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公开(公告)号：US06442606B1
公开(公告)日：2002-08-27
申请号：US09374315
申请日：1999-08-12
申请人： Ram Subbaroyan , Yongdong Wang , Paul Andre Gauthier , Douglas Michael Cook , Douglass Russell Judd
发明人： Ram Subbaroyan , Yongdong Wang , Paul Andre Gauthier , Douglas Michael Cook , Douglass Russell Judd
IPC分类号： G06F1300
CPC分类号： G06F17/218 , G06F17/2247 , G06F17/30864
摘要： A method and apparatus are provided for indexing electronic documents that include one or more visible text portions and one or more non-visible text portions. The method includes the step of identifying an electronic document. Once the electronic document is identified, a set of words is selected from a particular tag type that is associated with one or more non-visible text portions of the electronic document. Each word in the selected set of words is compared with words in the one or more visible text portions of the electronic document. An index word set is then determined for the electronic document based on matches between words in the selected set of words and words in the one or more visible text portions of the electronic document.
摘要翻译： 提供了一种用于对包括一个或多个可见文本部分和一个或多个不可见文本部分的电子文档进行索引的方法和装置。 该方法包括识别电子文档的步骤。 一旦识别了电子文档，就从与电子文档的一个或多个不可见的文本部分相关联的特定标签类型中选择一组单词。 将所选择的一组单词中的每个单词与电子文档的一个或多个可见文本部分中的单词进行比较。 然后基于电子文档的一个或多个可见文本部分中的所选择的单词和单词中的单词之间的匹配来确定电子文档的索引词组。
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公开(公告)号：US08927925B2
公开(公告)日：2015-01-06
申请号：US12475548
申请日：2009-05-31
申请人： Donald Kuehl , Yongdong Wang , Ming Gu
发明人： Donald Kuehl , Yongdong Wang , Ming Gu
IPC分类号： H01J49/00
CPC分类号： H01J49/0036 , H01J49/0009
摘要： A method for identifying ions that generated mass spectral data, comprises acquiring raw mass spectral data in profile mode containing at least one ion of interest; performing at least one of mass spectral calibration involving peak shape and a determination of actual peak shape function associated with the acquired raw mass spectral data; considering at least one possible elemental composition of the ion; calculating theoretical mass spectral data for said elemental composition using the actual peak shape function; performing a normalization between corresponding parts of the theoretical mass spectral data and that of the raw or calibrated mass spectral data; and displaying mass spectral congruence between at least two mass spectra where one spectrum is the normalized version of the other corresponding to said possible elemental composition. The unique display and method assist in readily identifying ions. A data storage medium having computer code thereon for causing a computer to performing the method; also in combination with a mass spectrometer.
摘要翻译： 一种用于识别产生质谱数据的离子的方法，包括获取包含至少一个感兴趣的离子的谱图模式中的原始质谱数据; 执行涉及峰形的质谱校准和与获取的原始质谱数据相关联的实际峰形状函数的确定中的至少一个; 考虑离子的至少一种可能的元素组成; 使用实际峰形函数计算所述元素组成的理论质谱数据; 在理论质谱数据的相应部分与原始或校准的质谱数据的相应部分之间执行归一化; 并且在至少两个质谱之间显示质谱一致性，其中一个光谱是对应于所述可能的元素组成的另一光谱的归一化版本。 独特的显示和方法有助于容易地识别离子。 一种数据存储介质，其上具有用于使计算机执行该方法的计算机代码; 也与质谱仪结合使用。
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3.发明申请公开(公告)号：US20120309103A1
公开(公告)日：2012-12-06
申请号：US13584628
申请日：2012-08-13
申请人： Michael Gambini , John C. Voyta , John Atwood , Susan A. Atwood-Stone , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
发明人： Michael Gambini , John C. Voyta , John Atwood , Susan A. Atwood-Stone , Bruce E. DeSimas, II , Edward Lakatos , Jeff Levi , Israel Metal , George Sabak , Yongdong Wang
IPC分类号： G01N21/76
CPC分类号： G01N21/763 , G01N21/15 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/76 , G01N33/581 , G01N2021/6471 , G01N2333/90241 , Y10T436/115831
摘要： A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. Luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. The samples may be injected in the wells, and the samples may be injected with buffers and reagents, by an injector. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, a filter, and a camera lens, whereupon a focused image is created by the optics on the charge-coupled device (CCD) camera. The use of a Fresnel field lens, in combination with a collimator and filter, reduces crosstalk between samples below the level attainable by the prior art. Preferred embodiments of the luminescence detecting apparatus and method disclosed include central processing control of all operations, multiple wavelength filter wheel, and robot handling of samples and reagents. Preferred embodiments of processing software integrated with the invention include elements for mechanical alignment, outlier shaving, edge detection and masking, manipulation of multiple integration times to expand the dynamic range, crosstalk correction, dark subtraction interpolation and drift correction, multi-component analysis applications specifically tailored for luminescence, and uniformity correction.
