利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

77 条记录 (耗时 0.035 秒)

    Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient
    1.
    发明授权
    Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient 失效
    含氮杂环衍生物和含有与活性成分相同的药物

    公开(公告)号：US08410276B2

    公开(公告)日：2013-04-02

    申请号：US13016849

    申请日：2011-01-28

    申请人： Yoshikazu Takaoka ,  Shiro Shibayama ,  Rena Nishizawa

    发明人： Yoshikazu Takaoka ,  Shiro Shibayama ,  Rena Nishizawa

    IPC分类号： C07D211/68 ,  A61K31/445

    CPC分类号： C07D413/12 ,  A61K31/00 ,  C07D211/58 ,  C07D231/12 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14

    摘要： A compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof: (wherein each symbol is as defined in the description.) The compounds represented by formula (I) has the antagonistic activity against CCR5, so they are useful in preventing and/or treating CCR5-related diseases, for example, various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, inflammatory bowel disease such as ulcerative colitis, etc.), immunological diseases (autoimmune diseases, rejection in organ transplantation (rejection of graft of solid organ, rejection of graft of pancreatic islet cells in therapy for diabetes, graft-versus-host disease, etc.), immunosuppression, psoriasis, multiple sclerosis, etc.), infectious diseases (infection with human immunodeficiency virus, acquired immunodeficiency syndrome, infection with RSV, etc.), allergic diseases (atopic dermatitis, urticaria, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis, etc.), cardiovascular diseases (arteriosclerosis, ischemic reperfusion injury, etc.), acute respiratory distress syndrome, shock accompanying bacterial infection, diabetes, cancer metastasis and so on.

    摘要翻译： 由式（I）表示的化合物，其盐，其N-氧化物，其溶剂合物或其前药：（其中各符号如说明书中所定义）。式（I）表示的化合物具有拮抗作用 因此它们可用于预防和/或治疗CCR5相关疾病，例如各种炎性疾病（哮喘，肾炎，肾病，肝炎，关节炎，类风湿关节炎，鼻炎，结膜炎，炎性肠病如溃疡性结肠炎） 等等），免疫疾病（自身免疫性疾病，器官移植排斥反应（实体器官移植排斥反应，胰岛细胞移植对糖尿病的治疗排斥反应，移植物抗宿主病等），免疫抑制，牛皮癣， 多发性硬化症等），感染性疾病（人类免疫缺陷病毒感染，获得性免疫缺陷综合征，RSV感染等），过敏性疾病（特应性皮炎，荨麻疹，过敏性 急性呼吸窘迫综合征，伴随细菌感染的休克，糖尿病，癌症转移等），心血管疾病（动脉硬化，缺血再灌注损伤等）。

    Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient
    2.
    发明授权
    Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient 有权
    含氮杂环衍生物和含有与活性成分相同的药物

    公开(公告)号：US07910741B2

    公开(公告)日：2011-03-22

    申请号：US10549120

    申请日：2004-03-12

    申请人： Rena Nishizawa ,  Yoshikazu Takaoka ,  Shiro Shibayama

    发明人： Rena Nishizawa ,  Yoshikazu Takaoka ,  Shiro Shibayama

    IPC分类号： C07D211/68 ,  A61K31/445

    CPC分类号： C07D211/32 ,  C07D211/22 ,  C07D211/34 ,  C07D211/48 ,  C07D211/58 ,  C07D211/62 ,  C07D211/66 ,  C07D211/72 ,  C07D211/74 ,  C07D241/04 ,  C07D295/108 ,  C07D401/04 ,  C07D401/06 ,  C07D401/08 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D487/08

    摘要： A compound represented by the following general formula (I), its salt, solvates thereof or prodrugs thereof: (wherein each symbol is as defined in the description.) The compounds represented by the general formula (I) are useful in preventing and/or treating various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis, etc.), immunological diseases (autoimmune diseases, rejection in organ transplantation, immunosuppression, psoriasis, multiple sclerosis, etc.), infection with human immunodeficiency virus (acquired immunodeficiency syndrome, etc.), allergic diseases (atopic dermatitis, urticaria, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis, etc.), ischemic reperfusion injury, acute respiratory distress syndrome, shock accompanying bacterial infection, diabetes, cancer metastasis and so on.

