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1.发明申请Pharmaceutical Or Cosmetic Or Dietetic Composition Suitable For Promoting A Hair Pigmentation Effect 审中-公开适用于促进头发着色作用的药物或化妆品或饮食组合物公开(公告)号：US20120121705A1
公开(公告)日：2012-05-17
申请号：US13387352
申请日：2010-07-29
申请人： Ralf Paus , Giammaria Giuliani , Yuval Ramot , Astrid Becker , Sergio Baroni
发明人： Ralf Paus , Giammaria Giuliani , Yuval Ramot , Astrid Becker , Sergio Baroni
IPC分类号： A61K8/41 , A61Q5/02 , A61Q5/06 , A61K8/02 , C07C211/13
CPC分类号： A61K8/41 , A61K8/0212 , A61K8/0225 , A61K8/11 , A61K2800/222 , A61K2800/74 , A61K2800/92 , A61Q5/00 , A61Q5/002 , A61Q5/02 , A61Q5/12
摘要： The invention relates to the use of spermidine or a pharmaceutically acceptable derivative thereof as the active principle in a pharmaceutical, cosmetic or dietetic composition. The composition is used for promoting pigmentation of the hair, particularly the shaft of the hair. The invention also relates to the composition which promotes this pigmentation effect, the composition containing spermidine or a derivative thereof (such as a salt) as an active principle and is intended for topical or oral administration.
摘要翻译： 本发明涉及亚精胺或其药学上可接受的衍生物作为药物，化妆品或饮食组合物中的活性成分的用途。 该组合物用于促进头发，特别是头发的色素沉着。 本发明还涉及促进这种色素沉着效应的组合物，含有亚精胺或其衍生物（例如盐）的组合物作为活性成分并用于局部或口服给药。
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2.发明授权Compounds with a skin pigmenting activity and pharmaceutical or cosmetic compositions containing them 有权具有皮肤着色活性的化合物和含有它们的药物或化妆品组合物公开(公告)号：US09192595B2
公开(公告)日：2015-11-24
申请号：US13807970
申请日：2011-07-15
申请人： Giammaria Giuliani , Ralf Paus , Yuval Ramot , Astrid Becker , Sergio Baroni
发明人： Giammaria Giuliani , Ralf Paus , Yuval Ramot , Astrid Becker , Sergio Baroni
IPC分类号： A61K31/232 , A61K8/36 , A61K8/37 , A61K31/202 , A61Q17/04 , A61Q19/04 , A61K31/192
CPC分类号： A61K31/232 , A61K8/361 , A61K8/37 , A61K31/192 , A61K31/202 , A61Q17/04 , A61Q19/04
摘要： The present invention relates to compounds having general formula (I): CH3—(CH═CH)n—R (I) where: n=3, 5, 7; R is chosen from —CH2—O—CO—R′, —CO—OR′ or —CO—O(−), R′ is chosen from H, C1-C22 alkyl or alkenyl, aryl or aralkyl, or sugars; and their pharmaceutically acceptable salts, such as sodium, potassium and lysine salts, for use as the active ingredient in pharmaceutical or cosmetic compositions for improving the pigmentation of the human skin, treating pigmentation disorders and/or improve both the photoprotective capacity of the skin and the intensity of its suntan.