摘要翻译： 公开了一种用于分析发光样品的发光检测装置和方法。 将发光样品放置在托盘中的多个样品孔中，并且将托盘放置在包含电荷耦合器件照相机的可见光不透水室中。 样品可以注入孔中，样品可以通过注射器注入缓冲液和试剂。 在室中，来自发光样品的光通过准直仪，菲涅尔场透镜，滤光器和照相机镜头，由此电荷耦合器件（CCD）照相机上的光学器件产生聚焦图像。 使用菲涅耳场透镜与准直器和滤光器结合使得样品之间的串扰降低到现有技术可获得的水平以下。 发光检测装置和方法的优选实施例包括所有操作，多波长滤光轮和样品和试剂的机器人处理的中央处理控制。 与本发明集成的处理软件的优选实施例包括用于机械对准，异常刮削，边缘检测和掩蔽的元件，多次积分时间的操纵以扩大动态范围，串扰校正，暗减法内插和漂移校正，特别是多组分分析应用 适合发光和均匀性校正。
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公开(公告)号：US07781729B2
公开(公告)日：2010-08-24
申请号：US11754305
申请日：2007-05-27
申请人： Yongdong Wang , Ming Gu
发明人： Yongdong Wang , Ming Gu
CPC分类号： H01J49/0036 , G06F19/703
摘要： A method for analyzing data from a mass spectrometer comprising obtaining calibrated continuum spectral data by processing raw spectral data; obtaining library spectral data which has been processed to form calibrated library data; and performing a least squares fit, preferably using matrix operations (equation 1), between the calibrated continuum spectral data and the calibrated library data to determine concentrations of components in a sample which generated the raw spectral data. A mass spectrometer system (FIG. 1) that operates in accordance with the method, a data library of transformed mass spectra, and a method for producing the data library.
摘要翻译： 一种用于分析来自质谱仪的数据的方法，包括通过处理原始光谱数据获得校准的连续谱光谱数据; 获得已经处理以形成校准库数据的库光谱数据; 并且在校准的连续谱数据和校准的库数据之间优选使用矩阵运算（等式1）进行最小二乘拟合，以确定产生原始光谱数据的样本中的分量的浓度。 根据该方法操作的质谱仪系统（图1），变换质谱的数据库以及用于产生数据库的方法。
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公开(公告)号：US20100171032A1
公开(公告)日：2010-07-08
申请号：US12602768
申请日：2008-06-02
申请人： Yongdong Wang , Donald Kuehl
发明人： Yongdong Wang , Donald Kuehl
CPC分类号： H01J49/0009 , B01D59/44 , H01J49/0036
摘要： Methods for analyzing mass spectral data, include acquiring profile mode mass spectral data containing at least on ion of interest whose elemental composition is determined; obtaining a correct peak shape function based on the actually measured peak shape of at least one of the isotypes of the same ion of interest; generating at least one possible elemental composition for the ion of interest; calculating a theoretical isotope cluster by applying correct peak shape function to the theoretical isotope distribution; comparing quantiatively the corresponding parts of the theoretical isotope cluster to that from acquired profile mode mass spectral data to obtain at least one of elemental composition determination, classification, or quantitation for the ion. A computer for and a computer readable medium having computer readable code thereon for performing the methods. A mass spectrometer having an associated computer for performing the methods.
