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1.发明授权2-Substituted-aminopropene-and propanenitrile antimicrobial and anti-inflammatory agents 失效2-取代的氨基丙烯和丙腈抗菌和抗炎剂
公开(公告)号：US4335141A
公开(公告)日：1982-06-15
申请号：US106616
申请日：1979-12-26
IPC分类号： A61K31/275 , A61K20060101 , A61P29/00 , A61P31/04 , C07C20060101 , C07C67/00 , C07C253/00 , C07C255/24 , C07C255/30 , C07C255/45 , C07C121/45 , C07C121/43 , C07C121/48
CPC分类号： C07C255/00
摘要： 2-Substituted-aminopropene and propanenitriles of the formula: ##STR1## are effective antimicrobial agents (compounds of Formula II.), and potent anti-inflammatory agents of decreased acute toxicity (compounds of Formula I.).
摘要翻译： 具有下式的2-取代的氨基丙烯和丙腈具有有效的抗微生物剂（式II化合物），以及急性毒性降低的有效抗炎剂（式Ⅰ化合物）。
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公开(公告)号：US4260760A
公开(公告)日：1981-04-07
申请号：US11294
申请日：1979-03-12
IPC分类号： A01N33/04 , A01N33/08 , A61K8/41 , A61Q11/00 , A61Q17/00 , A61Q19/00 , C07C45/42 , C07C45/48 , C07D241/04 , C07D295/00
CPC分类号： A61Q11/00 , A01N33/04 , A01N33/08 , A61K8/41 , A61Q17/005 , A61Q19/00 , C07C45/004 , C07C45/48 , C10M2201/02 , C10M2215/04 , C10M2215/042 , C10M2215/26 , C10M2217/046 , C10M2217/06 , C10N2240/401
摘要： Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
摘要翻译： 新的二苯基和低级烷基取代的二苯基多胺是有用的抗微生物剂，以及藻类抑制剂。 它们由于其低毒性而特别有用，因此有利地包括作为外科手术洗涤剂中的活性剂，抗菌皂，化妆品制剂中的防腐剂等。 它们也可用于局部治疗具有细菌来源或暗示的皮肤病学症状，例如寻常痤疮。
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公开(公告)号：US4340756A
公开(公告)日：1982-07-20
申请号：US231193
申请日：1981-02-04
CPC分类号： A61K8/41 , A01N33/04 , A01N33/08 , A61Q17/005 , C11D3/48
摘要： Novel halophenyl and loweralkyl substituted halophenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like.
摘要翻译： 新的卤代苯基和低级烷基取代的卤代苯基多胺是有用的抗微生物剂，以及藻类抑制剂。 它们由于其低毒性而特别有用，因此有利地包括作为外科手术洗涤剂中的活性剂，抗菌皂，化妆品制剂中的防腐剂等。
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公开(公告)号：US4339453A
公开(公告)日：1982-07-13
申请号：US59812
申请日：1979-07-23
申请人： Nathaniel Grier , Elbert E. Harris , Henry Joshua , Arthur A. Patchett , Bruce E. Witzel , Richard A. Dybas
发明人： Nathaniel Grier , Elbert E. Harris , Henry Joshua , Arthur A. Patchett , Bruce E. Witzel , Richard A. Dybas
IPC分类号： A01N43/54 , C07D239/42 , C07D239/48 , A01N21/02
CPC分类号： C07D239/42 , A01N43/54 , C07D239/48
摘要： 4-Amino- and 2,4-diaminopyrimidines with a quaternized ring nitrogen and an oxygen bearing substituent such as hydroxyalkyl, alkoxyalkyl, or alkanoyl on one of the exo- or endocyclic nitrogens and a C.sub.6-18 alkyl on another, are highly active antimicrobial agents with a relatively low acute mammalian toxicity.
摘要翻译： 具有季铵化环氮和含氧取代基的4-氨基 - 和2,4-二氨基嘧啶与外 - 或内环氮之间的羟烷基，烷氧基烷基或烷酰基和另一个上的C 6-18烷基是高活性抗微生物剂 急性哺乳动物毒性相对较低的药物。
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公开(公告)号：US4342872A
公开(公告)日：1982-08-03
申请号：US194489
申请日：1980-10-06
IPC分类号： C07D211/14 , C07D211/38 , C07D211/40 , C07D211/60 , C07D295/15
CPC分类号： C07D295/15 , C07D211/14 , C07D211/38 , C07D211/40 , C07D211/60
摘要： Antimicrobial agents suitable for use in aqueous systems for their prservation against biodeterioration include substitutedpiperidinomethylpropenenitriles and propanenitriles. The unsaturated compounds are prepared by reaction of a suitable piperidine with cyano acetic acid and formaledehyde: the propane derivatives therefrom by nucleophilic addition.
