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1.发明授权Combination degradable and non-degradable matrices for active agent delivery 有权用于活性剂递送的组合可降解和不可降解的基质公开(公告)号：US08968782B2
公开(公告)日：2015-03-03
申请号：US11770316
申请日：2007-06-28
IPC分类号： A61K47/30 , A61K38/02 , A61K9/00 , A61K39/395 , A61K45/00 , A61L27/58 , A61L27/48 , A61L27/54 , C08L23/08 , C08L33/08 , C08L71/02
CPC分类号： A61L27/58 , A61L27/48 , A61L27/54 , A61L2300/252 , A61L2300/256 , A61L2300/604 , C08L23/0853 , C08L23/0869 , C08L33/08 , C08L71/02 , C08L2201/06 , C08L2666/22
摘要： The present invention relates to relates to combination degradable and non-degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix including a degradable polymer network, a non-degradable polymer network, the non-degradable polymer network interspersed within the degradable polymer network, and an active agent. In an embodiment, the invention includes an active agent elution control matrix including a degradable polymer; and a non-degradable polymer interspersed with the degradable polymer. In an embodiment, the invention includes a method of making an active agent delivery matrix including mixing a degradable polymer with a first solvent to form a degradable polymer solution; mixing a non-degradable polymer with a second solvent to form a non-degradable polymer solution; and simultaneously depositing the degradable polymer solution and the non-degradable polymer solution onto a substrate.
摘要翻译： 本发明涉及可降解和不可降解的基质和相关方法。 在一个实施方案中，本发明包括活性剂递送基质，其包括可降解聚合物网络，不可降解聚合物网络，散布在可降解聚合物网络内的不可降解聚合物网络和活性剂。 在一个实施方案中，本发明包括包含可降解聚合物的活性剂洗脱控制基质; 和散布有可降解聚合物的不可降解聚合物。 在一个实施方案中，本发明包括制备活性剂递送基质的方法，包括将可降解聚合物与第一溶剂混合以形成可降解聚合物溶液; 将不可降解的聚合物与第二溶剂混合以形成不可降解的聚合物溶液; 同时将可降解聚合物溶液和不可降解聚合物溶液沉积在基材上。
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公开(公告)号：US20100008966A1
公开(公告)日：2010-01-14
申请号：US12502473
申请日：2009-07-14
IPC分类号： A61K9/14 , A61K31/7088 , A61K9/00 , A61K31/7105 , A61P35/00
CPC分类号： A61L27/54 , A61K48/0041 , A61L27/34 , A61L2300/258 , A61L2300/606
摘要： Embodiments of the invention include devices for the release of nucleic acids and related methods. In an embodiment, the invention includes an active agent eluting coating including a polymeric matrix, a cationic carrier agent disposed with the matrix, and an active agent disposed within the matrix, the active agent including nucleic acids substantially uncomplexed with the cationic carrier agent. In an embodiment, the invention includes a method of making an implantable medical device including selecting a concentration of a cationic carrier agent corresponding to a desired elution profile, combining a matrix forming polymer, an active agent, a solvent, and the cationic carrier agent to form a coating composition having the selected concentration of the cationic carrier agent, the active agent comprising nucleic acids, and depositing the coating composition onto the surface of a substrate. Other embodiments are included herein.
摘要翻译： 本发明的实施方案包括用于释放核酸的装置和相关方法。 在一个实施方案中，本发明包括活性剂洗脱涂层，其包括聚合物基质，与基质一起布置的阳离子载体剂和置于基质内的活性剂，所述活性剂包括与阳离子载体试剂基本上未络合的核酸。 在一个实施方案中，本发明包括制备可植入医疗装置的方法，包括选择对应于所需洗脱曲线的阳离子载体试剂的浓度，将形成基质的聚合物，活性剂，溶剂和阳离子载体试剂组合到 形成具有选定浓度的阳离子载体试剂，活性剂包含核酸并将该涂料组合物沉积在基材表面上的涂料组合物。 本文还包括其它实施例。
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公开(公告)号：US08697106B2
公开(公告)日：2014-04-15
申请号：US13242837
申请日：2011-09-23
申请人： Tim M. Kloke , Steven J. Keough , Nathan Lockwood , Margaret R. Gardner , Robert W. Hergenrother , Ralph A. Chappa
发明人： Tim M. Kloke , Steven J. Keough , Nathan Lockwood , Margaret R. Gardner , Robert W. Hergenrother , Ralph A. Chappa
CPC分类号： A61L31/16 , A61L17/005 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/406 , A61L2300/62
摘要： A wound spacer device comprising multiple beads connected by non-absorbable suture material is disclosed. The device can be applied, for example, by a first responder to an injured individual, or can be applied by a trauma treatment facility, such as a Level 2 medical unit. In typical embodiments the device allows for site-specific controlled elution of an antimicrobial agent, such as Tobramycin, including defined elution over a period of time, such as 48 or 72 hours.