摘要翻译： 本发明涉及具有通式（I）的化合物：CH 3 - （CH = CH）n -R（I）其中：n = 3,5,7; R选自-CH 2 -O-CO-R'，-CO-OR'或-CO-O（ - ），R'选自H，C 1 -C 22烷基或烯基，芳基或芳烷基或糖; 和其药学上可接受的盐，例如钠，钾和赖氨酸盐，用作药物或化妆品组合物中的活性成分，用于改善人皮肤的色素沉着，治疗色素沉着紊乱和/或改善皮肤的光保护能力和 其防晒的强度。
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3.发明申请Compounds with a Skin Pigmenting Activity And Pharmaceutical or Cosmetic Compositions Containing Them 有权具有皮肤色素活性的化合物和含有它们的药物或化妆品组合物公开(公告)号：US20130108564A1
公开(公告)日：2013-05-02
申请号：US13807970
申请日：2011-07-15
申请人： Giammaria Giuliani , Ralf Paus , Yuval Ramot , Astrid Becker , Sergio Baroni
发明人： Giammaria Giuliani , Ralf Paus , Yuval Ramot , Astrid Becker , Sergio Baroni
IPC分类号： A61K31/232 , A61K8/37 , A61K31/202 , A61K8/36 , A61K31/192
CPC分类号： A61K31/232 , A61K8/361 , A61K8/37 , A61K31/192 , A61K31/202 , A61Q17/04 , A61Q19/04
摘要： The present invention relates to compounds having general formula (I): CH3—(CH═CH)n—R (I) where: n=3, 5, 7; R is chosen from —CH2—O—CO—R′, —CO—OR′ or —CO—O(−), R′ is chosen from H, C1-C22 alkyl or alkenyl, aryl or aralkyl, or sugars; and their pharmaceutically acceptable salts, such as sodium, potassium and lysine salts, for use as the active ingredient in pharmaceutical or cosmetic compositions for improving the pigmentation of the human skin, treating pigmentation disorders and/or improve both the photoprotective capacity of the skin and the intensity of its suntan.
摘要翻译： 本发明涉及具有通式（I）的化合物：CH 3 - （CH = CH）n -R（I）其中：n = 3,5,7; R选自-CH 2 -O-CO-R'，-CO-OR'或-CO-O（ - ），R'选自H，C 1 -C 22烷基或烯基，芳基或芳烷基或糖; 和其药学上可接受的盐，例如钠，钾和赖氨酸盐，用作药物或化妆品组合物中的活性成分，用于改善人皮肤的色素沉着，治疗色素沉着紊乱和/或改善皮肤的光保护能力和 其防晒的强度。
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公开(公告)号：US09668984B2
公开(公告)日：2017-06-06
申请号：US13128394
申请日：2009-11-10
申请人： Giammaria Giuliani , Anna Benedusi , Sergio Baroni
发明人： Giammaria Giuliani , Anna Benedusi , Sergio Baroni
IPC分类号： A61K31/202 , C07C57/03 , C07C33/02 , A61K31/045 , A61K31/11 , A61K31/22 , A61K31/231 , A61K31/232
CPC分类号： A61K31/11 , A61K31/045 , A61K31/22 , A61K31/231 , A61K31/232
摘要： The object of the present invention is the use of compounds designed to inhibit the activity of the enzyme 5α-reductase. This is a novel use of compounds of general formula (I): CH3(—CH═CH)n—R (I) where n=from 2 to 7, and R is chosen from among: CHO, CH2OH, CH2O—CO—R′, CO—O(−), where R′ is chosen from among H, and the alky from C1 to C22, each compound of general formula (I) being used as such or in mixtures with other compounds, as the active principle in a pharmaceutical or cosmetic composition designed to inhibit the action of the enzyme 5α-reductase, and of the pharmaceutical or cosmetic compositions deriving therefrom.
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5.发明授权Therapeutic, dietary or cosmetic use of compounds with specific anti-apoptotic activity toward caspase-3, and compositions containing these compounds 有权对胱天蛋白酶-3具有特异性抗凋亡活性的化合物的治疗，膳食或化妆品用途以及含有这些化合物的组合物公开(公告)号：US08729033B2
公开(公告)日：2014-05-20
申请号：US13127446
申请日：2009-10-30
申请人： Giammaria Giuliani , Anna Benedusi , Sergio Baroni
发明人： Giammaria Giuliani , Anna Benedusi , Sergio Baroni
IPC分类号： A61K31/047 , C07H17/07
CPC分类号： C07H17/07
摘要： This invention regards the use of zeaxanthin and/or rutin, as such or further combined with spermidine, as the active principle in a pharmaceutical, dietary, or cosmetic composition, acting to inhibit caspase-3 and therefore to control apoptosis by preventing programmed cell death.The indication for this composition according to the invention is primarily the treatment of scalp disorders characterized by excessive cellular turnover including chemotherapy-induced alopecia, alopecia areata, androgenetic alopecia and telogen effluvium.
