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1.发明申请Composition containing an androgenous 11b-halogen steroid and a progestational hormone, and male contraceptive based on said composition 审中-公开含有雄激素11b-卤素类固醇和促孕激素的组合物，以及基于所述组合物的男性避孕药公开(公告)号：US20060100180A1
公开(公告)日：2006-05-11
申请号：US10522169
申请日：2003-07-25
IPC分类号： A61K31/56
CPC分类号： A61K31/56 , A61K31/565
摘要： The invention relates to a novel chemical composition containing an androgenous 11β-halogen steroid and the progestational hormone of formula (I), to a pharmaceutical composition containing said chemical composition and to a male contraceptive based on said pharmaceutical composition.
摘要翻译： 本发明涉及含有所述化学组合物的药物组合物和基于所述药物组合物的男性避孕药的含有雄激素11b-卤素类固醇和式（I）的孕激素的新型化学组合物。
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公开(公告)号：US20050075322A1
公开(公告)日：2005-04-07
申请号：US10467352
申请日：2002-01-24
CPC分类号： C07J1/0074 , C07J1/0022 , C07J1/0025 , C07J1/007
摘要： The invention relates to 11β-halogen steroids with general formula (I), whereby R11 is halogen, X—Y-Z represents a group with one of the two structures CH═C—C or CH2—C═C and the other radicals have the meaning that is indicated in the claims, also the production and use of these compounds for the production of pharmaceutical agents as well as pharmaceutical preparations that contain 11β-halogen steroids.
摘要翻译： 本发明涉及具有通式（I）的11b-卤素类固醇，其中R 11是卤素，XYZ代表具有CH = CC或CH 2 -C = C两种结构之一的基团，而其它基团具有如下含义： 也在这些化合物的生产和使用中用于生产药剂以及含有11β-卤素类固醇的药物制剂。
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公开(公告)号：US07361645B2
公开(公告)日：2008-04-22
申请号：US10467352
申请日：2002-01-24
CPC分类号： C07J1/0074 , C07J1/0022 , C07J1/0025 , C07J1/007
摘要： The invention relates to 11β-halogen steroids with general formula (I), whereby R11 is halogen, X—Y-Z represents a group with one of the two structures CH═C—C or CH2—C═C and the other radicals have the meaning that is indicated in the claims, also the production and use of these compounds for the production of pharmaceutical agents as well as pharmaceutical preparations that contain 11β-halogen steroids.
摘要翻译： 本发明涉及具有通式（I）的11b-卤素类固醇，其中R 11是卤素，XYZ代表具有两个结构之一的CH-CC或CH 2 2的基团 > -CC，其它基团具有权利要求书中所示的含义，以及这些化合物用于生产药物的生产和使用以及含有11b-卤素类固醇的药物制剂。
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4.发明申请Microbiological process for the production of 7-substitued 11-hydroxy steroids, 7,17-substituted 11-halogen steroids, and uses thereof 审中-公开用于制备7-取代的11-羟基类固醇，7,17-取代的11-卤素类固醇的微生物过程及其用途公开(公告)号：US20070298456A1
公开(公告)日：2007-12-27
申请号：US11826633
申请日：2007-07-17
申请人： Lud-wig Zorn , Rolf Bohlmann , Norbert Gallus , Hermann Kuenzer , Hans-Peter Muhn , Reinhard Nubbemeyer
发明人： Lud-wig Zorn , Rolf Bohlmann , Norbert Gallus , Hermann Kuenzer , Hans-Peter Muhn , Reinhard Nubbemeyer
IPC分类号： C12P33/00
CPC分类号： C07J1/00 , C07J1/0051 , C07J3/00 , C07J5/00 , C07J7/00 , C07J9/00 , C07J11/00 , C07J31/00 , C07J41/00 , C12P33/10 , C12P33/16
摘要： A novel method of synthesis for the manufacture of upstream products for the production of compounds with general formulas 8, 10, and 12 is described. In this synthesis, compounds with general formula 4,B are produced in a microbiological reaction. The meanings of R7, R10, R11, R13, R17 and R17′ as well as of the grouping U—V—W—X—Y-Z are indicated in the claims.
