the interior cavity to permit measurement by the replaceable analyte sensor. The resealable insertion site provides a for inserting the replaceable analyte sensor into the interior cavity of the site housing material.

摘要翻译： 与用于确定分析物水平的可更换分析物传感器一起使用的可重复使用的分析物传感器位点包括与场地外壳材料的一端连接的部位外壳材料和可重新密封的插入位置。 优选地，所述场地外壳材料形成为具有带有开口的内部空腔。 选择场地外壳材料以促进组织向内生长和血管形成，并且没有组织进入。 此外，现场外壳材料允许分析物通过现场外壳材料通过内部空腔，以允许通过可更换的分析物传感器进行测量。 可重新密封的插入位置提供用于将可更换的分析物传感器插入到场地外壳材料的内部空腔中。

公开(公告)号：US20050148832A1

公开(公告)日：2005-07-07

申请号：US10746129

申请日：2003-12-26

申请人： Bahar Reghabi ,  Rebecca Gottlieb ,  Rajiv Shah ,  Bradley Enegren ,  William Van Antwerp

发明人： Bahar Reghabi ,  Rebecca Gottlieb ,  Rajiv Shah ,  Bradley Enegren ,  William Van Antwerp

IPC分类号： A61B5/00 ,  A61B5/0215 ,  A61N1/30 ,  A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/14551 ,  A61B5/1459 ,  A61B5/412 ,  A61B5/4839 ,  A61B5/6852 ,  A61B2562/063

摘要： An apparatus for sensing multiple parameters includes an implantable housing and a plurality of implantable sensors disposed within the implantable housing. The plurality of implantable sensors sense parameters in a patient, such as biological or physiological parameters, for example, and each responds to an analyte in the patient. The plurality of implantable sensors may include, but is not limited to, electrochemical, potentiometric, current and optical sensors.

摘要翻译： 用于感测多个参数的装置包括可植入的壳体和设置在可植入壳体内的多个可植入传感器。 多个可植入传感器感测患者中的参数，例如生物或生理参数，并且各自对患者中的分析物进行响应。 多个可植入传感器可以包括但不限于电化学，电位，电流和光学传感器。

公开(公告)号：US07166074B2

公开(公告)日：2007-01-23

申请号：US10452521

申请日：2003-06-02

申请人： Bahar Reghabi ,  Rajiv Shah ,  Eunjoo Jin ,  Rebecca Gottlieb ,  Michael E. Miller ,  Nannette M. Van Antwerp ,  Bradley J. Enegren ,  William P. Van Antwerp ,  John J. Mastrototaro

发明人： Bahar Reghabi ,  Rajiv Shah ,  Eunjoo Jin ,  Rebecca Gottlieb ,  Michael E. Miller ,  Nannette M. Van Antwerp ,  Bradley J. Enegren ,  William P. Van Antwerp ,  John J. Mastrototaro

IPC分类号： A61B5/00 ,  A61B5/05

CPC分类号： A61B5/14532 ,  A61B5/076 ,  A61B5/14503 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61M39/0208

摘要： A reusable analyte sensor site for use with a replaceable analyte sensor for determining a level of an analyte includes a site housing and a resealable insertion site coupled to one end of the site housing. Preferably, the site housing is formed to have an interior cavity, and includes an outer membrane made of a material selected to promote vascularization and having a first pore size, and an inner membrane made of a material selected to be free of tissue ingress. Also, the site housing permits the analyte to pass through the site housing to the interior cavity to permit measurement by the replaceable analyte sensor. The resealable insertion site is provided for inserting the replaceable analyte sensor into the interior cavity of the site housing.

摘要翻译： 与用于确定分析物水平的可更换分析物传感器一起使用的可重复使用的分析物传感器位点包括与站点外壳的一端连接的现场外壳和可重新密封的插入位置。 优选地，所述部位壳体形成为具有内部空腔，并且包括由选择用于促进血管形成并具有第一孔径的材料制成的外膜和由选择为不具有组织进入的材料制成的内膜。 此外，现场外壳允许分析物通过现场外壳进入内腔，以允许通过可更换的分析物传感器进行测量。 可重新密封的插入位置用于将可更换的分析物传感器插入到现场外壳的内部空腔中。