摘要翻译： 用于分析质谱数据的方法包括获取包含至少基于其元素组成确定的感兴趣的离子的谱模式质谱数据; 基于相同目的离子的至少一种同种型的实际测量的峰形来获得正确的峰形函数; 为感兴趣的离子产生至少一种可能的元素组合物; 通过对理论同位素分布应用正确的峰形函数来计算理论同位素簇; 将理论同位素簇的相应部分定量地与获取的轮廓模式质谱数据进行比较，以获得离子的元素组成确定，分类或定量中的至少一种。 一种计算机及其计算机可读介质，其上具有用于执行所述方法的计算机可读代码。 一种具有用于执行该方法的相关计算机的质谱仪。
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公开(公告)号：US07405821B2
公开(公告)日：2008-07-29
申请号：US11552361
申请日：2006-10-24
IPC分类号： G01J3/00
摘要： In a spectroscopic process a sample for producing a test spectral line or spectrum of at least one component contained in the sample is stimulated and the transmitted and/or emitted electromagnetic rays are used to create the test spectral line or spectrum. In order to improve such a spectroscopic process to such an extent that variations of certain parameters, which alter the shape and/or occurrence of a spectral line, are compensated, a comparison spectral line or spectrum of a known comparison material is produced under substantially the same parameters as the sample. The comparison spectral line or spectrum is compared with an ideal comparison spectral line or spectrum in order to calculate a transfer function, and the transfer function is applied to the test spectral line or spectrum in order to calculate a corrected test spectral line or spectrum.
摘要翻译： 在分光过程中，刺激用于产生测试谱线或样品中包含的至少一种组分的光谱的样品，并且使用透射和/或发射的电磁波来产生测试光谱线或光谱。 为了改进这种光谱过程，使得补偿了改变光谱线的形状和/或出现的某些参数的变化，已知比较材料的比较光谱线或光谱基本上在 与样品相同的参数。 将比较谱线或频谱与理想的比较谱线或频谱进行比较，以计算传递函数，并将传递函数应用于测试谱线或频谱，以便计算校正的测试谱线或频谱。
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公开(公告)号：US20080001079A1
公开(公告)日：2008-01-03
申请号：US11754305
申请日：2007-05-27
申请人： Yongdong Wang , Ming Gu
发明人： Yongdong Wang , Ming Gu
CPC分类号： H01J49/0036 , G06F19/703
摘要： A method for analyzing data from a mass spectrometer comprising obtaining calibrated continuum spectral data by processing raw spectral data; obtaining library spectral data which has been processed to form calibrated library data; and performing a least squares fit, preferably using matrix operations (equation 1), between the calibrated continuum spectral data and the calibrated library data to determine concentrations of components in a sample which generated the raw spectral data. A mass spectrometer system (FIG. 1) that operates in accordance with the method, a data library of transformed mass spectra, and a method for producing the data library.
摘要翻译： 一种用于分析来自质谱仪的数据的方法，包括通过处理原始光谱数据获得校准的连续谱光谱数据; 获得已经处理以形成校准库数据的库光谱数据; 并且在校准的连续谱数据和校准的库数据之间优选使用矩阵运算（等式1）进行最小二乘拟合，以确定产生原始光谱数据的样本中的分量的浓度。 根据该方法操作的质谱仪系统（
图1 ），变换质谱的数据库以及用于产生数据库的方法。 -
公开(公告)号：US20070046933A1
公开(公告)日：2007-03-01
申请号：US11552361
申请日：2006-10-24
申请人： Yongdong Wang , Bernhard Radziuk , David Tracy
发明人： Yongdong Wang , Bernhard Radziuk , David Tracy
IPC分类号： G01J3/00
摘要： In a spectroscopic process a sample for producing a test spectral line or spectrum of at least one component contained in the sample is stimulated and the transmitted and/or emitted electromagnetic rays are used to create the test spectral line or spectrum. In order to improve such a spectroscopic process to such an extent that variations of certain parameters, which alter the shape and/or occurrence of a spectral line, are compensated, a comparison spectral line or spectrum of a known comparison material is produced under substantially the same parameters as the sample. The comparison spectral line or spectrum is compared with an ideal comparison spectral line or spectrum in order to calculate a transfer function, and the transfer function is applied to the test spectral line or spectrum in order to calculate a corrected test spectral line or spectrum.