摘要翻译： 公开了一种包含由不可吸收缝合材料连接的多个珠粒的伤口间隔器。 该装置可以例如由受伤个体的第一响应者应用，或者可以由诸如2级医疗单位的创伤治疗设施应用。 在典型的实施方案中，该装置允许抗微生物剂如妥布霉素的位点特异性受控洗脱，包括在一段时间内如48或72小时的定义的洗脱。
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公开(公告)号：US08685421B2
公开(公告)日：2014-04-01
申请号：US11774495
申请日：2007-07-06
申请人： Tim M. Kloke , Steven J. Keough , Nathan Lockwood , Margaret R. Gardner , Robert W. Hergenrother , Ralph A. Chappa
发明人： Tim M. Kloke , Steven J. Keough , Nathan Lockwood , Margaret R. Gardner , Robert W. Hergenrother , Ralph A. Chappa
CPC分类号： A61L31/16 , A61L17/005 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/406 , A61L2300/62
摘要： A wound spacer device comprising multiple beads connected by non-absorbable suture material is disclosed. The device can be applied, for example, by a first responder to an injured individual, or can be applied by a trauma treatment facility, such as a Level 2 medical unit. In typical embodiments the device allows for site-specific controlled elution of an antimicrobial agent, such as Tobramycin, including defined elution over a period of time, such as 48 or 72 hours.
摘要翻译： 公开了一种包含由不可吸收缝合材料连接的多个珠粒的伤口间隔器。 该装置可以例如由受伤个体的第一响应者应用，或者可以由诸如2级医疗单位的创伤治疗设施应用。 在典型的实施方案中，该装置允许抗微生物剂如妥布霉素的位点特异性受控洗脱，包括在一段时间内如48或72小时的定义的洗脱。
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公开(公告)号：US07833548B2
公开(公告)日：2010-11-16
申请号：US11207380
申请日：2005-08-19
申请人： Ralph A. Chappa , Robert W. Hergenrother , Aron B. Anderson , Linh V. Tran , Laurie R. Lawin , Ronald F. Ofstead
发明人： Ralph A. Chappa , Robert W. Hergenrother , Aron B. Anderson , Linh V. Tran , Laurie R. Lawin , Ronald F. Ofstead
IPC分类号： A61K9/14
CPC分类号： A61L31/16 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/602 , A61L2300/606
摘要： A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).
摘要翻译： 一种或多种制剂形式的涂料组合物，以及在受控湿度条件下施用这种组合物的方法，用于涂覆装置表面以控制和/或提高其在水性体系中释放生物活性剂的能力。 涂料组合物特别适用于在其递送和/或使用过程中经历显着弯曲和/或膨胀的医疗装置，例如支架和导管。 组合物包括与第一聚合物组分如（甲基）丙烯酸聚烷基酯，（甲基）丙烯酸聚芳酯，（甲基）丙烯酸聚烷基酯或（甲基）丙烯酰基烷基酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）。
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公开(公告)号：US20100158799A1
公开(公告)日：2010-06-24
申请号：US12716753
申请日：2010-03-03
申请人： Stephen J. Chudzik , Timothy M. Kloke , Laurie R. Lawin , Ronald F. Ofstead , Ralph A. Chappa , Robert W. Hergenrother , Aron B. Anderson , Linh V. Tran
发明人： Stephen J. Chudzik , Timothy M. Kloke , Laurie R. Lawin , Ronald F. Ofstead , Ralph A. Chappa , Robert W. Hergenrother , Aron B. Anderson , Linh V. Tran
IPC分类号： A61K51/00 , A61K47/32 , A61K31/7052 , A61K31/56 , A61K38/02 , A61K38/16 , A61K38/43 , A61P43/00
CPC分类号： A61L31/16 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/606 , C08L33/06
摘要： A composition for bioactive agent release in vivo. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).
