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    Interleukin-12 as an adjuvant for paramyxoviridae vaccines
    4.
    发明授权
    Interleukin-12 as an adjuvant for paramyxoviridae vaccines 失效
    白细胞介素-12作为副粘病毒疫苗的佐剂

    公开(公告)号：US6071893A

    公开(公告)日：2000-06-06

    申请号：US980160

    申请日：1997-11-26

    申请人： Barney S. Graham ,  Yi-Wei Tang

    发明人： Barney S. Graham ,  Yi-Wei Tang

    IPC分类号： A61K38/00 ,  A61K39/155 ,  A61K39/165 ,  A61K39/17 ,  A61K39/175 ,  A61K39/39 ,  A61K48/00

    CPC分类号： C07K16/1027 ,  A61K39/12 ,  A61K39/155 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/55538 ,  A61K2039/57 ,  C07K2317/52 ,  C12N2760/18534

    摘要： A method is disclosed of reducing viral replication of a virus of the paramyxoviridae family in a host, comprising administering to the host an antigen of the virus in combination with an effective adjuvant amount of interleukin-12 (IL-12). Human viruses of the paramyxoviridae family include paramyxoviruses (e.g., parainfluenza virus 1, parainfluenza virus 2, parainfluenza virus 3 and parainfluenza virus 4), morbilliviruses (e.g., measles virus) and pneumoviruses (e.g., respiratory syncytial virus); other non-human viruses of the paramyxoviridae family include canine distemper virus, bovine respiratory syncytial virus, Newcastle disease virus and rhinderpest virus. A composition is also disclosed comprising a mixture of an antigen of a virus of the Paramyxoviridae family and an effective adjuvant amount of interleukin-12 (IL-12).

    摘要翻译： 公开了减少宿主中副粘病毒科病毒的病毒复制的方法，包括向宿主施用病毒抗原与有效佐剂量的白细胞介素-12（IL-12）组合。 副粘病毒科的人类病毒包括副粘病毒（例如副流感病毒1，副流感病毒2，副流感病毒3和副流感病毒4），斑疹病毒（例如麻疹病毒）和肺炎链球菌（例如呼吸道合胞病毒）; 副粘病毒科其他非人类病毒包括犬瘟热病毒，牛呼吸道合胞病毒，新城疫病毒和牛瘟病毒。 还公开了一种组合物，其包含副粘病毒科的病毒抗原与有效佐剂量的白细胞介素-12（IL-12）的混合物。

    RSV IMMUNOGENS, ANTIBODIES AND COMPOSITIONS THEREOF
    5.
    发明申请
    RSV IMMUNOGENS, ANTIBODIES AND COMPOSITIONS THEREOF 审中-公开
    RSV免疫原，抗体及其组合物

    公开(公告)号：US20120315270A1

    公开(公告)日：2012-12-13

    申请号：US13502595

    申请日：2010-10-21

    申请人： Jason S. McLellan ,  Peter D. Kwong ,  Barney S. Graham ,  William R. Schief ,  Joe Jardine ,  Bruno Correia ,  Man Chen

    发明人： Jason S. McLellan ,  Peter D. Kwong ,  Barney S. Graham ,  William R. Schief ,  Joe Jardine ,  Bruno Correia ,  Man Chen

    IPC分类号： A61K39/12 ,  A61K39/42 ,  A61P31/14 ,  C07K16/10 ,  C07K14/08 ,  C07H21/04

    CPC分类号： A61K39/155 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/55561 ,  A61K2039/57 ,  A61K2039/645 ,  C07K14/005 ,  C07K16/1027 ,  C07K2317/34 ,  C12N2760/18522 ,  C12N2760/18534

    摘要： The present invention provides immunogens that protect against RSV infection. The present invention also provides antibody proteins that protect against RSV infection. Such immunogens and antibody proteins are produced based on three-dimensional models also included in the invention. One model is of a complex between motavizumab and its antibody-binding domain on RSV fusion (F) protein. A second model is of a complex between 10 IF antibody and its antibody-binding domain on RSV F protein. The immunogens disclosed herein have been modified to elicit a humoral response against RSV F protein without eliciting a significant cell-mediated response against RSV. Such immunogens can comprise a scaffold into which RSV contact residues are embedded. The present invention also includes methods that utilize the disclosed three-dimensional models to produce immunogens and antibody proteins of the present invention. Also disclosed are methods of using the disclosed immunogens, for example to protect individuals from RSV infection. Also disclosed are methods of using the disclosed antibody proteins, for example to protect individuals from RSV infection.

    摘要翻译： 本发明提供了防止RSV感染的免疫原。 本发明还提供了抗RSV感染的抗体蛋白。 此类免疫原和抗体蛋白是基于也包括在本发明中的三维模型产生的。 一个模型是在莫维珠单抗和其在RSV融合（F）蛋白上的抗体结合域之间的复合物。 第二个模型是10 IF抗体与RSV F蛋白的抗体结合结构域之间的复合物。 本文公开的免疫原已被修饰以引发针对RSV F蛋白的体液应答，而不引发针对RSV的显着的细胞介导的应答。 这样的免疫原可以包含嵌入RSV接触残基的支架。 本发明还包括利用所公开的三维模型产生本发明的免疫原和抗体蛋白的方法。 还公开了使用所公开的免疫原的方法，例如保护个体免受RSV感染。 还公开了使用所公开的抗体蛋白质的方法，例如保护个体免受RSV感染。