公开(公告)号：US20060089500A1

公开(公告)日：2006-04-27

申请号：US11296749

申请日：2005-12-07

申请人： Ranga Gurram ,  Venkateswarlu Akella ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Parimal Misra ,  Vidya Lohray ,  Braj Lohray ,  Rao Paraselli

发明人： Ranga Gurram ,  Venkateswarlu Akella ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Parimal Misra ,  Vidya Lohray ,  Braj Lohray ,  Rao Paraselli

IPC分类号： A61K31/513 ,  C07D239/02

CPC分类号： C07D239/36 ,  C07C217/22 ,  C07C237/32 ,  C07C247/04 ,  C07D239/90

摘要： The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their analogs, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. The present invention also relates to novel intermediates, processes for their preparation and their use in the preparation of compounds of formula (I).

公开(公告)号：US20050032864A1

公开(公告)日：2005-02-10

申请号：US10917221

申请日：2004-08-12

申请人： Vidya Lohray ,  Braj Lohray ,  Rao Paraselli ,  Ranga Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Sarma Pakala

发明人： Vidya Lohray ,  Braj Lohray ,  Rao Paraselli ,  Ranga Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Sarma Pakala

IPC分类号： C07D239/36 ,  C07D239/46 ,  C07D239/88 ,  C07D241/34 ,  C07D277/34 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  A61K31/4178 ,  C07D43/02

CPC分类号： C07D239/36 ,  C07D239/47 ,  C07D239/88 ,  C07D277/34 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04

摘要： The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

摘要翻译： 本发明涉及新的抗糖尿病化合物，其互变异构形式，其衍生物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 本发明特别涉及通式（I）的新的唑来二酮衍生物及其药学上可接受的盐，药学上可接受的溶剂合物和含有它们的药物组合物。

公开(公告)号：US20060148793A1

公开(公告)日：2006-07-06

申请号：US11182032

申请日：2005-07-14

申请人： Braj Lohray ,  Vidya Lohray ,  Ashok Bajji ,  Shivaramayya Kalchar ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

发明人： Braj Lohray ,  Vidya Lohray ,  Ashok Bajji ,  Shivaramayya Kalchar ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

IPC分类号： A61K31/5415 ,  A61K31/538 ,  A61K31/498 ,  C07D279/24 ,  C07D265/34

CPC分类号： C07C59/64 ,  C07C69/734 ,  C07D265/28 ,  C07D265/38 ,  C07D279/22 ,  C07D279/24 ,  C07D279/26 ,  C07D413/06 ,  C07D417/06

摘要： Novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses.

公开(公告)号：US07157581B2

公开(公告)日：2007-01-02

申请号：US11296749

申请日：2005-12-07

申请人： Ranga Madhavan Gurram ,  Venkateswarlu Akella ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Parimal Misra ,  Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli

发明人： Ranga Madhavan Gurram ,  Venkateswarlu Akella ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Parimal Misra ,  Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli

IPC分类号： C07D239/02

CPC分类号： C07D239/36 ,  C07C217/22 ,  C07C237/32 ,  C07C247/04 ,  C07D239/90

摘要： The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their analogs, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. The present invention also relates to novel intermediates, processes for their preparation and their use in the preparation of compounds of formula (I).

摘要翻译： 本发明涉及新型抗肥胖和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 更具体地，本发明涉及通式（I）的新型β-芳基-α-氧代取代的烷基羧酸，其衍生物，它们的类似物，其互变异构形式，它们的立体异构体，它们的多晶型物，其药学上可接受的盐，它们的药学上可接受的 溶剂合物和含有它们的药学上可接受的组合物。 本发明还涉及制备上述新化合物，其类似物，其衍生物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，药学上可接受的溶剂化物和含有它们的药物组合物的方法。 本发明还涉及新型中间体，其制备方法及其在制备式（I）化合物中的用途。

公开(公告)号：US07053217B2

公开(公告)日：2006-05-30

申请号：US10041384

申请日：2002-01-08

申请人： Ranga Madhavan Gurram ,  Venkateswarlu Akella ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Parimal Misra ,  Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli

发明人： Ranga Madhavan Gurram ,  Venkateswarlu Akella ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Parimal Misra ,  Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli

IPC分类号： C07D239/22

CPC分类号： C07D239/36 ,  C07C217/22 ,  C07C237/32 ,  C07C247/04 ,  C07D239/90

摘要： The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their analogs, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. The present invention also relates to novel intermediates, processes for their preparation and their use in the preparation of compounds of formula (I).

