公开(公告)号：US20060009805A1

公开(公告)日：2006-01-12

申请号：US11114976

申请日：2005-04-26

申请人： Ralph Jensen ,  Carmen Scholz ,  Luke Theogarajan

发明人： Ralph Jensen ,  Carmen Scholz ,  Luke Theogarajan

IPC分类号： A61N1/00

CPC分类号： A61N1/0543 ,  A61K9/0004 ,  A61K9/0051 ,  A61L27/50 ,  A61L2430/32 ,  A61N1/0551

摘要： A variety of neural stimulation devices are disclosed. The devices comprise an uptake component comprising means for selectively transporting a stimulating species into the device; a release component comprising means for releasing the stimulating species; and means for producing a concentration gradient of a second species. The concentration gradient of the second species provides energy to transport the stimulating species into the device. The stimulating species may be an ion, e.g., a potassium ion, or a neurotransmitter. In a preferred embodiment of the invention the stimulating species is a potassium ion. In a second preferred embodiment the stimulating species is dopamine. In certain embodiments of the invention countertransport across an uptake component comprising a synthetic ABA polymer membrane is achieved using a carboxylic acid crown ether. The gradient of the second species may be provided by means of a chemical reaction that takes place inside the device. The substrate for the chemical reaction is transported into the device from the external environment. In certain embodiments the neural stimulation device comprises light-sensitive elements that comprise light-sensitive proton pumps. The proton pumps translocate protons into the device in response to light, thereby triggering release of the stimulating species. In certain embodiments the neural stimulation device comprises electronic components that receive a signal and send an activating input to the device, thereby triggering release of the stimulating species.

摘要翻译： 公开了各种神经刺激装置。 所述装置包括吸收组分，其包括用于将刺激物质选择性地输送到装置中的装置; 释放组件，包括用于释放刺激物种的装置; 以及用于产生第二种类的浓度梯度的装置。 第二种物质的浓度梯度提供能量以将刺激物质运送到装置中。 刺激物质可以是离子，例如钾离子或神经递质。 在本发明的优选实施方案中，刺激物质是钾离子。 在第二优选实施方案中，刺激物质是多巴胺。 在本发明的某些实施方案中，通过使用羧酸冠醚实现包含合成ABA聚合物膜的吸收组分的反运送。 第二种类的梯度可以通过发生在装置内部的化学反应来提供。 用于化学反应的基材从外部环境输送到装置中。 在某些实施例中，神经刺激装置包括包含光敏质子泵的光敏元件。 质子泵响应于光将质子转移到器件中，从而引发刺激物质的释放。 在某些实施例中，神经刺激装置包括接收信号并向装置发送激活输入的电子部件，由此触发刺激物质的释放。

公开(公告)号：US06976998B2

公开(公告)日：2005-12-20

申请号：US10346701

申请日：2003-01-17

申请人： Joseph F. Rizzo ,  John L. Wyatt, Jr. ,  Luke Theogarajan

发明人： Joseph F. Rizzo ,  John L. Wyatt, Jr. ,  Luke Theogarajan

IPC分类号： A61F2/14 ,  A61F9/08 ,  A61N1/05 ,  A61N1/36 ,  A61F2/16

CPC分类号： A61N1/0543 ,  A61F2/14 ,  A61F9/08 ,  A61N1/36 ,  A61N1/36046 ,  A61N1/3787

摘要： An ocular device that can more safely and effectively perform all functions needed of a retinal prosthesis with electronic components that are placed outside the wall of an eye, are powered wirelessly provided by an external power source, and which provide a patient with a view determined by natural motion of the eye and triggered by natural incident light converging at the retina. In one aspect, the invention is an externally powered, light-activated, sub-retinal prosthesis in which natural light entering the eye conveys visual details to the sub-retinal prosthesis, while wireless radiofrequency transmission provides the power needed to stimulate the retina, which would be insufficient if it were obtained from the intensity of incoming light alone.

摘要翻译： 可以更安全和有效地执行放置在眼睛壁外部的电子部件的视网膜假体所需的所有功能的眼睛装置由外部电源无线提供，并且由患者提供由 眼睛自然运动并由自然光线会聚在视网膜上触发。 一方面，本发明是一种外部供电的光活化的次视网膜假体，其中进入眼睛的自然光将视觉细节传达到视网膜假体，而无线射频传输提供刺激视网膜所需的功率，其中 如果从独自的入射光强度获得的话将不足够。

公开(公告)号：US6046608A

公开(公告)日：2000-04-04

申请号：US987100

申请日：1997-12-08

申请人： Luke Theogarajan

发明人： Luke Theogarajan

IPC分类号： H03K19/173 ,  H03K19/0948

CPC分类号： H03K19/1738

摘要： A fast-switching differential precharge circuit is described. This circuit includes a precharging device for placing a first or a second node in a first desired state by providing a connection between that node and a first voltage supply. A second precharging device is also included, which places a second node in a second desired state, which is the logical inverse of the first desired state. Each precharging device includes a state maintaining device and a resetting device. The differential precharge circuit also includes first and second logical networks that are connected to both the first and second nodes and help to maintain the state of a given node. A method for differentially precharging a circuit is also described. The method includes applying a first state to a first node and applying a second state to a second node, such that the second state is the logical inverse of the first state. The second state on the second node is maintained, while a logic device coupled to the first node is reset. This enables the first node to be quickly charged to the second state and maintained in that state during the next input data transition, if so dictated.

摘要翻译： 描述了快速开关差动预充电电路。 该电路包括用于通过提供该节点和第一电压源之间的连接来将第一或第二节点放置在第一期望状态的预充电装置。 还包括第二预充电装置，其将第二节点放置在第二所需状态中，其是第一所需状态的逻辑倒数。 每个预充电装置包括状态维持装置和复位装置。 差分预充电电路还包括连接到第一和第二节点的第一和第二逻辑网络，并有助于维持给定节点的状态。 还描述了用于差分预充电的方法。 该方法包括将第一状态应用于第一节点并将第二状态应用于第二节点，使得第二状态是第一状态的逻辑倒数。 维持第二节点上的第二状态，同时耦合到第一节点的逻辑设备被复位。 这使得第一节点能够被快速充电到第二状态，并且在下一个输入数据转换期间保持在该状态，如果这样的话。