摘要翻译： 描述了用于制备用于生产具有通式8,10和12的化合物的上游产物的合成新方法。 在该合成中，通式4的化合物B在微生物反应中产生。 R 7，R 10，R 11，R 13，R 17，R 17，R 17， SUP＆gt;和R＆lt; 17＆gt;以及分组UVWXYZ在权利要求中表示。
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5.发明授权Microbiological process for the production of 7-substituted 11-hydroxy steroids, 7,17-substituted 11-Halogen steroids and uses thereof 失效用于生产7-取代的11-羟基类固醇，7,17-取代的11-卤素类固醇的微生物过程及其用途公开(公告)号：US07262023B2
公开(公告)日：2007-08-28
申请号：US10625559
申请日：2003-07-24
申请人： Ludwig Zorn , Rolf Bohlmann , Norbert Gallus , Hermann Kuenzer , Hans-Peter Muhn , Reinhard Nubbemeyer
发明人： Ludwig Zorn , Rolf Bohlmann , Norbert Gallus , Hermann Kuenzer , Hans-Peter Muhn , Reinhard Nubbemeyer
IPC分类号： C12P33/10
CPC分类号： C07J1/00 , C07J1/0051 , C07J3/00 , C07J5/00 , C07J7/00 , C07J9/00 , C07J11/00 , C07J31/00 , C07J41/00 , C12P33/10 , C12P33/16
摘要： A novel method of synthesis for the manufacture of upstream products for the production of compounds with general formulas 8, 10, and 12 is described. In this synthesis, compounds with general formula 4,B are produced in a microbiological reaction. The meanings of R7, R10, R11, R13, R17 and R17′ as well as of the grouping U—V—W—X—Y—Z are indicated in the claims
摘要翻译： 描述了用于制备用于生产具有通式8,10和12的化合物的上游产物的合成新方法。 在该合成中，通式4的化合物B在微生物反应中产生。 R 7，R 10，R 11，R 13，R 17，R 17，R 17， SUP＆gt;和R＆lt; 17＆gt;以及分组UVWXYZ在权利要求中表示
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![6,7-DIHYDRO-5H-BENZO[7]ANNULENE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, PHARMACEUTICAL PREPARATIONS COMPRISING THEM, AND THE USE THEREOF FOR PRODUCTION OF MEDICAMENTS](/abs-image/US/2013/09/26/US20130252890A1/abs.jpg.150x150.jpg)
6.发明申请6,7-DIHYDRO-5H-BENZO[7]ANNULENE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, PHARMACEUTICAL PREPARATIONS COMPRISING THEM, AND THE USE THEREOF FOR PRODUCTION OF MEDICAMENTS 审中-公开6,7-二氢-5H-苯并[7]蒽醌衍生物，其制备方法，包括它们的药物制剂及其用于生产药物的用途公开(公告)号：US20130252890A1
公开(公告)日：2013-09-26
申请号：US13806845
申请日：2011-06-21
申请人： Tim Wintermantel , Carsten Möller , Ulrich Bothe , Reinhard Nubbemeyer , Ludwig Zorn , Dirk Kosemund , Antonius Ter Laak , Rolf Bohlmann , Lars Wortmann , Donald Bierer
发明人： Tim Wintermantel , Carsten Möller , Ulrich Bothe , Reinhard Nubbemeyer , Ludwig Zorn , Dirk Kosemund , Antonius Ter Laak , Rolf Bohlmann , Lars Wortmann , Donald Bierer
IPC分类号： C07C317/28 , A61K38/22 , A61K31/18 , A61K31/216 , A61K31/165 , A61K31/277 , C07C323/25 , A61K31/145
CPC分类号： C07C317/28 , A61K31/145 , A61K31/165 , A61K31/18 , A61K31/216 , A61K31/277 , A61K38/22 , C07B59/001 , C07B2200/05 , C07C323/25 , C07C2601/02 , C07C2601/14 , C07C2602/12
摘要： The invention relates to selective oestrogen receptor modulators (SERM) and methods of production thereof, use thereof for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular of bleeding disorders, osteoporosis, endometriosis, myomata, hormone-dependent tumours, for hormone replacement therapy and for contraception.
