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公开(公告)号：US20050181979A1
公开(公告)日：2005-08-18
申请号：US11078507
申请日：2005-03-14
申请人： Ralph Alderson , Robert Melder , Viktor Roschke , Steven Ruben , Craig Rosen
发明人： Ralph Alderson , Robert Melder , Viktor Roschke , Steven Ruben , Craig Rosen
CPC分类号： A61K38/1866 , A61K48/00 , C07K16/22 , C07K2317/74 , C12N2799/026 , Y10S514/963 , Y10S514/964 , Y10S514/969
摘要： The present invention is directed to VEGF-2 polynucleotides and polypeptides and methods of using such polynucleotides and polypeptides. In particular, provided are methods of treating retinal disorders with VEGF-2 polynucleotides and polypeptides.
摘要翻译： 本发明涉及VEGF-2多核苷酸和多肽以及使用这些多核苷酸和多肽的方法。 特别地，提供了用VEGF-2多核苷酸和多肽治疗视网膜病症的方法。
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公开(公告)号：US20050154193A1
公开(公告)日：2005-07-14
申请号：US10994679
申请日：2004-11-23
申请人： Viktor Roschke , Craig Rosen , Steven Ruben
发明人： Viktor Roschke , Craig Rosen , Steven Ruben
IPC分类号： A61K38/00 , A61K48/00 , C07K14/715 , C07K16/24 , C07K16/46
CPC分类号： C07K14/7158 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K16/24 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.
摘要翻译： 本发明涉及一种称为人G蛋白趋化因子受体（CCR5）HDGNR10的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。 还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白质和这些新型人抗体相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20070292411A1
公开(公告)日：2007-12-20
申请号：US11745734
申请日：2007-05-08
申请人： Theodora Salcedo , Viktor Roschke , Steven Ruben , Craig Rosen
发明人： Theodora Salcedo , Viktor Roschke , Steven Ruben , Craig Rosen
CPC分类号： G01N33/57411 , A61K2039/505 , C07K16/2878 , C07K2317/73 , G01N33/57419
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptors. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TRAIL receptor antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor.
摘要翻译： 本发明涉及免疫特异性结合TRAIL受体的抗体和相关分子。 这样的抗体具有例如用于预防和治疗癌症和其它增殖性疾病的用途。 本发明还涉及编码抗TRAIL受体抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段 或其变体，或免疫特异性结合TRAIL受体的相关分子。
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公开(公告)号：US20070122405A1
公开(公告)日：2007-05-31
申请号：US11518949
申请日：2006-09-12
申请人： Viktor Roschke , Craig Rosen , Steven Ruben
发明人： Viktor Roschke , Craig Rosen , Steven Ruben
IPC分类号： G01N33/567 , C07H21/04 , C12P21/06 , A61K39/395 , C07K14/705 , C07K16/28
CPC分类号： C07K16/2866 , C07K14/7158 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N2333/715
摘要： The present invention relates to a human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this human protein and these human antibodies.
摘要翻译： 本发明涉及称为人G蛋白趋化因子受体（CCR5）HDGNR10的人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。 还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该人类蛋白质和这些人抗体相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20060062786A1
公开(公告)日：2006-03-23
申请号：US11221281
申请日：2005-09-08
申请人： Theodora Salcedo , Viktor Roschke , Steven Ruben , Craig Rosen
发明人： Theodora Salcedo , Viktor Roschke , Steven Ruben , Craig Rosen
IPC分类号： C07H21/02 , C12P21/06 , A61K39/395 , C07K16/30 , C12N5/06
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptors. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TRAIL receptor antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor.
