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公开(公告)号：US06878341B2
公开(公告)日：2005-04-12
申请号：US10010659
申请日：2001-12-06
申请人： Reid Burton Kowallis , David M. Cox
发明人： Reid Burton Kowallis , David M. Cox
CPC分类号： B01L3/5085 , G01N35/1065 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/2575
摘要： Generally, the present invention provides a device and method for accurately locating a multi-well plate at a plate-support location, e.g., a work surface, of an automated laboratory machine, such that one or more acting members of the machine, such as an array of pipette tips, optical sensors, or the like, can accurately address and operate on the individual wells. Interior and/or exterior surface regions of one or more wells of a multi-well plate are used as the primary plate features engaged by locating structure of the machine. In one particular embodiment one or more upwardly tapered projections extend from a plate-support surface of a plate-handling machine for mating engagement with the exterior surface regions of one or more wells. In another embodiment, the exterior surface regions along one or more well bottoms are engagingly received within bores, or other receiving structure, formed on the place-support surface of a machine. In a further embodiment, one or more downwardly extending projections depend from an acting-member support, along with the acting members of a machine. Introduction of the projections into some of the wells of a multi-well plate serves to align the acting members with the plate's other wells.
摘要翻译： 通常，本发明提供了一种用于在自动化实验室机器的板支撑位置（例如工作表面）处精确地定位多孔板的装置和方法，使得机器的一个或多个作用构件，例如 移液管尖端，光学传感器等的阵列可以精确地解决和操作各个井。 使用多孔板的一个或多个孔的内部和/或外部表面区域作为通过定位机器的结构而接合的主要板材特征。 在一个特定实施例中，一个或多个向上锥形突起从板处理机的板支撑表面延伸，用于与一个或多个井的外表面区域配合接合。 在另一个实施例中，沿着一个或多个井底的外表面区域被啮合地容纳在形成在机器的位置支撑表面上的孔或其它接收结构内。 在另一个实施例中，一个或多个向下延伸的突起与作用构件支撑件一起，与机器的作用构件一起。 将突出物引入多孔板的一些孔中用于使作用构件与板的其它孔对齐。
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公开(公告)号：US06916447B2
公开(公告)日：2005-07-12
申请号：US10016979
申请日：2001-12-12
申请人： Reid Burton Kowallis
发明人： Reid Burton Kowallis
IPC分类号： G01N35/10 , B01L3/02 , C12M1/00 , C12Q1/68 , C40B60/14 , G01N33/53 , G01N35/00 , G01N37/00 , G01N21/00
CPC分类号： B01L3/0244 , B01J2219/00367 , B01J2219/00459 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00605 , B01J2219/00648 , B01J2219/00659 , B01L3/0262 , B01L2300/0838 , C40B60/14 , G01N35/00009 , G01N35/10 , Y10T436/11 , Y10T436/110833 , Y10T436/112499 , Y10T436/114998 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： The present invention provides a method and apparatus for dispensing small volumes of selected substances, such as biological reagents or samples, onto substrates. According to one general embodiment, a plurality of spaced, tandemly-arranged substrates are advanced, e.g., by way of a conveyor, along a transport pathway extending over a reagent-supply location, such as a reservoir supported at a fixed position in a base. From a position over the reagent-supply location and the pathway, a reagent-transfer instrument, or tip, is extended along an axis through an intervening region, e.g., an opening defined by a surface of the conveyor, separating an adjacent pair of advancing substrates to contact reagent held at the reagent-supply location. The reagent-transfer instrument is then withdrawn, along with a portion of such reagent, through the intervening region to a position above the transport pathway. Once the conveyor has advanced a selected substrate, upstream of the intervening region, to a position aligned with the axis of the reagent-transfer instrument, a selected amount of reagent is transferred from the instrument onto a selected site of the substrate. Advantageously, the apparatus and method are readily adaptable for the production of micro-arrays having a great number of closely spaced spots.
