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公开(公告)号：US08100860B2
公开(公告)日：2012-01-24
申请号：US12328731
申请日：2008-12-04
CPC分类号： A61M25/0155 , A61M25/0013 , A61M25/0068 , A61M25/008 , A61M25/0082 , A61M25/0084 , A61M25/04 , A61M25/0606 , A61M25/1002 , A61M25/1011 , A61M2025/0081 , A61M2025/0092 , A61M2025/0096 , A61M2025/0681 , A61M2025/1047
摘要： A device and method is provided for localized agent delivery through a coronary vessel. In one configuration, the device includes an elongated member having a first and second end with a tip and an aperture positioned near the second end. An injection lumen places the first end of the elongated member in fluid communication with the aperture, permitting fluids such as contrast agent or therapeutic agents to be delivered therebetween. In an exemplary method, the device is tracked through a bend in the coronary anatomy, forcing the tip of the device toward the greater curve and through the vessel wall. The aperture may advanced to the desired location and agents may be delivered through the device into target tissue or space. Other configurations and embodiments of the device and method are presented.
摘要翻译： 提供了一种通过冠状动脉血管进行局部药剂输送的装置和方法。 在一种构造中，该装置包括细长构件，该细长构件具有带尖端的第一和第二端以及位于第二端附近的孔。 注射腔使细长构件的第一端与孔流体连通，允许诸如造影剂或治疗剂的流体在其间输送。 在示例性方法中，通过冠状动脉解剖结构中的弯曲来跟踪装置，迫使装置的尖端朝向更大的曲线并穿过血管壁。 孔可以前进到期望的位置，并且药剂可以通过装置输送到靶组织或空间中。 介绍了该设备和方法的其他配置和实施例。
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公开(公告)号：US20090254051A1
公开(公告)日：2009-10-08
申请号：US12328731
申请日：2008-12-04
CPC分类号： A61M25/0155 , A61M25/0013 , A61M25/0068 , A61M25/008 , A61M25/0082 , A61M25/0084 , A61M25/04 , A61M25/0606 , A61M25/1002 , A61M25/1011 , A61M2025/0081 , A61M2025/0092 , A61M2025/0096 , A61M2025/0681 , A61M2025/1047
摘要： A device and method is provided for localized agent delivery through a coronary vessel. In one configuration, the device includes an elongated member having a first and second end with a tip and an aperture positioned near the second end. An injection lumen places the first end of the elongated member in fluid communication with the aperture, permitting fluids such as contrast agent or therapeutic agents to be delivered therebetween. In an exemplary method, the device is tracked through a bend in the coronary anatomy, forcing the tip of the device toward the greater curve and through the vessel wall. The aperture may advanced to the desired location and agents may be delivered through the device into target tissue or space. Other configurations and embodiments of the device and method are presented,
摘要翻译： 提供了一种通过冠状动脉血管进行局部药剂输送的装置和方法。 在一种构造中，该装置包括细长构件，该细长构件具有带尖端的第一和第二端以及位于第二端附近的孔。 注射腔使细长构件的第一端与孔流体连通，允许诸如造影剂或治疗剂的流体在其间输送。 在示例性方法中，通过冠状动脉解剖结构中的弯曲来跟踪装置，迫使装置的尖端朝向更大的曲线并穿过血管壁。 孔可以前进到期望的位置，并且药剂可以通过装置输送到靶组织或空间中。 本发明提供了装置和方法的其他配置和实施例，
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公开(公告)号：US09060892B2
公开(公告)日：2015-06-23
申请号：US13063911
申请日：2009-09-11
申请人： Randolf Von Oepen , Lorcan James Coffey , Richard R. Newhauser , Thomas Rieth , Travis R. Yribarren
发明人： Randolf Von Oepen , Lorcan James Coffey , Richard R. Newhauser , Thomas Rieth , Travis R. Yribarren
CPC分类号： A61F2/915 , A61F2/89 , A61F2/91 , A61F2/95 , A61F2/958 , A61F2002/30019 , A61F2002/30484 , A61F2002/826 , A61F2002/828 , A61F2002/91583 , A61F2002/91591 , A61F2210/0004 , A61F2210/0014 , A61F2210/0076 , A61F2250/0071
摘要： A vascular endoprosthesis (100, 200, 300, 400, 500, 600) includes a radially-expandable first segment and a radially expandable second segment. The vascular endoprosthesis further includes first and second coupling elements. The first coupling element extends from the proximal end of the first segment toward the distal end of the second segment, and the second coupling element extends from the distal end of the second segment toward the proximal end of the first segment. The first and second coupling elements cooperate one with another to couple the first and second segments together when the vascular endoprosthesis is in a delivery configuration and to decouple the first and second segments when the vascular endoprosthesis is in a deployed configuration.
