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1.发明授权Use of an interleukin-10 antagonist to treat a B cell mediated autoimmune disorder 失效使用白细胞介素-10拮抗剂治疗B细胞介导的自身免疫性疾病
公开(公告)号：US5837232A
公开(公告)日：1998-11-17
申请号：US474851
申请日：1995-06-07
申请人： Rene De Waal Malefyt , Maureen Howard , Di-Hwei Hsu , Hiroshi Ishida , Anne O'Garra , Hergen Spits , Albert Zlotnik
发明人： Rene De Waal Malefyt , Maureen Howard , Di-Hwei Hsu , Hiroshi Ishida , Anne O'Garra , Hergen Spits , Albert Zlotnik
CPC分类号： C07K16/244 , C07K14/005 , C07K14/5428 , A61K38/00 , C07K2317/74 , C12N2710/16222 , Y10S514/886 , Y10S514/921
摘要： A method is provided for toting a B cell mediated autoimmune disorder comprising administering an effective amount of an interleukin-10 antagonist.
摘要翻译： 提供了一种用于治疗B细胞介导的自身免疫疾病的方法，包括施用有效量的白细胞介素-10拮抗剂。
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2.发明授权Use of interleukin-10 analogs for antagonists to treat endotoxin- or superantigen-induced toxicity 失效白介素-10类似物用于拮抗剂治疗内毒素或超抗原诱导的毒性
公开(公告)号：US5837293A
公开(公告)日：1998-11-17
申请号：US481560
申请日：1995-06-07
申请人： Rene De Waal Malefyt , Maureen Howard , Di-Hwei Hsu , Hiroshi Ishida , Anne O'Garra , Hergen Spits , Albert Zlotnik
发明人： Rene De Waal Malefyt , Maureen Howard , Di-Hwei Hsu , Hiroshi Ishida , Anne O'Garra , Hergen Spits , Albert Zlotnik
CPC分类号： C07K16/244 , C07K14/005 , C07K14/5428 , A61K38/00 , C07K2317/74 , C12N2710/16222 , Y10S514/886 , Y10S514/921
摘要： A method is provided for reducing an inflammatory response in a mammal comprising administering to a mammal at risk of developing or afflicted with an inflammatory response characterized by substantially elevated levels of IL-1.alpha., IL-1.beta., IL-6, IL-8 and TNF.alpha., an amount of IL-10 effective to substantially lower the levels of such cytokines.
摘要翻译： 提供了一种用于减少哺乳动物炎症反应的方法，其包括给患有风险发展或患有炎症反应的哺乳动物，其特征在于IL-1α，IL-1β，IL-6，IL-8水平显着升高 和TNFα，一定量的IL-10有效地显着降低这些细胞因子的水平。
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3.发明授权Use of interleukin-10 (IL-10) to treat endotoxin- or superantigen-induced toxicity 失效使用白细胞介素-10（IL-10）治疗内毒素或超抗原诱导的毒性
公开(公告)号：US5833976A
公开(公告)日：1998-11-10
申请号：US410654
申请日：1995-03-24
申请人： Rene de Waal Malefyt , Maureen Howard , Di-Hwei Hsu , Hiroshi Ishida , Anne O'Garra , Hergen Spits , Albert Zlotnik
发明人： Rene de Waal Malefyt , Maureen Howard , Di-Hwei Hsu , Hiroshi Ishida , Anne O'Garra , Hergen Spits , Albert Zlotnik
CPC分类号： C07K16/244 , C07K14/005 , C07K14/5428 , A61K38/00 , C07K2317/74 , C12N2710/16222 , Y10S514/886 , Y10S514/921
摘要： A method is provided for treating septic shock or toxic shock that comprises administering an effective amount of interleukin-10.
摘要翻译： 提供了一种治疗败血性休克或中毒性休克的方法，包括给予有效量的白细胞介素-10。
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公开(公告)号：US5776451A
公开(公告)日：1998-07-07
申请号：US270805
申请日：1994-07-05
申请人： Di-Hwei Hsu , Kevin W. Moore , Hergen Spits
发明人： Di-Hwei Hsu , Kevin W. Moore , Hergen Spits
IPC分类号： A61K38/00 , A61K35/14 , A61K38/20 , A61P35/00 , C07K14/05 , C07K14/54 , C12N5/0783 , A61K45/05
CPC分类号： C12N5/0636 , A61K35/17 , A61K38/2013 , C07K14/005 , C07K14/5428 , A61K2039/5158 , C12N2501/23 , C12N2710/16222
摘要： A method is provided for using interleukin-10 in adoptive immunotherapy of cancer. A population of tumor-infiltrating lymphocytes (TILs) are expanded in culture in the presence of interleukin-2 (IL-2) and interleukin-10 (IL-10). After administration of the TILs to a patient, effective amounts of both IL-2 and IL-10 are administered to enhance the tumor cell cytoxicity of the TILs and to reduce side effects caused by IL-2-induced cytokine production in the TILs and other cells of the patient.