摘要翻译： 本发明涉及新型抗肥胖和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 更具体地，本发明涉及通式（I）的新型β-芳基-α-氧代取代的烷基羧酸，其衍生物，它们的类似物，其互变异构形式，它们的立体异构体，它们的多晶型物，其药学上可接受的盐，它们的药学上可接受的 溶剂合物和含有它们的药学上可接受的组合物。 本发明还涉及制备上述新化合物，其类似物，其衍生物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，药学上可接受的溶剂化物和含有它们的药物组合物的方法。 本发明还涉及新型中间体，其制备方法及其在制备式（I）化合物中的用途。

公开(公告)号：US06369067B1

公开(公告)日：2002-04-09

申请号：US09507371

申请日：2000-02-18

申请人： Ranga Madhavan Gurram ,  Venkateswarlu Akella ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Parimal Misra ,  Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli

发明人： Ranga Madhavan Gurram ,  Venkateswarlu Akella ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Parimal Misra ,  Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli

IPC分类号： A01N4354

CPC分类号： C07D239/36 ,  C07C217/22 ,  C07C237/32 ,  C07C247/04 ,  C07D239/90

摘要： The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel &bgr;-aryl-&agr;-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their analogs, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. The present invention also relates to novel intermediates, processes for their preparation and their use in the preparation of compounds of formula (I).

摘要翻译： 本发明涉及新型抗肥胖和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 更具体地，本发明涉及通式（I）的新型β-芳基-α-氧代取代的烷基羧酸，其衍生物，它们的类似物，其互变异构形式，它们的立体异构体，它们的多晶型物，其药学上可接受的盐，它们的药学上可接受的 溶剂合物和含有它们的药学上可接受的组合物。 本发明还涉及制备上述新化合物，其类似物，其衍生物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，药学上可接受的溶剂化物和含有它们的药物组合物的方法。 本发明还涉及新型中间体，其制备方法及其在制备式（I）化合物中的用途。

公开(公告)号：US06444816B1

公开(公告)日：2002-09-03

申请号：US09507373

申请日：2000-02-18

申请人： Saibal Kumar Das ,  Papi Reddy Purma ,  Venkateswarlu Akella ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli

发明人： Saibal Kumar Das ,  Papi Reddy Purma ,  Venkateswarlu Akella ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli

IPC分类号： C07D23902

CPC分类号： C07C217/22 ,  C07C237/32 ,  C07C247/04 ,  C07D239/36 ,  C07D239/90

摘要： The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel &bgr;-aryl-&agr;-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their analogs, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. The present invention also relates to novel intermediates, processes for their preparation and their use in the preparation of compounds of formula (I).

摘要翻译： 本发明涉及新型抗肥胖和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 更具体地，本发明涉及通式（I）的新型β-芳基-α-氧代取代的烷基羧酸，其衍生物，它们的类似物，其互变异构形式，它们的立体异构体，它们的多晶型物，其药学上可接受的盐，它们的药学上可接受的 溶剂合物和含有它们的药学上可接受的组合物。 本发明还涉及制备上述新化合物，其类似物，其衍生物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，药学上可接受的溶剂化物和含有它们的药物组合物的方法。 本发明还涉及新型中间体，其制备方法及其在制备式（I）化合物中的用途。

公开(公告)号：US06686390B2

公开(公告)日：2004-02-03

申请号：US09861903

申请日：2001-05-21

申请人： Manojit Pal ,  Koteswar Rao Yeleswarapu ,  Rajagopalan Ramanujam ,  Parimal Misra ,  Prem Kumar Mamnoor ,  Seshagiri Rao Casturi

发明人： Manojit Pal ,  Koteswar Rao Yeleswarapu ,  Rajagopalan Ramanujam ,  Parimal Misra ,  Prem Kumar Mamnoor ,  Seshagiri Rao Casturi

IPC分类号： A61K3134

CPC分类号： C07D207/444 ,  C07D207/38 ,  C07D307/58 ,  C07D307/60 ,  C07D409/04 ,  C07D417/10

摘要： The present invention relates to novel heterocyclic compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their regioisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.

摘要翻译： 本发明涉及通式（I）的新型杂环化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其区域异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物 。

公开(公告)号：US6130214A

公开(公告)日：2000-10-10

申请号：US179141

申请日：1998-10-26

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

IPC分类号： C07C235/48 ,  C07C323/62 ,  C07C327/48 ,  C07D239/90 ,  C07D265/22 ,  C07D279/08 ,  A61K31/54 ,  A61K31/535 ,  C07D265/12 ,  C07D279/16

CPC分类号： C07C323/62 ,  C07C235/48 ,  C07C327/48 ,  C07D239/90 ,  C07D265/22 ,  C07D279/08

摘要： The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel .beta.-aryl-.alpha.-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. ##STR1##

摘要翻译： 本发明涉及新型抗肥胖和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 更具体地说，本发明涉及通式（I）的新型β-芳基-α-氧基取代的烷基羧酸，其衍生物，它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，它们的药学上可接受的盐，它们的药学上可接受的 溶剂合物和含有它们的药学上可接受的组合物。

公开(公告)号：USRE39266E1

公开(公告)日：2006-09-05

申请号：US10697926

申请日：2003-10-30

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Ranga Madhavan Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Sarma K. S. Pakala

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Ranga Madhavan Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Sarma K. S. Pakala

IPC分类号： A01K31/505 ,  C07D239/02 ,  C07D239/70

CPC分类号： C07D239/36 ,  C07D239/47 ,  C07D239/88 ,  C07D277/34 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04

摘要： The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them.