摘要翻译： 适用于水性体系以防止生物降解的抗微生物剂包括取代的哌啶基甲基丙烯腈和丙腈。 不饱和化合物通过合适的哌啶与氰基乙酸和缩甲醛的反应来制备：通过亲核加成从其中得到的丙烷衍生物。
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6.发明授权Treatment of pain, fever, and inflammation with compositions containing 2-(substitutedpiperidinomethyl)propane and propene nitriles 失效用包含2-（取代的哌啶甲基）丙烷和丙烯腈的组合物治疗疼痛，发热和炎症
公开(公告)号：US4254131A
公开(公告)日：1981-03-03
申请号：US68376
申请日：1979-08-21
IPC分类号： C07D221/20 , A61K31/445 , A61K31/451 , A61P25/04 , A61P29/00 , C07D211/14 , C07D211/22 , C07D211/26 , C07D211/38 , C07D211/46 , C07D211/52 , C07D211/62 , C07D295/145
CPC分类号： C07D295/145 , C07D211/14 , C07D211/22 , C07D211/26 , C07D211/38 , C07D211/46 , C07D211/62
摘要： A method of treating pain, fever, and inflammation and pharmaceutical compositions for use therein, wherein the active ingredient comprises a compound of the formula: ##STR1## wherein A and R.sub.1 represent various substituents.
摘要翻译： 一种治疗疼痛，发烧和炎症的方法及其中使用的药物组合物，其中活性成分包含下式的化合物：其中A和R 1代表各种取代基。
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公开(公告)号：US4247700A
公开(公告)日：1981-01-27
申请号：US8985
申请日：1979-02-05
IPC分类号： C07D211/14 , C07D211/38 , C07D211/40 , C07D211/60 , C07D295/15 , C07D211/26
CPC分类号： C07D295/15 , C07D211/14 , C07D211/38 , C07D211/40 , C07D211/60
摘要： Antimicrobial agents suitable for use in aqueous systems for their preservation against biodeterioration include substitutedpiperidinomethyl-propenenitriles and propanenitriles. The unsaturated compounds are prepared by reaction of a suitable piperidine with cyano acetic acid and formaldehyde: the propane derivatives therefrom by nucleophilic addition. spThis application is a continuation-in-part of Ser. No. 795,693, filed May 11, 1977, now abandoned.
摘要翻译： 适用于水性体系以防止生物降解的抗微生物剂包括取代的哌啶基甲基 - 丙烯腈和丙腈。 通过合适的哌啶与氰基乙酸和甲醛反应制备不饱和化合物：通过亲核加成从其中得到丙烷衍生物。
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公开(公告)号：US4145426A
公开(公告)日：1979-03-20
申请号：US816613
申请日：1977-07-18
IPC分类号： C07D211/46 , C07D295/108 , A61K31/445 , C07D211/22 , C07D211/32 , C07D211/44
CPC分类号： C07D295/108 , C07D211/46
摘要： Compounds of the structure: ##STR1## where A is either ##STR2## where R.sub.1 to R.sub.4 are various substituents are active as antibacterials and antifungals.
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公开(公告)号：US4070400A
公开(公告)日：1978-01-24
申请号：US622935
申请日：1975-10-16
IPC分类号： A01N33/08 , C07C45/00 , C07C49/215 , C07C87/38
CPC分类号： C07C49/215 , A01N33/08 , C07C45/004
摘要： Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
摘要翻译： 新的二苯基和低级烷基取代的二苯基多胺是有用的抗微生物剂，以及藻类抑制剂。 它们由于其低毒性而特别有用，因此有利地包括作为外科手术洗涤剂中的活性剂，抗菌皂，化妆品制剂中的防腐剂等。 它们也可用于局部治疗具有细菌来源或暗示的皮肤病学症状，例如寻常痤疮。
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公开(公告)号：US4061775A
公开(公告)日：1977-12-06
申请号：US609773
申请日：1975-09-02
IPC分类号： A61K31/135 , A01N33/02 , A01N33/04 , A61K8/41 , A61P31/04 , A61Q11/00 , A61Q17/00 , C07C45/48 , C07C49/215 , C07C67/00 , C07C209/00 , C07C209/52 , C07C211/27 , C07C213/00 , C07C215/18 , A01N9/20
CPC分类号： A61Q17/005 , A61K8/41 , A61Q11/00 , C07C45/48 , C07C49/215 , C10M2201/02 , C10M2215/04 , C10M2215/042 , C10M2215/26 , C10M2217/046 , C10M2217/06 , C10N2240/401
摘要： Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
摘要翻译： 新的二苯基和低级烷基取代的二苯基多胺是有用的抗微生物剂，以及藻类抑制剂。 它们由于其低毒性而特别有用，因此有利地包括作为外科手术洗涤剂中的活性剂，抗菌皂，化妆品制剂中的防腐剂等。 它们也可用于局部治疗具有细菌来源或暗示的皮肤病学症状，例如寻常痤疮。
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