    摘要翻译： 由以下通式（I）表示的化合物，其盐，溶剂合物或其前药：（其中每个符号如说明书中所定义）。由通式（I）表示的化合物可用于预防和/或 治疗各种炎性疾病（哮喘，肾炎，肾病，肝炎，关节炎，类风湿性关节炎，鼻炎，结膜炎，溃疡性结肠炎等），免疫疾病（器官移植中的自身免疫性疾病，排斥反应，免疫抑制，牛皮癣，多发性硬化症等） ，过敏性疾病（特应性皮炎，荨麻疹，过敏性支气管肺曲霉病，过敏性嗜酸性胃肠炎等），缺血性再灌注损伤，急性呼吸窘迫综合征，伴随细菌感染的休克，糖尿病等的免疫缺陷病毒（获得性免疫缺陷综合征等）感染 ，癌转移等。

    Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient
    3.
    发明申请
    Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient 有权
    含氮杂环衍生物和含有与活性成分相同的药物

    公开(公告)号：US20060178399A1

    公开(公告)日：2006-08-10

    申请号：US10549120

    申请日：2004-03-12

    申请人： Rena Nishizawa ,  Yoshikazu Takaoka ,  Shiro Shibayama

    发明人： Rena Nishizawa ,  Yoshikazu Takaoka ,  Shiro Shibayama

    IPC分类号： A61K31/4545 ,  A61K31/454 ,  C07D417/02 ,  C07D403/02 ,  C07D401/02

    CPC分类号： C07D211/32 ,  C07D211/22 ,  C07D211/34 ,  C07D211/48 ,  C07D211/58 ,  C07D211/62 ,  C07D211/66 ,  C07D211/72 ,  C07D211/74 ,  C07D241/04 ,  C07D295/108 ,  C07D401/04 ,  C07D401/06 ,  C07D401/08 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D487/08

    摘要： A compound represented by the following general formula (I), its salt, solvates thereof or prodrugs thereof: (wherein each symbol is as defined in the description.) The compounds represented by the general formula (I) are useful in preventing and/or treating various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis, etc.), immunological diseases (autoimmune diseases, rejection in organ transplantation, immunosuppression, psoriasis, multiple sclerosis, etc.), infection with human immunodeficiency virus (acquired immunodeficiency syndrome, etc.), allergic diseases (atopic dermatitis, urticaria, allergic bronchoplumonary aspergillosis, allergic eosinophilic gastroenteritis, etc.), ischemic reperfusion injury, acute respiratory distress syndrome, shock accompanying bacterial infection, diabetes, cancer metastasis and so on.

    摘要翻译： 由以下通式（I）表示的化合物，其盐，溶剂合物或其前药：（其中每个符号如说明书中所定义）。由通式（I）表示的化合物可用于预防和/或 治疗各种炎性疾病（哮喘，肾炎，肾病，肝炎，关节炎，类风湿性关节炎，鼻炎，结膜炎，溃疡性结肠炎等），免疫疾病（器官移植中的自身免疫性疾病，排斥反应，免疫抑制，牛皮癣，多发性硬化症等） ，人类免疫缺陷病毒（获得性免疫缺陷综合征等）感染，过敏性疾病（特应性皮炎，荨麻疹，过敏性支气管曲霉曲霉菌，过敏性嗜酸性胃肠炎等），缺血再灌注损伤，急性呼吸窘迫综合征，伴随细菌感染的休克，糖尿病 ，癌转移等。

    Nitrogenous heterocylic derivative and medicine containing the same as an active ingredient
    5.
    发明授权
    Nitrogenous heterocylic derivative and medicine containing the same as an active ingredient 有权
    含氮杂环衍生物和含有与活性成分相同的药物

    公开(公告)号：US08143404B2

    公开(公告)日：2012-03-27

    申请号：US11662639

    申请日：2005-09-12

    申请人： Yoshikazu Takaoka ,  Shiro Shibayama ,  Rena Nishizawa

    发明人： Yoshikazu Takaoka ,  Shiro Shibayama ,  Rena Nishizawa

    IPC分类号： C07D211/68 ,  A61K31/445

    CPC分类号： C07D413/12 ,  A61K31/00 ,  C07D211/58 ,  C07D231/12 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14

    摘要： A compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof: (wherein each symbol is as defined in the description.) The compounds represented by formula (I) has the antagonistic activity against CCR5, so they are useful in preventing and/or treating CCR5-related diseases, for example, various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, inflammatory bowel disease such as ulcerative colitis, etc.), immunological diseases (autoimmune diseases, rejection in organ transplantation (rejection of graft of solid organ, rejection of graft of pancreatic islet cells in therapy for diabetes, graft-versus-host disease, etc.), immunosuppression, psoriasis, multiple sclerosis, etc.), infectious diseases (infection with human immunodeficiency virus, acquired immunodeficiency syndrome, infection with RSV, etc.), allergic diseases (atopic dermatitis, urticaria, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis, etc.), cardiovascular diseases (arteriosclerosis, ischemic reperfusion injury, etc.), acute respiratory distress syndrome, shock accompanying bacterial infection, diabetes, cancer metastasis and so on.

