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    Epicardial patch including isolated extracellular matrix with pacing electrodes
    1.
    发明申请
    Epicardial patch including isolated extracellular matrix with pacing electrodes 失效
    心外膜包括分离的细胞外基质与起搏电极

    公开(公告)号：US20060136028A1

    公开(公告)日：2006-06-22

    申请号：US11017627

    申请日：2004-12-20

    申请人： Jeffrey Ross ,  John Kim ,  Rodney Salo ,  Ronald Heil ,  Randy Westlund

    发明人： Jeffrey Ross ,  John Kim ,  Rodney Salo ,  Ronald Heil ,  Randy Westlund

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0587 ,  A61N1/0568 ,  A61N1/059

    摘要： An epicardial patch includes an extracellular matrix (ECM) and a plurality of electrodes. The isolated ECM is configured for epicardial attachment over a myocardial region including an injured area to control post-injury remodeling of the myocardial region. The plurality of electrodes is configured for delivering electrical stimulation to enhance the effect of the isolated ECM in remodeling control by altering workload and stress on the myocardial region.

    摘要翻译： 心外膜贴片包括细胞外基质（ECM）和多个电极。 分离的ECM被配置用于在包括受伤区域的心肌区域上的心外膜附着以控制心肌区域的损伤后重建。 多个电极被配置为通过改变心肌区域上的工作负荷和压力来传递电刺激以增强孤立的ECM在重塑控制中的作用。

    Method for manipulating an adjustable shape guide catheter
    7.
    发明授权
    Method for manipulating an adjustable shape guide catheter 失效
    用于操纵可调整导向导管的方法

    公开(公告)号：US07875018B2

    公开(公告)日：2011-01-25

    申请号：US11027114

    申请日：2004-12-30

    申请人： Bruce Tockman ,  Randy Westlund

    发明人： Bruce Tockman ,  Randy Westlund

    IPC分类号： A61M31/00

    CPC分类号： A61M25/0041 ,  A61M25/0105 ,  A61M25/0136

    摘要： A method of manipulating a catheter assembly involves providing an inner catheter member movably disposed within an outer catheter member. At least a distal end portion of the inner catheter member has a stiffness greater than that of at least a distal end portion of the outer catheter member. The distal end portion of the outer catheter member includes a deflectable distal end. The method further involves advancing the inner catheter member through the outer catheter member toward the deflectable distal end of the outer catheter member, and longitudinally displacing the distal end portion of the inner catheter member relative to the deflectable distal end of the outer catheter member to alter a shape of the deflectable distal end.

    摘要翻译： 操作导管组件的方法包括提供可移动地设置在外导管构件内的内导管构件。 至少内导管部件的远端部分的刚度大于外导管部件的至少远端部分的刚度。 外导管构件的远端部分包括可偏转的远端。 该方法还包括使内部导管构件通过外部导管构件朝向外部导管构件的可偏转远端推进，并且相对于外部导管构件的可偏转远端纵向移动内部导管构件的远端部分以改变 可偏转的远端的形状。

    Seal for use with cardiac lead
    8.
    发明授权
    Seal for use with cardiac lead 失效
    密封用于心脏铅

    公开(公告)号：US07657324B2

    公开(公告)日：2010-02-02

    申请号：US10617881

    申请日：2003-07-14

    申请人： Randy Westlund ,  Bruce Tockman ,  Gwen Crevensten ,  Lili Liu ,  Christopher M. Zerby

    发明人： Randy Westlund ,  Bruce Tockman ,  Gwen Crevensten ,  Lili Liu ,  Christopher M. Zerby

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0565 ,  A61N1/056 ,  A61N1/0573

    摘要： A seal adapted for use with medical devices is provided. The medical device may be a lead having a distal tip adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity. The lead assembly in one embodiment includes an atraumatic tip. A seal is provided within the lead tip assembly, which prevents or limits further entry of fluids through the lead tip. The lead may be a left ventricular lead with a hemostasis mechanism provided therewithin.

    摘要翻译： 提供适于与医疗装置一起使用的密封件。 医疗装置可以是具有适于植入在心脏上或周围的远端的引线，并且用于连接到用于监测或刺激心脏活动的系统。 在一个实施例中的引线组件包括无创伤的尖端。 在引线端头组件内提供密封件，其防止或限制流体进一步进入引线尖端。 铅可以是在其中设置有止血机构的左心室导联。

    Coronary vein leads having an atraumatic tip and method therefor
    9.
    发明授权
    Coronary vein leads having an atraumatic tip and method therefor 有权
    冠状静脉引导具有无创伤的尖端及其方法

    公开(公告)号：US07628801B2

    公开(公告)日：2009-12-08

    申请号：US10128997

    申请日：2002-04-23

    申请人： Randy Westlund ,  Bruce Tockman ,  Christina Repasky ,  Lyle A. Bye ,  Brian D. Soltis

    发明人： Randy Westlund ,  Bruce Tockman ,  Christina Repasky ,  Lyle A. Bye ,  Brian D. Soltis

    IPC分类号： A61F7/00

    CPC分类号： A61N1/056 ,  A61N1/057 ,  A61N2001/0585

    摘要： A lead having an atraumatic tip is adapted for implantation on or about the heart within the coronary vasculature and for connection to a signal generator. The lead is constructed and arranged so that when it is implanted, the electrodes are housed in the coronary vasculature and are biased toward a vessel wall by a preformed biased portion. Near the distal end, the lead has an optional tapered portion and a flexible portion, where the flexible portion is more flexible than the biased portion.

    摘要翻译： 具有无创尖端的引线适于植入在冠状脉管系统内或心脏周围并用于连接到信号发生器。 引线被构造和布置成使得当其被植入时，电极被容纳在冠状脉管系统中并且被预先偏置的部分偏压到血管壁。 在远端附近，引线具有可选的锥形部分和柔性部分，其中柔性部分比偏置部分更柔性。

    SELECTIVE NERVE STIMULATION WITH OPTIONALLY CLOSED-LOOP CAPABILITIES
    10.
    发明申请
    SELECTIVE NERVE STIMULATION WITH OPTIONALLY CLOSED-LOOP CAPABILITIES 有权
    选择性神经刺激具有可选的闭环能力

    公开(公告)号：US20080234780A1

    公开(公告)日：2008-09-25

    申请号：US11687809

    申请日：2007-03-19

    申请人： David J. Smith ,  Randy Westlund ,  Imad Libbus

    发明人： David J. Smith ,  Randy Westlund ,  Imad Libbus

    IPC分类号： A61N1/05

    CPC分类号： A61N1/36139 ,  A61N1/36071 ,  A61N1/36114 ,  A61N1/36185

    摘要： Systems and methods for steering one or more stimulation fields to a selected nerve target, thereby optimizing one or a combination of low stimulation thresholds, desired therapy outcomes, or a minimization of adverse stimulation side-effects. An array of electrodes disposed, at least in part, on two or more neural stimulation leads are used for steering the stimulation fields to the selected nerve target and are positioned adjacent the selected target. The stimulation may be titrated based on, among other things, a detected physiologic response to the applied stimulation.

    摘要翻译： 用于将一个或多个刺激场转向所选择的神经靶的系统和方法，从而优化低刺激阈值，期望的治疗结果或不利刺激副作用的最小化中的一个或组合。 使用至少部分地设置在两个或更多个神经刺激引线上的电极阵列，用于将刺激场转向所选择的神经靶，并且定位成与所选择的靶相邻。 基于对所施加的刺激的检测到的生理反应，刺激可以被滴定。