摘要翻译： 本发明提供了用于将小体积的选定物质（例如生物试剂或样品）分配到基底上的方法和装置。 根据一个一般实施例，沿着沿着试剂供应位置延伸的输送路径，例如通过输送机前进的多个间隔开的串列布置的基板，例如支撑在基座中的固定位置处的储存器 。 从试剂供应位置和路径上的位置，试剂转移仪器或尖端沿着轴线延伸穿过中间区域，例如由输送机的表面限定的开口，分离相邻的一对前进 接触试剂供应位置的接触试剂的底物。 然后将试剂转移仪器连同一部分这种试剂一起通过中间区域排出到输送通道上方的位置。 一旦输送机将所选择的基板在中间区域的上游推进到与试剂转移仪器的轴线对准的位置，则将选定量的试剂从仪器转移到基板的选定位置。 有利地，该装置和方法容易适用于生产具有大量紧密间隔的点的微阵列。
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公开(公告)号：US06355487B2
公开(公告)日：2002-03-12
申请号：US09846467
申请日：2001-04-30
申请人： Reid Burton Kowallis
发明人： Reid Burton Kowallis
IPC分类号： G01N3500
CPC分类号： B01L3/0244 , B01J2219/00367 , B01J2219/00459 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00605 , B01J2219/00648 , B01J2219/00659 , B01L3/0262 , B01L2300/0838 , C40B60/14 , G01N35/00009 , G01N35/10 , Y10T436/11 , Y10T436/110833 , Y10T436/112499 , Y10T436/114998 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： The present invention provides a method and apparatus for dispensing small volumes of selected substances, such as biological reagents or samples, onto substrates. According to one general embodiment, a plurality of spaced, tandemly-arranged substrates are advanced, e.g., by way of a conveyor, along a transport pathway extending over a reagent-supply location, such as a reservoir supported at a fixed position in a base. From a position over the reagent-supply location and the pathway, a reagent-transfer instrument, or tip, is extended along an axis through an intervening region, e.g., an opening defined by a surface of the conveyor, separating an adjacent pair of advancing substrates to contact reagent held at the reagent-supply location. The reagent-transfer instrument is then withdrawn, along with a portion of such reagent, through the intervening region to a position above the transport pathway. Once the conveyor has advanced a selected substrate, upstream of the intervening region, to a position aligned with the axis of the reagent-transfer instrument, a selected amount of reagent is transferred from the instrument onto a selected site of the substrate. Advantageously, the apparatus and method are readily adaptable for the production of micro-arrays having a great number of closely spaced spots.
摘要翻译： 本发明提供了用于将小体积的选定物质（例如生物试剂或样品）分配到基底上的方法和装置。 根据一个一般实施例，沿着沿着试剂供应位置延伸的输送路径，例如通过输送机前进的多个间隔开的串列布置的基板，例如支撑在基座中的固定位置处的储存器 。 从试剂供应位置和路径上的位置，试剂转移仪器或尖端沿着轴线延伸穿过中间区域，例如由输送机的表面限定的开口，分离相邻的一对前进 接触试剂供应位置的接触试剂的底物。 然后将试剂转移仪器连同一部分这种试剂一起通过中间区域排出到输送通道上方的位置。 一旦输送机将所选择的基板在中间区域的上游推进到与试剂转移仪器的轴线对准的位置，则将选定量的试剂从仪器转移到基板的选定位置。 有利地，该装置和方法容易适用于生产具有大量紧密间隔的点的微阵列。
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公开(公告)号：US06245297B1
公开(公告)日：2001-06-12
申请号：US09293659
申请日：1999-04-16
申请人： Reid Burton Kowallis
发明人： Reid Burton Kowallis
IPC分类号： G01N2100
CPC分类号： B01L3/0244 , B01J2219/00367 , B01J2219/00459 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00605 , B01J2219/00648 , B01J2219/00659 , B01L3/0262 , B01L2300/0838 , C40B60/14 , G01N35/00009 , G01N35/10 , Y10T436/11 , Y10T436/110833 , Y10T436/112499 , Y10T436/114998 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： The present invention provides a method and apparatus for dispensing small volumes of selected substances, such as biological reagents or samples, onto substrates. According to one general embodiment, a plurality of spaced, tandemly-arranged substrates are advanced, e.g., by way of a conveyor, along a transport pathway extending over a reagent-supply location, such as a reservoir supported at a fixed position in a base. From a position over the reagent-supply location and the pathway, a reagent-transfer instrument, or tip, is extended along an axis through an intervening region, e.g., an opening defined by a surface of the conveyor, separating an adjacent pair of advancing substrates to contact reagent held at the reagent-supply location. The reagent-transfer instrument is then withdrawn, along with a portion of such reagent, through the intervening region to a position above the transport pathway. Once the conveyor has advanced a selected substrate, upstream of the intervening region, to a position aligned with the axis of the reagent-transfer instrument, a selected amount of reagent is transferred from the instrument onto a selected site of the substrate. Advantageously, the apparatus and method are readily adaptable for the production of micro-arrays having a great number of closely spaced spots.
摘要翻译： 本发明提供了用于将小体积的选定物质（例如生物试剂或样品）分配到基底上的方法和装置。 根据一个一般实施例，沿着沿着试剂供应位置延伸的输送路径，例如通过输送机前进的多个间隔开的串列布置的基板，例如支撑在基座中的固定位置处的储存器 。 从试剂供应位置和路径上的位置，试剂转移仪器或尖端沿着轴线延伸穿过中间区域，例如由输送机的表面限定的开口，分离相邻的一对前进 接触试剂供应位置的接触试剂的底物。 然后将试剂转移仪器连同一部分这种试剂一起通过中间区域排出到输送通道上方的位置。 一旦输送机将所选择的基板在中间区域的上游推进到与试剂转移仪器的轴线对准的位置，则将选定量的试剂从仪器转移到基板的选定位置。 有利地，该装置和方法容易适用于生产具有大量紧密间隔的点的微阵列。
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