    摘要翻译： 由式（I）表示的化合物，其盐，其N-氧化物，其溶剂合物或其前药：（其中各符号如说明书中所定义）。式（I）表示的化合物具有拮抗作用 因此它们可用于预防和/或治疗CCR5相关疾病，例如各种炎性疾病（哮喘，肾炎，肾病，肝炎，关节炎，类风湿关节炎，鼻炎，结膜炎，炎性肠病如溃疡性结肠炎） 等等），免疫疾病（自身免疫性疾病，器官移植排斥反应（实体器官移植排斥反应，胰岛细胞移植对糖尿病的治疗排斥反应，移植物抗宿主病等），免疫抑制，牛皮癣， 多发性硬化症等），感染性疾病（人类免疫缺陷病毒感染，获得性免疫缺陷综合征，RSV感染等），过敏性疾病（特应性皮炎，荨麻疹，过敏性 急性呼吸窘迫综合征，伴随细菌感染的休克，糖尿病，癌症转移等），心血管疾病（动脉硬化，缺血再灌注损伤等）。

    Nitrogen-containing heterocyclic compounds and use thereof
    6.
    发明申请
    Nitrogen-containing heterocyclic compounds and use thereof 审中-公开
    含氮杂环化合物及其用途

    公开(公告)号：US20070155713A1

    公开(公告)日：2007-07-05

    申请号：US10554096

    申请日：2004-04-20

    申请人： Rena Nishizawa ,  Yoshikazu Takaoka ,  Shiro Shibayama

    发明人： Rena Nishizawa ,  Yoshikazu Takaoka ,  Shiro Shibayama

    IPC分类号： A61K31/55 ,  A61K31/498 ,  C07D487/10

    CPC分类号： C07D471/10 ,  A61K31/499

    摘要： A pharmaceutical composition comprising, as an active ingredient, the compounds represented by formula (I) (wherein all of the symbols have the same meanings as defined in specification.), salts thereof, solvates thereof, or prodrugs thereof. The compounds represented by formula (I) are used for prevention and/or treatment of various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, chronic rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis and the like), immunologic diseases (treatment of autoimmune diseases, transplant rejection, immunosuppression, psoriasis, multiple sclerosis and the like), human immunodeficiency virus infection (acquired immunodeficiency syndrome and the like), allergic diseases (atopic dermatitis, nettle rash, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis and the like), suppression of ischemia-reperfusion injury, acute respiratory distress syndrome, shock accompanied by bacterial infection, diabetes mellitus, or metastasis and the like.

    摘要翻译： 一种药物组合物，其包含作为活性成分的由式（I）表示的化合物（其中所有符号具有与说明书中定义相同的含义），其盐，溶剂化物或其前药。 由式（I）表示的化合物用于预防和/或治疗各种炎性疾病（哮喘，肾炎，肾病，肝炎，关节炎，慢性类风湿性关节炎，鼻炎，结膜炎，溃疡性结肠炎等），免疫疾病 自身免疫性疾病，移植排斥反应，免疫抑制，牛皮癣，多发性硬化等），人类免疫缺陷病毒感染（获得性免疫缺陷综合征等），过敏性疾病（特应性皮炎，荨麻疹，过敏性支气管肺曲霉病，过敏嗜酸性胃肠炎等） ），抑制缺血再灌注损伤，急性呼吸窘迫综合征，伴随细菌感染的休克，糖尿病或转移等。

    Nitrogenous Heterocylic Derivative and Medicine Containing the Same as an Active Ingredient
    9.
    发明申请
    Nitrogenous Heterocylic Derivative and Medicine Containing the Same as an Active Ingredient 有权
    含氮异构衍生物和含有与活性成分相同的药物