摘要翻译： 血管内假体（100,200,300,400,500,600）包括径向可扩张的第一段和可径向扩张的第二段。 血管内假体进一步包括第一和第二联接元件。 第一联接元件从第一段的近端延伸到第二段的远端，并且第二联接元件从第二段的远端朝向第一段的近端延伸。 当血管内用假体处于输送构型中时，第一和第二联接元件彼此配合以将第一和第二段联接在一起，并且当血管内用假体处于展开构型时将第一和第二段分离。
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公开(公告)号：US20130006220A1
公开(公告)日：2013-01-03
申请号：US13616305
申请日：2012-09-14
申请人： Travis R. Yribarren , Randolf von Oepen , Kevin J. Ehrenreich , William E. Webler, JR. , Richard R. Newhauser
发明人： Travis R. Yribarren , Randolf von Oepen , Kevin J. Ehrenreich , William E. Webler, JR. , Richard R. Newhauser
IPC分类号： A61M25/10
CPC分类号： A61M25/1006 , A61F2/958 , A61M25/0119 , A61M2025/1015 , A61M2025/105 , A61M2025/1059 , A61M2025/1065 , A61M2025/1068
摘要： The present invention relates to balloon catheters for treating a luminal system of a patient. Specifically, the invention relates to catheters having a flexible membrane positioned at a distal portion of the catheter, the flexible membrane retained in a substantially unexposed conformation prior to deployment. Preferably the flexible membrane is capable of delivering a therapeutic agent to a localized environment when deployed to an exposed conformation.
摘要翻译： 本发明涉及用于治疗患者的管腔系统的气囊导管。 具体地，本发明涉及具有位于导管的远端部分的柔性膜的导管，柔性膜在展开之前保持基本上未曝光的构象。 优选地，当部署到暴露的构象时，柔性膜能够将治疗剂递送至局部环境。
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5.发明授权Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery 有权具有由用于管腔内药物递送的纤维基质形成的覆盖物的可膨胀构件公开(公告)号：US08226603B2
公开(公告)日：2012-07-24
申请号：US12237998
申请日：2008-09-25
申请人： Randolf Von Oepen , John Stankus , Barbara Stamberg , Travis R. Yribarren , Richard R. Newhauser
发明人： Randolf Von Oepen , John Stankus , Barbara Stamberg , Travis R. Yribarren , Richard R. Newhauser
CPC分类号： A61M25/10 , A61F2/958 , A61F2002/9583 , A61L29/085 , A61M25/1027 , A61M25/1029 , A61M25/1038 , A61M2025/1004 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086 , A61M2025/1088 , Y10T29/49826
摘要： The present invention generally relates to an intraluminal catheter device for use in angioplasty and delivery of a therapeutic agent. Particularly, the present invention is directed to a catheter having an expandable member having a therapeutic agent disposed thereon and a fibrous matrix covering for delivering a therapeutic agent and methods of using the same.
摘要翻译： 本发明一般涉及用于血管成形术和治疗剂递送的管腔内导管装置。 特别地，本发明涉及具有设置在其上的治疗剂的可膨胀构件的导管和用于递送治疗剂的纤维基质覆盖物及其使用方法。
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公开(公告)号：US20110224777A1
公开(公告)日：2011-09-15
申请号：US13063911
申请日：2009-09-11
申请人： Randolf Von Oepen , Lorcan James Coffey , Richard R. Newhauser , Thomas Rieth , Travis R. Yribarren
发明人： Randolf Von Oepen , Lorcan James Coffey , Richard R. Newhauser , Thomas Rieth , Travis R. Yribarren
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2/89 , A61F2/91 , A61F2/95 , A61F2/958 , A61F2002/30019 , A61F2002/30484 , A61F2002/826 , A61F2002/828 , A61F2002/91583 , A61F2002/91591 , A61F2210/0004 , A61F2210/0014 , A61F2210/0076 , A61F2250/0071
摘要： A vascular endoprosthesis (100, 200, 300, 400, 500, 600) includes a radially-expandable first segment and a radially expandable second segment. The vascular endoprosthesis further includes first and second coupling elements. The first coupling element extends from the proximal end of the first segment toward the distal end of the second segment, and the second coupling element extends from the distal end of the second segment toward the proximal end of the first segment. The first and second coupling elements cooperate one with another to couple the first and second segments together when the vascular endoprosthesis is in a delivery configuration and to decouple the first and second segments when the vascular endoprosthesis is in a deployed configuration.