摘要翻译： 本发明涉及玉米黄质和/或芦丁，或与亚精胺进一步联合作为药物，膳食或化妆品组合物中的活性成分，用于抑制胱天蛋白酶-3，因此通过预防程序性细胞死亡来控制凋亡 。 根据本发明的该组合物的适应症主要是治疗特征在于过度细胞周转的头皮疾病，包括化疗诱导的脱发，斑秃，雄激素性脱发和休止期脱落。
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公开(公告)号：US20140030207A1
公开(公告)日：2014-01-30
申请号：US14111661
申请日：2012-04-13
CPC分类号： A61K8/553 , A61K8/735 , A61K8/87 , A61K2800/5426 , A61K2800/594 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q7/00 , A61Q19/10
摘要： The present invention relates to a system for the release of cosmetic agents comprising at least one phospholipid, hyaluronic acid or derivatives thereof and a cationic polyurethane derivative. The system of the invention may be used in the formulation of cosmetic preparations for obtaining the protracted release of cosmetic agents or active substances to the epidermis or the keratinic structures of the human body, with a simultaneous reduction in the frequency of application.
摘要翻译： 本发明涉及包含至少一种磷脂，透明质酸或其衍生物和阳离子聚氨酯衍生物的化妆品的释放系统。 本发明的系统可以用于化妆品制剂的制剂中，以获得化妆品或活性物质向人体表皮或角质结构的延长释放，同时降低施用频率。
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7.发明申请FERMENTED SOYA BASED MIXTURE COMPRISING ISOFLAVONES- AGLICONES, EQUOL AND LUNASIL, PROCESS FOR THE PREPARATION AND USES THEREOF IN FOOD, MEDICAL AND COSMETIC FIELDS 审中-公开包含ISOFLAVONES- AGLICONES，EQUOL和LUNASIL的基于大豆的混合物，其在食品，医疗和化妆品领域中的制备及其用途的方法公开(公告)号：US20130231291A1
公开(公告)日：2013-09-05
申请号：US13806746
申请日：2011-07-11
申请人： Giammaria Giuliani , Anna Benedusi , Marco Gobbetti , Raffaella Di Cagno , Sergio Baroni , Carlo Giuseppe Rizzello
发明人： Giammaria Giuliani , Anna Benedusi , Marco Gobbetti , Raffaella Di Cagno , Sergio Baroni , Carlo Giuseppe Rizzello
CPC分类号： C12P21/00 , A23C11/106 , A23L11/09 , A23L33/105 , A23L33/135 , A23V2002/00 , A23Y2220/35 , A23Y2220/67 , A23Y2220/73 , A61K8/645 , A61K8/97 , A61K31/352 , A61K31/353 , A61K35/747 , A61K36/48 , A61K38/168 , A61Q7/00 , A61Q19/00 , C12N1/20 , C12R1/225 , C12R1/25 , A61K2300/00 , A23V2200/318 , A23V2200/32 , A23V2200/324
摘要： The present invention concerns a mixture comprising isoflavones-aglicones, such as daidzein, genistein and glycitein, in addition to equol and lunasin, said mixture being based on soya fermented using lactic acid bacteria isolated from food matrices and use of said mixture for protection of skin and similar and of human intestinal cells with particular reference to prevention of inflammatory state and protection of barrier functions and hair loss treatment.
摘要翻译： 本发明涉及除了雌马酚和lunasin之外，还含有黄豆苷元，染料木黄酮和黄豆黄素等异黄酮 - 琼脂糖的混合物，所述混合物基于使用从食品基质分离的乳酸菌发酵的大豆，并使用所述混合物保护皮肤 以及类似的人类肠细胞，特别是关于预防炎症状态和保护屏障功能和脱发治疗。
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公开(公告)号：US20130102712A1
公开(公告)日：2013-04-25
申请号：US13806754
申请日：2011-06-23
IPC分类号： C08G65/00
CPC分类号： C08G65/00 , A61K8/19 , A61K8/24 , A61K8/27 , A61K8/365 , A61K8/676 , A61K8/70 , A61K8/732 , A61K8/8111 , A61Q17/04 , A61Q19/00
摘要： The present invention relates, in one aspect, to an adduct of formula O-PF-A, in which O is an oil; PF is a perfluoropolyether phosphate (PFPE phosphate); A is at least one substance selected from: (X) a water-soluble polyhydroxylated substance and (Y) a water-insoluble inorganic substance and to topical applications thereof in particular in the cosmetic and pharmaceutical field.