摘要翻译： 生物活性剂在体内释放的组合物。 组合物包括与第一聚合物组分如聚（甲基丙烯酸丁酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）的混合物的组合的生物活性剂。
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公开(公告)号：US20120021038A1
公开(公告)日：2012-01-26
申请号：US13242837
申请日：2011-09-23
申请人： Tim M. Kloke , Steven J. Keough , Nathan Lockwood , Margaret R. Gardner , Robert W. Hergenrother , Ralph A. Chappa
发明人： Tim M. Kloke , Steven J. Keough , Nathan Lockwood , Margaret R. Gardner , Robert W. Hergenrother , Ralph A. Chappa
IPC分类号： A61K9/00 , A61K38/14 , A61P31/04 , A61K31/7036
CPC分类号： A61L31/16 , A61L17/005 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/406 , A61L2300/62
摘要： A wound spacer device comprising multiple beads connected by non-absorbable suture material is disclosed. The device can be applied, for example, by a first responder to an injured individual, or can be applied by a trauma treatment facility, such as a Level 2 medical unit. In typical embodiments the device allows for site-specific controlled elution of an antimicrobial agent, such as Tobramycin, including defined elution over a period of time, such as 48 or 72 hours.
摘要翻译： 公开了一种包含由不可吸收缝合材料连接的多个珠粒的伤口间隔器。 该装置可以例如由受伤个体的第一响应者应用，或者可以由诸如2级医疗单位的创伤治疗设施应用。 在典型的实施方案中，该装置允许抗微生物剂如妥布霉素的位点特异性受控洗脱，包括在一段时间内如48或72小时的定义的洗脱。
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公开(公告)号：US20070248637A1
公开(公告)日：2007-10-25
申请号：US11207380
申请日：2005-08-19
申请人： Ralph A. Chappa , Robert W. Hergenrother , Aron B. Anderson , Linh V. Tran , Laurie R. Lawin , Ronald F. Ofstead
发明人： Ralph A. Chappa , Robert W. Hergenrother , Aron B. Anderson , Linh V. Tran , Laurie R. Lawin , Ronald F. Ofstead
CPC分类号： A61L31/16 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/602 , A61L2300/606
摘要： A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).
摘要翻译： 一种或多种制剂形式的涂料组合物，以及在受控湿度条件下施用这种组合物的方法，用于涂覆装置表面以控制和/或提高其在水性体系中释放生物活性剂的能力。 涂层组合物特别适用于在其递送和/或使用过程中经历显着弯曲和/或膨胀的医疗装置，例如支架和导管。 组合物包括与第一聚合物组分如（甲基）丙烯酸聚烷基酯，（甲基）丙烯酸聚芳酯，（甲基）丙烯酸聚烷基酯或（甲基）丙烯酰基烷基酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）。
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公开(公告)号：US08496954B2
公开(公告)日：2013-07-30
申请号：US12386469
申请日：2009-04-17
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/232 , A61L2300/252 , A61L2300/256 , A61L2300/258 , A61L2300/608 , A61L2420/08 , C08L31/04
摘要： Described are coating systems for the controlled delivery of hydrophilic bioactive agents, for example, from implantable medical devices. The coating systems of the invention comprise (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents; and (b) an elution-controlling topcoat layer that comprises a poly(ethylene-co-vinyl acetate) copolymer. The elution rate of the hydrophilic bioactive agent can be controlled by varying the vinyl acetate concentration in the elution-controlling topcoat layer.
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公开(公告)号：US20110054417A1
公开(公告)日：2011-03-03
申请号：US12941132
申请日：2010-11-08
申请人： Ralph A. Chappa , Robert W. Hergenrother , Aron B. Anderson , Linh V. Tran , Laurie R. Lawin , Ronald F. Ofstead
发明人： Ralph A. Chappa , Robert W. Hergenrother , Aron B. Anderson , Linh V. Tran , Laurie R. Lawin , Ronald F. Ofstead
CPC分类号： A61L31/16 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/602 , A61L2300/606
摘要： A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).
摘要翻译： 一种或多种制剂形式的涂料组合物，以及在受控湿度条件下施用这种组合物的方法，用于涂覆装置表面以控制和/或提高其在水性体系中释放生物活性剂的能力。 涂层组合物特别适用于在其递送和/或使用过程中经历显着弯曲和/或膨胀的医疗装置，例如支架和导管。 组合物包括与第一聚合物组分如（甲基）丙烯酸聚烷基酯，（甲基）丙烯酸聚芳酯，（甲基）丙烯酸聚烷基酯或（甲基）丙烯酰基烷基酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）。
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