摘要翻译： 血管内假体（100,200,300,400,500,600）包括径向可扩张的第一段和可径向扩张的第二段。 血管内假体进一步包括第一和第二联接元件。 第一联接元件从第一段的近端延伸到第二段的远端，并且第二联接元件从第二段的远端朝向第一段的近端延伸。 当血管内用假体处于输送构型中时，第一和第二联接元件彼此配合以将第一和第二段联接在一起，并且当血管内用假体处于展开构型时将第一和第二段分离。
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7.发明申请Expandable Member Having A Covering Formed Of A Fibrous Matrix For Intraluminal Drug Delivery 有权具有用于腔内药物递送的纤维基质覆盖物的可膨胀构件公开(公告)号：US20100076401A1
公开(公告)日：2010-03-25
申请号：US12237998
申请日：2008-09-25
申请人： Randolf Von Oepen , John Stankus , Barbara Stamberg , Travis R. Yribarren , Richard R. Newhauser
发明人： Randolf Von Oepen , John Stankus , Barbara Stamberg , Travis R. Yribarren , Richard R. Newhauser
CPC分类号： A61M25/10 , A61F2/958 , A61F2002/9583 , A61L29/085 , A61M25/1027 , A61M25/1029 , A61M25/1038 , A61M2025/1004 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086 , A61M2025/1088 , Y10T29/49826
摘要： The present invention generally relates to an intraluminal catheter device for use in angioplasty and delivery of a therapeutic agent. Particularly, the present invention is directed to a catheter having an expandable member having a therapeutic agent disposed thereon and a fibrous matrix covering for delivering a therapeutic agent and methods of using the same.
摘要翻译： 本发明一般涉及用于血管成形术和治疗剂递送的管腔内导管装置。 特别地，本发明涉及具有设置在其上的治疗剂的可膨胀构件的导管和用于递送治疗剂的纤维基质覆盖物及其使用方法。
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公开(公告)号：US08690823B2
公开(公告)日：2014-04-08
申请号：US12171134
申请日：2008-07-10
申请人： Travis R. Yribarren , Randolf von Oepen , Kevin J. Ehrenreich , William E. Webler, Jr. , Richard R. Newhauser
发明人： Travis R. Yribarren , Randolf von Oepen , Kevin J. Ehrenreich , William E. Webler, Jr. , Richard R. Newhauser
IPC分类号： A61M31/00
CPC分类号： A61M25/1006 , A61F2/958 , A61M25/0119 , A61M2025/1015 , A61M2025/105 , A61M2025/1059 , A61M2025/1065 , A61M2025/1068
摘要： The present invention relates to balloon catheters for treating a luminal system of a patient. Specifically, the invention relates to catheters having a flexible membrane positioned at a distal portion of the catheter, the flexible membrane retained in a substantially unexposed conformation prior to deployment. Preferably the flexible membrane is capable of delivering a therapeutic agent to a localized environment when deployed to an exposed conformation.
摘要翻译： 本发明涉及用于治疗患者的管腔系统的气囊导管。 具体地，本发明涉及具有位于导管的远端部分的柔性膜的导管，柔性膜在展开之前保持基本上未曝光的构象。 优选地，当部署到暴露的构象时，柔性膜能够将治疗剂递送至局部环境。
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公开(公告)号：US08617114B2
公开(公告)日：2013-12-31
申请号：US12371430
申请日：2009-02-13
申请人： Randolf von Oepen , Travis R. Yribarren , Kevin J. Ehrenreich , William E. Webler, Jr. , Richard R. Newhauser
发明人： Randolf von Oepen , Travis R. Yribarren , Kevin J. Ehrenreich , William E. Webler, Jr. , Richard R. Newhauser
CPC分类号： A61M25/1006 , A61M2025/1015 , A61M2025/105 , A61M2025/1081
摘要： The present invention relates to balloon catheters for treating a luminal system of a patient. Specifically, the invention relates to catheters having a flexible membrane positioned at a distal portion of the catheter, the flexible membrane retained in a substantially unexposed conformation prior to deployment. Preferably the flexible membrane is capable of delivering a therapeutic agent to a localized environment when deployed to an exposed conformation.
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公开(公告)号：US08617104B2
公开(公告)日：2013-12-31
申请号：US13616305
申请日：2012-09-14
申请人： Travis R. Yribarren , Randolf von Oepen , Kevin J. Ehrenreich , William E. Webler, Jr. , Richard R. Newhauser
发明人： Travis R. Yribarren , Randolf von Oepen , Kevin J. Ehrenreich , William E. Webler, Jr. , Richard R. Newhauser
IPC分类号： A61M37/00
CPC分类号： A61M25/1006 , A61F2/958 , A61M25/0119 , A61M2025/1015 , A61M2025/105 , A61M2025/1059 , A61M2025/1065 , A61M2025/1068
摘要： The present invention relates to balloon catheters for treating a luminal system of a patient. Specifically, the invention relates to catheters having a flexible membrane positioned at a distal portion of the catheter, the flexible membrane retained in a substantially unexposed conformation prior to deployment. Preferably the flexible membrane is capable of delivering a therapeutic agent to a localized environment when deployed to an exposed conformation.
摘要翻译： 本发明涉及用于治疗患者的管腔系统的气囊导管。 具体地，本发明涉及具有位于导管的远端部分的柔性膜的导管，柔性膜在展开之前保持基本上未曝光的构象。 优选地，当部署到暴露的构象时，柔性膜能够将治疗剂递送至局部环境。
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