摘要翻译： 本发明一方面涉及式O-PF-A的加合物，其中O是油; PF是全氟聚醚磷酸盐（PFPE磷酸盐）; A是选自：（X）水溶性多羟基化物质和（Y）水不溶性无机物质中的至少一种物质，特别是在化妆品和药物领域中的局部应用。
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9.发明申请DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM 审中-公开用于人体细胞修复的二烯化合物和含有它们的药物和化妆品组合物公开(公告)号：US20110224298A1
公开(公告)日：2011-09-15
申请号：US13128393
申请日：2009-11-10
申请人： Giammaria Giuliani , Anna Benedusi , Sergio Baroni
发明人： Giammaria Giuliani , Anna Benedusi , Sergio Baroni
IPC分类号： A61K31/22 , A61K31/20 , A61K31/045 , A61P43/00
CPC分类号： A61K31/045 , A61K8/342 , A61K8/361 , A61K8/37 , A61K31/11 , A61K31/202 , A61K31/22 , A61K31/23 , A61K31/231 , A61K31/232 , A61P17/00 , A61P17/10 , A61P17/16 , A61Q17/04 , A61Q19/00 , A61Q19/08
摘要： The present invention relates to a novel use of compounds having the general formula (I): CH3(—CH═CH)n—R (I) where n=from 2 to 7, and R is chosen from among: CHO, CH2OH, CH2O—CO—R′, CO—OR′, CO—O(−), where R′ is chosen from among H, the alkyl from C1 to C22, each compound of general formula (I) being used as such or in a mixture, as an active principle in a pharmaceutical or cosmetic composition to improve the human epidermal cell repair activity by means of the production of keratin mediated by the cytokeratins cK-19.
摘要翻译： 本发明涉及具有通式（I）的化合物的新用途：CH 3（-CH = CH）n -R（I）其中n = 2-7，R选自：CHO，CH 2 OH， CH 2 CO-R'，CO-OR'，CO-O（ - ），其中R'选自H，C1至C22的烷基，通式（I）的每种化合物原样使用或在 混合物作为药物或化妆品组合物中的活性成分，以通过由细胞角蛋白cK-19介导的角蛋白的产生来改善人表皮细胞修复活性。
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10.发明申请USE OF COMPOUNDS TO INHIBIT 5A-REDUCTASE ENZYME ACTIVITY, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM 有权使用化合物抑制5A降低酶活性，以及含有它们的药物和化妆品组合物公开(公告)号：US20110218245A1
公开(公告)日：2011-09-08
申请号：US13128394
申请日：2009-11-10
申请人： Giammaria Giuliani , Anna Benedusi , Sergio Baroni
发明人： Giammaria Giuliani , Anna Benedusi , Sergio Baroni
IPC分类号： A61K31/202 , C07C57/03 , C07C33/02 , A61K31/045 , C07C47/21 , A61K31/11 , C07C69/24 , A61K31/23 , A61P17/00 , A61P17/10 , A61P17/08 , A61P17/14
CPC分类号： A61K31/11 , A61K31/045 , A61K31/22 , A61K31/231 , A61K31/232
摘要： The object of the present invention is the use of compounds designed to inhibit the activity of the enzyme 5α-reductase. This is a novel use of compounds of general formula (I): CH3(—CH═CH)n—R (I) where n=from 2 to 7, and R is chosen from among: CHO, CH2OH, CH2O—CO—R′, CO—O(−), where R′ is chosen from among H, and the alky from C1 to C22, each compound of general formula (I) being used as such or in mixtures with other compounds, as the active principle in a pharmaceutical or cosmetic composition designed to inhibit the action of the enzyme 5α-reductase, and of the pharmaceutical or cosmetic compositions deriving therefrom.
摘要翻译： 本发明的目的是使用旨在抑制酶5α-还原酶活性的化合物。 这是通式（I）的化合物的新用途：CH 3（-CH = CH）n -R（I）其中n = 2-7，R选自：CHO，CH 2 OH，CH 2 O-CO- R'，CO-O（ - ），其中R'选自H，和C1至C22的烷基，通式（I）的每种化合物原样使用或与其它化合物的混合物作为活性成分 在设计用于抑制酶5α-还原酶的作用的药物或化妆品组合物中，以及由其衍生的药物或化妆品组合物。
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