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公开(公告)号：US20050026838A1
公开(公告)日：2005-02-03
申请号：US10932284
申请日：2004-09-02
申请人： John Greene , Joachim Gruber , Craig Rosen , Ralph Alderson , Robert Melder , D. Duan
发明人： John Greene , Joachim Gruber , Craig Rosen , Ralph Alderson , Robert Melder , D. Duan
CPC分类号： C07K14/50 , A01K67/027 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to a novel human protein called Fibroblast Growth Factor 13, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
摘要翻译： 本发明涉及称为成纤维细胞生长因子13的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。
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公开(公告)号：US20050019824A1
公开(公告)日：2005-01-27
申请号：US10935226
申请日：2004-09-08
申请人： Ralph Alderson , Robert Melder , D. Duan , Craig Rosen , Jing-Shan Hu , Jeannine Gocayne
发明人： Ralph Alderson , Robert Melder , D. Duan , Craig Rosen , Jing-Shan Hu , Jeannine Gocayne
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , C07K16/22 , C07K2317/622 , C12N2799/026
摘要： The present invention relates to a novel human protein called Fibroblast Growth Factor 10, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
摘要翻译： 本发明涉及称为成纤维细胞生长因子10的新型人类蛋白质和编码该蛋白质的分离的多核苷酸。 还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。
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公开(公告)号：US08263743B2
公开(公告)日：2012-09-11
申请号：US12270673
申请日：2008-11-13
IPC分类号： C07K16/00
CPC分类号： C07K16/2875 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Disclosed are humanized antibodies that bind specifically to the receptor TNF superfamily member 15 (TNFSF15), also known as TL1A. Methods of making and using the anti-TL1A antibodies are also described. The humanized antibodies may be antagonists and may used to treat or diagnose conditions associated with TL1A function.
摘要翻译： 公开了特异性结合受体TNF超家族成员15（TNFSF15）（也称为TL1A）的人源化抗体。 还描述了制备和使用抗TL1A抗体的方法。 人源化抗体可以是拮抗剂，可用于治疗或诊断与TL1A功能相关的病症。
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公开(公告)号：US20120100074A1
公开(公告)日：2012-04-26
申请号：US13256425
申请日：2010-03-22
IPC分类号： A61K49/00 , C07K19/00 , C12N9/96 , A61K39/395 , C12N15/13 , C12P21/02 , C12N1/21 , C12N5/10 , C12N1/19 , A61P29/00 , A61P37/00 , A61P35/00 , A61P37/06 , A61P1/00 , A61P11/00 , A61P19/02 , A61P25/00 , A61P17/06 , A61P35/02 , A61P9/10 , A61P1/16 , C07K16/28
CPC分类号： C07K16/2875 , C07K2317/24 , C07K2317/34 , G01N33/53
摘要： The present invention is directed to antigen-binding polypeptides, or variants or derivatives thereof which specifically bind the LIGHT polypeptide. The invention is also directed to methods of making and using such antibodies specifically in the treatment or diagnosis of immune, inflammatory and malignant diseases or conditions (e.g. inflammatory bowel disease; Crohn's disease, ulcerative colitis, multiple sclerosis, rheumatoid arthritis and transplantation).
摘要翻译： 本发明涉及特异性结合LIGHT多肽的抗原结合多肽或其变体或衍生物。 本发明还涉及特异性地在免疫，炎症和恶性疾病或病症（例如炎性肠病，克罗恩病，溃疡性结肠炎，多发性硬化症，类风湿性关节炎和移植）的治疗或诊断中制备和使用这些抗体的方法。
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公开(公告)号：US08728482B2
公开(公告)日：2014-05-20
申请号：US13585792
申请日：2012-08-14
IPC分类号： A61K39/395
CPC分类号： C07K16/2875 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Disclosed are humanized antibodies that bind specifically to TNF superfamily member 15 (TNFSF15), also known as TL1A. Methods of making and using the anti-TL1A antibodies are also described. The humanized antibodies may be antagonists and may used to treat or diagnose conditions associated with TL1A function.
摘要翻译： 公开了特异性结合TNF超家族成员15（TNFSF15）（也称为TL1A）的人源化抗体。 还描述了制备和使用抗TL1A抗体的方法。 人源化抗体可以是拮抗剂，可用于治疗或诊断与TL1A功能相关的病症。
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