摘要翻译： 本发明涉及选择性雌激素受体调节剂（SERM）及其生产方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是 出血性疾病，骨质疏松症，子宫内膜异位症，肌瘤，激素依赖性肿瘤，用于激素替代疗法和避孕。
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7.发明申请Microbiological process for the production of 7-substituted 11-hydroxy steroids, 7,17-substituted 11-halogen steroids that can be produced therefrom, their process for production and use as well as pharmaceutical prepartions that contain these compounds, as well as 7-substituted estra-1,3,5(10)-trienses that can be produced therefrom 失效用于生产7-取代的11-羟基类固醇，可由其制备的7,17-取代的11-卤素类固醇，其生产和使用方法以及含有这些化合物的药物制剂的微生物过程，以及7- 取代的雌-1,3,5（10） - 三核苷酸公开(公告)号：US20050090477A1
公开(公告)日：2005-04-28
申请号：US10625559
申请日：2003-07-24
申请人： Ludwig Zorn , Rolf Bohlmann , Norbert Gallus , Hermann Kuenzer , Hans-Peter Muhn , Reinhard Nubbemeyer
发明人： Ludwig Zorn , Rolf Bohlmann , Norbert Gallus , Hermann Kuenzer , Hans-Peter Muhn , Reinhard Nubbemeyer
IPC分类号： C07J1/00 , C07J3/00 , C07J5/00 , C07J7/00 , C07J9/00 , C07J11/00 , C07J31/00 , C07J41/00 , C12P33/10 , C12P33/16
CPC分类号： C07J1/00 , C07J1/0051 , C07J3/00 , C07J5/00 , C07J7/00 , C07J9/00 , C07J11/00 , C07J31/00 , C07J41/00 , C12P33/10 , C12P33/16
摘要： A novel method of synthesis for the manufacture of upstream products for the production of compounds with general formulas 8, 10, and 12 is described. In this synthesis, compounds with general formula 4,B are produced in a microbiological reaction. The meanings of R7, R10, R11, R13, R17 and R17′ as well as of the grouping U-V-W-X-Y-Z are indicated in the claims.
摘要翻译： 描述了用于制备用于生产具有通式8,10和12的化合物的上游产物的合成新方法。 在该合成中，通式4的化合物B在微生物反应中产生。 R 7，R 10，R 11，R 13，R 17，R 17，R 17， SUP＆gt;和R＆lt; 17＆gt;以及分组UVWXYZ在权利要求中表示。
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公开(公告)号：US20070135375A1
公开(公告)日：2007-06-14
申请号：US11605473
申请日：2006-11-29
申请人： Ralf Wyrwa , Reinhard Nubbemeyer , Ursula Ganzer
发明人： Ralf Wyrwa , Reinhard Nubbemeyer , Ursula Ganzer
IPC分类号： A61K31/7072 , A61K31/56 , A61K31/4745 , C07H19/12 , C07D453/04 , C07J1/00
CPC分类号： C07D453/04 , C07H19/12
摘要： The invention relates to sulfamoyl sulfonate prodrugs of general formula I, a process for their production, pharmaceutical compositions that contain these compounds, and their use for the production of orally available pharmaceutical agents. The compounds according to the invention bind to carbonic anhydrases and inhibit these enzymes.
摘要翻译： 本发明涉及通式I的氨磺酰磺酸酯前药，其制备方法，含有这些化合物的药物组合物及其用于生产口服可用药剂的用途。 根据本发明的化合物结合碳酸酐酶并抑制这些酶。
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公开(公告)号：US20060069239A1
公开(公告)日：2006-03-30
申请号：US10532482
申请日：2003-10-21
申请人： Christiane Kirchhoff , Heike Obermann-Pless , Annemarie Samalecos , Caroline Osterhoff , Ulrich Gottwald , Reinhard Nubbemeyer
发明人： Christiane Kirchhoff , Heike Obermann-Pless , Annemarie Samalecos , Caroline Osterhoff , Ulrich Gottwald , Reinhard Nubbemeyer
CPC分类号： C07K14/705 , A61K38/00 , A61K2039/505 , C07K16/28 , C07K2317/34
摘要： Isolated splice variant polypeptides from the family of human epididymis-specific receptors called HE6, and related polypeptides from mouse (ME6) and rat (RE6), are described. Also described are isolated polynucleotides encoding the polypeptides, and fragments and variants of the polypeptides and polynucleotides. The polypeptides are involved in maturation of sperm during their passage through the epididymis, and can be used, e.g., to isolate agents for diagnosing and treating male infertility or for male contraception.
摘要翻译： 描述了称为HE6的人附睾特异性受体家族的分离的剪接变体多肽，以及来自小鼠（ME6）和大鼠（RE6）的相关多肽）。 还描述了编码多肽的分离的多核苷酸，以及多肽和多核苷酸的片段和变体。 这些多肽在穿过附睾的过程中参与精子的成熟，并且可以用于例如分离用于诊断和治疗男性不育症或男性避孕的药剂。
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