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公开(公告)号：US09254100B2
公开(公告)日：2016-02-09
申请号：US11900596
申请日：2007-09-12
申请人： Kenneth Beck , Ramesh Wariar , Chie Kawahara , Gerrard M. Carlson
发明人： Kenneth Beck , Ramesh Wariar , Chie Kawahara , Gerrard M. Carlson
CPC分类号： A61B5/1118 , A61B5/0002 , A61B5/4866
摘要： An implantable activity detector can detect metabolic stress levels, which can be normalized, such as to identify times of activities such as walking and running or to identify trends such as a decrease in metabolic activity. The data can be derived from different sources such as an accelerometer and pedometer. This data can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with other congestive heart failure (CHF) indications. The alert can notify the patient or a caregiver, such as via remote monitoring. Metabolic activity data from one or more of the activity detectors can be used to establish a model of metabolic stress, to which further activity data can be compared for identifying periods of increased or decreased metabolic stress.
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2.发明授权Tracking progression of congestive heart failure via a force-frequency relationship 有权通过力 - 频率关系跟踪充血性心力衰竭的进展公开(公告)号：US08755883B2
公开(公告)日：2014-06-17
申请号：US12634277
申请日：2009-12-09
申请人： Ramesh Wariar , Gerrard M. Carlson
发明人： Ramesh Wariar , Gerrard M. Carlson
CPC分类号： A61B7/023 , A61B5/0031 , A61B5/0215 , A61B5/024 , A61B5/0456 , A61B5/11 , A61N1/3627
摘要： A system, method, or device monitor a force-frequency relationship exhibited by a patient's heart. A contractility characteristic, such as a heart sound characteristic of an S1 heart sound, is measured. The contractility characteristic indicates the forcefulness of a contraction of the heart. The frequency at which the heart is contracting is determined. A group of (contractility characteristic, heart rate) pairs is stored in a memory device. The group of pairs defines a force-frequency relationship for the heart. The method may be implemented by an implantable device, or by a system including a implantable device.
摘要翻译： 系统，方法或设备监测患者心脏展示的力 - 频率关系。 测量S1心音的心音特征的收缩特性。 收缩性特征表明心脏收缩的强度。 确定心脏收缩的频率。 一组（收缩特性，心率）对存储在存储器件中。 一组对定义了心脏的力 - 频率关系。 该方法可以由可植入装置或包括可植入装置的系统来实现。
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3.发明申请SENSING RATE OF CHANGE OF PRESSURE IN THE LEFT VENTRICLE WITH AN IMPLANTED DEVICE 有权在具有嵌入式装置的左心室中的压力变化率的感测率公开(公告)号：US20120330174A1
公开(公告)日：2012-12-27
申请号：US13605397
申请日：2012-09-06
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。
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4.发明申请MANAGING PRELOAD RESERVE BY TRACKING THE VENTRICULAR OPERATING POINT WITH HEART SOUNDS 有权通过用心脏声音追踪心室操作点来管理前端保留公开(公告)号：US20120203116A1
公开(公告)日：2012-08-09
申请号：US13447506
申请日：2012-04-16
IPC分类号： A61N1/365 , A61B5/0205 , A61B5/021
CPC分类号： A61N1/36585 , A61B5/021 , A61B5/0452 , A61B7/04 , A61M5/1723 , A61N1/37
摘要： A system and method for managing preload reserve and tracking the inotropic state of a patient's heart. The S1 heart sound is measured as a proxy for direct measurement of stroke volume. The S3 heart sound may be measured as a proxy for direct measurement of preload level. The S1-S3 pair yield a point on a Frank Starling type of curve, and reveal information regarding the patient's ventricular operating point and inotropic state. As an alternative, or in addition to, measurement of the S3 heart sound, the S4 heart sound may be measured or a direct pressure measurement may be made for the sake of determining the patient's preload level. The aforementioned measurements may be made by a cardiac rhythm management device, such as a pacemaker or implantable defibrillator.