    公开(公告)号：US20080057074A1

    公开(公告)日：2008-03-06

    申请号：US11662639

    申请日：2005-09-12

    申请人： Yoshikazu Takaoka ,  Shiro Shibayama ,  Rena Nishizawa

    发明人： Yoshikazu Takaoka ,  Shiro Shibayama ,  Rena Nishizawa

    IPC分类号： C07D401/02 ,  A61K31/4427 ,  A61K31/444 ,  A61K31/4523 ,  A61K31/5377 ,  A61K31/55 ,  C07D401/14 ,  C07D451/02 ,  C07D413/02 ,  A61K39/21 ,  A61K39/42 ,  A61P31/12 ,  A61P31/18 ,  C07D211/68

    CPC分类号： C07D413/12 ,  A61K31/00 ,  C07D211/58 ,  C07D231/12 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14

    摘要： A compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof: (wherein each symbol is as defined in the description.) The compounds represented by formula (I) has the antagonistic activity against CCR5, so they are useful in preventing and/or treating CCR5-related diseases, for example, various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, inflammatory bowel disease such as ulcerative colitis, etc.), immunological diseases (autoimmune diseases, rejection in organ transplantation (rejection of graft of solid organ, rejection of graft of pancreatic islet cells in therapy for diabetes, graft-versus-host disease, etc.), immunosuppression, psoriasis, multiple sclerosis, etc.), infectious diseases (infection with human immunodeficiency virus, acquired immunodeficiency syndrome, infection with RSV, etc.), allergic diseases (atopic dermatitis, urticaria, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis, etc.), cardiovascular diseases (arteriosclerosis, ischemic reperfusion injury, etc.), acute respiratory distress syndrome, shock accompanying bacterial infection, diabetes, cancer metastasis and so on.

    摘要翻译： 由式（I）表示的化合物，其盐，其N-氧化物，其溶剂合物或其前药：（其中各符号如说明书中所定义）。式（I）表示的化合物具有拮抗作用 因此它们可用于预防和/或治疗CCR5相关疾病，例如各种炎性疾病（哮喘，肾炎，肾病，肝炎，关节炎，类风湿关节炎，鼻炎，结膜炎，炎性肠病如溃疡性结肠炎） 等等），免疫疾病（自身免疫性疾病，器官移植排斥反应（实体器官移植排斥反应，胰岛细胞移植对糖尿病的治疗排斥反应，移植物抗宿主病等），免疫抑制，牛皮癣， 多发性硬化症等），感染性疾病（人类免疫缺陷病毒感染，获得性免疫缺陷综合征，RSV感染等），过敏性疾病（特应性皮炎，荨麻疹，过敏性 急性呼吸窘迫综合征，伴随细菌感染的休克，糖尿病，癌症转移等），心血管疾病（动脉硬化，缺血再灌注损伤等）。

    Compound containing basic group and use thereof
    10.
    发明授权
    Compound containing basic group and use thereof 有权
    含有碱性基团的化合物及其用途

    公开(公告)号：US08822459B2

    公开(公告)日：2014-09-02

    申请号：US13027957

    申请日：2011-02-15

    申请人： Masaya Kokubo ,  Yoshikazu Takaoka ,  Shiro Shibayama

    发明人： Masaya Kokubo ,  Yoshikazu Takaoka ,  Shiro Shibayama

    IPC分类号： A61K31/535 ,  C07D265/28 ,  C07D471/10 ,  C07D233/90 ,  C07D401/14 ,  C07D487/10 ,  C07D233/16 ,  C07D233/84 ,  C07D403/12 ,  C07D403/14

    CPC分类号： C07D471/10 ,  C07D233/16 ,  C07D233/84 ,  C07D233/90 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D487/10

    摘要： The present invention relates to a compound represented by formula (I-0): wherein symbols in formula have the same meanings as described in the present specification, a salt thereof, an N-oxide thereof or a solvate thereof or a prodrug thereof, and medical use thereof. The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.

    摘要翻译： 本发明涉及由式（I-0）表示的化合物：其中式中的符号与本说明书中所述的相同含义，其盐，其N-氧化物或其溶剂合物或其前药，以及 医疗用途。 本发明的化合物对CXCR4具有拮抗作用，因此可用作CXCR4介导的疾病的预防和/或治疗剂，例如炎性和免疫疾病（例如类风湿性关节炎，关节炎，视网膜病变，肺纤维化 ，移植器官排斥反应等），过敏性疾病，感染（例如人类免疫缺陷病毒感染，获得性免疫缺陷综合征等），精神神经病，脑疾病，心血管疾病，代谢疾病和癌性疾病（例如癌症 ，癌转移等）或再生治疗剂。