摘要翻译： 在分光过程中，刺激用于产生测试谱线或样品中包含的至少一种组分的光谱的样品，并且使用透射和/或发射的电磁波来产生测试光谱线或光谱。 为了改进这种光谱过程，使得补偿了改变光谱线的形状和/或出现的某些参数的变化，已知比较材料的比较光谱线或光谱基本上在 与样品相同的参数。 将比较谱线或频谱与理想的比较谱线或频谱进行比较，以计算传递函数，并将传递函数应用于测试谱线或频谱，以便计算校正的测试谱线或频谱。
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公开(公告)号：US07145650B2
公开(公告)日：2006-12-05
申请号：US10370910
申请日：2003-02-20
摘要： In a spectroscopic process a sample for producing a test spectral line or spectrum of at least one component contained in the sample is stimulated and the transmitted and/or emitted electromagnetic rays are used to create the test spectral line or spectrum. In order to improve such a spectroscopic process to such an extent that variations of certain parameters, which alter the shape and/or occurrence of a spectral line, are compensated, a comparison spectral line or spectrum of a known comparison material is produced under substantially the same parameters as the sample. The comparison spectral line or spectrum is compared with an ideal comparison spectral line or spectrum in order to calculate a transfer function, and the transfer function is applied to the test spectral line or spectrum in order to calculate a corrected test spectral line or spectrum.
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公开(公告)号：US06029115A
公开(公告)日：2000-02-22
申请号：US940575
申请日：1997-09-30
申请人： David H. Tracy , Alan M. Ganz , Yongdong Wang , David A. Huppler , Juan C. Ivaldi , Christopher B. Hanna
发明人： David H. Tracy , Alan M. Ganz , Yongdong Wang , David A. Huppler , Juan C. Ivaldi , Christopher B. Hanna
CPC分类号： G01J3/28 , G01J3/2803 , G01J3/457 , G01J2003/2866
摘要： A spectrometric instrument includes a detector with detecting subarrays on small portions of the surface. Spectral data are acquired for selected subarrays at a first time for a drift standard, and compared to a zero position to obtain first offset data. Data are acquired similarly at a second time to obtain second offset data. The offset data are utilized to obtain a spectral shift for any subarray position at any selected time. The shift is applied to a matrix model used for converting test data to compositional information. Archive data for the model is obtained in the foregoing manner, using slit scanning in the instrument to achieve sub-increments smaller than the detector pixel size, with a procedure to assure that there is an integral number of scanning steps across one pixel. The drift standard may be chemical analytes, or an optical interference element producing fringes related to spectral positions in each subarray. A procedure is used to identify the fringe peaks to spectral position, with temperature correction.
摘要翻译： 光谱测量仪器包括一个检测器，在表面的小部分具有检测子阵列。 针对漂移标准在第一时间针对所选择的子阵列采集光谱数据，并与零位置进行比较以获得第一偏移数据。 在第二时间类似地获取数据以获得第二偏移数据。 偏移数据用于在任何选定的时间获得任何子阵列位置的光谱偏移。 该转移被应用于用于将测试数据转换成组合信息的矩阵模型。 以上述方式获得用于模型的存档数据，使用仪器中的狭缝扫描来实现小于检测器像素尺寸的次增量，以确保跨越一个像素存在整数个扫描步骤的过程。 漂移标准可以是化学分析物，或者产生与每个子阵列中的光谱位置相关的条纹的光学干涉元件。 使用一个程序来确定边缘峰到光谱位置，并进行温度校正。
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