摘要翻译： 一种用于管理预负荷储备并跟踪患者心脏的变力状态的系统和方法。 测量S1心音作为直接测量行程体积的代理。 可以将S3心音测量为用于直接测量预载水平的代理。 S1-S3对在Frank Starling曲线上产生一个点，并显示关于患者的心室手术点和变力状态的信息。 作为S3心音的测量或除了测量S3心音之外，也可以测量S4心音，或者为了确定患者的预压水平可以进行直接的压力测量。 上述测量可以由诸如起搏器或可植入除颤器的心律管理装置进行。
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5.发明申请SENSING RATE OF CHANGE OF PRESSURE IN THE LEFT VENTRICLE WITH AN IMPLANTED DEVICE 有权在具有嵌入式装置的左心室中的压力变化率的感测率公开(公告)号：US20100145403A1
公开(公告)日：2010-06-10
申请号：US12703533
申请日：2010-02-10
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。
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6.发明授权公开(公告)号：US08535235B2
公开(公告)日：2013-09-17
申请号：US13605397
申请日：2012-09-06
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。
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7.发明申请SYSTEM AND METHOD FOR ASSESSING CARDIAC PERFORMANCE THROUGH CARDIAC VIBRATION MONITORING 有权通过心脏振动监测评估心脏性能的系统和方法公开(公告)号：US20110301473A1
公开(公告)日：2011-12-08
申请号：US13208722
申请日：2011-08-12
申请人： Ramesh Wariar , Gerrard M. Carlson
发明人： Ramesh Wariar , Gerrard M. Carlson
摘要： A system and method for assessing cardiac performance through cardiac vibration monitoring is described. Cardiac vibration measures are directly collected through an implantable medical device. Cardiac events including at least one first heart sound reflected by the cardiac vibration measures are identified. The first heart sound is correlated to cardiac dimensional measures relative to performance of an intrathoracic pressure maneuver. The cardiac dimensional measures are grouped into at least one measures set corresponding to a temporal phase of the intrathoracic pressure maneuver. The at least one cardiac dimensional measures set is evaluated against a cardiac dimensional trend for the corresponding intrathoracic pressure maneuver temporal phase to represent cardiac performance.
摘要翻译： 描述了通过心脏振动监测来评估心脏性能的系统和方法。 通过植入式医疗设备直接收集心脏振动。 识别心脏事件，包括由心脏振动测量反射的至少一个第一心音。 第一个心音与胸腔内压力作用的心脏尺寸相关。 心脏尺寸测量被分组为对应于胸内压力操纵的时间相位的至少一个测量组。 针对相应的胸内压力机动时间阶段的心脏尺寸趋势来评估至少一个心脏尺寸测量集合以表示心脏性能。
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8.发明授权公开(公告)号：US08007442B2
公开(公告)日：2011-08-30
申请号：US12703533
申请日：2010-02-10
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。
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公开(公告)号：US20090069720A1
公开(公告)日：2009-03-12
申请号：US11900596
申请日：2007-09-12
申请人： Kenneth Beck , Ramesh Wariar , Chie Kawahara , Gerrard M. Carlson
发明人： Kenneth Beck , Ramesh Wariar , Chie Kawahara , Gerrard M. Carlson
IPC分类号： A61B5/00
CPC分类号： A61B5/1118 , A61B5/0002 , A61B5/4866
摘要： An implantable activity detector can detect metabolic stress levels, which can be normalized, such as to identify times of activities such as walking and running or to identify trends such as a decrease in metabolic activity. The data can be derived from different sources such as an accelerometer and pedometer. This data can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with other congestive heart failure (CHF) indications. The alert can notify the patient or a caregiver, such as via remote monitoring. Metabolic activity data from one or more of the activity detectors can be used to establish a model of metabolic stress, to which further activity data can be compared for identifying periods of increased or decreased metabolic stress.
摘要翻译： 可植入活动检测器可以检测代谢应激水平，其可以被归一化，例如识别诸如步行和跑步的活动的时间，或者识别诸如代谢活动降低的趋势。 数据可以来自不同的来源，例如加速度计和计步器。 该数据可以与独立指定的阈值进行比较，例如触发警报或响应治疗，或显示一个或多个趋势。 信息也可以与其他充血性心力衰竭（CHF）指征结合使用。 该警报可以通过远程监视来通知病人或看护者。 来自一个或多个活性检测器的代谢活动数据可以用于建立代谢应激模型，进一步的活动数据可以被比较以识别增加或减少的代谢应激的时期。
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10.发明授权System and method for assessing cardiac performance through cardiac vibration monitoring 有权通过心脏振动监测评估心脏性能的系统和方法公开(公告)号：US08888710B2
公开(公告)日：2014-11-18
申请号：US13208722
申请日：2011-08-12
申请人： Ramesh Wariar , Gerrard M. Carlson
发明人： Ramesh Wariar , Gerrard M. Carlson
摘要： A system and method for assessing cardiac performance through cardiac vibration monitoring is described. Cardiac vibration measures are directly collected through an implantable medical device. Cardiac events including at least one first heart sound reflected by the cardiac vibration measures are identified. The first heart sound is correlated to cardiac dimensional measures relative to performance of an intrathoracic pressure maneuver. The cardiac dimensional measures are grouped into at least one measures set corresponding to a temporal phase of the intrathoracic pressure maneuver. The at least one cardiac dimensional measures set is evaluated against a cardiac dimensional trend for the corresponding intrathoracic pressure maneuver temporal phase to represent cardiac performance.
摘要翻译： 描述了通过心脏振动监测来评估心脏性能的系统和方法。 通过植入式医疗设备直接收集心脏振动。 识别心脏事件，包括由心脏振动测量反射的至少一个第一心音。 第一个心音与胸腔内压力作用的心脏尺寸相关。 心脏尺寸测量被分组为对应于胸内压力操纵的时间相位的至少一个测量组。 针对相应的胸内压力机动时间阶段的心脏尺寸趋势来评估至少一个心脏尺寸测量集合以表示心脏性能。
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