摘要翻译： 提供了一种在癌症的过继性免疫治疗中使用白细胞介素-10的方法。 在白细胞介素-2（IL-2）和白细胞介素-10（IL-10）存在下，在培养物中扩增肿瘤浸润淋巴细胞群体（TILs）。 在向患者施用TIL后，施用有效量的IL-2和IL-10以增强TIL的肿瘤细胞的细胞毒性，并且减少由TIL等中IL-2诱导的细胞因子产生引起的副作用 患者细胞。
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公开(公告)号：US5789192A
公开(公告)日：1998-08-04
申请号：US110683
申请日：1993-08-23
申请人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , J. Fernando Bazan , Jimmy C. Tan , Chuan-Chu Chou
发明人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , J. Fernando Bazan , Jimmy C. Tan , Chuan-Chu Chou
IPC分类号： G01N33/577 , A61K38/00 , A61K39/395 , A61P31/04 , A61P37/00 , C07H21/04 , C07K14/54 , C07K14/715 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91
CPC分类号： C07K14/7155 , C07K14/5428 , A61K38/00 , C07K2319/00
摘要： Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.
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6.发明授权Antibodies which specifically bind mammalian receptors for interleukin-10 (IL-10) 失效特异性结合哺乳动物受体的白细胞介素-10（IL-10）
公开(公告)号：US5863796A
公开(公告)日：1999-01-26
申请号：US477166
申请日：1995-06-07
申请人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , J. Fernando Bazan , Jimmy C. Tan , Chuan-Chu Chou
发明人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , J. Fernando Bazan , Jimmy C. Tan , Chuan-Chu Chou
IPC分类号： G01N33/577 , A61K38/00 , A61K39/395 , A61P31/04 , A61P37/00 , C07H21/04 , C07K14/54 , C07K14/715 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , C07K16/28 , C12N5/12 , G01N33/53
CPC分类号： C07K14/7155 , C07K14/5428 , A61K38/00 , C07K2319/00
摘要： Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.
摘要翻译： 分离和表征IL-10的受体组分。 公开了编码受体的各种变体的氨基酸序列和核酸。 公开了纯化的受体基因和多肽的用途，包括用于筛选受体配体的激动剂和拮抗剂，用于产生诊断或治疗试剂以及产生抗体的手段。 还提供治疗或诊断试剂和试剂盒。
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公开(公告)号：US06423500B1
公开(公告)日：2002-07-23
申请号：US09439672
申请日：1999-11-15
申请人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , Bazan Fernando J. , Jimmy C. Tan , Chuan-Chu Chou
发明人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , Bazan Fernando J. , Jimmy C. Tan , Chuan-Chu Chou
IPC分类号： G01N3353
CPC分类号： C07K14/7155 , A61K38/00 , C07K14/5428 , C07K2319/00
摘要： Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.
摘要翻译： 分离和表征IL-10的受体组分。 公开了编码受体的各种变体的氨基酸序列和核酸。 公开了纯化的受体基因和多肽的用途，包括用于筛选受体配体的激动剂和拮抗剂，用于产生诊断或治疗试剂以及产生抗体的手段。 还提供治疗或诊断试剂和试剂盒。
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公开(公告)号：US5985828A
公开(公告)日：1999-11-16
申请号：US472097
申请日：1995-06-07
申请人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , J. Fernando Bazan , Jimmy C. Tan , Chuan-Chu Chou
发明人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , J. Fernando Bazan , Jimmy C. Tan , Chuan-Chu Chou
IPC分类号： G01N33/577 , A61K38/00 , A61K39/395 , A61P31/04 , A61P37/00 , C07H21/04 , C07K14/54 , C07K14/715 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , A61K38/16
CPC分类号： C07K14/7155 , C07K14/5428 , A61K38/00 , C07K2319/00
摘要： Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.
摘要翻译： 分离和表征IL-10的受体组分。 公开了编码受体的各种变体的氨基酸序列和核酸。 公开了纯化的受体基因和多肽的用途，包括用于筛选受体配体的激动剂和拮抗剂，用于产生诊断或治疗试剂以及产生抗体的手段。 还提供治疗或诊断试剂和试剂盒。
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